Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tylosin?

Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tylosin

MeSH term MeSH ID Detail
Poultry Diseases D011201 21 associated lipids
Pneumonia, Mycoplasma D011019 6 associated lipids
Pasteurella Infections D010326 8 associated lipids
Occupational Diseases D009784 42 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Mycoplasma Infections D009175 13 associated lipids
Lymphadenitis D008199 8 associated lipids
Liver Abscess D008100 6 associated lipids
Keratoconjunctivitis, Infectious D007639 2 associated lipids
Hyperplasia D006965 34 associated lipids
Per page 10 20 50 | Total 47

PubChem Associated disorders and diseases

What pathways are associated with Tylosin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tylosin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tylosin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tylosin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Tylosin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tylosin?

Knock-out

Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tylosin

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Per page 10 20 50 100 | Total 931
Authors Title Published Journal PubMed Link
Readnour RS et al. Determination of tilmicosin in swine feeds by liquid chromatography. 1997 Nov-Dec J AOAC Int pmid:9419854
Moran JW et al. Determination of tilmicosin in bovine and porcine sera by liquid chromatography. 1997 Nov-Dec J AOAC Int pmid:9419857
Gramse MJ et al. Determination of tylosin in feeds by liquid chromatography with solid-phase extraction. 2004 Mar-Apr J AOAC Int pmid:15164825
Markakis PK Microbiological method for determining macrolides in animal feeds in the presence of other drugs by thin-layer chromatography detection. 1996 Nov-Dec J AOAC Int pmid:8946704
Ragheb HS Antibiotics in feeds. 2001 Jan-Feb J AOAC Int pmid:11234833
Murphy MW et al. Airborne antibiotic concentrations in a swine feeding operation. 2007 J Agric Saf Health pmid:18075012
Dykman LA et al. [Immunogenic properties of the colloidal gold]. 2004 Jan-Feb Izv. Akad. Nauk. Ser. Biol. pmid:15049073
Anderegg TR and Jones RN Initial disk diffusion quality control guidelines for tylosin tested against Staphylococcus aureus ATCC 25923 and Streptococcus pneumoniae ATCC 49619. 2003 Int. J. Antimicrob. Agents pmid:12791478
Cao XY et al. Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes. 2006 Int. J. Antimicrob. Agents pmid:16647840
Diarra MS et al. Postantibiotic and physiological effects of tilmicosin, tylosin, and apramycin at subminimal and suprainhibitory concentrations on some swine and bovine respiratory tract pathogens. 1999 Int. J. Antimicrob. Agents pmid:10461841
Niwa H et al. Rapid detection of mutations associated with resistance to erythromycin in Campylobacter jejuni/coli by PCR and line probe assay. 2001 Int. J. Antimicrob. Agents pmid:11691569
Lim J and Yun H Postantibiotic effects and postantibiotic sub-MIC effects of erythromycin, roxithromycin, tilmicosin, and tylosin on Pasteurella multocida. 2001 Int. J. Antimicrob. Agents pmid:11397617
Chen X et al. Preparation and evaluation of tilmicosin-loaded hydrogenated castor oil nanoparticle suspensions of different particle sizes. 2014 Int J Nanomedicine pmid:24920902
Zhu L et al. Evaluation of the antibacterial activity of tilmicosin-SLN against : in vitro and in vivo studies. 2018 Int J Nanomedicine pmid:30147316
El-Mahmoudy A and Gheith I The anti-nociceptive potential of tilmicosin against chemical-induced but not thermal-induced pain in mice. 2016 Int J Immunopathol Pharmacol pmid:26519523
Ci X et al. Anti-inflammatory effects of tilmicosin in a noninfectious mouse model of allergic asthma. 2011 Immunopharmacol Immunotoxicol pmid:21428709
Guan S et al. Immunosuppressive activity of tilmicosin on the immune responses in mice. 2011 Immunopharmacol Immunotoxicol pmid:20718577
Forrester MB Human exposures to tilmicosin reported to poison centres, Texas, 1998-2003. 2005 Hum Exp Toxicol pmid:16004193
Takhirov MT et al. [Determination of tylosin in the water supply using a chromatographic method]. 1993 Gig Sanit pmid:8244081
Inouye M et al. Cloning and sequences of two macrolide-resistance-encoding genes from mycinamicin-producing Micromonospora griseorubida. 1994 Gene pmid:8163173
