| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Appl. Environ. Microbiol. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- FEMS Microbiol. Lett. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ose EE and Tonkinson LV | Single-dose treatment of neonatal calf pneumonia with the new macrolide antibiotic tilmicosin. | 1988 | Vet. Rec. | pmid:3195026 |
| Fujiwara T et al. | 19-Deformyl-4'-deoxydesmycosin (TMC-016): synthesis and biological properties of a unique 16-membered macrolide antibiotic. | 1989 | J. Antibiot. | pmid:2500413 |
| Kiyoshima K et al. | Structure-activity relationship studies on 4''-O-acyltylosin derivatives: significance of their 23-O-mycinosyl and 4''-O-acyl moieties in antimicrobial activity against macrolide-resistant microbes. | 1989 | J. Antibiot. | pmid:2584151 |
| Matsushima P et al. | Transduction and transformation of plasmid DNA in Streptomyces fradiae strains that express different levels of restriction. | 1989 | J. Bacteriol. | pmid:2542216 |
| Debono M et al. | Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. | 1989 | J. Antibiot. | pmid:2668243 |
| Gollins WJ | Occupational asthma due to tylosin tartrate. | 1989 | Br J Ind Med | pmid:2611166 |
| Kirst HA et al. | Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides. | 1989 | J. Antibiot. | pmid:2684947 |
| Lee HS et al. | Occupational asthma due to tylosin tartrate. | 1989 | Br J Ind Med | pmid:2765423 |
| Gourlay RN et al. | Effect of a new macrolide antibiotic (tilmicosin) on pneumonia experimentally induced in calves by Mycoplasma bovis and Pasteurella haemolytica. | 1989 | Res. Vet. Sci. | pmid:2772410 |
| Anti-infective drug use in relation to the risk of agranulocytosis and aplastic anemia. A report from the International Agranulocytosis and Aplastic Anemia Study. | 1989 | Arch. Intern. Med. | pmid:2785785 | |
| Bébrová E et al. | [Immunologic reactivity of tylosin and erythromycin]. | 1989 | Cesk Epidemiol Mikrobiol Imunol | pmid:2790978 |
| Ruggeri C et al. | Synthesis and antibacterial activity of 9-O-[(2-methoxyethoxy)methyl]-oximes of tylosin and demycarosyltylosin. | 1989 | J. Antibiot. | pmid:2793598 |
| Kempf I et al. | [Efficacy of spiramycin and tylosin in preventing mycoplasmosis in chicks experimentally infected with mycoplasma gallisepticum]. | 1989 | Pathol. Biol. | pmid:2797880 |
| Zalacain M and Cundliffe E | Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. | 1989 | J. Bacteriol. | pmid:2753855 |
| Synek M et al. | [Immunologic aspects of macrolide antibiotics]. | 1989 | Cas. Lek. Cesk. | pmid:2731206 |
| Ryoo JP et al. | Data acquisition and processing system for drug release characterization by thin layer chromatography. | 1989 | Biomed Sci Instrum | pmid:2742974 |
| Marshall VP et al. | Enzymic inactivation of lincosaminide and macrolide antibiotics: divalent metal cation and coenzyme specificities. | 1989 | J. Antibiot. | pmid:2722691 |
| de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 2. Amidines. | 1989 | J. Med. Chem. | pmid:2913309 |
| Ball HJ and Campbell JN | Antibiotic treatment of experimental Mycoplasma californicum mastitis. | 1989 | Vet. Rec. | pmid:2815518 |
| Yao RC and Mahoney DF | Enzyme immunoassay for macrolide antibiotics: characterization of an antibody to 23-amino-O-mycaminosyltylonolide. | 1989 | Appl. Environ. Microbiol. | pmid:2764563 |
| Salamakha OV et al. | [The study of the growth of tylosin producer using differential centrifugation of mycelium in a sucrose density gradient]. | 1989 Sep-Oct | Mikrobiologiia | pmid:2635267 |
| Cacciapuoti AF et al. | Microbiological and pharmacokinetic studies of acyl demycinosyltylosin and related tylosin derivatives. | 1990 | J. Antibiot. | pmid:2145254 |
| Navashin SM et al. | [Genetic and biochemical control of biosynthesis of macrolide antibiotics]. | 1990 | Antibiot. Khimioter. | pmid:2078074 |
| Fujiwara T and Takenaka S | Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide to 19-deformyl-4'-deoxydesmycosin (TMC-016). | 1990 | FEMS Microbiol. Lett. | pmid:2379808 |
