| MeSH term | MeSH ID | Detail |
|---|---|---|
| Digital Dermatitis | D058066 | 3 associated lipids |
| Bovine Respiratory Disease Complex | D048090 | 2 associated lipids |
| Pneumonia of Calves, Enzootic | D048089 | 2 associated lipids |
| Desulfovibrionaceae Infections | D045824 | 5 associated lipids |
| Pneumonia of Swine, Mycoplasmal | D045729 | 2 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Primate Diseases | D018419 | 2 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Neisseriaceae Infections | D016870 | 3 associated lipids |
| Ureaplasma Infections | D016869 | 5 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Appl. Environ. Microbiol. (2)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marosevic D et al. | In vivo spread of macrolide-lincosamide-streptogramin B (MLSB) resistance--a model study in chickens. | 2014 | Vet. Microbiol. | pmid:24467930 |
| Woolums AR et al. | Multidrug resistant Mannheimia haemolytica isolated from high-risk beef stocker cattle after antimicrobial metaphylaxis and treatment for bovine respiratory disease. | 2018 | Vet. Microbiol. | pmid:29981701 |
| Blondeau JM et al. | Comparative minimum inhibitory and mutant prevention drug concentrations of enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin against bovine clinical isolates of Mannheimia haemolytica. | 2012 | Vet. Microbiol. | pmid:22677482 |
| Entorf M et al. | Tylosin susceptibility of Staphylococci from bovine mastitis. | 2014 | Vet. Microbiol. | pmid:24461550 |
| Ozaki H et al. | Antimicrobial resistance in fecal Escherichia coli isolated from growing chickens on commercial broiler farms. | 2011 | Vet. Microbiol. | pmid:21232883 |
| Lerner U et al. | Acquired resistance to the 16-membered macrolides tylosin and tilmicosin by Mycoplasma bovis. | 2014 | Vet. Microbiol. | pmid:24393633 |
| Paraud C et al. | Evaluation of oral tilmicosin efficacy against severe cryptosporidiosis in neonatal kids under field conditions. | 2010 | Vet. Parasitol. | pmid:20149542 |
| Angell JW et al. | Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial. | 2016 | Vet. Rec. | pmid:27450091 |
| Scott PR | Field study of undifferentiated respiratory disease in housed beef calves. | 1994 | Vet. Rec. | pmid:8203107 |
| Henderson JP and Ball HJ | Polyarthritis due to Mycoplasma bovis infection in adult dairy cattle in Northern Ireland. | 1999 | Vet. Rec. | pmid:10573196 |
| Ayling RD et al. | Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against Mycoplasma mycoides subspecies mycoides small colony type. | 2000 | Vet. Rec. | pmid:10737293 |
| Vicca J et al. | Efficacy of in-feed medication with tylosin for the treatment and control of Mycoplasma hyopneumoniae infections. | 2005 | Vet. Rec. | pmid:15879541 |
| Industry guidance on the administration of tilmicosin. | 2006 | Vet. Rec. | pmid:16924727 | |
| Ayling RD et al. | Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against recent field isolates of Mycoplasma bovis. | 2000 | Vet. Rec. | pmid:10909906 |
| Couper A et al. | Treatment of pneumonia in pigs with long-acting injectable tylosin. | 2006 | Vet. Rec. | pmid:17158711 |
| Mackie DP et al. | Mixed mycoplasma mastitis outbreak in a dairy herd. | 2000 | Vet. Rec. | pmid:11058024 |
| Lawrence K | Change to user warning for Micotil. | 2004 | Vet. Rec. | pmid:15200081 |
| Mackinnon JD et al. | Effect of tylosin on milk yield and dry matter intake of lactating dairy cows. | 1984 | Vet. Rec. | pmid:6495581 |
| Giadinis ND et al. | Mortality in adult goats attributed to Mycoplasma capricolum subspecies capricolum. | 2008 | Vet. Rec. | pmid:18757908 |
| Usui M et al. | Selection of macrolide-resistant Campylobacter in pigs treated with macrolides. | 2014 | Vet. Rec. | pmid:25163817 |
| TavÃo MM et al. | In vitro activity of tylvalosin against Spanish field strains of Mycoplasma hyopneumoniae. | 2014 | Vet. Rec. | pmid:25185108 |
| Harvey RG | Tylosin in the treatment of canine superficial pyoderma. | 1996 | Vet. Rec. | pmid:8873399 |
