| MeSH term | MeSH ID | Detail |
|---|---|---|
| Primate Diseases | D018419 | 2 associated lipids |
| Pneumonia of Calves, Enzootic | D048089 | 2 associated lipids |
| Pneumonia of Swine, Mycoplasmal | D045729 | 2 associated lipids |
| Bacillaceae Infections | D016863 | 1 associated lipids |
| Erysipelothrix Infections | D004889 | 1 associated lipids |
| Conjunctivitis, Viral | D003236 | 1 associated lipids |
| Enterotoxemia | D004767 | 1 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Appl. Environ. Microbiol. (2)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sato T et al. | Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA. | 2017 | Microbiol. Immunol. | pmid:28504455 |
| Trovatelli LD et al. | The effect of some antibiotics on Enterococcus faecium SF 68 inoculated in germ-free mice. | 1994 | Microbiol. Res. | pmid:7987613 |
| Khaliq S et al. | Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702. | 2009 | Microbiol. Res. | pmid:17475458 |
| Nguyen LT et al. | The tylosin producer, Streptomyces fradiae, contains a second valine dehydrogenase. | 1995 | Microbiology (Reading, Engl.) | pmid:7773408 |
| Bate N et al. | The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. | 2000 | Microbiology (Reading, Engl.) | pmid:10658660 |
| Köhler B et al. | Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains. | 2000 | Microbiology (Reading, Engl.) | pmid:10832635 |
| Fish SA and Cundliffe E | Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors. | 1997 | Microbiology (Reading, Engl.) | pmid:9421911 |
| Fouces R et al. | The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region. | 1999 | Microbiology (Reading, Engl.) | pmid:10220165 |
| Butler AR et al. | Feedback control of polyketide metabolism during tylosin production. | 2001 | Microbiology (Reading, Engl.) | pmid:11283275 |
| Salamakha OV et al. | [The study of the growth of tylosin producer using differential centrifugation of mycelium in a sucrose density gradient]. | 1989 Sep-Oct | Mikrobiologiia | pmid:2635267 |
| Lee HJ and Jin HJ | Renaturation of recombinant ErmSF and its refolding behavior. | 2003 | Mol. Cells | pmid:14651260 |
| Stonesifer J et al. | High frequency conjugal transfer of tylosin genes and amplifiable DNA in Streptomyces fradiae. | 1986 | Mol. Gen. Genet. | pmid:3458997 |
| Stratigopoulos G et al. | Positive control of tylosin biosynthesis: pivotal role of TylR. | 2004 | Mol. Microbiol. | pmid:15554972 |
| Gaisser S et al. | A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. | 2000 | Mol. Microbiol. | pmid:10792725 |
| Bate N et al. | Regulation of tylosin biosynthesis involving 'SARP-helper' activity. | 2006 | Mol. Microbiol. | pmid:16942604 |
| Merson-Davies LA and Cundliffe E | Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. | 1994 | Mol. Microbiol. | pmid:7984112 |
| Bignell DR et al. | Regulation of tylosin production: role of a TylP-interactive ligand. | 2007 | Mol. Microbiol. | pmid:17181783 |
| Kelemen GH et al. | Transcriptional attenuation control of the tylosin-resistance gene tlrA in Streptomyces fradiae. | 1994 | Mol. Microbiol. | pmid:7534372 |
| Catchpole I and Dyke KG | Replication mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance plasmid pT48. | 1991 | Mol. Microbiol. | pmid:1906970 |
| Stratigopoulos G et al. | Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. | 2002 | Mol. Microbiol. | pmid:12139619 |
| Bate N et al. | Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. | 2002 | Mol. Microbiol. | pmid:11985721 |
| Karahalios P et al. | On the mechanism of action of 9-O-arylalkyloxime derivatives of 6-O-mycaminosyltylonolide, a new class of 16-membered macrolide antibiotics. | 2006 | Mol. Pharmacol. | pmid:16873579 |
| Dinos GP et al. | Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex. | 2001 | Mol. Pharmacol. | pmid:11353804 |
| Lemli B et al. | Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin. | 2018 | Molecules | pmid:30065238 |
| Nobel YR et al. | Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. | 2015 | Nat Commun | pmid:26123276 |
