Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tylosin?

Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tylosin

MeSH term MeSH ID Detail
Erysipelothrix Infections D004889 1 associated lipids
Conjunctivitis, Viral D003236 1 associated lipids
Enterotoxemia D004767 1 associated lipids
Bacillaceae Infections D016863 1 associated lipids
Primate Diseases D018419 2 associated lipids
Pneumonia of Calves, Enzootic D048089 2 associated lipids
Keratoconjunctivitis, Infectious D007639 2 associated lipids
Pneumonia of Swine, Mycoplasmal D045729 2 associated lipids
Bovine Respiratory Disease Complex D048090 2 associated lipids
Neisseriaceae Infections D016870 3 associated lipids
Digital Dermatitis D058066 3 associated lipids
Pasteurellosis, Pneumonic D012766 3 associated lipids
Tracheal Diseases D014133 3 associated lipids
Treponemal Infections D014211 3 associated lipids
Dysentery D004403 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Pyoderma D011711 5 associated lipids
Clostridium Infections D003015 5 associated lipids
Mycotoxicosis D015651 5 associated lipids
Ureaplasma Infections D016869 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Tylosin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tylosin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tylosin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tylosin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Tylosin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tylosin?

Knock-out

Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tylosin

Download all related citations
Per page 10 20 50 100 | Total 931
Authors Title Published Journal PubMed Link
Jackson CR et al. Effects of tylosin use on erythromycin resistance in enterococci isolated from swine. 2004 Appl. Environ. Microbiol. pmid:15240302
Lum AM et al. Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. 2004 Metab. Eng. pmid:15256208
Mathers JJ et al. Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations. 2004 Apr-Jun Avian Dis. pmid:15283418
Poole TL et al. Competitive exclusion of a glycopeptide-resistant Enterococcus faecium in the presence of vancomycin but not equivalent concentrations of tylosin or gentamicin. 2004 Poult. Sci. pmid:15285499
Brumbaugh GW et al. Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model. 2004 Can. J. Vet. Res. pmid:15352541
Novotny GW et al. Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA. 2004 Antimicrob. Agents Chemother. pmid:15388419
Kageyama S et al. Synthesis of 3,4'-dideoxymycaminosyl tylonolide, a novel type of macrolide derivative. 1992 J. Antibiot. pmid:1548187
Civitareale C et al. Identification and quantification method of spiramycin and tylosin in feedingstuffs with HPLC-UV/DAD at 1 ppm level. 2004 J Pharm Biomed Anal pmid:15496324
Elitok B and Elitok OM Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease. 2004 J. Vet. Pharmacol. Ther. pmid:15500569
Clark C et al. A preliminary investigation of the disposition of tilmicosin residues in elk tissues and serum. 2004 J. Vet. Pharmacol. Ther. pmid:15500580
Brain RA et al. Aquatic microcosm assessment of the effects of tylosin on Lemna gibba and Myriophyllum spicatum. 2005 Environ. Pollut. pmid:15519715
Stratigopoulos G et al. Positive control of tylosin biosynthesis: pivotal role of TylR. 2004 Mol. Microbiol. pmid:15554972
Kay P et al. A lysimeter experiment to investigate the leaching of veterinary antibiotics through a clay soil and comparison with field data. 2005 Environ. Pollut. pmid:15589660
Rooklidge SJ et al. Modeling antimicrobial contaminant removal in slow sand filtration. 2005 Jan-Feb Water Res. pmid:15644241
Thompson TS et al. Determination of lincomycin and tylosin residues in honey by liquid chromatography/tandem mass spectrometry. 2005 Rapid Commun. Mass Spectrom. pmid:15645470
Menozzi A et al. Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat. 2005 Pharmacology pmid:15756055
Kolz AC et al. Degradation and metabolite production of tylosin in anaerobic and aerobic swine-manure lagoons. 2005 Jan-Feb Water Environ. Res. pmid:15765935
Wang J et al. Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry. 2005 J. Agric. Food Chem. pmid:15769104
Blackwell PA et al. Evaluation of a lower tier exposure assessment model for veterinary medicines. 2005 J. Agric. Food Chem. pmid:15769156
Pfister P et al. 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15795375