| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma | D001249 | 52 associated lipids |
| Ataxia | D001259 | 20 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Bacteriuria | D001437 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Campylobacter Infections | D002169 | 13 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Clostridium Infections | D003015 | 5 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Conjunctivitis, Viral | D003236 | 1 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Appl. Environ. Microbiol. (2)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Evans RD et al. | Field evaluation of tylosin premix in layers previously vaccinated with a live Mycoplasma gallisepticum vaccine. | 2002 Jan-Mar | Avian Dis. | pmid:11922337 |
| Cerdá RO et al. | In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina. | 2002 Jan-Mar | Avian Dis. | pmid:11922338 |
| Müller AK et al. | The diversity and function of soil microbial communities exposed to different disturbances. | 2002 | Microb. Ecol. | pmid:11976785 |
| Bate N et al. | Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. | 2002 | Mol. Microbiol. | pmid:11985721 |
| Stratigopoulos G and Cundliffe E | Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:11986923 |
| Van Donkersgoed J et al. | The effect of administering long-acting oxytetracycline and tilmicosin either by dart gun or by hand on injection site lesions and drug residues in beef cattle. | 1999 | Can. Vet. J. | pmid:12001341 |
| Schunich OC et al. | A comparison of prophylactic efficacy of tilmicosin and a new formulation of oxytetracycline in feedlot calves. | 2002 | Can. Vet. J. | pmid:12001501 |
| Han H et al. | Carbohydrate fermentation and nitrogen metabolism of a finishing beef diet by ruminal microbes in continuous cultures as affected by ethoxyquin and(or) supplementation of monensin and tylosin. | 2002 | J. Anim. Sci. | pmid:12002320 |
| Altunok V et al. | Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12002421 |
| Hranjec M et al. | New amidino-benzimidazolyl derivatives of tylosin and desmycosin. | 2002 | J. Antibiot. | pmid:12014447 |
| Lakritz J et al. | Tilmicosin reduces lipopolysaccharide-stimulated bovine alveolar macrophage prostaglandin E(2) production via a mechanism involving phospholipases. | 2002 | Vet. Ther. | pmid:12050824 |
| Hibbard B et al. | Dose determination and confirmation for ceftiofur crystalline-free acid administered in the posterior aspect of the ear for control and treatment of bovine respiratory disease. | 2002 | Vet. Ther. | pmid:12050825 |
| Creemer LC et al. | Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin. | 2002 | J. Antibiot. | pmid:12061552 |
| Yazar E et al. | The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12069277 |
| Flint SA et al. | Expression of tylM genes during tylosin production: phantom promoters and enigmatic translational coupling motifs. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:12074090 |
| Stephanopoulos G | Metabolic engineering by genome shuffling. | 2002 | Nat. Biotechnol. | pmid:12089547 |
| Gautier-Bouchardon AV et al. | In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae. | 2002 | Vet. Microbiol. | pmid:12119137 |
| Stratigopoulos G et al. | Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. | 2002 | Mol. Microbiol. | pmid:12139619 |
| Loke ML et al. | Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosin A, olaquindox and metronidazole in manure. | 2002 | Chemosphere | pmid:12146624 |
| Carter JN et al. | Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease. | 2002 | Am. J. Vet. Res. | pmid:12171163 |
| Takahashi I et al. | [In vitro resistance acquisition in Mycoplasma gallisepticum against ofloxacin, tylosin and spectinomycin]. | 2002 | Jpn J Antibiot | pmid:12199113 |
| Prats C et al. | Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs. | 2002 | Res. Vet. Sci. | pmid:12204632 |
| Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease. | 2002 | J. Vet. Diagn. Invest. | pmid:12296390 |