Solenberg PJ et al. Transposition mutagenesis in Streptomyces fradiae: identification of a neutral site for the stable insertion of DNA by transposon exchange. 1996 Gene pmid:8626067
Gandecha AR et al. Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. 1997 Gene pmid:9031628
Gandecha AR and Cundliffe E Molecular analysis of tlrD, an MLS resistance determinant from the tylosin producer, Streptomyces fradiae. 1996 Gene pmid:8973363
Rosteck PR et al. Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. 1991 Gene pmid:1864505
Zalacain M and Cundliffe E Cloning of tlrD, a fourth resistance gene, from the tylosin producer, Streptomyces fradiae. 1991 Gene pmid:1995426
Wilson VT and Cundliffe E Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae. 1998 Gene pmid:9651492
Kuhstoss S et al. Production of a novel polyketide through the construction of a hybrid polyketide synthase. 1996 Gene pmid:8996112
Baltz RH et al. Transposition of Tn5096 and related transposons in Streptomyces species. 1992 Gene pmid:1319378
Kounenis G et al. Comparative study of erythromycin, troleandomycin and tylosin on the rabbit intestine. 1994 Fundam Clin Pharmacol pmid:8020874
Ramlachan N et al. A comparative study on the effects of tylosin on select bacteria during continuous flow culture of mixed populations of gut microflora derived from a feral and a domestic pig. 2008 Foodborne Pathog. Dis. pmid:18260812
Hume ME and Donskey CJ Effect of Vancomycin, Tylosin, and Chlortetracycline on Vancomycin-Resistant Enterococcus faecium Colonization of Broiler Chickens During Grow-Out. 2017 Foodborne Pathog. Dis. pmid:28128649
Amachawadi RG et al. Effects of In-Feed Copper, Chlortetracycline, and Tylosin on the Prevalence of Transferable Copper Resistance Gene, tcrB, Among Fecal Enterococci of Weaned Piglets. 2015 Foodborne Pathog. Dis. pmid:26258261
Apley MD et al. Use estimates of in-feed antimicrobials in swine production in the United States. 2012 Foodborne Pathog. Dis. pmid:22324295
Lin J et al. Response of intestinal microbiota to antibiotic growth promoters in chickens. 2013 Foodborne Pathog. Dis. pmid:23461609
Molognoni L et al. Development of a LC-MS/MS method for the simultaneous determination of sorbic acid, natamycin and tylosin in Dulce de leche. 2016 Food Chem pmid:27283692
Baggio A et al. Residues of antibacterial drugs in honey from the Italian market. 2009 Food Addit Contam Part B Surveill pmid:24784967
Patyra E et al. Development and validation of an LC-MS/MS method for the quantification of tiamulin, trimethoprim, tylosin, sulfadiazine and sulfamethazine in medicated feed. 2018 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:29324179
Cornejo J et al. Depletion of tylosin residues in feathers, muscle and liver from broiler chickens after completion of antimicrobial therapy. 2018 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:29111882
De Baere S et al. In vitro model to assess the adsorption of oral veterinary drugs to mycotoxin binders in a feed- and aflatoxin B1-containing buffered matrix. 2018 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:30016205
Le T et al. A quantum dot-based immunoassay for screening of tylosin and tilmicosin in edible animal tissues. 2015 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:25822697
Stead SL et al. Development and validation of a potentiometric biosensor assay for tylosin with demonstrated applicability for the detection of two other antimicrobial growth-promoter compounds in feedstuffs. 2011 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:21574083
Gaudin V et al. Validation of two ELISA kits for the screening of tylosin and streptomycin in honey according to the European decision 2002/657/EC. 2013 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:23013044
Pol-Hofstad I et al. Collaborative study of a microbiological screening method (three-plate) for the banned antimicrobial growth promotors tylosin, virginiamycin, spiramycin, zinc bacitracin and avoparcin in animal feed. 2008 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:19680856
Higgins HC and McEvoy JD Accelerated solvent extraction of animal feedingstuffs for microbial growth inhibition screening for the presence of antimicrobial feed additives. 2002 Food Addit Contam pmid:12396393
Montesissa C et al. Tylosin depletion in edible tissues of turkeys. 1999 Food Addit Contam pmid:10755131
