| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pyoderma | D011711 | 5 associated lipids |
| Lymphadenitis | D008199 | 8 associated lipids |
| Campylobacter Infections | D002169 | 13 associated lipids |
| Mycoplasma Infections | D009175 | 13 associated lipids |
| Pasteurellosis, Pneumonic | D012766 | 3 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Liver Abscess | D008100 | 6 associated lipids |
| Treponemal Infections | D014211 | 3 associated lipids |
| Dysentery | D004403 | 4 associated lipids |
| Mycoplasmatales Infections | D009180 | 6 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Appl. Environ. Microbiol. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Maxwell CL et al. | Effects of beef production system on animal performance and carcass characteristics. | 2014 | J. Anim. Sci. | pmid:25403195 |
| Creemer LC et al. | Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin. | 2002 | J. Antibiot. | pmid:12061552 |
| Shimi IR et al. | Staphcoccomycin, a new basic macrolide antibiotic. | 1979 | J. Antibiot. | pmid:541251 |
| Kádár-Pauncz J et al. | Isolation and structure elucidation of new antibiotics related to angolamycin. | 1992 | J. Antibiot. | pmid:1399843 |
| Fujiwara T et al. | 19-Deformyl-4'-deoxydesmycosin (TMC-016): synthesis and biological properties of a unique 16-membered macrolide antibiotic. | 1989 | J. Antibiot. | pmid:2500413 |
| Kiyoshima K et al. | Structure-activity relationship studies on 4''-O-acyltylosin derivatives: significance of their 23-O-mycinosyl and 4''-O-acyl moieties in antimicrobial activity against macrolide-resistant microbes. | 1989 | J. Antibiot. | pmid:2584151 |
| Narandja A et al. | Structure-activity relationship among polyhydro derivatives of tylosin. | 1994 | J. Antibiot. | pmid:8040056 |
| Mandić Z et al. | New derivatives of tylosin: chemical and electrochemical oxidation products of desmycosin. | 2002 | J. Antibiot. | pmid:12458770 |
| Creemer LC et al. | Facile synthesis of tilmicosin and tylosin related haptens for use as protein conjugates. | 2003 | J. Antibiot. | pmid:12870814 |
| Bobillot S et al. | Chemical modification of tylosin. | 1995 | J. Antibiot. | pmid:7649866 |
| Creemer LC et al. | Synthesis, antimicrobial activity and in vivo fluorine NMR of a hexafluorinated derivative of tilmicosin. | 1995 | J. Antibiot. | pmid:7649867 |
| Narandja A et al. | 10,11,12,13-Tetrahydro derivatives of tylosin. II. Synthesis, antibacterial activity and tissue of 4'-deoxy-10,11,12,13-tetrahydrodesmycosin. | 1995 | J. Antibiot. | pmid:7730160 |
| Omura S et al. | Ammonium ions suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fradiae. | 1984 | J. Antibiot. | pmid:6511663 |
| Arisawa A et al. | Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae. | 1996 | J. Antibiot. | pmid:8641997 |
| Mandić Z et al. | Tylosin derivatives. V. Electrochemical opening of oxirane ring. | 1999 | J. Antibiot. | pmid:10695679 |
| Baltz RH et al. | Biosynthesis of the macrolide antibiotic tylosin. A preferred pathway from tylactone to tylosin. | 1983 | J. Antibiot. | pmid:6833128 |
| Omura S et al. | Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis. | 1983 | J. Antibiot. | pmid:6860432 |
| Tsuchiya M et al. | Binding of 3-O-acetyl-4"-O-isovaleryltylosin to ribosomes from a macrolide-resistant strain of Staphylococcus aureus. | 1982 | J. Antibiot. | pmid:7118723 |
| Sadakane N et al. | Hybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms. | 1982 | J. Antibiot. | pmid:7118724 |
| Vaughan RW et al. | Isolation and characterization of two 16-membered lactones: 20-deoxorosaramicin and 20-deoxo-12,13-desepoxy-12,13-dehydrorosaramicin aglycones, from a mutant strain of Micromonospora rosaria. | 1982 | J. Antibiot. | pmid:7076570 |
| Tsuchiya M et al. | Studies on the effects of 3-acetyl-4"-isovaleryltylosin against multiple-drug resistant strains of Staphylococcus aureus. | 1981 | J. Antibiot. | pmid:7275812 |
| Omura S et al. | X-ray crystallography of protylonolide and absolute configuration of tylosin. | 1980 | J. Antibiot. | pmid:7429997 |