| Ruiz VE et al. | A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. | 2017 | Nat Commun | pmid:28894149 |
| Trefzer A et al. | Genes and enzymes involved in deoxysugar biosynthesis in bacteria. | 1999 | Nat Prod Rep | pmid:10399362 |
| Stephanopoulos G | Metabolic engineering by genome shuffling. | 2002 | Nat. Biotechnol. | pmid:12089547 |
| Zhang YX et al. | Genome shuffling leads to rapid phenotypic improvement in bacteria. | 2002 | Nature | pmid:11832946 |
| Engi H | [Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments]. | 2009 | Orv Hetil | pmid:19293063 |
| Westermarck E et al. | Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. | 1993 | Pancreas | pmid:8302792 |
| Xie S et al. | Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles. | 2011 | Part Fibre Toxicol | pmid:22098626 |
| Kempf I et al. | [Efficacy of spiramycin and tylosin in preventing mycoplasmosis in chicks experimentally infected with mycoplasma gallisepticum]. | 1989 | Pathol. Biol. | pmid:2797880 |
| Muraina IA et al. | Antimycoplasmal activity of some plant species from northern Nigeria compared to the currently used therapeutic agent. | 2010 | Pharm Biol | pmid:20819025 |
| Meisel ML et al. | Effects of tylosin on the pituitary-gonadal axis in male rats. | 1993 Apr-May | Pharmacol. Toxicol. | pmid:8372057 |
| Menozzi A et al. | Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat. | 2005 | Pharmacology | pmid:15756055 |
| Krongdang S et al. | Multilocus sequence typing, biochemical and antibiotic resistance characterizations reveal diversity of North American strains of the honey bee pathogen Paenibacillus larvae. | 2017 | PLoS ONE | pmid:28467471 |
| Zhang N et al. | Determination of the Mutant Selection Window and Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin. | 2017 | PLoS ONE | pmid:28052123 |
| Galmozzi CV et al. | The Cyanobacterial Ribosomal-Associated Protein LrtA Is Involved in Post-Stress Survival in Synechocystis sp. PCC 6803. | 2016 | PLoS ONE | pmid:27442126 |
| Danzeisen JL et al. | Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment. | 2011 | PLoS ONE | pmid:22114729 |
| Kowalski C et al. | Pharmacokinetics of tylosin in broiler chickens. | 2002 | Pol J Vet Sci | pmid:12448074 |
| De Mil T et al. | Influence of mycotoxin binders on the oral bioavailability of tylosin, doxycycline, diclazuril, and salinomycin in fed broiler chickens. | 2017 | Poult. Sci. | pmid:28160001 |
| Poole TL et al. | Competitive exclusion of a glycopeptide-resistant Enterococcus faecium in the presence of vancomycin but not equivalent concentrations of tylosin or gentamicin. | 2004 | Poult. Sci. | pmid:15285499 |
| Vandenberge V et al. | Transfer of flubendazole and tylosin from feed at cross-contamination levels to various poultry matrices. | 2012 | Poult. Sci. | pmid:22912473 |
| Dafwang II et al. | Broiler chick growth response to antibiotics, 1981-1982. | 1984 | Poult. Sci. | pmid:6610176 |
| Vandenberge V et al. | Transfer of flubendazole and tylosin at cross contamination levels in the feed to egg matrices and distribution between egg yolk and egg white. | 2012 | Poult. Sci. | pmid:22499885 |
| Garcés-Narro C et al. | Efficacy of low-dose tylvalosin for the control of clostridiosis in broilers and its effect on productive parameters. | 2013 | Poult. Sci. | pmid:23472021 |
| Khalifeh MS et al. | Assessment of humoral and cellular-mediated immune response in chickens treated with tilmicosin, florfenicol, or enrofloxacin at the time of Newcastle disease vaccination. | 2009 | Poult. Sci. | pmid:19762865 |
| Scorneaux B and Shryock TR | Intracellular accumulation, subcellular distribution, and efflux of tilmicosin in chicken phagocytes. | 1998 | Poult. Sci. | pmid:9776059 |
| Baba T et al. | Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens. | 1998 | Poult. Sci. | pmid:9733118 |
| Brennan J et al. | Efficacy of in-feed tylosin phosphate for the treatment of necrotic enteritis in broiler chickens. | 2001 | Poult. Sci. | pmid:11599704 |