| Higgins HC and McEvoy JD | Accelerated solvent extraction of animal feedingstuffs for microbial growth inhibition screening for the presence of antimicrobial feed additives. | 2002 | Food Addit Contam | pmid:12396393 |
| Liu M and Douthwaite S | Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12417742 |
| Christodoulopoulos G et al. | Tilmicosin administration to young lambs with respiratory infection: safety and efficacy considerations. | 2002 | J. Vet. Pharmacol. Ther. | pmid:12423233 |
| Hwang YH et al. | Simultaneous determination of various macrolides by liquid chromatography/mass spectrometry. | 2002 | J. Vet. Sci. | pmid:12441679 |
| Lee SW et al. | Prevalence of porcine proliferative enteropathy and its control with tylosin in Korea. | 2001 | J. Vet. Sci. | pmid:12441690 |
| Prats C et al. | Tylosin depletion from edible pig tissues. | 2002 | Res. Vet. Sci. | pmid:12443694 |
| Kowalski C et al. | Pharmacokinetics of tylosin in broiler chickens. | 2002 | Pol J Vet Sci | pmid:12448074 |
| Mandić Z et al. | New derivatives of tylosin: chemical and electrochemical oxidation products of desmycosin. | 2002 | J. Antibiot. | pmid:12458770 |
| Ives SE et al. | Effects of virginiamycin and monensin plus tylosin on ruminal protein metabolism in steers fed corn-based finishing diets with or without wet corn gluten feed. | 2002 | J. Anim. Sci. | pmid:12462270 |
| Clark SB et al. | Interlaboratory comparison of methods for the determination of incurred tilmicosin residues in bovine liver. | 2002 Nov-Dec | J AOAC Int | pmid:12477187 |
| Poole TL et al. | Effect of subtherapeutic concentrations of tylosin on the inhibitory stringency of a mixed anaerobe continuous-flow culture of chicken microflora against Escherichia coli O157:H7. | 2003 | J. Appl. Microbiol. | pmid:12492926 |
| Dingwell RT et al. | The efficacy of intramammary tilmicosin at drying-off, and other risk factors for the prevention of new intramammary infections during the dry period. | 2002 | J. Dairy Sci. | pmid:12512598 |
| Lebars I et al. | Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII. | 2003 | EMBO J. | pmid:12514124 |
| Elzen PJ et al. | Method of application of tylosin, an antibiotic for American foulbrood control, with effects on small hive beetle (Coleoptera: Nitidulidae) populations. | 2002 | J. Econ. Entomol. | pmid:12539820 |
| German AJ et al. | Comparison of direct and indirect tests for small intestinal bacterial overgrowth and antibiotic-responsive diarrhea in dogs. | 2003 Jan-Feb | J. Vet. Intern. Med. | pmid:12564725 |
| Dingwell RT et al. | Efficacy of intramammary tilmicosin and risk factors for cure of Staphylococcus aureus infection in the dry period. | 2003 | J. Dairy Sci. | pmid:12613861 |
| Onan LJ and LaPara TM | Tylosin-resistant bacteria cultivated from agricultural soil. | 2003 | FEMS Microbiol. Lett. | pmid:12644222 |
| Althaus RL et al. | Detection limits of antimicrobials in ewe milk by delvotest photometric measurements. | 2003 | J. Dairy Sci. | pmid:12647952 |
| Iveković D et al. | Electrochemical reduction of desmycosin, structure investigation and antibacterial evaluation of the resulting products. | 2003 | Eur J Pharm Sci | pmid:12694884 |
| Rodriguez E et al. | Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12698320 |
| De Liguoro M et al. | Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil. | 2003 | Chemosphere | pmid:12729703 |
| Marks SL and Kather EJ | Antimicrobial susceptibilities of canine Clostridium difficile and Clostridium perfringens isolates to commonly utilized antimicrobial drugs. | 2003 | Vet. Microbiol. | pmid:12742714 |
| Fajt VR et al. | The effects of danofloxacin and tilmicosin on neutrophil function and lung consolidation in beef heifer calves with induced Pasteurella (Mannheimia) haemolytica pneumonia. | 2003 | J. Vet. Pharmacol. Ther. | pmid:12755900 |
| Neiffer DL | Clostridium perfringens enterotoxicosis in two Amur leopards (Panthera pardus orientalis). | 2001 | J. Zoo Wildl. Med. | pmid:12790411 |
| Anderegg TR and Jones RN | Initial disk diffusion quality control guidelines for tylosin tested against Staphylococcus aureus ATCC 25923 and Streptococcus pneumoniae ATCC 49619. | 2003 | Int. J. Antimicrob. Agents | pmid:12791478 |
