Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tylosin?

Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tylosin

PubChem Associated disorders and diseases

What pathways are associated with Tylosin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tylosin?

Related references are published most in these journals:

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What functions are associated with Tylosin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tylosin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Tylosin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tylosin?

Knock-out

Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tylosin

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Authors Title Published Journal PubMed Link
Evans RD et al. Field evaluation of tylosin premix in layers previously vaccinated with a live Mycoplasma gallisepticum vaccine. 2002 Jan-Mar Avian Dis. pmid:11922337
Cerdá RO et al. In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina. 2002 Jan-Mar Avian Dis. pmid:11922338
Müller AK et al. The diversity and function of soil microbial communities exposed to different disturbances. 2002 Microb. Ecol. pmid:11976785
Bate N et al. Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. 2002 Mol. Microbiol. pmid:11985721
Stratigopoulos G and Cundliffe E Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae. 2002 J. Ind. Microbiol. Biotechnol. pmid:11986923
Van Donkersgoed J et al. The effect of administering long-acting oxytetracycline and tilmicosin either by dart gun or by hand on injection site lesions and drug residues in beef cattle. 1999 Can. Vet. J. pmid:12001341
Schunich OC et al. A comparison of prophylactic efficacy of tilmicosin and a new formulation of oxytetracycline in feedlot calves. 2002 Can. Vet. J. pmid:12001501
Han H et al. Carbohydrate fermentation and nitrogen metabolism of a finishing beef diet by ruminal microbes in continuous cultures as affected by ethoxyquin and(or) supplementation of monensin and tylosin. 2002 J. Anim. Sci. pmid:12002320
Altunok V et al. Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits. 2002 J. Vet. Med. B Infect. Dis. Vet. Public Health pmid:12002421
Hranjec M et al. New amidino-benzimidazolyl derivatives of tylosin and desmycosin. 2002 J. Antibiot. pmid:12014447
Lakritz J et al. Tilmicosin reduces lipopolysaccharide-stimulated bovine alveolar macrophage prostaglandin E(2) production via a mechanism involving phospholipases. 2002 Vet. Ther. pmid:12050824
Hibbard B et al. Dose determination and confirmation for ceftiofur crystalline-free acid administered in the posterior aspect of the ear for control and treatment of bovine respiratory disease. 2002 Vet. Ther. pmid:12050825
Creemer LC et al. Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin. 2002 J. Antibiot. pmid:12061552
Yazar E et al. The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities. 2002 J. Vet. Med. B Infect. Dis. Vet. Public Health pmid:12069277
Flint SA et al. Expression of tylM genes during tylosin production: phantom promoters and enigmatic translational coupling motifs. 2002 J. Ind. Microbiol. Biotechnol. pmid:12074090
Stephanopoulos G Metabolic engineering by genome shuffling. 2002 Nat. Biotechnol. pmid:12089547
Gautier-Bouchardon AV et al. In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae. 2002 Vet. Microbiol. pmid:12119137
Stratigopoulos G et al. Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. 2002 Mol. Microbiol. pmid:12139619
Loke ML et al. Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosin A, olaquindox and metronidazole in manure. 2002 Chemosphere pmid:12146624
Carter JN et al. Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease. 2002 Am. J. Vet. Res. pmid:12171163
Takahashi I et al. [In vitro resistance acquisition in Mycoplasma gallisepticum against ofloxacin, tylosin and spectinomycin]. 2002 Jpn J Antibiot pmid:12199113
Prats C et al. Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs. 2002 Res. Vet. Sci. pmid:12204632
Shryock TR et al. Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease. 2002 J. Vet. Diagn. Invest. pmid:12296390