| Berrang ME et al. | Subtherapeutic tylosin phosphate in broiler feed affects Campylobacter on carcasses during processing. | 2007 | Poult. Sci. | pmid:17495097 |
| Weber NR et al. | Batch medication of intestinal infections in nursery pigs-A randomised clinical trial on the efficacy of treatment strategy, type of antibiotic and bacterial load on average daily weight gain. | 2017 | Prev. Vet. Med. | pmid:28107883 |
| Rérat M et al. | Bovine respiratory disease: efficacy of different prophylactic treatments in veal calves and antimicrobial resistance of isolated Pasteurellaceae. | 2012 | Prev. Vet. Med. | pmid:21945813 |
| Persoons D et al. | Antimicrobial use in Belgian broiler production. | 2012 | Prev. Vet. Med. | pmid:22459488 |
| Liutskanova DG et al. | [Increase in tylosin production by a commercial strain of Streptomyces fradiae]. | 2005 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:15859462 |
| Baltadzhieva D et al. | [Tylosin-specific proliferation in vitro of the peripheral blood mononuclear cells in occupational tylosin allergy]. | 1997 | Probl Khig | pmid:10202771 |
| Liu M and Douthwaite S | Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12417742 |
| Pfister P et al. | 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15795375 |
| Kim HB et al. | Microbial shifts in the swine distal gut in response to the treatment with antimicrobial growth promoter, tylosin. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22955886 |
| Fishman SE et al. | Cloning genes for the biosynthesis of a macrolide antibiotic. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3479787 |
| Thompson TS et al. | Determination of lincomycin and tylosin residues in honey by liquid chromatography/tandem mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15645470 |
| Kiehl DE and Kennington AS | Analysis of tilmicosin in swine liver extracts by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. | 1995 | Rapid Commun. Mass Spectrom. | pmid:8527821 |
| Stoev G and Nazarov V | Identification of the related substances of tilmicosin by liquid chromatography/ion trap mass spectrometry. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18491285 |
| Song W et al. | Determination of amprolium, carbadox, monensin, and tylosin in surface water by liquid chromatography/tandem mass spectrometry. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17510929 |
| Hao H et al. | Microbiological toxicity of tilmicosin on human colonic microflora in chemostats. | 2015 | Regul. Toxicol. Pharmacol. | pmid:26190303 |
| Akhter S et al. | Effect of antibiotics in extender on bacterial and spermatozoal quality of cooled buffalo (Bubalus bubalis) bull semen. | 2008 | Reprod. Domest. Anim. | pmid:18042206 |
| Yildiz S et al. | Tylosin does not affect GnRH-induced LH secretion in rams. | 2004 Jan-Feb | Reprod. Toxicol. | pmid:15013072 |
| Loria GR et al. | In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. | 2003 | Res. Vet. Sci. | pmid:12801456 |
| Prats C et al. | Tylosin depletion from edible pig tissues. | 2002 | Res. Vet. Sci. | pmid:12443694 |
| Timsit E et al. | Effects of nasal instillation of a nitric oxide-releasing solution or parenteral administration of tilmicosin on the nasopharyngeal microbiota of beef feedlot cattle at high-risk of developing respiratory tract disease. | 2017 | Res. Vet. Sci. | pmid:28231472 |
| Cooper AC et al. | In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance. | 1993 | Res. Vet. Sci. | pmid:8393208 |
| Cester CC et al. | Effect of stage of oestrous cycle on tylosin disposition in genital tract secretions of cows. | 1993 | Res. Vet. Sci. | pmid:8434145 |
| Crepieux T et al. | Randomized, non-inferiority trial comparing a nitric oxide releasing solution with a macrolide antibiotic for control of bovine respiratory disease in beef feedlot calves at high-risk of developing respiratory tract disease. | 2016 | Res. Vet. Sci. | pmid:27033936 |
| El-Ela FI et al. | Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens. | 2016 | Res. Vet. Sci. | pmid:27663366 |