| Roudaut B and Moretain JP | Residues of macrolide antibiotics in eggs following medication of laying hens. | 1990 | Br. Poult. Sci. | pmid:2245358 |
| Morris FE et al. | Effect of rotating monensin plus tylosin and lasalocid on performance, ruminal fermentation, and site and extent of digestion in feedlot cattle. | 1990 | J. Anim. Sci. | pmid:2254185 |
| MiliavskiÄ EB et al. | [Electrophoretic separation of spores of producers of kanamycin and tylosin]. | 1990 | Antibiot. Khimioter. | pmid:2334246 |
| Fujiwara T et al. | Absorption, tissue distribution and excretion of 19-deformyldesmycosin derivatives, new 16-membered macrolides, in mice. | 1990 | J. Antibiot. | pmid:2324015 |
| Panfilova ZI et al. | [Obtaining of mutants of Streptomyces fradiae producing tylosin by action of nitrosomethylurea on synchronously germinating spores]. | 1990 | Antibiot. Khimioter. | pmid:2383150 |
| Collington GK et al. | The influence of inclusion of either an antibiotic or a probiotic in the diet on the development of digestive enzyme activity in the pig. | 1990 | Br. J. Nutr. | pmid:2119223 |
| Huber ML et al. | Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin. | 1990 | Antimicrob. Agents Chemother. | pmid:2221862 |
| Coleman MR and Mowrey DH | Turbidimetric assay of tylosin in animal feeds containing urea. | 1990 Nov-Dec | J Assoc Off Anal Chem | pmid:2289924 |
| Nakura H et al. | Formation of an antibacterial metabolite from a new macrolide compound 23-O-benzyl-5-mycaminosyl-tylonolide (TMC-101), by a hepatic microsomal drug-metabolizing enzyme system. | 1991 | J. Pharmacobio-dyn. | pmid:1802985 |
| Rezanka T et al. | Isobutyrate as a precursor of n-butyrate in the biosynthesis of tylosine and fatty acids. | 1991 | FEMS Microbiol. Lett. | pmid:1769552 |
| Rosteck PR et al. | Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. | 1991 | Gene | pmid:1864505 |
| Lee SH and Lee KJ | Relationship between threonine dehydratase and biosynthesis of tylosin in Streptomyces fradiae. | 1991 | J. Gen. Microbiol. | pmid:1783901 |
| Atef M et al. | Disposition of tylosin in goats. | 1991 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:1790764 |
| Hue KK and Bechhofer DH | Effect of ermC leader region mutations on induced mRNA stability. | 1991 | J. Bacteriol. | pmid:1711026 |
| Tikhomirova LA et al. | [Cytomorphological and cultural characteristics of tylosin-producing strains with different antibiotic activity]. | 1991 | Antibiot. Khimioter. | pmid:1755702 |
| Residues of some veterinary drugs in animals and foods. Monographs prepared by the thirty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives. | 1991 | FAO Food Nutr Pap | pmid:1687815 | |
| Zalacain M and Cundliffe E | Cloning of tlrD, a fourth resistance gene, from the tylosin producer, Streptomyces fradiae. | 1991 | Gene | pmid:1995426 |
| Dzapo V and Reiner G | [The nutritive effect of avilamycin in swine breeding and fattening]. | 1991 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:1954859 |
| Catchpole I and Dyke KG | Replication mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance plasmid pT48. | 1991 | Mol. Microbiol. | pmid:1906970 |
| Smith SC et al. | In-vitro antimicrobial susceptibility of Australian isolates of Treponema hyodysenteriae. | 1991 | Aust. Vet. J. | pmid:1839652 |
| Schumann FJ et al. | Prophylactic medication of feedlot calves with tilmicosin. | 1991 | Vet. Rec. | pmid:2038809 |
| Laven R and Andrews AH | Long-acting antibiotic formulations in the treatment of calf pneumonia: a comparative study of tilmicosin and oxytetracycline. | 1991 | Vet. Rec. | pmid:1926728 |
| de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of amides and amidines derived from 2-amino-1,10-phenanthroline. | 1991 | J. Med. Chem. | pmid:2002460 |
| Picavet T et al. | Efficacy of tilmicosin in treatment of pulmonary infections in calves. | 1991 | Vet. Rec. | pmid:1837391 |
