Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Herd MB et al. | Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. | 2013 | J. Neurosci. | pmid:24027285 |
Zhang Q et al. | Sorption of tylosin on clay minerals. | 2013 | Chemosphere | pmid:24007614 |
GarcÃa-Sánchez L et al. | Occurrence of tylosin in swine wastewater in Mexico. | 2013 | Water Sci. Technol. | pmid:23985521 |
Svartström O et al. | Characterization of Treponema spp. isolates from pigs with ear necrosis and shoulder ulcers. | 2013 | Vet. Microbiol. | pmid:23948134 |
Buß M et al. | Quality control ranges for tylosin 30 μg and 15 μg discs applicable to Staphylococcus aureus ATCC(R) 25923. | 2014 | J. Antimicrob. Chemother. | pmid:23928021 |
Panfilova ZI et al. | [Obtaining of mutants of Streptomyces fradiae producing tylosin by action of nitrosomethylurea on synchronously germinating spores]. | 1990 | Antibiot. Khimioter. | pmid:2383150 |
Mitchell JD et al. | In vitro pharmacodynamics of gamithromycin against Mycoplasma mycoides subspecies mycoides Small Colony. | 2013 | Vet. J. | pmid:23810743 |
Fujiwara T and Takenaka S | Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide to 19-deformyl-4'-deoxydesmycosin (TMC-016). | 1990 | FEMS Microbiol. Lett. | pmid:2379808 |
Topp E et al. | Accelerated Biodegradation of Veterinary Antibiotics in Agricultural Soil following Long-Term Exposure, and Isolation of a Sulfamethazine-degrading sp. | J. Environ. Qual. | pmid:23673752 | |
Amachawadi RG et al. | Occurrence of the transferable copper resistance gene tcrB among fecal enterococci of U.S. feedlot cattle fed copper-supplemented diets. | 2013 | Appl. Environ. Microbiol. | pmid:23666328 |
Chopra S et al. | Characterization of impurities in tylosin using dual liquid chromatography combined with ion trap mass spectrometry. | 2013 | Talanta | pmid:23598092 |
Pan R et al. | Extraction of trace tilmicosin in real water samples using ionic liquid-based aqueous two-phase systems. | 2013 | Water Sci. Technol. | pmid:23579819 |
Garcés-Narro C et al. | Efficacy of low-dose tylvalosin for the control of clostridiosis in broilers and its effect on productive parameters. | 2013 | Poult. Sci. | pmid:23472021 |
Lin J et al. | Response of intestinal microbiota to antibiotic growth promoters in chickens. | 2013 | Foodborne Pathog. Dis. | pmid:23461609 |
Meyer NF et al. | Effects of monensin and tylosin in finishing diets containing corn wet distillers grains with solubles with differing corn processing methods. | 2013 | J. Anim. Sci. | pmid:23422007 |
Pinckney JL et al. | Sublethal effects of the antibiotic tylosin on estuarine benthic microalgal communities. | 2013 | Mar. Pollut. Bull. | pmid:23398744 |
Holman DB and Chénier MR | Impact of subtherapeutic administration of tylosin and chlortetracycline on antimicrobial resistance in farrow-to-finish swine. | 2013 | FEMS Microbiol. Ecol. | pmid:23397987 |
Ali M et al. | Effect of redox potential and pH status on degradation and adsorption behavior of tylosin in dairy lagoon sediment suspension. | 2013 | Chemosphere | pmid:23352520 |
MiliavskiÄ EB et al. | [Electrophoretic separation of spores of producers of kanamycin and tylosin]. | 1990 | Antibiot. Khimioter. | pmid:2334246 |
Whitehead TR and Cotta MA | Stored swine manure and swine faeces as reservoirs of antibiotic resistance genes. | 2013 | Lett. Appl. Microbiol. | pmid:23297734 |
Hao H et al. | Mutational and transcriptomic changes involved in the development of macrolide resistance in Campylobacter jejuni. | 2013 | Antimicrob. Agents Chemother. | pmid:23274667 |
Fujiwara T et al. | Absorption, tissue distribution and excretion of 19-deformyldesmycosin derivatives, new 16-membered macrolides, in mice. | 1990 | J. Antibiot. | pmid:2324015 |
Burkin MA and Galvidis IA | Hapten modification approach for switching immunoassay specificity from selective to generic. | 2013 | J. Immunol. Methods | pmid:23234756 |
Tsutsui A et al. | Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. | 2013 | J. Antibiot. | pmid:23232930 |
Er A and Yazar E | Effects of tylosin, tilmicosin and tulathromycin on inflammatory mediators in bronchoalveolar lavage fluid of lipopolysaccharide-induced lung injury. | 2012 | Acta Vet. Hung. | pmid:23160029 |
Westermarck E and Wiberg M | Exocrine pancreatic insufficiency in the dog: historical background, diagnosis, and treatment. | 2012 | Top Companion Anim Med | pmid:23148848 |
