| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Foreign Bodies | D005547 | 5 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Erysipelothrix Infections | D004889 | 1 associated lipids |
| Enterotoxemia | D004767 | 1 associated lipids |
| Dysentery | D004403 | 4 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Conjunctivitis, Viral | D003236 | 1 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Clostridium Infections | D003015 | 5 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Appl. Environ. Microbiol. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Westermarck E et al. | Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. | 1993 | Pancreas | pmid:8302792 |
| Engi H | [Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments]. | 2009 | Orv Hetil | pmid:19293063 |
| Zhang YX et al. | Genome shuffling leads to rapid phenotypic improvement in bacteria. | 2002 | Nature | pmid:11832946 |
| Stephanopoulos G | Metabolic engineering by genome shuffling. | 2002 | Nat. Biotechnol. | pmid:12089547 |
| Trefzer A et al. | Genes and enzymes involved in deoxysugar biosynthesis in bacteria. | 1999 | Nat Prod Rep | pmid:10399362 |
| Nobel YR et al. | Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. | 2015 | Nat Commun | pmid:26123276 |
| Ruiz VE et al. | A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. | 2017 | Nat Commun | pmid:28894149 |
| Lemli B et al. | Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin. | 2018 | Molecules | pmid:30065238 |
| Karahalios P et al. | On the mechanism of action of 9-O-arylalkyloxime derivatives of 6-O-mycaminosyltylonolide, a new class of 16-membered macrolide antibiotics. | 2006 | Mol. Pharmacol. | pmid:16873579 |
| Dinos GP et al. | Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex. | 2001 | Mol. Pharmacol. | pmid:11353804 |
| Stratigopoulos G et al. | Positive control of tylosin biosynthesis: pivotal role of TylR. | 2004 | Mol. Microbiol. | pmid:15554972 |
| Gaisser S et al. | A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. | 2000 | Mol. Microbiol. | pmid:10792725 |
| Bate N et al. | Regulation of tylosin biosynthesis involving 'SARP-helper' activity. | 2006 | Mol. Microbiol. | pmid:16942604 |
| Merson-Davies LA and Cundliffe E | Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. | 1994 | Mol. Microbiol. | pmid:7984112 |
| Bignell DR et al. | Regulation of tylosin production: role of a TylP-interactive ligand. | 2007 | Mol. Microbiol. | pmid:17181783 |
| Kelemen GH et al. | Transcriptional attenuation control of the tylosin-resistance gene tlrA in Streptomyces fradiae. | 1994 | Mol. Microbiol. | pmid:7534372 |
| Catchpole I and Dyke KG | Replication mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance plasmid pT48. | 1991 | Mol. Microbiol. | pmid:1906970 |
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| Lee HJ and Jin HJ | Renaturation of recombinant ErmSF and its refolding behavior. | 2003 | Mol. Cells | pmid:14651260 |
| Salamakha OV et al. | [The study of the growth of tylosin producer using differential centrifugation of mycelium in a sucrose density gradient]. | 1989 Sep-Oct | Mikrobiologiia | pmid:2635267 |
| Nguyen LT et al. | The tylosin producer, Streptomyces fradiae, contains a second valine dehydrogenase. | 1995 | Microbiology (Reading, Engl.) | pmid:7773408 |
| Bate N et al. | The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. | 2000 | Microbiology (Reading, Engl.) | pmid:10658660 |
| Köhler B et al. | Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains. | 2000 | Microbiology (Reading, Engl.) | pmid:10832635 |
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| Fouces R et al. | The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region. | 1999 | Microbiology (Reading, Engl.) | pmid:10220165 |
| Butler AR et al. | Feedback control of polyketide metabolism during tylosin production. | 2001 | Microbiology (Reading, Engl.) | pmid:11283275 |
| Trovatelli LD et al. | The effect of some antibiotics on Enterococcus faecium SF 68 inoculated in germ-free mice. | 1994 | Microbiol. Res. | pmid:7987613 |
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| Sato T et al. | Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA. | 2017 | Microbiol. Immunol. | pmid:28504455 |
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| Müller AK et al. | The diversity and function of soil microbial communities exposed to different disturbances. | 2002 | Microb. Ecol. | pmid:11976785 |
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| Lu C et al. | Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes. | 2015 | Microb. Cell Fact. | pmid:26525981 |
| Lum AM et al. | Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. | 2004 | Metab. Eng. | pmid:15256208 |
| Baltadzhieva D et al. | [Analysis of immunological indices of occupational sensibilization to tylosin]. | 1999 | Med Tr Prom Ekol | pmid:10605285 |
| Lowell JE et al. | Growth performance, carcass quality, fresh belly characteristics, and commercial bacon slicing yields of growing-finishing pigs fed a subtherapeutic dose of an antibiotic, a natural antimicrobial, or not fed an antibiotic or antimicrobial. | 2018 | Meat Sci. | pmid:29107868 |
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| Meisel ML et al. | Tylosin inhibits the steroidogenesis in mouse Leydig cells "in vitro". | 1993 | Life Sci. | pmid:8390595 |
| Davies R and Roberts TA | Antimicrobial susceptibility of enterococci recovered from commercial swine carcasses: effect of feed additives. | 1999 | Lett. Appl. Microbiol. | pmid:10664974 |
| Patterson J et al. | Selected culturable enteric bacterial populations are modified by diet acidification and the growth promotant Tylosin. | 2005 | Lett. Appl. Microbiol. | pmid:16033507 |
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