| Mee JF and O'Farrell K | Tilmicosin and calf pneumonia. | 1991 | Vet. Rec. | pmid:1858280 |
| Atef M et al. | Disposition of tylosin in goats. | 1991 May-Jun | Br. Vet. J. | pmid:1878767 |
| Chuard C et al. | In-vitro and in-vivo evaluation of the antistaphylococcal activity of S-5556, a new 16-membered macrolide. | 1992 | J. Antimicrob. Chemother. | pmid:1452498 |
| Kádár-Pauncz J et al. | Isolation and structure elucidation of new antibiotics related to angolamycin. | 1992 | J. Antibiot. | pmid:1399843 |
| Kageyama S et al. | Synthesis of 3,4'-dideoxymycaminosyl tylonolide, a novel type of macrolide derivative. | 1992 | J. Antibiot. | pmid:1548187 |
| Mathieson PW et al. | Mercuric chloride-treated brown Norway rats develop widespread tissue injury including necrotizing vasculitis. | 1992 | Lab. Invest. | pmid:1625442 |
| Arzey GG and Arzey KE | Successful treatment of mycoplasmosis in layer chickens with single dose therapy. | 1992 | Aust. Vet. J. | pmid:1379426 |
| Kempf I et al. | Efficacy of danofloxacin in the therapy of experimental mycoplasmosis in chicks. | 1992 | Res. Vet. Sci. | pmid:1332154 |
| Malanicheva IA et al. | [Protoplast fusion in Streptomyces fradiae strains producing neomycin and tylosin]. | 1992 | Antibiot. Khimioter. | pmid:1296531 |
| Baltz RH et al. | Transposition of Tn5096 and related transposons in Streptomyces species. | 1992 | Gene | pmid:1319378 |
| Brahimi-Horn MC et al. | Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae. | 1992 | J. Ind. Microbiol. | pmid:1381591 |
| Gummow B et al. | The diagnosis and treatment of bovine genital ureaplasmosis: a case study. | 1992 | J S Afr Vet Assoc | pmid:1404223 |
| Chin NX and Neu HC | In vitro activity of MC-352, a new 16-membered macrolide. | 1992 | Antimicrob. Agents Chemother. | pmid:1416853 |
| Galyean ML et al. | Performance of feedlot steers fed diets containing laidlomycin propionate or monensin plus tylosin, and effects of laidlomycin propionate concentration on intake patterns and ruminal fermentation in beef steers during adaptation to a high-concentrate diet. | 1992 | J. Anim. Sci. | pmid:1429270 |
| Fodor L et al. | Treatment of calf pneumonia with tilmicosin. | 1993 | Acta Vet. Hung. | pmid:8116500 |
| Hartman EG and Geryl J | Comparison between the minimal inhibitory concentration of tilmicosin and oxytetracycline for bovine pneumonic Pasteurella haemolytica isolates. | 1993 | Vet Q | pmid:8122359 |
| Takhirov MT et al. | [Determination of tylosin in the water supply using a chromatographic method]. | 1993 | Gig Sanit | pmid:8244081 |
| Tanner AC et al. | Adaptation of the Sensititre broth microdilution technique to antimicrobial susceptibility testing of Mycoplasma hyopneumoniae. | 1993 | Vet. Microbiol. | pmid:8273275 |
| Stephens CP et al. | In-vitro antibacterial properties of tilmicosin against Australian isolates of Pasteurella multocida and Pasteurella haemolytica from cattle. | 1993 | Aust. Vet. J. | pmid:8257321 |
| Westermarck E et al. | Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. | 1993 | Pancreas | pmid:8302792 |
| Cooper AC et al. | In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance. | 1993 | Res. Vet. Sci. | pmid:8393208 |
| Huang SL et al. | Purification and properties of NADPH-dependent tylosin reductase from Streptomyces fradiae. | 1993 | J. Biol. Chem. | pmid:8360186 |
| Binder S et al. | [The effectiveness of tilmicosin in respiratory diseases of swine]. | 1993 | Berl. Munch. Tierarztl. Wochenschr. | pmid:8431202 |
| Cester CC et al. | Effect of stage of oestrous cycle on tylosin disposition in genital tract secretions of cows. | 1993 | Res. Vet. Sci. | pmid:8434145 |
| Jordan FT et al. | A comparison of the efficacy of danofloxacin and tylosin in the control of Mycoplasma gallisepticum infection in broiler chicks. | 1993 | J. Vet. Pharmacol. Ther. | pmid:8386777 |
| Meisel ML et al. | Tylosin inhibits the steroidogenesis in mouse Leydig cells "in vitro". | 1993 | Life Sci. | pmid:8390595 |