Del Pozo Sacristán R et al. | Efficacy of in-feed medication with chlortetracycline in a farrow-to-finish herd against a clinical outbreak of respiratory disease in fattening pigs. | 2012 Dec 22-29 | Vet. Rec. | pmid:23136309 |
Devreese M et al. | An in vitro model using the IPEC-J2 cell line for efficacy and drug interaction testing of mycotoxin detoxifying agents. | 2013 | Toxicol In Vitro | pmid:23078954 |
Gaudin V et al. | Validation of two ELISA kits for the screening of tylosin and streptomycin in honey according to the European decision 2002/657/EC. | 2013 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:23013044 |
Malaiyandi V et al. | Airborne allergic contact dermatitis from tylosin in pharmacy compounders and cross-sensitization to macrolide antibiotics. | 2012 Sep-Oct | Dermatitis | pmid:23010831 |
Kim HB et al. | Microbial shifts in the swine distal gut in response to the treatment with antimicrobial growth promoter, tylosin. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22955886 |
Liu Y et al. | Transcriptional profiling of Haemophilus parasuis SH0165 response to tilmicosin. | 2012 | Microb. Drug Resist. | pmid:22935051 |
Andersen NM et al. | Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. | 2012 | Antimicrob. Agents Chemother. | pmid:22926570 |
Vandenberge V et al. | Transfer of flubendazole and tylosin from feed at cross-contamination levels to various poultry matrices. | 2012 | Poult. Sci. | pmid:22912473 |
Coleman MR and Mowrey DH | Turbidimetric assay of tylosin in animal feeds containing urea. | 1990 Nov-Dec | J Assoc Off Anal Chem | pmid:2289924 |
Srinivasan P et al. | Development of an HPLC method to analyze four veterinary antibiotics in soils and aqueous media and validation through fate studies. | 2012 | J Environ Sci Health A Tox Hazard Subst Environ Eng | pmid:22871010 |
Sakai A et al. | Production of a hybrid 16-membered macrolide antibiotic by genetic engineering of Micromonospora sp. TPMA0041. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22842988 |
Hagenbuch IM and Pinckney JL | Toxic effect of the combined antibiotics ciprofloxacin, lincomycin, and tylosin on two species of marine diatoms. | 2012 | Water Res. | pmid:22819871 |
Abutarbush SM et al. | Comparison of enrofloxacin and ceftiofur sodium for the treatment of relapse of undifferentiated fever/bovine respiratory disease in feedlot cattle. | 2012 | Can. Vet. J. | pmid:22753964 |
Jeong CY et al. | Effect of biochar amendment on tylosin adsorption-desorption and transport in two different soils. | 2012 Jul-Aug | J. Environ. Qual. | pmid:22751061 |
Devreese M et al. | Interaction between tylosin and bentonite clay from a pharmacokinetic perspective. | 2012 | Vet. J. | pmid:22749117 |
Granados-Chinchilla F et al. | A novel green chemistry method for nonaqueous extraction and high-performance liquid chromatography detection of first-, second-, and third-generation tetracyclines, 4-epitetracycline, and tylosin in animal feeds. | 2012 | J. Agric. Food Chem. | pmid:22738432 |
Blondeau JM et al. | Comparative minimum inhibitory and mutant prevention drug concentrations of enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin against bovine clinical isolates of Mannheimia haemolytica. | 2012 | Vet. Microbiol. | pmid:22677482 |
Kim HY et al. | Biochemical effects of veterinary antibiotics on proliferation and cell cycle arrest of human HEK293 cells. | 2012 | Bull Environ Contam Toxicol | pmid:22673765 |
Eguchi K et al. | Establishment of evaluation method to determine effects of veterinary medicinal products on manure fermentation using small-scale composting apparatus. | 2012 | J. Biosci. Bioeng. | pmid:22595343 |
Poehlsgaard J et al. | Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site. | 2012 | ACS Chem. Biol. | pmid:22563863 |
Morris FE et al. | Effect of rotating monensin plus tylosin and lasalocid on performance, ruminal fermentation, and site and extent of digestion in feedlot cattle. | 1990 | J. Anim. Sci. | pmid:2254185 |
Rose M et al. | Pharmacokinetics of tildipirosin in porcine plasma, lung tissue, and bronchial fluid and effects of test conditions on in vitro activity against reference strains and field isolates of Actinobacillus pleuropneumoniae. | 2013 | J. Vet. Pharmacol. Ther. | pmid:22500881 |
