Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Moubareck C et al. | Multiple antibiotic resistance gene transfer from animal to human enterococci in the digestive tract of gnotobiotic mice. | 2003 | Antimicrob. Agents Chemother. | pmid:12937011 |
Szczepanowski R et al. | Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. | 2007 | Antimicrob. Agents Chemother. | pmid:17101677 |
Seno ET and Baltz RH | Properties of S-adenosyl-L-methionine:macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylations. | 1981 | Antimicrob. Agents Chemother. | pmid:7305323 |
Achard A et al. | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. | 2008 | Antimicrob. Agents Chemother. | pmid:18519724 |
Caldwell DB et al. | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. | 2008 | Antimicrob. Agents Chemother. | pmid:18779354 |
Hao H et al. | Mutational and transcriptomic changes involved in the development of macrolide resistance in Campylobacter jejuni. | 2013 | Antimicrob. Agents Chemother. | pmid:23274667 |
Elkins CA et al. | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. | 2010 | Antimicrob. Agents Chemother. | pmid:20038628 |
Rodionova II et al. | [Effect of protoplast formation on the antibiotic activity of the Streptomyces fradiae 165 strain--a producer of tylosin]. | 1987 | Antibiot. Med. Biotekhnol. | pmid:2830838 |
Panfilova ZI et al. | [Obtaining of mutants of Streptomyces fradiae producing tylosin by action of nitrosomethylurea on synchronously germinating spores]. | 1990 | Antibiot. Khimioter. | pmid:2383150 |
Malanicheva IA et al. | [Protoplast fusion in Streptomyces fradiae strains producing neomycin and tylosin]. | 1992 | Antibiot. Khimioter. | pmid:1296531 |