Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Suchodolski JS et al. | The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencing. | 2009 | BMC Microbiol. | pmid:19799792 |
Berman J et al. | A randomised clinical trial of a metaphylactic treatment with tildipirosin for bovine respiratory disease in veal calves. | 2017 | BMC Vet. Res. | pmid:28615070 |
Kreizinger Z et al. | Antibiotic susceptibility profiles of Mycoplasma synoviae strains originating from Central and Eastern Europe. | 2017 | BMC Vet. Res. | pmid:29149886 |
Qekwana DN et al. | Patterns and predictors of antimicrobial resistance among Staphylococcus spp. from canine clinical cases presented at a veterinary academic hospital in South Africa. | 2017 | BMC Vet. Res. | pmid:28454567 |
Li Y et al. | In vitro susceptibility of four antimicrobials against Riemerella anatipestifer isolates: a comparison of minimum inhibitory concentrations and mutant prevention concentrations for ceftiofur, cefquinome, florfenicol, and tilmicosin. | 2016 | BMC Vet. Res. | pmid:27829415 |
Huang L et al. | Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs. | 2018 | BMC Vet. Res. | pmid:30355326 |
Pedersen KB | Some growth promoters in animals do confer antimicrobial resistance in humans. | 1999 | BMJ | pmid:10205122 |
Gollins WJ | Occupational asthma due to tylosin tartrate. | 1989 | Br J Ind Med | pmid:2611166 |
Lee HS et al. | Occupational asthma due to tylosin tartrate. | 1989 | Br J Ind Med | pmid:2765423 |
Gyémánt N et al. | In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin. | 2010 | Br. J. Cancer | pmid:20551959 |
Collington GK et al. | The influence of inclusion of either an antibiotic or a probiotic in the diet on the development of digestive enzyme activity in the pig. | 1990 | Br. J. Nutr. | pmid:2119223 |
Lilia G et al. | Circadian serum concentrations of tylosin in broilers after feed or water medication. | 2008 | Br. Poult. Sci. | pmid:18836909 |
Roudaut B and Moretain JP | Residues of macrolide antibiotics in eggs following medication of laying hens. | 1990 | Br. Poult. Sci. | pmid:2245358 |
Hunter RP et al. | Letter to the editor. | 2009 | Br. Poult. Sci. | pmid:19904632 |
Scott PR | Efficacy of strategic tilmicosin injection during an outbreak of respiratory disease in housed beef calves. | 1995 Sep-Oct | Br. Vet. J. | pmid:8556318 |
Atef M et al. | Disposition of tylosin in goats. | 1991 May-Jun | Br. Vet. J. | pmid:1878767 |
Kim HY et al. | Biochemical effects of veterinary antibiotics on proliferation and cell cycle arrest of human HEK293 cells. | 2012 | Bull Environ Contam Toxicol | pmid:22673765 |
DOORNENBAL H | CLINICAL EVALUATION OF TYLOSIN AS A TREATMENT OF VIBRIONIC DYSENTERY IN SWINE. | 1965 | Can J Comp Med Vet Sci | pmid:14300858 |
Truscott RB and Ruhnke HL | The effect of antibiotics against bovine mycoplasmas and ureaplasmas. | 1984 | Can. J. Comp. Med. | pmid:6232992 |
Truscott RB | Factors associated with the determination of antibiotic activity in bovine semen. | 1983 | Can. J. Comp. Med. | pmid:6230144 |