Vandenberge V et al. | Transfer of flubendazole and tylosin at cross contamination levels in the feed to egg matrices and distribution between egg yolk and egg white. | 2012 | Poult. Sci. | pmid:22499885 |
Persoons D et al. | Antimicrobial use in Belgian broiler production. | 2012 | Prev. Vet. Med. | pmid:22459488 |
Roudaut B and Moretain JP | Residues of macrolide antibiotics in eggs following medication of laying hens. | 1990 | Br. Poult. Sci. | pmid:2245358 |
Apley MD et al. | Use estimates of in-feed antimicrobials in swine production in the United States. | 2012 | Foodborne Pathog. Dis. | pmid:22324295 |
Huber ML et al. | Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin. | 1990 | Antimicrob. Agents Chemother. | pmid:2221862 |
Menge M et al. | Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). | 2012 | J. Vet. Pharmacol. Ther. | pmid:22188102 |
Peng D et al. | Development and validation of an indirect competitive enzyme-linked immunosorbent assay for the screening of tylosin and tilmicosin in muscle, liver, milk, honey and eggs. | 2012 | J. Agric. Food Chem. | pmid:22136611 |
Giordano R et al. | Effect of a high dose of three antibiotics on the reproduction of a parthenogenetic strain of Folsomia candida (Isotomidae: Collembola). | 2010 | Environ. Entomol. | pmid:22127168 |
Danzeisen JL et al. | Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment. | 2011 | PLoS ONE | pmid:22114729 |
Forrester CA et al. | Mycoplasma gallisepticum in pheasants and the efficacy of tylvalosin to treat the disease. | 2011 | Avian Pathol. | pmid:22107092 |
Xie S et al. | Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles. | 2011 | Part Fibre Toxicol | pmid:22098626 |
Pakpour S et al. | Frequency of antibiotic resistance in a swine facility 2.5 years after a ban on antibiotics. | 2012 | Microb. Ecol. | pmid:21997543 |
Rérat M et al. | Bovine respiratory disease: efficacy of different prophylactic treatments in veal calves and antimicrobial resistance of isolated Pasteurellaceae. | 2012 | Prev. Vet. Med. | pmid:21945813 |
Wang XF et al. | Enhancement of antibacterial activity of tilmicosin against Staphylococcus aureus by solid lipid nanoparticles in vitro and in vivo. | 2012 | Vet. J. | pmid:21900026 |
Stone JJ et al. | Land application of tylosin and chlortetracycline swine manure: Impacts to soil nutrients and soil microbial community structure. | 2011 | J Environ Sci Health B | pmid:21877979 |
Chelliapan S et al. | Tolerance of the antibiotic tylosin on treatment performance of an up-flow anaerobic stage reactor (UASR). | 2011 | Water Sci. Technol. | pmid:21866757 |
Kim KR et al. | Decline in extractable antibiotics in manure-based composts during composting. | 2012 | Waste Manag | pmid:21865024 |
Ashenafi D et al. | An improved liquid chromatographic method for the analysis of tylosin and its impurities. | 2011 | J Sep Sci | pmid:21812113 |
Gerchman I et al. | Characterization of in vivo-acquired resistance to macrolides of Mycoplasma gallisepticum strains isolated from poultry. | 2011 | Vet. Res. | pmid:21810258 |
Dinh QT et al. | Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC-MS/MS. | 2011 | Talanta | pmid:21807177 |
Bohm DA et al. | Preparation and characterisation of in-house reference material of tylosin in honey and results of a proficiency test. | 2011 | Anal. Chim. Acta | pmid:21742117 |
Bosi P et al. | Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota. | 2011 | J. Anim. Sci. | pmid:21724943 |
McClary DG et al. | Relationship of in vitro minimum inhibitory concentrations of tilmicosin against Mannheimia haemolytica and Pasteurella multocida and in vivo tilmicosin treatment outcome among calves with signs of bovine respiratory disease. | 2011 | J. Am. Vet. Med. Assoc. | pmid:21718206 |
Han AR et al. | Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae. | 2011 | J. Microbiol. Biotechnol. | pmid:21715968 |
Stead SL et al. | Development and validation of a potentiometric biosensor assay for tylosin with demonstrated applicability for the detection of two other antimicrobial growth-promoter compounds in feedstuffs. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21574083 |
Hidalgo à et al. | Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain. | 2011 | Antimicrob. Agents Chemother. | pmid:21555771 |
