| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Appl. Environ. Microbiol. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- FEMS Microbiol. Lett. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Barth AD and Wood MR | The effect of streptomycin, oxytetracycline, tilmicosin and phenylbutazone on spermatogenesis in bulls. | 1998 | Can. Vet. J. | pmid:10051958 |
| Aarestrup FM and Jensen NE | Susceptibility testing of Actinobacillus pleuropneumoniae in Denmark. Evaluation of three different media of MIC-determinations and tablet diffusion tests. | 1999 | Vet. Microbiol. | pmid:10063535 |
| Jim GK et al. | A comparison of florfenicol and tilmicosin for the treatment of undifferentiated fever in feedlot calves in western Canada. | 1999 | Can. Vet. J. | pmid:10086218 |
| Zweers-Zeilmaker WM et al. | In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle. | 1999 | Res. Vet. Sci. | pmid:10088712 |
| Naranda A and Lopotar N | New derivatives of tylosin. IV. Dihydro and tetrahydro desmycosin oximes. | 1999 | J. Antibiot. | pmid:10092201 |
| Karlsson M et al. | Genetic basis of macrolide and lincosamide resistance in Brachyspira (Serpulina) hyodysenteriae. | 1999 | FEMS Microbiol. Lett. | pmid:10188254 |
| Owens WE et al. | Efficacy of parenterally or intramammarily administered tilmicosin or ceftiofur against Staphylococcus aureus mastitis during lactation. | 1999 | J. Dairy Sci. | pmid:10194686 |
| Baltadzhieva D et al. | [Tylosin-specific proliferation in vitro of the peripheral blood mononuclear cells in occupational tylosin allergy]. | 1997 | Probl Khig | pmid:10202771 |
| Pedersen KB | Some growth promoters in animals do confer antimicrobial resistance in humans. | 1999 | BMJ | pmid:10205122 |
| Lee SH and Rho YT | Improvement of tylosin fermentation by mutation and medium optimization. | 1999 | Lett. Appl. Microbiol. | pmid:10206653 |
| Scorneaux B and Shryock TR | The determination of the cellular volume of avian, porcine and bovine phagocytes and bovine mammary epithelial cells and its relationship to uptake of tilmicosin. | 1999 | J. Vet. Pharmacol. Ther. | pmid:10211711 |
| Nickerson SC et al. | Comparison of tilmicosin and cephapirin as therapeutics for Staphylococcus aureus mastitis at dry-off. | 1999 | J. Dairy Sci. | pmid:10212455 |
| Fouces R et al. | The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region. | 1999 | Microbiology (Reading, Engl.) | pmid:10220165 |
| Robredo B et al. | From vanA Enterococcus hirae to vanA Enterococcus faecium: a study of feed supplementation with avoparcin and tylosin in young chickens. | 1999 | Antimicrob. Agents Chemother. | pmid:10223926 |
| Huwyler U et al. | Efficacy evaluation of the use of oral tilmicosin in pneumonic calves. | 1999 | Schweiz. Arch. Tierheilkd. | pmid:10228400 |
| Butler AR et al. | Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae. | 1999 | Chem. Biol. | pmid:10322123 |
| Nagaraja TG et al. | Bacterial flora of liver abscesses in feedlot cattle fed tylosin or no tylosin. | 1999 | J. Anim. Sci. | pmid:10328365 |
| Wilson VT and Cundliffe E | Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism. | 1999 | J. Antibiot. | pmid:10348045 |
| Wallgren P et al. | Experimental infections with Actinobacillus pleuropneumoniae in pigs--II. Comparison of antibiotics for oral strategic treatment. | 1999 | Zentralblatt Veterinarmedizin Reihe B | pmid:10379236 |
| Scorneaux B and Shryock TR | Intracellular accumulation, subcellular distribution, and efflux of tilmicosin in bovine mammary, blood, and lung cells. | 1999 | J. Dairy Sci. | pmid:10386306 |
| Trefzer A et al. | Genes and enzymes involved in deoxysugar biosynthesis in bacteria. | 1999 | Nat Prod Rep | pmid:10399362 |
| Modric S et al. | Effect of respiratory tract disease on pharmacokinetics of tilmicosin in rats. | 1999 | Lab. Anim. Sci. | pmid:10403438 |
| Diarra MS et al. | Postantibiotic and physiological effects of tilmicosin, tylosin, and apramycin at subminimal and suprainhibitory concentrations on some swine and bovine respiratory tract pathogens. | 1999 | Int. J. Antimicrob. Agents | pmid:10461841 |
| Bate N et al. | Multiple regulatory genes in the tylosin biosynthetic cluster of Streptomyces fradiae. | 1999 | Chem. Biol. | pmid:10467127 |