Higgins HC and McEvoy JD Accelerated solvent extraction of animal feedingstuffs for microbial growth inhibition screening for the presence of antimicrobial feed additives. 2002 Food Addit Contam pmid:12396393
Liu M and Douthwaite S Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12417742
Christodoulopoulos G et al. Tilmicosin administration to young lambs with respiratory infection: safety and efficacy considerations. 2002 J. Vet. Pharmacol. Ther. pmid:12423233
Hwang YH et al. Simultaneous determination of various macrolides by liquid chromatography/mass spectrometry. 2002 J. Vet. Sci. pmid:12441679
Lee SW et al. Prevalence of porcine proliferative enteropathy and its control with tylosin in Korea. 2001 J. Vet. Sci. pmid:12441690
Prats C et al. Tylosin depletion from edible pig tissues. 2002 Res. Vet. Sci. pmid:12443694
Kowalski C et al. Pharmacokinetics of tylosin in broiler chickens. 2002 Pol J Vet Sci pmid:12448074
Mandić Z et al. New derivatives of tylosin: chemical and electrochemical oxidation products of desmycosin. 2002 J. Antibiot. pmid:12458770
Ives SE et al. Effects of virginiamycin and monensin plus tylosin on ruminal protein metabolism in steers fed corn-based finishing diets with or without wet corn gluten feed. 2002 J. Anim. Sci. pmid:12462270
Clark SB et al. Interlaboratory comparison of methods for the determination of incurred tilmicosin residues in bovine liver. 2002 Nov-Dec J AOAC Int pmid:12477187
Poole TL et al. Effect of subtherapeutic concentrations of tylosin on the inhibitory stringency of a mixed anaerobe continuous-flow culture of chicken microflora against Escherichia coli O157:H7. 2003 J. Appl. Microbiol. pmid:12492926
Dingwell RT et al. The efficacy of intramammary tilmicosin at drying-off, and other risk factors for the prevention of new intramammary infections during the dry period. 2002 J. Dairy Sci. pmid:12512598
Lebars I et al. Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII. 2003 EMBO J. pmid:12514124
Elzen PJ et al. Method of application of tylosin, an antibiotic for American foulbrood control, with effects on small hive beetle (Coleoptera: Nitidulidae) populations. 2002 J. Econ. Entomol. pmid:12539820
German AJ et al. Comparison of direct and indirect tests for small intestinal bacterial overgrowth and antibiotic-responsive diarrhea in dogs. 2003 Jan-Feb J. Vet. Intern. Med. pmid:12564725
Dingwell RT et al. Efficacy of intramammary tilmicosin and risk factors for cure of Staphylococcus aureus infection in the dry period. 2003 J. Dairy Sci. pmid:12613861
Onan LJ and LaPara TM Tylosin-resistant bacteria cultivated from agricultural soil. 2003 FEMS Microbiol. Lett. pmid:12644222
Althaus RL et al. Detection limits of antimicrobials in ewe milk by delvotest photometric measurements. 2003 J. Dairy Sci. pmid:12647952
Iveković D et al. Electrochemical reduction of desmycosin, structure investigation and antibacterial evaluation of the resulting products. 2003 Eur J Pharm Sci pmid:12694884
Rodriguez E et al. Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains. 2003 J. Ind. Microbiol. Biotechnol. pmid:12698320
De Liguoro M et al. Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil. 2003 Chemosphere pmid:12729703
Marks SL and Kather EJ Antimicrobial susceptibilities of canine Clostridium difficile and Clostridium perfringens isolates to commonly utilized antimicrobial drugs. 2003 Vet. Microbiol. pmid:12742714
Fajt VR et al. The effects of danofloxacin and tilmicosin on neutrophil function and lung consolidation in beef heifer calves with induced Pasteurella (Mannheimia) haemolytica pneumonia. 2003 J. Vet. Pharmacol. Ther. pmid:12755900
Neiffer DL Clostridium perfringens enterotoxicosis in two Amur leopards (Panthera pardus orientalis). 2001 J. Zoo Wildl. Med. pmid:12790411
Anderegg TR and Jones RN Initial disk diffusion quality control guidelines for tylosin tested against Staphylococcus aureus ATCC 25923 and Streptococcus pneumoniae ATCC 49619. 2003 Int. J. Antimicrob. Agents pmid:12791478
Tarabla H and Canavesio V Prevalence of intramammary infections by major pathogens at parturition in dairy cows after intramuscular antibiotic therapy at drying-off: a preliminary report. 2003 J. Dairy Res. pmid:12800878
Loria GR et al. In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. 2003 Res. Vet. Sci. pmid:12801456