| Tarabla H and Canavesio V | Prevalence of intramammary infections by major pathogens at parturition in dairy cows after intramuscular antibiotic therapy at drying-off: a preliminary report. | 2003 | J. Dairy Res. | pmid:12800878 |
| Loria GR et al. | In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. | 2003 | Res. Vet. Sci. | pmid:12801456 |
| Von Essen S et al. | Unintentional human exposure to tilmicosin (Micotil 300). | 2003 | J. Toxicol. Clin. Toxicol. | pmid:12807303 |
| Del Vecchio F et al. | Active-site residue, domain and module swaps in modular polyketide synthases. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12811585 |
| Teeter JS and Meyerhoff RD | Aerobic degradation of tylosin in cattle, chicken, and swine excreta. | 2003 | Environ. Res. | pmid:12865047 |
| Creemer LC et al. | Facile synthesis of tilmicosin and tylosin related haptens for use as protein conjugates. | 2003 | J. Antibiot. | pmid:12870814 |
| Van Lunen TA | Growth performance of pigs fed diets with and without tylosin phosphate supplementation and reared in a biosecure all-in all-out housing system. | 2003 | Can. Vet. J. | pmid:12892287 |
| Moubareck C et al. | Multiple antibiotic resistance gene transfer from animal to human enterococci in the digestive tract of gnotobiotic mice. | 2003 | Antimicrob. Agents Chemother. | pmid:12937011 |
| Malanicheva IA et al. | [Protoplast fusion in Streptomyces fradiae strains producing neomycin and tylosin]. | 1992 | Antibiot. Khimioter. | pmid:1296531 |
| Horie M et al. | [Determination of spiramycin and tilmicosin in meat and fish by LC/MS]. | 2003 | Shokuhin Eiseigaku Zasshi | pmid:12968469 |
| Baltz RH et al. | Transposition of Tn5096 and related transposons in Streptomyces species. | 1992 | Gene | pmid:1319378 |
| Kempf I et al. | Efficacy of danofloxacin in the therapy of experimental mycoplasmosis in chicks. | 1992 | Res. Vet. Sci. | pmid:1332154 |
| DENNY CB et al. | Effects of tylosin and nisin on canned food spoilage bacteria. | 1961 | Appl Microbiol | pmid:13721908 |
| Arzey GG and Arzey KE | Successful treatment of mycoplasmosis in layer chickens with single dose therapy. | 1992 | Aust. Vet. J. | pmid:1379426 |
| Brahimi-Horn MC et al. | Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae. | 1992 | J. Ind. Microbiol. | pmid:1381591 |
| Kádár-Pauncz J et al. | Isolation and structure elucidation of new antibiotics related to angolamycin. | 1992 | J. Antibiot. | pmid:1399843 |
| Gummow B et al. | The diagnosis and treatment of bovine genital ureaplasmosis: a case study. | 1992 | J S Afr Vet Assoc | pmid:1404223 |
| Chin NX and Neu HC | In vitro activity of MC-352, a new 16-membered macrolide. | 1992 | Antimicrob. Agents Chemother. | pmid:1416853 |
| Galyean ML et al. | Performance of feedlot steers fed diets containing laidlomycin propionate or monensin plus tylosin, and effects of laidlomycin propionate concentration on intake patterns and ruminal fermentation in beef steers during adaptation to a high-concentrate diet. | 1992 | J. Anim. Sci. | pmid:1429270 |
| DOORNENBAL H | CLINICAL EVALUATION OF TYLOSIN AS A TREATMENT OF VIBRIONIC DYSENTERY IN SWINE. | 1965 | Can J Comp Med Vet Sci | pmid:14300858 |
| Collier CT et al. | Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis. | 2003 | Antimicrob. Agents Chemother. | pmid:14506046 |
| Chuard C et al. | In-vitro and in-vivo evaluation of the antistaphylococcal activity of S-5556, a new 16-membered macrolide. | 1992 | J. Antimicrob. Chemother. | pmid:1452498 |
| Jost BH et al. | Tylosin resistance in Arcanobacterium pyogenes is encoded by an erm X determinant. | 2003 | Antimicrob. Agents Chemother. | pmid:14576111 |
| Sumbatyan NV et al. | Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors. | 2003 | Biochemistry Mosc. | pmid:14616087 |
| Montesissa C et al. | Metabolism of tilmicosin by rabbit liver microsomes and hepatocytes. | 2004 | Vet. J. | pmid:14623156 |
| Lee HJ and Jin HJ | Renaturation of recombinant ErmSF and its refolding behavior. | 2003 | Mol. Cells | pmid:14651260 |
