| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma | D001249 | 52 associated lipids |
| Ataxia | D001259 | 20 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Bacteriuria | D001437 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Campylobacter Infections | D002169 | 13 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Clostridium Infections | D003015 | 5 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Conjunctivitis, Viral | D003236 | 1 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Appl. Environ. Microbiol. (2)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Appl. Environ. Microbiol. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Omura S et al. | Novel dimeric derivatives of leucomycins and tylosin, sixteen-membered macrolides. | 1982 | J. Med. Chem. | pmid:7040661 |
| Kirst HA et al. | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. | 1988 | J. Med. Chem. | pmid:3398001 |
| de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. | 1988 | J. Med. Chem. | pmid:3351847 |
| Nowakiewicz A et al. | Determination of antimicrobial resistance of Enterococcus strains isolated from pigs and their genotypic characterization by method of amplification of DNA fragments surrounding rare restriction sites (ADSRRS fingerprinting). | 2017 | J. Med. Microbiol. | pmid:28260584 |
| Karlsson M et al. | Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin. | 2004 | J. Med. Microbiol. | pmid:15017283 |
| Kim J et al. | Effects of the Antibiotics Growth Promoter Tylosin on Swine Gut Microbiota. | 2016 | J. Microbiol. Biotechnol. | pmid:26869601 |
| Cundliffe E | Control of tylosin biosynthesis in Streptomyces fradiae. | 2008 | J. Microbiol. Biotechnol. | pmid:18852501 |
| Han AR et al. | Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae. | 2011 | J. Microbiol. Biotechnol. | pmid:21715968 |
| Choi D et al. | Tylosin production by Streptomyces fradiae using raw cornmeal in airlift bioreactor. | 2007 | J. Microbiol. Biotechnol. | pmid:18051315 |
| Douthwaite S et al. | Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I. | 2008 | J. Mol. Biol. | pmid:18406425 |
| Douthwaite S et al. | The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748. | 2004 | J. Mol. Biol. | pmid:15046978 |
| Poulsen SM et al. | Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin. | 2000 | J. Mol. Biol. | pmid:11090288 |
| Petropoulos AD et al. | Time-resolved binding of azithromycin to Escherichia coli ribosomes. | 2009 | J. Mol. Biol. | pmid:19071138 |
| Kim E et al. | Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin. | 2016 | J. Nat. Prod. | pmid:27453999 |
| Herd MB et al. | Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. | 2013 | J. Neurosci. | pmid:24027285 |
| Nakura H et al. | Formation of an antibacterial metabolite from a new macrolide compound 23-O-benzyl-5-mycaminosyl-tylonolide (TMC-101), by a hepatic microsomal drug-metabolizing enzyme system. | 1991 | J. Pharmacobio-dyn. | pmid:1802985 |
| Von Essen S et al. | Unintentional human exposure to tilmicosin (Micotil 300). | 2003 | J. Toxicol. Clin. Toxicol. | pmid:12807303 |
| Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease. | 2002 | J. Vet. Diagn. Invest. | pmid:12296390 |
| DeRosa DC et al. | In vitro susceptibility of porcine respiratory pathogens to tilmicosin. | 2000 | J. Vet. Diagn. Invest. | pmid:11108454 |
| Harvey RB et al. | Influence of the antibiotics lincomycin and tylosin on aflatoxicosis when added to aflatoxin-contaminated diets of growing swine. | 1995 | J. Vet. Diagn. Invest. | pmid:7578454 |
| Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella spp. associated with bovine respiratory disease. | 1996 | J. Vet. Diagn. Invest. | pmid:8844577 |
| Westermarck E et al. | Tylosin-responsive chronic diarrhea in dogs. | 2005 Mar-Apr | J. Vet. Intern. Med. | pmid:15822561 |
| German AJ et al. | Comparison of direct and indirect tests for small intestinal bacterial overgrowth and antibiotic-responsive diarrhea in dogs. | 2003 Jan-Feb | J. Vet. Intern. Med. | pmid:12564725 |
| Westermarck E et al. | Effect of diet and tylosin on chronic diarrhea in beagles. | 2005 Nov-Dec | J. Vet. Intern. Med. | pmid:16355675 |
| Mateusen B et al. | A comparative study of the preventive use of tilmicosin phosphate (Pulmotil premix) and Mycoplasma hyopneumoniae vaccination in a pig herd with chronic respiratory disease. | 2001 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:11846018 |
