| MeSH term | MeSH ID | Detail |
|---|---|---|
| Digital Dermatitis | D058066 | 3 associated lipids |
| Bovine Respiratory Disease Complex | D048090 | 2 associated lipids |
| Pneumonia of Calves, Enzootic | D048089 | 2 associated lipids |
| Desulfovibrionaceae Infections | D045824 | 5 associated lipids |
| Pneumonia of Swine, Mycoplasmal | D045729 | 2 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Primate Diseases | D018419 | 2 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Neisseriaceae Infections | D016870 | 3 associated lipids |
| Ureaplasma Infections | D016869 | 5 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Appl. Environ. Microbiol. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- FEMS Microbiol. Lett. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shimi IR et al. | Staphcoccomycin, a new basic macrolide antibiotic. | 1979 | J. Antibiot. | pmid:541251 |
| Kádár-Pauncz J et al. | Isolation and structure elucidation of new antibiotics related to angolamycin. | 1992 | J. Antibiot. | pmid:1399843 |
| Fujiwara T et al. | 19-Deformyl-4'-deoxydesmycosin (TMC-016): synthesis and biological properties of a unique 16-membered macrolide antibiotic. | 1989 | J. Antibiot. | pmid:2500413 |
| Kiyoshima K et al. | Structure-activity relationship studies on 4''-O-acyltylosin derivatives: significance of their 23-O-mycinosyl and 4''-O-acyl moieties in antimicrobial activity against macrolide-resistant microbes. | 1989 | J. Antibiot. | pmid:2584151 |
| Creemer LC et al. | Facile synthesis of tilmicosin and tylosin related haptens for use as protein conjugates. | 2003 | J. Antibiot. | pmid:12870814 |
| Kageyama S et al. | Synthesis of 3-deoxy-3,4-didehydro derivatives of 5-O-mycaminosyltylonolide, 5-O-(4-deoxymycaminosyl) tylonolide, and desmycosin. | 1993 | J. Antibiot. | pmid:8407589 |
| Mandić Z et al. | Tylosin derivatives. V. Electrochemical opening of oxirane ring. | 1999 | J. Antibiot. | pmid:10695679 |
| Vaughan RW et al. | Isolation and characterization of two 16-membered lactones: 20-deoxorosaramicin and 20-deoxo-12,13-desepoxy-12,13-dehydrorosaramicin aglycones, from a mutant strain of Micromonospora rosaria. | 1982 | J. Antibiot. | pmid:7076570 |
| Tsuchiya M et al. | Studies on the effects of 3-acetyl-4"-isovaleryltylosin against multiple-drug resistant strains of Staphylococcus aureus. | 1981 | J. Antibiot. | pmid:7275812 |
| Omura S et al. | X-ray crystallography of protylonolide and absolute configuration of tylosin. | 1980 | J. Antibiot. | pmid:7429997 |
| Tanaka A et al. | Synthesis of 4'-deoxymycaminosyl tylonolide. | 1981 | J. Antibiot. | pmid:7309633 |
| Tanaka A et al. | Syntheses of derivatives of 4'-deoxymycaminosyl tylonolide and mycaminosyl tylonolide modified AT C-23. | 1981 | J. Antibiot. | pmid:7309634 |
| Tanaka A et al. | Syntheses of 4'-deoxy-demycarosyl tylosin and its analogues. | 1981 | J. Antibiot. | pmid:7309635 |
| Inouye S et al. | Modifications of a macrolide antibiotic midecamycin. II. Reaction of midecamycin and 9-acetylmidecamycin with dimethylsulfoxide and acetic anhydride. | 1980 | J. Antibiot. | pmid:7372551 |
| Omura S et al. | Chemical modification of tylosin. Thioether derivatives of tylosin and demycarosyltylosin. | 1984 | J. Antibiot. | pmid:6501102 |
| Naranda A et al. | New dihydro and tetrahydro derivatives of desmycosin. III. The opening of oxirane ring of 12,13-epoxydesmycosin. | 1997 | J. Antibiot. | pmid:9402992 |
| Fish SA and Cundliffe E | Structure-activity studies of tylosin-related macrolides. | 1996 | J. Antibiot. | pmid:8968399 |
| Tsutsui A et al. | Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. | 2013 | J. Antibiot. | pmid:23232930 |
| Cacciapuoti AF et al. | Microbiological and pharmacokinetic studies of acyl demycinosyltylosin and related tylosin derivatives. | 1990 | J. Antibiot. | pmid:2145254 |
| Kageyama S et al. | Synthesis of 3,4'-dideoxymycaminosyl tylonolide, a novel type of macrolide derivative. | 1992 | J. Antibiot. | pmid:1548187 |
| Ruggeri C et al. | Synthesis and antibacterial activity of 9-O-[(2-methoxyethoxy)methyl]-oximes of tylosin and demycarosyltylosin. | 1989 | J. Antibiot. | pmid:2793598 |
| Marshall VP et al. | Enzymic inactivation of lincosaminide and macrolide antibiotics: divalent metal cation and coenzyme specificities. | 1989 | J. Antibiot. | pmid:2722691 |
| Omura S et al. | Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone. | 1984 | J. Antibiot. | pmid:6735923 |
| Omura S et al. | Valine as a precursor of n-butyrate unit in the biosynthesis of macrolide aglycone. | 1983 | J. Antibiot. | pmid:6874580 |