| Thompson TS et al. | Determination of lincomycin and tylosin residues in honey using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. | 2003 | J Chromatogr A | pmid:14661747 |
| Prapasarakul N et al. | In vitro susceptibility and a new point mutation associated with tylosin-resistance in Japanese canine intestinal spirochetes. | 2003 | J. Vet. Med. Sci. | pmid:14709813 |
| Mutak S et al. | Semisynthetic macrolide antibacterials derived from tylosin. Synthesis and structure-activity relationships of novel desmycosin analogues. | 2004 | J. Med. Chem. | pmid:14711312 |
| Wang J | Determination of five macrolide antibiotic residues in honey by LC-ESI-MS and LC-ESI-MS/MS. | 2004 | J. Agric. Food Chem. | pmid:14733491 |
| Ammida NH et al. | Analysis of erythromycin and tylosin in bovine muscle using disposable screen printed electrodes. | 2004 | Analyst | pmid:14737577 |
| Moretto A et al. | Slow release of two antibiotics of veterinary interest from PVA hydrogels. | 2004 | Farmaco | pmid:14751309 |
| Kumar K et al. | Enzyme-linked immunosorbent assay for ultratrace determination of antibiotics in aqueous samples. | 2004 Jan-Feb | J. Environ. Qual. | pmid:14964379 |
| Paradis MA et al. | Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine. | 2004 | Can. J. Vet. Res. | pmid:14979429 |
| Jost BH et al. | A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes. | 2004 | Antimicrob. Agents Chemother. | pmid:14982756 |
| Yildiz S et al. | Tylosin does not affect GnRH-induced LH secretion in rams. | 2004 Jan-Feb | Reprod. Toxicol. | pmid:15013072 |
| Karlsson M et al. | Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin. | 2004 | J. Med. Microbiol. | pmid:15017283 |
| Taniguchi K et al. | The role of histidine residues conserved in the putative ATP-binding region of macrolide 2'-phosphotransferase II. | 2004 | FEMS Microbiol. Lett. | pmid:15033229 |
| Douthwaite S et al. | The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748. | 2004 | J. Mol. Biol. | pmid:15046978 |
| Dykman LA et al. | [Immunogenic properties of the colloidal gold]. | 2004 Jan-Feb | Izv. Akad. Nauk. Ser. Biol. | pmid:15049073 |
| Chirase NK et al. | Effect of simulated ambient particulate matter exposure on performance, rectal temperature, and leukocytosis of young Spanish goats with or without tilmicosin phosphate. | 2004 | J. Anim. Sci. | pmid:15080345 |
| Cusack PM | Effect of mass medication with antibiotics at feedlot entry on the health and growth rate of cattle destined for the Australian domestic market. | 2004 | Aust. Vet. J. | pmid:15088981 |
| Lee WD et al. | Tilmicosin-induced bovine neutrophil apoptosis is cell-specific and downregulates spontaneous LTB4 synthesis without increasing Fas expression. | 2004 Mar-Apr | Vet. Res. | pmid:15099497 |
| Zhang Y et al. | Residue depletion of tilmicosin in chicken tissues. | 2004 | J. Agric. Food Chem. | pmid:15113165 |
| Van Poucke C et al. | Tylosin detection in animal feed by liquid chromatography-tandem mass spectrometry with enzymatic hydrolysis of the tylosin urea adduct. | 2004 | J. Agric. Food Chem. | pmid:15137817 |
| Fajt VR et al. | Effect of danofloxacin and tilmicosin on body temperatures of beef calves with pneumonia experimentally induced by inoculation with Mannheimia haemolytica. | 2004 | Am. J. Vet. Res. | pmid:15141881 |
| Pettis JS et al. | Larval Apis mellifera L. (Hymenoptera: Apidae) mortality after topical application of antibiotics and dusts. | 2004 | J. Econ. Entomol. | pmid:15154433 |
| Rowan TG et al. | Efficacy of danofloxacin in the treatment of respiratory disease in European cattle. | 2004 | Vet. Rec. | pmid:15160844 |
| Phan LT et al. | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. | 2004 | J. Med. Chem. | pmid:15163176 |
| Gramse MJ et al. | Determination of tylosin in feeds by liquid chromatography with solid-phase extraction. | 2004 Mar-Apr | J AOAC Int | pmid:15164825 |
| Kay P et al. | Fate of veterinary antibiotics in a macroporous tile drained clay soil. | 2004 | Environ. Toxicol. Chem. | pmid:15180364 |
| Lawrence K | Change to user warning for Micotil. | 2004 | Vet. Rec. | pmid:15200081 |