Smee NM and Towell TL | What is the evidence? Inflammatory bowel disease in a dog. | 2011 | J. Am. Vet. Med. Assoc. | pmid:21529230 |
Bernal J et al. | Determination of tylosins A, B, C and D in bee larvae by liquid chromatography coupled to ion trap-tandem mass spectrometry. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21498134 |
Kilpinen S et al. | Effect of tylosin on dogs with suspected tylosin-responsive diarrhea: a placebo-controlled, randomized, double-blinded, prospective clinical trial. | 2011 | Acta Vet. Scand. | pmid:21489311 |
Cacciapuoti AF et al. | Microbiological and pharmacokinetic studies of acyl demycinosyltylosin and related tylosin derivatives. | 1990 | J. Antibiot. | pmid:2145254 |
Zheng Y et al. | Molecularly imprinted solid-phase extraction for determination of tilmicosin in feed using high performance liquid chromatography. | 2011 | Anal. Chim. Acta | pmid:21435486 |
Ci X et al. | Anti-inflammatory effects of tilmicosin in a noninfectious mouse model of allergic asthma. | 2011 | Immunopharmacol Immunotoxicol | pmid:21428709 |
Cooprider KL et al. | Feedlot efficiency implications on greenhouse gas emissions and sustainability. | 2011 | J. Anim. Sci. | pmid:21398565 |
Juntunen P et al. | Longitudinal on-farm study of the development of antimicrobial resistance in Campylobacter coli from pigs before and after danofloxacin and tylosin treatments. | 2011 | Vet. Microbiol. | pmid:21397412 |
Kalmokoff M et al. | Continuous feeding of antimicrobial growth promoters to commercial swine during the growing/finishing phase does not modify faecal community erythromycin resistance or community structure. | 2011 | J. Appl. Microbiol. | pmid:21395944 |
Lombardi KR et al. | Pharmacokinetics of tilmicosin in beef cattle following intravenous and subcutaneous administration. | 2011 | J. Vet. Pharmacol. Ther. | pmid:21323676 |
Kucerova Z et al. | Antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolates from clinical outbreaks of porcine respiratory diseases. | 2011 | Vet. Microbiol. | pmid:21316872 |
Alexander TW et al. | Longitudinal characterization of antimicrobial resistance genes in feces shed from cattle fed different subtherapeutic antibiotics. | 2011 | BMC Microbiol. | pmid:21261985 |
Ozaki H et al. | Antimicrobial resistance in fecal Escherichia coli isolated from growing chickens on commercial broiler farms. | 2011 | Vet. Microbiol. | pmid:21232883 |
Reynaldi FJ et al. | [Binding of tylosin, tilmicosin and oxytetracycline to proteins from honeybees, larvae and beehive products]. | 2010 Oct-Dec | Rev. Argent. Microbiol. | pmid:21229198 |
Song M et al. | The controlled release of tilmicosin from silica nanoparticles. | 2011 | Drug Dev Ind Pharm | pmid:21204738 |
Collington GK et al. | The influence of inclusion of either an antibiotic or a probiotic in the diet on the development of digestive enzyme activity in the pig. | 1990 | Br. J. Nutr. | pmid:2119223 |
Park JW et al. | Generation of reduced macrolide analogs by regio-specific biotransformation. | 2011 | J. Antibiot. | pmid:21102594 |
Kim EY et al. | Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs. | 2011 | J. Vet. Med. Sci. | pmid:21068517 |
Scott BA et al. | Efficacy of tylosin tartrate on canine Staphylococcus intermedius isolates in vitro. | 2010 | Vet. Ther. | pmid:20960412 |
Shimada T et al. | Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor. | 2011 | Biotechnol. Bioeng. | pmid:20830676 |
Mazzilli M and Zecconi A | Assessment of epithelial cells' immune and inflammatory response to Staphylococcus aureus when exposed to a macrolide. | 2010 | J. Dairy Res. | pmid:20822561 |
Muraina IA et al. | Antimycoplasmal activity of some plant species from northern Nigeria compared to the currently used therapeutic agent. | 2010 | Pharm Biol | pmid:20819025 |
Navashin SM et al. | [Genetic and biochemical control of biosynthesis of macrolide antibiotics]. | 1990 | Antibiot. Khimioter. | pmid:2078074 |
Stone JJ et al. | Tylosin and chlortetracycline effects during swine manure digestion: influence of sodium azide. | 2010 | Bioresour. Technol. | pmid:20728345 |
Guan S et al. | Immunosuppressive activity of tilmicosin on the immune responses in mice. | 2011 | Immunopharmacol Immunotoxicol | pmid:20718577 |
Juntunen P et al. | Antimicrobial resistance in Campylobacter coli selected by tylosin treatment at a pig farm. | 2010 | Vet. Microbiol. | pmid:20684867 |