| MeSH term | MeSH ID | Detail |
|---|---|---|
| Digital Dermatitis | D058066 | 3 associated lipids |
| Bovine Respiratory Disease Complex | D048090 | 2 associated lipids |
| Pneumonia of Calves, Enzootic | D048089 | 2 associated lipids |
| Desulfovibrionaceae Infections | D045824 | 5 associated lipids |
| Pneumonia of Swine, Mycoplasmal | D045729 | 2 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Primate Diseases | D018419 | 2 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Neisseriaceae Infections | D016870 | 3 associated lipids |
| Ureaplasma Infections | D016869 | 5 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Appl. Environ. Microbiol. (2)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jost BH et al. | A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes. | 2004 | Antimicrob. Agents Chemother. | pmid:14982756 |
| Douthwaite S et al. | The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748. | 2004 | J. Mol. Biol. | pmid:15046978 |
| Elitok B and Elitok OM | Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease. | 2004 | J. Vet. Pharmacol. Ther. | pmid:15500569 |
| Clark C et al. | A preliminary investigation of the disposition of tilmicosin residues in elk tissues and serum. | 2004 | J. Vet. Pharmacol. Ther. | pmid:15500580 |
| Civitareale C et al. | Identification and quantification method of spiramycin and tylosin in feedingstuffs with HPLC-UV/DAD at 1 ppm level. | 2004 | J Pharm Biomed Anal | pmid:15496324 |
| Novotny GW et al. | Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA. | 2004 | Antimicrob. Agents Chemother. | pmid:15388419 |
| Phan LT et al. | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. | 2004 | J. Med. Chem. | pmid:15163176 |
| Brumbaugh GW et al. | Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model. | 2004 | Can. J. Vet. Res. | pmid:15352541 |
| Poole TL et al. | Competitive exclusion of a glycopeptide-resistant Enterococcus faecium in the presence of vancomycin but not equivalent concentrations of tylosin or gentamicin. | 2004 | Poult. Sci. | pmid:15285499 |
| Lum AM et al. | Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. | 2004 | Metab. Eng. | pmid:15256208 |
| Jackson CR et al. | Effects of tylosin use on erythromycin resistance in enterococci isolated from swine. | 2004 | Appl. Environ. Microbiol. | pmid:15240302 |
| Lawrence K | Change to user warning for Micotil. | 2004 | Vet. Rec. | pmid:15200081 |
| German AJ et al. | Comparison of direct and indirect tests for small intestinal bacterial overgrowth and antibiotic-responsive diarrhea in dogs. | 2003 Jan-Feb | J. Vet. Intern. Med. | pmid:12564725 |
| Onan LJ and LaPara TM | Tylosin-resistant bacteria cultivated from agricultural soil. | 2003 | FEMS Microbiol. Lett. | pmid:12644222 |
| Von Essen S et al. | Unintentional human exposure to tilmicosin (Micotil 300). | 2003 | J. Toxicol. Clin. Toxicol. | pmid:12807303 |
| Del Vecchio F et al. | Active-site residue, domain and module swaps in modular polyketide synthases. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12811585 |
| Anderegg TR and Jones RN | Initial disk diffusion quality control guidelines for tylosin tested against Staphylococcus aureus ATCC 25923 and Streptococcus pneumoniae ATCC 49619. | 2003 | Int. J. Antimicrob. Agents | pmid:12791478 |
| Tarabla H and Canavesio V | Prevalence of intramammary infections by major pathogens at parturition in dairy cows after intramuscular antibiotic therapy at drying-off: a preliminary report. | 2003 | J. Dairy Res. | pmid:12800878 |
| Loria GR et al. | In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. | 2003 | Res. Vet. Sci. | pmid:12801456 |
| Althaus RL et al. | Detection limits of antimicrobials in ewe milk by delvotest photometric measurements. | 2003 | J. Dairy Sci. | pmid:12647952 |
| Horie M et al. | [Determination of spiramycin and tilmicosin in meat and fish by LC/MS]. | 2003 | Shokuhin Eiseigaku Zasshi | pmid:12968469 |
| Marks SL and Kather EJ | Antimicrobial susceptibilities of canine Clostridium difficile and Clostridium perfringens isolates to commonly utilized antimicrobial drugs. | 2003 | Vet. Microbiol. | pmid:12742714 |
| Iveković D et al. | Electrochemical reduction of desmycosin, structure investigation and antibacterial evaluation of the resulting products. | 2003 | Eur J Pharm Sci | pmid:12694884 |