| Del Pozo Sacristán R et al. | Efficacy of in-feed medication with chlortetracycline in a farrow-to-finish herd against a clinical outbreak of respiratory disease in fattening pigs. | 2012 Dec 22-29 | Vet. Rec. | pmid:23136309 |
| Guedes RM et al. | Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. | 2009 | Vet. Rec. | pmid:19767637 |
| Fitzgerald J | Administration of micotil. | 2009 | Vet. Rec. | pmid:19767643 |
| Warner K et al. | Control of Ornithobacterium rhinotracheale in poultry. | 2009 | Vet. Rec. | pmid:19946131 |
| Molnár L | Sensitivity of strains of Serpulina hyodysenteriae isolated in Hungary to chemotherapeutic drugs. | 1996 | Vet. Rec. | pmid:8677605 |
| Schumann FJ et al. | Prophylactic medication of feedlot calves with tilmicosin. | 1991 | Vet. Rec. | pmid:2038809 |
| Laven R and Andrews AH | Long-acting antibiotic formulations in the treatment of calf pneumonia: a comparative study of tilmicosin and oxytetracycline. | 1991 | Vet. Rec. | pmid:1926728 |
| Blaha T et al. | Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme. | 1987 | Vet. Rec. | pmid:3424604 |
| Rowan TG et al. | Efficacy of danofloxacin in the treatment of respiratory disease in European cattle. | 2004 | Vet. Rec. | pmid:15160844 |
| Picavet T et al. | Efficacy of tilmicosin in treatment of pulmonary infections in calves. | 1991 | Vet. Rec. | pmid:1837391 |
| Mee JF and O'Farrell K | Tilmicosin and calf pneumonia. | 1991 | Vet. Rec. | pmid:1858280 |
| Ball HJ and Campbell JN | Antibiotic treatment of experimental Mycoplasma californicum mastitis. | 1989 | Vet. Rec. | pmid:2815518 |
| Beechinor JG and Bloomfield FJ | Variability in residue concentrations of tilmicosin in cattle muscle. | 2001 | Vet. Rec. | pmid:11530904 |
| Naccari F et al. | Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep. | 2001 | Vet. Rec. | pmid:11465263 |
| Ball HJ and McCaughey WJ | Experimental intramuscular inoculation of tylosin in the elimination of ureaplasmas from ewes. | 1987 | Vet. Rec. | pmid:3617407 |
| Ose EE and Tonkinson LV | Single-dose treatment of neonatal calf pneumonia with the new macrolide antibiotic tilmicosin. | 1988 | Vet. Rec. | pmid:3195026 |
| Lawrence K | Micotil: safe use and administration. | 2007 | Vet. Rec. | pmid:18037699 |
| Lee WD et al. | Tilmicosin-induced bovine neutrophil apoptosis is cell-specific and downregulates spontaneous LTB4 synthesis without increasing Fas expression. | 2004 Mar-Apr | Vet. Res. | pmid:15099497 |
| Gerchman I et al. | Characterization of in vivo-acquired resistance to macrolides of Mycoplasma gallisepticum strains isolated from poultry. | 2011 | Vet. Res. | pmid:21810258 |
| Abu-Basha EA et al. | Pharmacokinetics of tilmicosin (Provitil powder and Pulmotil liquid AC) oral formulations in chickens. | 2007 | Vet. Res. Commun. | pmid:17225089 |
| Gallina G et al. | Acute toxicity evaluation of four antibacterials with Daphnia magna. | 2008 | Vet. Res. Commun. | pmid:18688742 |
| Gallina G et al. | Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits. | 2010 | Vet. Res. Commun. | pmid:20480234 |
| Saurit AR et al. | Some comparative aspects of the pharmacokinetics of tylosin in buffaloes and cattle. | 2002 | Vet. Res. Commun. | pmid:11860087 |
| Nutsch RG et al. | Comparative efficacy of tulathromycin, tilmicosin, and florfenicol in the treatment of bovine respiratory disease in stocker cattle. | 2005 | Vet. Ther. | pmid:16094564 |
| Skogerboe TL et al. | Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle. | 2005 | Vet. Ther. | pmid:16094565 |
| Van Donkersgoed J et al. | Comparative efficacy of tilmicosin versus tulathromycin as a metaphylactic antimicrobial in feedlot calves at moderate risk for respiratory disease. | 2008 | Vet. Ther. | pmid:19177334 |
| Zielinski GC et al. | Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). | 2002 | Vet. Ther. | pmid:19750751 |
| Marsteller T et al. | Efficacy of intramuscular tylosin for the treatment and control of porcine proliferative enteropathy caused by Lawsonia intracellularis. | 2001 | Vet. Ther. | pmid:19753698 |