| Wilson VT and Cundliffe E | Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism. | 1999 | J. Antibiot. | pmid:10348045 |
| Ose EE | In vitro antibacterial properties of EL-870, a new semi-synthetic macrolide antibiotic. | 1987 | J. Antibiot. | pmid:3570967 |
| Wiley PF et al. | Enzymatic phosphorylation of macrolide antibiotics. | 1987 | J. Antibiot. | pmid:3570968 |
| Kiyoshima K et al. | New tylosin analogs produced by mutants of Streptomyces fradiae. | 1987 | J. Antibiot. | pmid:3680024 |
| Takeuchi T et al. | 4''-O-(4-methoxyphenyl)-acetyltylosin, a new macrolide derivative of therapeutic importance. | 1987 | J. Antibiot. | pmid:3680047 |
| Morisaki N et al. | Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain. | 2001 | J. Antibiot. | pmid:11302489 |
| Jacob ME et al. | Effects of feeding wet corn distillers grains with solubles with or without monensin and tylosin on the prevalence and antimicrobial susceptibilities of fecal foodborne pathogenic and commensal bacteria in feedlot cattle. | 2008 | J. Anim. Sci. | pmid:18192558 |
| Duff GC et al. | Effects of lasalocid and monensin plus tylosin on serum metabolic hormones and clinical chemistry profiles of beef steers fed a 90% concentrate diet. | 1994 | J. Anim. Sci. | pmid:8014140 |
| Maxwell CL et al. | The effects of technology use in feedlot production systems on feedlot performance and carcass characteristics. | 2015 | J. Anim. Sci. | pmid:26020911 |
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| Mercadante VR et al. | Effects of anti-phospholipase A(2) antibody supplementation on dry matter intake feed efficiency, acute phase response, and blood differentials of steers fed forage- and grain-based diets. | 2015 | J. Anim. Sci. | pmid:26020758 |
| Maxwell CL et al. | Effects of beef production system on animal performance and carcass characteristics. | 2014 | J. Anim. Sci. | pmid:25403195 |
| Tennant TC et al. | Comparison of tulathromycin and tilmicosin on the prevalence and severity of bovine respiratory disease in feedlot cattle in association with feedlot performance, carcass characteristics, and economic factors. | 2014 | J. Anim. Sci. | pmid:25349362 |
| Beck P et al. | Additive effects of growth promoting technologies on performance of grazing steers and economics of the wheat pasture enterprise. | 2014 | J. Anim. Sci. | pmid:24492552 |
| DiLorenzo N et al. | Effects of feeding polyclonal antibody preparations on ruminal bacterial populations and ruminal pH of steers fed high-grain diets. | 2006 | J. Anim. Sci. | pmid:16864880 |
| Abell KM et al. | A mixed treatment comparison meta-analysis of metaphylaxis treatments for bovine respiratory disease in beef cattle. | 2017 | J. Anim. Sci. | pmid:28380607 |
| Bosi P et al. | Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota. | 2011 | J. Anim. Sci. | pmid:21724943 |
| Cooprider KL et al. | Feedlot efficiency implications on greenhouse gas emissions and sustainability. | 2011 | J. Anim. Sci. | pmid:21398565 |
| Meyer NF et al. | Effect of essential oils, tylosin, and monensin on finishing steer performance, carcass characteristics, liver abscesses, ruminal fermentation, and digestibility. | 2009 | J. Anim. Sci. | pmid:19359504 |
| Stackhouse-Lawson KR et al. | Growth promoting technologies reduce greenhouse gas, alcohol, and ammonia emissions from feedlot cattle. | 2013 | J. Anim. Sci. | pmid:24085413 |
| Weber TE and Kerr BJ | Effect of sodium butyrate on growth performance and response to lipopolysaccharide in weanling pigs. | 2008 | J. Anim. Sci. | pmid:17998428 |
| Nagaraja TG et al. | Bacterial flora of liver abscesses in feedlot cattle fed tylosin or no tylosin. | 1999 | J. Anim. Sci. | pmid:10328365 |
| Morris FE et al. | Effect of rotating monensin plus tylosin and lasalocid on performance, ruminal fermentation, and site and extent of digestion in feedlot cattle. | 1990 | J. Anim. Sci. | pmid:2254185 |
| Brumm MC and Peo ER | Effect of receiving diets containing alfalfa and certain feed additives on performance of feeder pigs transported long distances. | 1985 | J. Anim. Sci. | pmid:4030523 |
| Potter EL et al. | Effect of monensin and tylosin on average daily gain, feed efficiency and liver abscess incidence in feedlot cattle. | 1985 | J. Anim. Sci. | pmid:4077750 |
| Han H et al. | Carbohydrate fermentation and nitrogen metabolism of a finishing beef diet by ruminal microbes in continuous cultures as affected by ethoxyquin and(or) supplementation of monensin and tylosin. | 2002 | J. Anim. Sci. | pmid:12002320 |