Koenen-Dierick K and De Beer JO Optimization of an antibiotic residue screening test, based on inhibition of Bacillus subtilis BGA, with experimental design. 1998 Food Addit Contam pmid:9829036
Vincent U et al. Validation of an analytical method for the determination of spiramycin, virginiamycin and tylosin in feeding-stuffs by thin-layer chromatography and bio-autography. 2007 Food Addit Contam pmid:17454108
Onan LJ and LaPara TM Tylosin-resistant bacteria cultivated from agricultural soil. 2003 FEMS Microbiol. Lett. pmid:12644222
Taniguchi K et al. The role of histidine residues conserved in the putative ATP-binding region of macrolide 2'-phosphotransferase II. 2004 FEMS Microbiol. Lett. pmid:15033229
Fouces R et al. Conjugation and transformation of Streptomyces species by tylosin resistance. 2000 FEMS Microbiol. Lett. pmid:10802191
Wu CM et al. Induction of macrolide resistance in Mycoplasma gallisepticum in vitro and its resistance-related mutations within domain V of 23S rRNA. 2005 FEMS Microbiol. Lett. pmid:15936901
Rezanka T et al. Isobutyrate as a precursor of n-butyrate in the biosynthesis of tylosine and fatty acids. 1991 FEMS Microbiol. Lett. pmid:1769552
Fujiwara T and Takenaka S Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide to 19-deformyl-4'-deoxydesmycosin (TMC-016). 1990 FEMS Microbiol. Lett. pmid:2379808
Karlsson M et al. Genetic basis of macrolide and lincosamide resistance in Brachyspira (Serpulina) hyodysenteriae. 1999 FEMS Microbiol. Lett. pmid:10188254
Holman DB and Chénier MR Temporal changes and the effect of subtherapeutic concentrations of antibiotics in the gut microbiota of swine. 2014 FEMS Microbiol. Ecol. pmid:25187398
Cleary DW et al. Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons. 2016 FEMS Microbiol. Ecol. pmid:27495240
Holman DB and Chénier MR Impact of subtherapeutic administration of tylosin and chlortetracycline on antimicrobial resistance in farrow-to-finish swine. 2013 FEMS Microbiol. Ecol. pmid:23397987
Moretto A et al. Slow release of two antibiotics of veterinary interest from PVA hydrogels. 2004 Farmaco pmid:14751309
Residues of some veterinary drugs in animals and foods. Monographs prepared by the Forty-Seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 4-13 June 1996. 1997 FAO Food Nutr Pap pmid:9253593
Residues of some veterinary drugs in animals and foods. Monographs prepared by the thirty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives. 1991 FAO Food Nutr Pap pmid:1687815
Shakeri-Nejad K and Stahlmann R Drug interactions during therapy with three major groups of antimicrobial agents. 2006 Expert Opin Pharmacother pmid:16556082
Iveković D et al. Electrochemical reduction of desmycosin, structure investigation and antibacterial evaluation of the resulting products. 2003 Eur J Pharm Sci pmid:12694884
Sassman SA et al. Sorption of tylosin A, D, and A-aldol and degradation of tylosin A in soils. 2007 Environ. Toxicol. Chem. pmid:17702335
Loftin KA et al. Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartrate. 2005 Environ. Toxicol. Chem. pmid:15839550
Halling-Sørensen B et al. Dissipation and effects of chlortetracycline and tylosin in two agricultural soils: a field-scale study in southern Denmark. 2005 Environ. Toxicol. Chem. pmid:15839553
Carlson JC and Mabury SA Dissipation kinetics and mobility of chlortetracycline, tylosin, and monensin in an agricultural soil in Northumberland County, Ontario, Canada. 2006 Environ. Toxicol. Chem. pmid:16494218
ter Laak TL et al. The effect of pH and ionic strength on the sorption of sulfachloropyridazine, tylosin, and oxytetracycline to soil. 2006 Environ. Toxicol. Chem. pmid:16629129
ter Laak TL et al. Estimation of soil sorption coefficients of veterinary pharmaceuticals from soil properties. 2006 Environ. Toxicol. Chem. pmid:16629132
Kay P et al. Fate of veterinary antibiotics in a macroporous tile drained clay soil. 2004 Environ. Toxicol. Chem. pmid:15180364
Hu D and Coats JR Aerobic degradation and photolysis of tylosin in water and soil. 2007 Environ. Toxicol. Chem. pmid:17521133
Hu D et al. Identification of tylosin photoreaction products and comparison of ELISA and HPLC methods for their detection in water. 2008 Environ. Sci. Technol. pmid:18497154