| Crown LA and Smith RB | Accidental veterinary antibiotic injection into a farm worker. | 1999 | Tenn Med | pmid:10474305 |
| Atef M et al. | Elimination of tilmicosin in lactating ewes. | 1999 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:10481373 |
| Nagaraja TG et al. | Effects of tylosin on concentrations of Fusobacterium necrophorum and fermentation products in the rumen of cattle fed a high-concentrate diet. | 1999 | Am. J. Vet. Res. | pmid:10490072 |
| Jordan FT et al. | The comparison of an aqueous preparation of tilmicosin with tylosin in the treatment of Mycoplasma gallisepticum infection of turkey poults. | 1999 Jul-Sep | Avian Dis. | pmid:10494422 |
| Juhel-Gaugain M et al. | Multiresidue chromatographic method for the determination of macrolide residues in muscle by high-performance liquid chromatography with UV detection. | 1999 Sep-Oct | J AOAC Int | pmid:10513006 |
| Tobback K et al. | Micellar electrokinetic capillary chromatography of macrolide antibiotics. Separation of tylosin, erythromycin and their related substances. | 1999 | J Chromatogr A | pmid:10536850 |
| Short CR | Comparative pharmacokinetics--sorting the sheep from the goats. | 1999 | Vet. J. | pmid:10558834 |
| Taha AA et al. | Disposition kinetics of tylosin administered intravenously and intramuscularly in desert sheep and Nubian goats. | 1999 | Vet. J. | pmid:10558841 |
| Henderson JP and Ball HJ | Polyarthritis due to Mycoplasma bovis infection in adult dairy cattle in Northern Ireland. | 1999 | Vet. Rec. | pmid:10573196 |
| Dudriková E et al. | Liquid chromatographic determination of tylosin in mastitic cow's milk following therapy. | 1999 Nov-Dec | J AOAC Int | pmid:10589481 |
| Baltadzhieva D et al. | [Analysis of immunological indices of occupational sensibilization to tylosin]. | 1999 | Med Tr Prom Ekol | pmid:10605285 |
| Bate N et al. | The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. | 2000 | Microbiology (Reading, Engl.) | pmid:10658660 |
| Davies R and Roberts TA | Antimicrobial susceptibility of enterococci recovered from commercial swine carcasses: effect of feed additives. | 1999 | Lett. Appl. Microbiol. | pmid:10664974 |
| Vissiennon T et al. | Effect of avilamycin, tylosin and ionophore anticoccidials on Clostridium perfringens enterotoxaemia in chickens. | 2000 | Berl. Munch. Tierarztl. Wochenschr. | pmid:10684178 |
| Mandić Z et al. | Tylosin derivatives. V. Electrochemical opening of oxirane ring. | 1999 | J. Antibiot. | pmid:10695679 |
| Rabølle M and Spliid NH | Sorption and mobility of metronidazole, olaquindox, oxytetracycline and tylosin in soil. | 2000 | Chemosphere | pmid:10705549 |
| Halling-Sørensen B | Algal toxicity of antibacterial agents used in intensive farming. | 2000 | Chemosphere | pmid:10705551 |
| Baguer AJ et al. | Effects of the antibiotics oxytetracycline and tylosin on soil fauna. | 2000 | Chemosphere | pmid:10705553 |
| Loke ML et al. | Stability of Tylosin A in manure containing test systems determined by high performance liquid chromatography. | 2000 | Chemosphere | pmid:10705554 |
| Duff GC et al. | Effects of preshipping vs. arrival medication with tilmicosin phosphate and feeding chlortetracycline on health and performance of newly received beef cattle. | 2000 | J. Anim. Sci. | pmid:10709916 |
| Fodor L et al. | Efficacy evaluations of the use of oral tilmicosin in pneumonic calves. | 2000 | Vet. J. | pmid:10712808 |
| Visser IJ et al. | Failure of antibiotics gentamycin, tylosin, lincomycin and spectinomycin to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 1999 | Theriogenology | pmid:10728994 |
| Ayling RD et al. | Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against Mycoplasma mycoides subspecies mycoides small colony type. | 2000 | Vet. Rec. | pmid:10737293 |
| Montesissa C et al. | Tylosin depletion in edible tissues of turkeys. | 1999 | Food Addit Contam | pmid:10755131 |
| Croft A et al. | The effect of tilmicosin administered to ewes prior to lambing on incidence of clinical mastitis and subsequent lamb performance. | 2000 | Can. Vet. J. | pmid:10769768 |
| Pai MP et al. | Macrolide drug interactions: an update. | 2000 | Ann Pharmacother | pmid:10772438 |