| Tanaka A et al. | Synthesis of 4'-deoxymycaminosyl tylonolide. | 1981 | J. Antibiot. | pmid:7309633 |
| Tanaka A et al. | Syntheses of derivatives of 4'-deoxymycaminosyl tylonolide and mycaminosyl tylonolide modified AT C-23. | 1981 | J. Antibiot. | pmid:7309634 |
| Tanaka A et al. | Syntheses of 4'-deoxy-demycarosyl tylosin and its analogues. | 1981 | J. Antibiot. | pmid:7309635 |
| Omura S et al. | Ribosome-binding activities and antimicrobial activities of tylosin and its related compounds. | 1983 | J. Antibiot. | pmid:6662812 |
| Matsubara H et al. | Chemical modification of tylosin: synthesis of amino derivatives at C-20 position of tylosin and demycarosyltylosin. | 1983 | J. Antibiot. | pmid:6662813 |
| Tanaka Y et al. | Mechanism of nitrogen regulation of protylonolide biosynthesis in Streptomyces fradiae. | 1986 | J. Antibiot. | pmid:3733529 |
| Omura S et al. | Ammonium ion suppresses the biosynthesis of tylosin aglycone by interference with valine catabolism in Streptomyces fradiae. | 1983 | J. Antibiot. | pmid:6662823 |
| Park JW et al. | Generation of reduced macrolide analogs by regio-specific biotransformation. | 2011 | J. Antibiot. | pmid:21102594 |
| Lee BK et al. | Multistep bioconversion of 20-deoxo-20-dihydro-12,13-deepoxy-12,13-dehydrorosaranolide to 22-hydroxy-23-O-mycinosyl-20-deoxo-20-dihydro-12,13-deepoxy-rosaramicin. | 1983 | J. Antibiot. | pmid:6874596 |
| Sadakane N et al. | Hybrid biosynthesis of a new macrolide antibiotic by a daunomycin-producing microorganism. | 1983 | J. Antibiot. | pmid:6885644 |
| Naranda A et al. | New dihydro and tetrahydro derivatives of desmycosin. III. The opening of oxirane ring of 12,13-epoxydesmycosin. | 1997 | J. Antibiot. | pmid:9402992 |
| Fish SA and Cundliffe E | Structure-activity studies of tylosin-related macrolides. | 1996 | J. Antibiot. | pmid:8968399 |
| Tsutsui A et al. | Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. | 2013 | J. Antibiot. | pmid:23232930 |
| Norcia LJ et al. | In vitro microbiological characterization of novel macrolide CP-163,505 for animal health specific use. | 1998 | J. Antibiot. | pmid:9544934 |
| Fujiwara T et al. | Absorption, tissue distribution and excretion of 19-deformyldesmycosin derivatives, new 16-membered macrolides, in mice. | 1990 | J. Antibiot. | pmid:2324015 |
| Debono M et al. | Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. | 1989 | J. Antibiot. | pmid:2668243 |
| Kirst HA et al. | Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides. | 1989 | J. Antibiot. | pmid:2684947 |
| Naranda A and Lopotar N | New derivatives of tylosin. IV. Dihydro and tetrahydro desmycosin oximes. | 1999 | J. Antibiot. | pmid:10092201 |
| Omura S et al. | Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone. | 1984 | J. Antibiot. | pmid:6735923 |
| Omura S et al. | Valine as a precursor of n-butyrate unit in the biosynthesis of macrolide aglycone. | 1983 | J. Antibiot. | pmid:6874580 |
| Butler AR et al. | Influence of ancillary genes, encoding aspects of methionine metabolism, on tylosin biosynthesis in Streptomyces fradiae. | 2001 | J. Antibiot. | pmid:11594346 |
| Tsuzuki K et al. | Syntheses and antimicrobial activities of 9-O-acyl derivatives of tylosin and demycarosyltylosin. | 1986 | J. Antibiot. | pmid:3818453 |
| Kirst HA et al. | In vitro and in vivo evaluation of C-20- and C-23-modified derivatives of tylosin against veterinary pathogens. | 1988 | J. Antibiot. | pmid:3417566 |
| Ose EE | In vitro antibacterial properties of EL-870, a new semi-synthetic macrolide antibiotic. | 1987 | J. Antibiot. | pmid:3570967 |
| Wiley PF et al. | Enzymatic phosphorylation of macrolide antibiotics. | 1987 | J. Antibiot. | pmid:3570968 |
| Kiyoshima K et al. | New tylosin analogs produced by mutants of Streptomyces fradiae. | 1987 | J. Antibiot. | pmid:3680024 |
| Baltz RH and Stonesifer J | Phenotypic changes associated with loss of expression of tylosin biosynthesis and resistance genes in Streptomyces fradiae. | 1985 | J. Antibiot. | pmid:4066505 |
| Hranjec M et al. | New amidino-benzimidazolyl derivatives of tylosin and desmycosin. | 2002 | J. Antibiot. | pmid:12014447 |