Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Prapasarakul N et al. | In vitro susceptibility and a new point mutation associated with tylosin-resistance in Japanese canine intestinal spirochetes. | 2003 | J. Vet. Med. Sci. | pmid:14709813 |
Katoh T et al. | Effect of a combination of antimicrobial agents for the treatment of respiratory disease in cattle. | 1996 | J. Vet. Med. Sci. | pmid:8877980 |
Kobayashi H et al. | In vitro susceptibility of Mycoplasma hyosynoviae and M. hyorhinis to antimicrobial agents. | 1996 | J. Vet. Med. Sci. | pmid:8959659 |
Mateusen B et al. | A comparative study of the preventive use of tilmicosin phosphate (Pulmotil premix) and Mycoplasma hyopneumoniae vaccination in a pig herd with chronic respiratory disease. | 2001 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:11846018 |
Hoflack G et al. | Efficacy of tilmicosin phosphate (Pulmotil premix) in feed for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs. | 2001 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:11765801 |
Altunok V et al. | Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12002421 |
Yazar E et al. | The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12069277 |
Westermarck E et al. | Tylosin-responsive chronic diarrhea in dogs. | 2005 Mar-Apr | J. Vet. Intern. Med. | pmid:15822561 |
German AJ et al. | Comparison of direct and indirect tests for small intestinal bacterial overgrowth and antibiotic-responsive diarrhea in dogs. | 2003 Jan-Feb | J. Vet. Intern. Med. | pmid:12564725 |
Westermarck E et al. | Effect of diet and tylosin on chronic diarrhea in beagles. | 2005 Nov-Dec | J. Vet. Intern. Med. | pmid:16355675 |
Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease. | 2002 | J. Vet. Diagn. Invest. | pmid:12296390 |
DeRosa DC et al. | In vitro susceptibility of porcine respiratory pathogens to tilmicosin. | 2000 | J. Vet. Diagn. Invest. | pmid:11108454 |
Harvey RB et al. | Influence of the antibiotics lincomycin and tylosin on aflatoxicosis when added to aflatoxin-contaminated diets of growing swine. | 1995 | J. Vet. Diagn. Invest. | pmid:7578454 |
Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella spp. associated with bovine respiratory disease. | 1996 | J. Vet. Diagn. Invest. | pmid:8844577 |
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Herd MB et al. | Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. | 2013 | J. Neurosci. | pmid:24027285 |
Kim E et al. | Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin. | 2016 | J. Nat. Prod. | pmid:27453999 |
Douthwaite S et al. | Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I. | 2008 | J. Mol. Biol. | pmid:18406425 |
Douthwaite S et al. | The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748. | 2004 | J. Mol. Biol. | pmid:15046978 |
Poulsen SM et al. | Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin. | 2000 | J. Mol. Biol. | pmid:11090288 |
Petropoulos AD et al. | Time-resolved binding of azithromycin to Escherichia coli ribosomes. | 2009 | J. Mol. Biol. | pmid:19071138 |
Kim J et al. | Effects of the Antibiotics Growth Promoter Tylosin on Swine Gut Microbiota. | 2016 | J. Microbiol. Biotechnol. | pmid:26869601 |
Cundliffe E | Control of tylosin biosynthesis in Streptomyces fradiae. | 2008 | J. Microbiol. Biotechnol. | pmid:18852501 |
Han AR et al. | Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae. | 2011 | J. Microbiol. Biotechnol. | pmid:21715968 |
Choi D et al. | Tylosin production by Streptomyces fradiae using raw cornmeal in airlift bioreactor. | 2007 | J. Microbiol. Biotechnol. | pmid:18051315 |
Nowakiewicz A et al. | Determination of antimicrobial resistance of Enterococcus strains isolated from pigs and their genotypic characterization by method of amplification of DNA fragments surrounding rare restriction sites (ADSRRS fingerprinting). | 2017 | J. Med. Microbiol. | pmid:28260584 |
Karlsson M et al. | Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin. | 2004 | J. Med. Microbiol. | pmid:15017283 |
Mutak S et al. | Semisynthetic macrolide antibacterials derived from tylosin. Synthesis and structure-activity relationships of novel desmycosin analogues. | 2004 | J. Med. Chem. | pmid:14711312 |
Phan LT et al. | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. | 2004 | J. Med. Chem. | pmid:15163176 |
Omura S et al. | Novel dimeric derivatives of leucomycins and tylosin, sixteen-membered macrolides. | 1982 | J. Med. Chem. | pmid:7040661 |
McFarland JW et al. | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. | 1997 | J. Med. Chem. | pmid:9135031 |
McFarland JW et al. | Repromicin derivatives with potent antibacterial activity against Pasteurella multocida. | 1997 | J. Med. Chem. | pmid:9083494 |
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de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of amides and amidines derived from 2-amino-1,10-phenanthroline. | 1991 | J. Med. Chem. | pmid:2002460 |
de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 2. Amidines. | 1989 | J. Med. Chem. | pmid:2913309 |
Kirst HA et al. | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. | 1988 | J. Med. Chem. | pmid:3398001 |
de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. | 1988 | J. Med. Chem. | pmid:3351847 |
Peng CY et al. | Laboratory and field studies on the effects of the antibiotic tylosin on honey bee Apis mellifera L. (Hymenoptera: Apidae) development and prevention of American foulbrood disease. | 1996 | J. Invertebr. Pathol. | pmid:8812572 |
Del Vecchio F et al. | Active-site residue, domain and module swaps in modular polyketide synthases. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12811585 |
Rodriguez E et al. | Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12698320 |
Flint SA et al. | Expression of tylM genes during tylosin production: phantom promoters and enigmatic translational coupling motifs. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:12074090 |
Zhu H et al. | Immobilization of Streptomyces thermotolerans 11432 on polyurethane foam to improve production of acetylisovaleryltylosin. | 2015 | J. Ind. Microbiol. Biotechnol. | pmid:25413211 |
Yeh WK | Evolving enzyme technology for pharmaceutical applications: case studies. | 1997 Nov-Dec | J. Ind. Microbiol. Biotechnol. | pmid:9451830 |
Sakai A et al. | Production of a hybrid 16-membered macrolide antibiotic by genetic engineering of Micromonospora sp. TPMA0041. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22842988 |
Butler AR and Cundliffe E | Influence of dimethylsulfoxide on tylosin production in Streptomyces fradiae. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11598810 |
Stratigopoulos G and Cundliffe E | Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:11986923 |
Brahimi-Horn MC et al. | Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae. | 1992 | J. Ind. Microbiol. | pmid:1381591 |
Burkin MA and Galvidis IA | Hapten modification approach for switching immunoassay specificity from selective to generic. | 2013 | J. Immunol. Methods | pmid:23234756 |
Wayner EA and Brooks CG | Induction of NKCF-like activity in mixed lymphocyte-tumor cell culture: direct involvement of mycoplasma infection of tumor cells. | 1984 | J. Immunol. | pmid:6230401 |