| Rodriguez E et al. | Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12698320 |
| De Liguoro M et al. | Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil. | 2003 | Chemosphere | pmid:12729703 |
| Fajt VR et al. | The effects of danofloxacin and tilmicosin on neutrophil function and lung consolidation in beef heifer calves with induced Pasteurella (Mannheimia) haemolytica pneumonia. | 2003 | J. Vet. Pharmacol. Ther. | pmid:12755900 |
| Dingwell RT et al. | Efficacy of intramammary tilmicosin and risk factors for cure of Staphylococcus aureus infection in the dry period. | 2003 | J. Dairy Sci. | pmid:12613861 |
| Poole TL et al. | Effect of subtherapeutic concentrations of tylosin on the inhibitory stringency of a mixed anaerobe continuous-flow culture of chicken microflora against Escherichia coli O157:H7. | 2003 | J. Appl. Microbiol. | pmid:12492926 |
| Lebars I et al. | Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII. | 2003 | EMBO J. | pmid:12514124 |
| Moubareck C et al. | Multiple antibiotic resistance gene transfer from animal to human enterococci in the digestive tract of gnotobiotic mice. | 2003 | Antimicrob. Agents Chemother. | pmid:12937011 |
| Van Lunen TA | Growth performance of pigs fed diets with and without tylosin phosphate supplementation and reared in a biosecure all-in all-out housing system. | 2003 | Can. Vet. J. | pmid:12892287 |
| Teeter JS and Meyerhoff RD | Aerobic degradation of tylosin in cattle, chicken, and swine excreta. | 2003 | Environ. Res. | pmid:12865047 |
| Creemer LC et al. | Facile synthesis of tilmicosin and tylosin related haptens for use as protein conjugates. | 2003 | J. Antibiot. | pmid:12870814 |
| Collier CT et al. | Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis. | 2003 | Antimicrob. Agents Chemother. | pmid:14506046 |
| Thompson TS et al. | Determination of lincomycin and tylosin residues in honey using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. | 2003 | J Chromatogr A | pmid:14661747 |
| Sumbatyan NV et al. | Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors. | 2003 | Biochemistry Mosc. | pmid:14616087 |
| Jost BH et al. | Tylosin resistance in Arcanobacterium pyogenes is encoded by an erm X determinant. | 2003 | Antimicrob. Agents Chemother. | pmid:14576111 |
| Lee HJ and Jin HJ | Renaturation of recombinant ErmSF and its refolding behavior. | 2003 | Mol. Cells | pmid:14651260 |
| Prapasarakul N et al. | In vitro susceptibility and a new point mutation associated with tylosin-resistance in Japanese canine intestinal spirochetes. | 2003 | J. Vet. Med. Sci. | pmid:14709813 |
| Clark SB et al. | Interlaboratory comparison of methods for the determination of incurred tilmicosin residues in bovine liver. | 2002 Nov-Dec | J AOAC Int | pmid:12477187 |
| Evans RD et al. | Field evaluation of tylosin premix in layers previously vaccinated with a live Mycoplasma gallisepticum vaccine. | 2002 Jan-Mar | Avian Dis. | pmid:11922337 |
| Cerdá RO et al. | In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina. | 2002 Jan-Mar | Avian Dis. | pmid:11922338 |
| Liu M and Douthwaite S | Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12417742 |
| Higgins HC and McEvoy JD | Accelerated solvent extraction of animal feedingstuffs for microbial growth inhibition screening for the presence of antimicrobial feed additives. | 2002 | Food Addit Contam | pmid:12396393 |
| Brumbaugh GW et al. | Effect of tilmicosin on chemotactic, phagocytic, and bactericidal activities of bovine and porcine alveolar macrophages. | 2002 | Am. J. Vet. Res. | pmid:16206777 |
| Zielinski GC et al. | Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). | 2002 | Vet. Ther. | pmid:19750751 |
| Gautier-Bouchardon AV et al. | In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae. | 2002 | Vet. Microbiol. | pmid:12119137 |
| Carter JN et al. | Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease. | 2002 | Am. J. Vet. Res. | pmid:12171163 |
| Loke ML et al. | Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosin A, olaquindox and metronidazole in manure. | 2002 | Chemosphere | pmid:12146624 |
| Takahashi I et al. | [In vitro resistance acquisition in Mycoplasma gallisepticum against ofloxacin, tylosin and spectinomycin]. | 2002 | Jpn J Antibiot | pmid:12199113 |