Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tylosin?

Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tylosin

MeSH term MeSH ID Detail
Pyoderma D011711 5 associated lipids
Lymphadenitis D008199 8 associated lipids
Campylobacter Infections D002169 13 associated lipids
Mycoplasma Infections D009175 13 associated lipids
Pasteurellosis, Pneumonic D012766 3 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Liver Abscess D008100 6 associated lipids
Treponemal Infections D014211 3 associated lipids
Dysentery D004403 4 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Mycotoxicosis D015651 5 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Ureaplasma Infections D016869 5 associated lipids
Pneumonia, Mycoplasma D011019 6 associated lipids
Tracheal Diseases D014133 3 associated lipids
Bacillaceae Infections D016863 1 associated lipids
Erysipelothrix Infections D004889 1 associated lipids
Keratoconjunctivitis, Infectious D007639 2 associated lipids
Neisseriaceae Infections D016870 3 associated lipids
Conjunctivitis, Viral D003236 1 associated lipids
Per page 10 20 50 | Total 47

PubChem Associated disorders and diseases

What pathways are associated with Tylosin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tylosin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tylosin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tylosin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Tylosin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tylosin?

Knock-out

Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tylosin

Download all related citations
Per page 10 20 50 100 | Total 931
Authors Title Published Journal PubMed Link
Sato T et al. Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA. 2017 Microbiol. Immunol. pmid:28504455
Trovatelli LD et al. The effect of some antibiotics on Enterococcus faecium SF 68 inoculated in germ-free mice. 1994 Microbiol. Res. pmid:7987613
Khaliq S et al. Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702. 2009 Microbiol. Res. pmid:17475458
Nguyen LT et al. The tylosin producer, Streptomyces fradiae, contains a second valine dehydrogenase. 1995 Microbiology (Reading, Engl.) pmid:7773408
Bate N et al. The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. 2000 Microbiology (Reading, Engl.) pmid:10658660
Köhler B et al. Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains. 2000 Microbiology (Reading, Engl.) pmid:10832635
Fish SA and Cundliffe E Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors. 1997 Microbiology (Reading, Engl.) pmid:9421911
Fouces R et al. The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region. 1999 Microbiology (Reading, Engl.) pmid:10220165
Butler AR et al. Feedback control of polyketide metabolism during tylosin production. 2001 Microbiology (Reading, Engl.) pmid:11283275
Salamakha OV et al. [The study of the growth of tylosin producer using differential centrifugation of mycelium in a sucrose density gradient]. 1989 Sep-Oct Mikrobiologiia pmid:2635267
Lee HJ and Jin HJ Renaturation of recombinant ErmSF and its refolding behavior. 2003 Mol. Cells pmid:14651260
Stonesifer J et al. High frequency conjugal transfer of tylosin genes and amplifiable DNA in Streptomyces fradiae. 1986 Mol. Gen. Genet. pmid:3458997
Stratigopoulos G et al. Positive control of tylosin biosynthesis: pivotal role of TylR. 2004 Mol. Microbiol. pmid:15554972
Gaisser S et al. A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. 2000 Mol. Microbiol. pmid:10792725
Bate N et al. Regulation of tylosin biosynthesis involving 'SARP-helper' activity. 2006 Mol. Microbiol. pmid:16942604
Merson-Davies LA and Cundliffe E Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. 1994 Mol. Microbiol. pmid:7984112
Bignell DR et al. Regulation of tylosin production: role of a TylP-interactive ligand. 2007 Mol. Microbiol. pmid:17181783
Catchpole I and Dyke KG Replication mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance plasmid pT48. 1991 Mol. Microbiol. pmid:1906970
Stratigopoulos G et al. Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. 2002 Mol. Microbiol. pmid:12139619
Bate N et al. Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. 2002 Mol. Microbiol. pmid:11985721