Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fujiwara T et al. | 19-Deformyl-4'-deoxydesmycosin (TMC-016): synthesis and biological properties of a unique 16-membered macrolide antibiotic. | 1989 | J. Antibiot. | pmid:2500413 |
Kiyoshima K et al. | Structure-activity relationship studies on 4''-O-acyltylosin derivatives: significance of their 23-O-mycinosyl and 4''-O-acyl moieties in antimicrobial activity against macrolide-resistant microbes. | 1989 | J. Antibiot. | pmid:2584151 |
Anti-infective drug use in relation to the risk of agranulocytosis and aplastic anemia. A report from the International Agranulocytosis and Aplastic Anemia Study. | 1989 | Arch. Intern. Med. | pmid:2785785 | |
Bébrová E et al. | [Immunologic reactivity of tylosin and erythromycin]. | 1989 | Cesk Epidemiol Mikrobiol Imunol | pmid:2790978 |
Ruggeri C et al. | Synthesis and antibacterial activity of 9-O-[(2-methoxyethoxy)methyl]-oximes of tylosin and demycarosyltylosin. | 1989 | J. Antibiot. | pmid:2793598 |
Kempf I et al. | [Efficacy of spiramycin and tylosin in preventing mycoplasmosis in chicks experimentally infected with mycoplasma gallisepticum]. | 1989 | Pathol. Biol. | pmid:2797880 |
Zalacain M and Cundliffe E | Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. | 1989 | J. Bacteriol. | pmid:2753855 |
Synek M et al. | [Immunologic aspects of macrolide antibiotics]. | 1989 | Cas. Lek. Cesk. | pmid:2731206 |
Ryoo JP et al. | Data acquisition and processing system for drug release characterization by thin layer chromatography. | 1989 | Biomed Sci Instrum | pmid:2742974 |
Marshall VP et al. | Enzymic inactivation of lincosaminide and macrolide antibiotics: divalent metal cation and coenzyme specificities. | 1989 | J. Antibiot. | pmid:2722691 |
Bauer NJ et al. | Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae. | 1988 | J. Biol. Chem. | pmid:3170601 |
Kreuzman AJ et al. | Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism. | 1988 | J. Biol. Chem. | pmid:3170602 |
Kirst HA et al. | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. | 1988 | J. Med. Chem. | pmid:3398001 |
Kirst HA et al. | In vitro and in vivo evaluation of C-20- and C-23-modified derivatives of tylosin against veterinary pathogens. | 1988 | J. Antibiot. | pmid:3417566 |
de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. | 1988 | J. Med. Chem. | pmid:3351847 |
Ose EE and Tonkinson LV | Single-dose treatment of neonatal calf pneumonia with the new macrolide antibiotic tilmicosin. | 1988 | Vet. Rec. | pmid:3195026 |
Stipkovits L et al. | In vitro testing of the anti-mycoplasma effect of some anti-coccidial drugs. | 1987 | Vet. Microbiol. | pmid:3439016 |
Blaha T et al. | Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme. | 1987 | Vet. Rec. | pmid:3424604 |
Rodionova II et al. | [Effect of protoplast formation on the antibiotic activity of the Streptomyces fradiae 165 strain--a producer of tylosin]. | 1987 | Antibiot. Med. Biotekhnol. | pmid:2830838 |
Vancura A et al. | Fatty acids and production of tylosin-like compounds in Streptomyces fradiae. | 1987 | J. Basic Microbiol. | pmid:3625475 |