| Kageyama S et al. | Synthesis of 3-deoxy-3,4-didehydro derivatives of 5-O-mycaminosyltylonolide, 5-O-(4-deoxymycaminosyl) tylonolide, and desmycosin. | 1993 | J. Antibiot. | pmid:8407589 |
| Roets E et al. | Quantitative analysis of tylosin by column liquid chromatography. | 1993 | J. Chromatogr. | pmid:8445000 |
| Danielson ND et al. | Simple methods for the qualitative identification and quantitative determination of macrolide antibiotics. | 1993 | J Pharm Biomed Anal | pmid:8504183 |
| Lee SH and Lee KJ | Aspartate aminotransferase and tylosin biosynthesis in Streptomyces fradiae. | 1993 | Appl. Environ. Microbiol. | pmid:8481008 |
| Morck DW et al. | Prophylactic efficacy of tilmicosin for bovine respiratory tract disease. | 1993 | J. Am. Vet. Med. Assoc. | pmid:8428833 |
| Jordan WH et al. | A review of the toxicology of the antibiotic MICOTIL 300. | 1993 | Vet Hum Toxicol | pmid:8470360 |
| Arisawa A et al. | Cloning and nucleotide sequences of two genes involved in the 4''-O-acylation of macrolide antibiotics from Streptomyces thermotolerans. | 1993 | Biosci. Biotechnol. Biochem. | pmid:7764361 |
| Riddell KP et al. | Antibiotic treatment of bovine embryos. | 1993 | J. Assist. Reprod. Genet. | pmid:8069094 |
| Clary EM et al. | Supplemental fat and ionophores in finishing diets: feedlot performance and ruminal digesta kinetics in steers. | 1993 | J. Anim. Sci. | pmid:8270535 |
| Migaki TT et al. | Efficacy of danofloxacin and tylosin in the control of mycoplasmosis in chicks infected with tylosin-susceptible or tylosin-resistant field isolates of Mycoplasma gallisepticum. | 1993 Apr-Jun | Avian Dis. | pmid:8395803 |
| Tanner AC et al. | A comparison of danofloxacin and tylosin in the control of induced Mycoplasma gallisepticum infection in broiler chicks. | 1993 Apr-Jun | Avian Dis. | pmid:8395804 |
| Meisel ML et al. | Effects of tylosin on the pituitary-gonadal axis in male rats. | 1993 Apr-May | Pharmacol. Toxicol. | pmid:8372057 |
| Coleman MR et al. | The need for larger analytical samples with granulated feed additives. | 1993 Sep-Oct | J AOAC Int | pmid:8241822 |
| McGuigan MA | Human exposures to tilmicosin (MICOTIL). | 1994 | Vet Hum Toxicol | pmid:7975134 |
| Arisawa A et al. | Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic. | 1994 | Appl. Environ. Microbiol. | pmid:8074537 |
| Wardlaw AC et al. | Bactericidal activity in the pig roundworm Ascaris suum. | 1994 | J. Appl. Bacteriol. | pmid:8144403 |
| Inouye M et al. | Cloning and sequences of two macrolide-resistance-encoding genes from mycinamicin-producing Micromonospora griseorubida. | 1994 | Gene | pmid:8163173 |
| Scott PR | Field study of undifferentiated respiratory disease in housed beef calves. | 1994 | Vet. Rec. | pmid:8203107 |
| Coronato S et al. | A simple method to eliminate mycoplasma from cell cultures. | 1994 | J. Virol. Methods | pmid:8175949 |
| Tang L et al. | Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. | 1994 | J. Bacteriol. | pmid:7928973 |
| Kageyama S and Tsuchiya T | Synthesis of 2-C-methyl derivatives of 3,4'-dideoxymycaminosyltylonolide, a novel type of 16-membered macrolide antibiotic. | 1994 | J. Antibiot. | pmid:7928687 |
| Trovatelli LD et al. | The effect of some antibiotics on Enterococcus faecium SF 68 inoculated in germ-free mice. | 1994 | Microbiol. Res. | pmid:7987613 |
| Merson-Davies LA and Cundliffe E | Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. | 1994 | Mol. Microbiol. | pmid:7984112 |
| Inamoto T et al. | Antibacterial activity of tilmicosin against Pasteurella multocida and Actinobacillus pleuropneumoniae isolated from pneumonic lesions in swine. | 1994 | J. Vet. Med. Sci. | pmid:7865594 |
| Tan ZL et al. | Serum neutralizing antibodies against Fusobacterium necrophorum leukotoxin in cattle with experimentally induced or naturally developed hepatic abscesses. | 1994 | J. Anim. Sci. | pmid:8157537 |
| Buller NB and Hampson DJ | Antimicrobial susceptibility testing of Serpulina hyodysenteriae. | 1994 | Aust. Vet. J. | pmid:7945100 |