| Baggesen DL et al. | Effects of the antimicrobial growth promoter tylosin on subclinical infection of pigs with Salmonella enterica serotype Typhimurium. | 1999 | Am. J. Vet. Res. | pmid:10791930 |
| Gaisser S et al. | A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. | 2000 | Mol. Microbiol. | pmid:10792725 |
| Fouces R et al. | Conjugation and transformation of Streptomyces species by tylosin resistance. | 2000 | FEMS Microbiol. Lett. | pmid:10802191 |
| Frank GH et al. | Effects of tilmicosin treatment on Pasteurella haemolytica organisms in nasal secretion specimens of calves with respiratory tract disease. | 2000 | Am. J. Vet. Res. | pmid:10803647 |
| Köhler B et al. | Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains. | 2000 | Microbiology (Reading, Engl.) | pmid:10832635 |
| Stobba-Wiley CM and Readnour RS | Determination of tilmicosin residues in cow and sheep milk by liquid chromatography. | 2000 May-Jun | J AOAC Int | pmid:10868576 |
| Ayling RD et al. | Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against recent field isolates of Mycoplasma bovis. | 2000 | Vet. Rec. | pmid:10909906 |
| Chin AC et al. | Tilmicosin induces apoptosis in bovine peripheral neutrophils in the presence or in the absence of Pasteurella haemolytica and promotes neutrophil phagocytosis by macrophages. | 2000 | Antimicrob. Agents Chemother. | pmid:10952596 |
| Doak GA | Failure of antibiotics gentamicin, tylosin, lincomycin and spectinomycin (GTLS) to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 2000 | Theriogenology | pmid:10990358 |
| Kim S | Failure of antibiotics gentamicin, tylosin, lincomycin and spectinomycin to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 2000 | Theriogenology | pmid:10990359 |
| Rosenbusch RF | Failure of antibiotics gentamicin, tylosin, lincomycin and spectinomycin (GTLS) to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 2000 | Theriogenology | pmid:10990360 |
| Thomas CB | Failure of antibiotics gentamicin, tylosin, lincomycin and spectinomycin (GTLS) to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 2000 | Theriogenology | pmid:10990361 |
| Stobba-Wiley CM et al. | Determination of tilmicosin residues in chicken, cattle, swine, and sheep tissues by liquid chromatography. | 2000 Jul-Aug | J AOAC Int | pmid:10995110 |
| Dinos GP and Kalpaxis DL | Kinetic studies on the interaction between a ribosomal complex active in peptide bond formation and the macrolide antibiotics tylosin and erythromycin. | 2000 | Biochemistry | pmid:10995229 |
| Goubau S et al. | Tilmicosin does not inhibit interleukin-8 gene expression in the bovine lung experimentally infected with Mannheimia (Pasteurella) haemolytica. | 2000 | Can. J. Vet. Res. | pmid:11041503 |
| Mackie DP et al. | Mixed mycoplasma mastitis outbreak in a dairy herd. | 2000 | Vet. Rec. | pmid:11058024 |
| Poulsen SM et al. | Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin. | 2000 | J. Mol. Biol. | pmid:11090288 |
| DeRosa DC et al. | In vitro susceptibility of porcine respiratory pathogens to tilmicosin. | 2000 | J. Vet. Diagn. Invest. | pmid:11108454 |
| Fajt VR et al. | Effects of danofloxacin and tilmicosin on circulating neutrophils in beef heifers. | 2000 | J. Vet. Pharmacol. Ther. | pmid:11110107 |
| Frank GH and Duff GC | Effects of tilmicosin phosphate, administered prior to transport or at time of arrival, and feeding of chlortetracycline, after arrival in a feedlot, on Mannheimia haemolytica in nasal secretions of transported steers. | 2000 | Am. J. Vet. Res. | pmid:11131584 |
| Nolan PM et al. | Maintenance of a captive flock of house finches free of infection by Mycoplasma gallisepticum. | 2000 Oct-Dec | Avian Dis. | pmid:11195652 |
| Ingerslev F and Halling-Sørensen B | Biodegradability of metronidazole, olaquindox, and tylosin and formation of tylosin degradation products in aerobic soil--manure slurries. | 2001 | Ecotoxicol. Environ. Saf. | pmid:11222042 |
| Ragheb HS | Antibiotics in feeds. | 2001 Jan-Feb | J AOAC Int | pmid:11234833 |
| Butler AR et al. | Feedback control of polyketide metabolism during tylosin production. | 2001 | Microbiology (Reading, Engl.) | pmid:11283275 |
