Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sato T et al. | Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA. | 2017 | Microbiol. Immunol. | pmid:28504455 |
Trovatelli LD et al. | The effect of some antibiotics on Enterococcus faecium SF 68 inoculated in germ-free mice. | 1994 | Microbiol. Res. | pmid:7987613 |
Khaliq S et al. | Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702. | 2009 | Microbiol. Res. | pmid:17475458 |
Nguyen LT et al. | The tylosin producer, Streptomyces fradiae, contains a second valine dehydrogenase. | 1995 | Microbiology (Reading, Engl.) | pmid:7773408 |
Bate N et al. | The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. | 2000 | Microbiology (Reading, Engl.) | pmid:10658660 |
Köhler B et al. | Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains. | 2000 | Microbiology (Reading, Engl.) | pmid:10832635 |
Fish SA and Cundliffe E | Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors. | 1997 | Microbiology (Reading, Engl.) | pmid:9421911 |
Fouces R et al. | The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region. | 1999 | Microbiology (Reading, Engl.) | pmid:10220165 |
Butler AR et al. | Feedback control of polyketide metabolism during tylosin production. | 2001 | Microbiology (Reading, Engl.) | pmid:11283275 |
Salamakha OV et al. | [The study of the growth of tylosin producer using differential centrifugation of mycelium in a sucrose density gradient]. | 1989 Sep-Oct | Mikrobiologiia | pmid:2635267 |
Lee HJ and Jin HJ | Renaturation of recombinant ErmSF and its refolding behavior. | 2003 | Mol. Cells | pmid:14651260 |
Stonesifer J et al. | High frequency conjugal transfer of tylosin genes and amplifiable DNA in Streptomyces fradiae. | 1986 | Mol. Gen. Genet. | pmid:3458997 |
Stratigopoulos G et al. | Positive control of tylosin biosynthesis: pivotal role of TylR. | 2004 | Mol. Microbiol. | pmid:15554972 |
Gaisser S et al. | A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. | 2000 | Mol. Microbiol. | pmid:10792725 |
Bate N et al. | Regulation of tylosin biosynthesis involving 'SARP-helper' activity. | 2006 | Mol. Microbiol. | pmid:16942604 |
Merson-Davies LA and Cundliffe E | Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. | 1994 | Mol. Microbiol. | pmid:7984112 |
Bignell DR et al. | Regulation of tylosin production: role of a TylP-interactive ligand. | 2007 | Mol. Microbiol. | pmid:17181783 |
Catchpole I and Dyke KG | Replication mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance plasmid pT48. | 1991 | Mol. Microbiol. | pmid:1906970 |
Stratigopoulos G et al. | Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. | 2002 | Mol. Microbiol. | pmid:12139619 |
Bate N et al. | Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. | 2002 | Mol. Microbiol. | pmid:11985721 |