Demoling LA and Bååth E No long-term persistence of bacterial pollution-induced community tolerance in tylosin-polluted soil. 2008 Environ. Sci. Technol. pmid:18853809
Teeter JS and Meyerhoff RD Aerobic degradation of tylosin in cattle, chicken, and swine excreta. 2003 Environ. Res. pmid:12865047
Aust MO et al. Distribution of sulfamethazine, chlortetracycline and tylosin in manure and soil of Canadian feedlots after subtherapeutic use in cattle. 2008 Environ. Pollut. pmid:18440678
Kay P et al. A lysimeter experiment to investigate the leaching of veterinary antibiotics through a clay soil and comparison with field data. 2005 Environ. Pollut. pmid:15589660
Brain RA et al. Aquatic microcosm assessment of the effects of tylosin on Lemna gibba and Myriophyllum spicatum. 2005 Environ. Pollut. pmid:15519715
Zhang YJ et al. Temporal succession of soil antibiotic resistance genes following application of swine, cattle and poultry manures spiked with or without antibiotics. 2017 Environ. Pollut. pmid:28964602
Kline A and Pinckney JL Size-selective toxicity effects of the antimicrobial tylosin on estuarine phytoplankton communities. 2016 Environ. Pollut. pmid:27376985
Pei Z et al. Effects of copper and aluminum on the adsorption of sulfathiazole and tylosin on peat and soil. 2014 Environ. Pollut. pmid:24201036
Liu F et al. Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. 2009 Environ. Pollut. pmid:19157661
Giordano R et al. Effect of a high dose of three antibiotics on the reproduction of a parthenogenetic strain of Folsomia candida (Isotomidae: Collembola). 2010 Environ. Entomol. pmid:22127168
Yahiaoui I et al. Removal of a mixture tetracycline-tylosin from water based on anodic oxidation on a glassy carbon electrode coupled to activated sludge. Environ Technol pmid:25650749
Dong H et al. Synthesis and characterization of Ag/BiWO/GO composite for the fast degradation of tylosin under visible light. 2018 Environ Sci Pollut Res Int pmid:29442310
Ferrag-Siagh F et al. Electro-Fenton pretreatment for the improvement of tylosin biodegradability. 2014 Environ Sci Pollut Res Int pmid:24705893
Guo X et al. The influences of pH and ionic strength on the sorption of tylosin on goethite. 2014 Environ Sci Pollut Res Int pmid:24197966
Lebars I et al. Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII. 2003 EMBO J. pmid:12514124
Guo X et al. Maize straw decorated with sulfide for tylosin removal from the water. 2018 Ecotoxicol. Environ. Saf. pmid:29355772
Ingerslev F and Halling-Sørensen B Biodegradability of metronidazole, olaquindox, and tylosin and formation of tylosin degradation products in aerobic soil--manure slurries. 2001 Ecotoxicol. Environ. Saf. pmid:11222042
Nathues H and grosse Beilage E Diagnosis of Lawsonia intracellularis infection in pigs after vaccination or antimicrobial treatment. 2008 DTW. Dtsch. Tierarztl. Wochenschr. pmid:19024547
Atef M et al. Disposition of tylosin in goats. 1991 DTW. Dtsch. Tierarztl. Wochenschr. pmid:1790764
Dzapo V and Reiner G [The nutritive effect of avilamycin in swine breeding and fattening]. 1991 DTW. Dtsch. Tierarztl. Wochenschr. pmid:1954859
Atef M et al. Elimination of tilmicosin in lactating ewes. 1999 DTW. Dtsch. Tierarztl. Wochenschr. pmid:10481373
el-Sayed MG et al. Pharmacokinetic profile of tylosin in mastitic cows. 1986 DTW. Dtsch. Tierarztl. Wochenschr. pmid:3530702
Kietzmann M [Comparative study of the distribution and excretion of tylosin of various origins]. 1985 DTW. Dtsch. Tierarztl. Wochenschr. pmid:3899580
Atef M et al. Effect of albendazole administration on pharmacokinetic aspects of tylosin in lactating goats. 2009 Drug Metab Lett pmid:19702546
Song M et al. The controlled release of tilmicosin from silica nanoparticles. 2011 Drug Dev Ind Pharm pmid:21204738
Jung HD [Occupationally-induced contact eczema by tylosin (Tylan)]. 1983 Dermatol Monatsschr pmid:6222923
Zhang AJ and Warshaw EM Pet Consort Dermatitis: The Importance of Asking About Pets. Dermatitis pmid:29901502
Malaiyandi V et al. Airborne allergic contact dermatitis from tylosin in pharmacy compounders and cross-sensitization to macrolide antibiotics. 2012 Sep-Oct Dermatitis pmid:23010831
Whitehead TR and Cotta MA Sequence analyses of a broad host-range plasmid containing ermT from a tylosin-resistant Lactobacillus sp. Isolated from swine feces. 2001 Curr. Microbiol. pmid:11375658