| Morisaki N et al. | Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain. | 2001 | J. Antibiot. | pmid:11302489 |
| Dinos GP et al. | Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex. | 2001 | Mol. Pharmacol. | pmid:11353804 |
| Whitehead TR and Cotta MA | Sequence analyses of a broad host-range plasmid containing ermT from a tylosin-resistant Lactobacillus sp. Isolated from swine feces. | 2001 | Curr. Microbiol. | pmid:11375658 |
| Lim J and Yun H | Postantibiotic effects and postantibiotic sub-MIC effects of erythromycin, roxithromycin, tilmicosin, and tylosin on Pasteurella multocida. | 2001 | Int. J. Antimicrob. Agents | pmid:11397617 |
| Wang C et al. | In vitro susceptibility of avian mycoplasmas to enrofloxacin, sarafloxacin, tylosin, and oxytetracycline. | 2001 Apr-Jun | Avian Dis. | pmid:11417828 |
| Vaidyanathan S et al. | Assessment of near-infrared spectral information for rapid monitoring of bioprocess quality. | 2001 | Biotechnol. Bioeng. | pmid:11427939 |
| Naccari F et al. | Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep. | 2001 | Vet. Rec. | pmid:11465263 |
| Beechinor JG and Bloomfield FJ | Variability in residue concentrations of tilmicosin in cattle muscle. | 2001 | Vet. Rec. | pmid:11530904 |
| Alt DP et al. | Evaluation of antibiotics for treatment of cattle infected with Leptospira borgpetersenii serovar hardjo. | 2001 | J. Am. Vet. Med. Assoc. | pmid:11549093 |
| Draisci R et al. | Confirmatory method for macrolide residues in bovine tissues by micro-liquid chromatography-tandem mass spectrometry. | 2001 | J Chromatogr A | pmid:11554423 |
| Butler AR et al. | Influence of ancillary genes, encoding aspects of methionine metabolism, on tylosin biosynthesis in Streptomyces fradiae. | 2001 | J. Antibiot. | pmid:11594346 |
| Butler AR and Cundliffe E | Influence of dimethylsulfoxide on tylosin production in Streptomyces fradiae. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11598810 |
| Brennan J et al. | Efficacy of in-feed tylosin phosphate for the treatment of necrotic enteritis in broiler chickens. | 2001 | Poult. Sci. | pmid:11599704 |
| Boerlin P et al. | Antimicrobial growth promoter ban and resistance to macrolides and vancomycin in enterococci from pigs. | 2001 | J. Clin. Microbiol. | pmid:11682559 |
| Niwa H et al. | Rapid detection of mutations associated with resistance to erythromycin in Campylobacter jejuni/coli by PCR and line probe assay. | 2001 | Int. J. Antimicrob. Agents | pmid:11691569 |
| Thomas E et al. | A field comparison of the efficacy and tolerance of marbofloxacin in the treatment of bovine respiratory disease. | 2001 | J. Vet. Pharmacol. Ther. | pmid:11696086 |
| Draisci R et al. | A new electrochemical enzyme-linked immunosorbent assay for the screening of macrolide antibiotic residues in bovine meat. | 2001 | Analyst | pmid:11763071 |
| Hoflack G et al. | Efficacy of tilmicosin phosphate (Pulmotil premix) in feed for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs. | 2001 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:11765801 |
| Cundliffe E et al. | The tylosin-biosynthetic genes of Streptomyces fradiae. | 2001 | Antonie Van Leeuwenhoek | pmid:11816964 |
| Prats C et al. | Determination of tylosin residues in different animal tissues by high performance liquid chromatography. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:11820296 |
| Zhang YX et al. | Genome shuffling leads to rapid phenotypic improvement in bacteria. | 2002 | Nature | pmid:11832946 |
| Stratigopoulos G and Cundliffe E | Expression analysis of the tylosin-biosynthetic gene cluster: pivotal regulatory role of the tylQ product. | 2002 | Chem. Biol. | pmid:11841940 |
| Mateusen B et al. | A comparative study of the preventive use of tilmicosin phosphate (Pulmotil premix) and Mycoplasma hyopneumoniae vaccination in a pig herd with chronic respiratory disease. | 2001 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:11846018 |
| Saurit AR et al. | Some comparative aspects of the pharmacokinetics of tylosin in buffaloes and cattle. | 2002 | Vet. Res. Commun. | pmid:11860087 |
| Brumm MC et al. | Effect of wean-to-finish management on pig performance. | 2002 | J. Anim. Sci. | pmid:11881920 |