| Hoflack G et al. | Efficacy of tilmicosin phosphate (Pulmotil premix) in feed for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs. | 2001 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:11765801 |
| Altunok V et al. | Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12002421 |
| Yazar E et al. | The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12069277 |
| Prapasarakul N et al. | In vitro susceptibility and a new point mutation associated with tylosin-resistance in Japanese canine intestinal spirochetes. | 2003 | J. Vet. Med. Sci. | pmid:14709813 |
| Kim EY et al. | Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs. | 2011 | J. Vet. Med. Sci. | pmid:21068517 |
| Katoh T et al. | The fractional inhibitory concentration index of antimicrobial agents for bacteria and Mycoplasma isolated from the nasal swabs of cattle with respiratory diseases. | 1996 | J. Vet. Med. Sci. | pmid:8877979 |
| Katoh T et al. | Effect of a combination of antimicrobial agents for the treatment of respiratory disease in cattle. | 1996 | J. Vet. Med. Sci. | pmid:8877980 |
| Inamoto T et al. | Antibacterial activity of tilmicosin against Pasteurella multocida and Actinobacillus pleuropneumoniae isolated from pneumonic lesions in swine. | 1994 | J. Vet. Med. Sci. | pmid:7865594 |
| Kobayashi H et al. | In vitro susceptibility of Mycoplasma hyosynoviae and M. hyorhinis to antimicrobial agents. | 1996 | J. Vet. Med. Sci. | pmid:8959659 |
| Kim MH et al. | Comparative pharmacokinetics of tylosin or florfenicol after a single intramuscular administration at two different doses of tylosin-florfenicol combination in pigs. | 2008 | J. Vet. Med. Sci. | pmid:18250580 |
| Fajt VR et al. | The effects of danofloxacin and tilmicosin on neutrophil function and lung consolidation in beef heifer calves with induced Pasteurella (Mannheimia) haemolytica pneumonia. | 2003 | J. Vet. Pharmacol. Ther. | pmid:12755900 |
| Jordan FT et al. | A comparison of the efficacy of danofloxacin and tylosin in the control of Mycoplasma gallisepticum infection in broiler chicks. | 1993 | J. Vet. Pharmacol. Ther. | pmid:8386777 |
| Fajt VR et al. | Effects of danofloxacin and tilmicosin on circulating neutrophils in beef heifers. | 2000 | J. Vet. Pharmacol. Ther. | pmid:11110107 |
| Canning P et al. | Concentrations of tylvalosin and 3-O-acetyltylosin attained in the synovial fluid of swine after administration by oral gavage at 50 and 5Â mg/kg. | 2016 | J. Vet. Pharmacol. Ther. | pmid:27086612 |
| Ling Z et al. | Preparation, characterization, and pharmacokinetics of tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles. | 2017 | J. Vet. Pharmacol. Ther. | pmid:27687707 |
| Menge M et al. | Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). | 2012 | J. Vet. Pharmacol. Ther. | pmid:22188102 |
| Wang J et al. | Pharmacokinetics of tildipirosin in beagle dogs. | 2018 | J. Vet. Pharmacol. Ther. | pmid:28892155 |
| Mohammadsadegh M | Impact of intramammary tilmicosin infusion as a dry cow therapy. | 2018 | J. Vet. Pharmacol. Ther. | pmid:28600854 |
| Han C et al. | Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies. | 2009 | J. Vet. Pharmacol. Ther. | pmid:19290940 |
| Scorneaux B and Shryock TR | Intracellular accumulation, subcellular distribution and efflux of tilmicosin in swine phagocytes. | 1998 | J. Vet. Pharmacol. Ther. | pmid:9731947 |
| Scorneaux B and Shryock TR | The determination of the cellular volume of avian, porcine and bovine phagocytes and bovine mammary epithelial cells and its relationship to uptake of tilmicosin. | 1999 | J. Vet. Pharmacol. Ther. | pmid:10211711 |
| Cerdá RO et al. | Impact of the type of catheter on the absorption of tylvalosin (acetylvaleryltylosin) administered orally to broiler chickens. | 2010 | J. Vet. Pharmacol. Ther. | pmid:20444046 |
| Lombardi KR et al. | Pharmacokinetics of tilmicosin in beef cattle following intravenous and subcutaneous administration. | 2011 | J. Vet. Pharmacol. Ther. | pmid:21323676 |
| Modric S et al. | Pharmacokinetics and pharmacodynamics of tilmicosin in sheep and cattle. | 1998 | J. Vet. Pharmacol. Ther. | pmid:9885967 |
| Foster DM et al. | Comparison of direct sampling and brochoalveolar lavage for determining active drug concentrations in the pulmonary epithelial lining fluid of calves injected with enrofloxacin or tilmicosin. | 2017 | J. Vet. Pharmacol. Ther. | pmid:28457009 |