| Ramadan A | Pharmacokinetics of tilmicosin in serum and milk of goats. | 1997 Jan-Feb | Res. Vet. Sci. | pmid:9160424 |
| Hannan PC et al. | Tylosin tartrate and tiamutilin effects on experimental piglet pneumonia induced with pneumonic pig lung homogenate containing mycoplasmas, bacteria and viruses. | 1982 | Res. Vet. Sci. | pmid:7134653 |
| Zweers-Zeilmaker WM et al. | In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle. | 1999 | Res. Vet. Sci. | pmid:10088712 |
| Allan EM and Pirie HM | In vitro activity of tiamulin against bovine respiratory tract mycoplasmas. | 1981 | Res. Vet. Sci. | pmid:7323463 |
| Pringle M et al. | Tiamulin resistance in porcine Brachyspira pilosicoli isolates. | 2006 | Res. Vet. Sci. | pmid:16253666 |
| Gourlay RN et al. | Effect of a new macrolide antibiotic (tilmicosin) on pneumonia experimentally induced in calves by Mycoplasma bovis and Pasteurella haemolytica. | 1989 | Res. Vet. Sci. | pmid:2772410 |
| Goodwin RF | In vitro activity of tiamulin against porcine mycoplasmas. | 1985 | Res. Vet. Sci. | pmid:3975477 |
| Prats C et al. | Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs. | 2002 | Res. Vet. Sci. | pmid:12204632 |
| Kempf I et al. | Efficacy of danofloxacin in the therapy of experimental mycoplasmosis in chicks. | 1992 | Res. Vet. Sci. | pmid:1332154 |
| Reynaldi FJ et al. | [Binding of tylosin, tilmicosin and oxytetracycline to proteins from honeybees, larvae and beehive products]. | 2010 Oct-Dec | Rev. Argent. Microbiol. | pmid:21229198 |
| Greer RT and Ryoo JP | Development of ocular inserts for cattle. | 1987 | Scanning Microsc. | pmid:3616580 |
| Huwyler U et al. | Efficacy evaluation of the use of oral tilmicosin in pneumonic calves. | 1999 | Schweiz. Arch. Tierheilkd. | pmid:10228400 |
| Xia X et al. | Proteomic analysis of tylosin-resistant Mycoplasma gallisepticum reveals enzymatic activities associated with resistance. | 2015 | Sci Rep | pmid:26584633 |
| Brown K et al. | Antimicrobial growth promoters modulate host responses in mice with a defined intestinal microbiota. | 2016 | Sci Rep | pmid:27929072 |
| Sura S et al. | Transport of three veterinary antimicrobials from feedlot pens via simulated rainfall runoff. | 2015 | Sci. Total Environ. | pmid:25839178 |
| Luby EM et al. | Fate and transport of tylosin-resistant bacteria and macrolide resistance genes in artificially drained agricultural fields receiving swine manure. | 2016 | Sci. Total Environ. | pmid:26874610 |
| Li Q et al. | Co-addition of manure increases the dissipation rates of tylosin A and the numbers of resistance genes in laboratory incubation experiments. | 2015 | Sci. Total Environ. | pmid:25958362 |
| Ishikawa NK et al. | Determination of tylosin excretion from sheep to assess tylosin spread to agricultural fields by manure application. | 2018 | Sci. Total Environ. | pmid:29579651 |
| Washington MT et al. | Monitoring tylosin and sulfamethazine in a tile-drained agricultural watershed using polar organic chemical integrative sampler (POCIS). | 2018 | Sci. Total Environ. | pmid:28854391 |
| Srinivasan P et al. | Sorption of selected veterinary antibiotics onto dairy farming soils of contrasting nature. | 2014 | Sci. Total Environ. | pmid:24326064 |
| Avci T and Elmas M | Milk and blood pharmacokinetics of tylosin and tilmicosin following parenteral administrations to cows. | 2014 | ScientificWorldJournal | pmid:25177733 |
| Xie W et al. | [Determination of five macrolide antibiotic residues in royal jelly samples by using high performance liquid chromatography tandem mass spectrometry]. | 2007 | Se Pu | pmid:17679440 |
| Horie M et al. | [Determination of spiramycin and tilmicosin in meat and fish by LC/MS]. | 2003 | Shokuhin Eiseigaku Zasshi | pmid:12968469 |
| Fang XM et al. | [A study on space mutation of Streptomyces fradiae]. | 2005 | Space Med Med Eng (Beijing) | pmid:15977391 |
| Dinh QT et al. | Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC-MS/MS. | 2011 | Talanta | pmid:21807177 |