erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Xu P et al. | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19560350 |
De Rosa R et al. | [Disappearance of Streptococcus pyogenes macrolide resistance in an area of northeastern Italy: a possible link with rational long-acting macrolide consumption]. | 2009 | Infez Med | pmid:19602920 |
Chu YW et al. | Resistance to tetracycline, erythromycin and clindamycin in Streptococcus suis serotype 2 in Hong Kong. | 2009 | Int. J. Antimicrob. Agents | pmid:19380213 |
Mehta N and Laddha KS | A modified method for isolation of rhein from senna. | 2009 | Indian J Pharm Sci | pmid:20336207 |
Du Y and He Q | [The mechanism of alleviation of paraquat induced vascular endothelial permeability by erythromycin through adenosine 3'5'-cyclic monophosphate pathway]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19930884 |
Röhm KD et al. | Motility disorders in the ICU: recent therapeutic options and clinical practice. | 2009 | Curr Opin Clin Nutr Metab Care | pmid:19202387 |
Zou X et al. | Enhancement of erythromycin A production with feeding available nitrogen sources in erythromycin biosynthesis phase. | 2009 | Bioresour. Technol. | pmid:19268575 |
Tonelli AR et al. | Erythromycin improves gastric emptying half-time in adult cystic fibrosis patients with gastroparesis. | 2009 | J. Cyst. Fibros. | pmid:19269261 |
Beeton ML et al. | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. | 2009 | Antimicrob. Agents Chemother. | pmid:19273669 |
Yu L and Ran PX | [Effects of erythromycin on the synthesis of interleukin-8 and gamma-glutamylcysteine synthetase induced by 4-hydroxynonenal in the bronchial epithelial cells]. | 2009 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:19567187 |
Mortison JD et al. | Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases. | 2009 | J. Am. Chem. Soc. | pmid:19810731 |
Vachée A et al. | [Antibiotics susceptibility of Streptococcus and Enterococcus: data of Onerba network]. | 2009 | Pathol. Biol. | pmid:18343047 |
Hirabayashi T et al. | Stimulatory action of mitemcinal (GM-611), an acid-resistant non-peptide motilin receptor agonist, on colonic motor activity and defecation: spontaneous and mitemcinal-induced giant migrating contractions during defecation in dogs. | 2009 | Neurogastroenterol. Motil. | pmid:19508333 |
Billal DS et al. | Loss of erythromycin resistance genes from strains of Streptococcus pyogenes that have developed resistance to levofloxacin. | 2009 | Diagn. Microbiol. Infect. Dis. | pmid:19345038 |
Takanashi H and Cynshi O | Motilides: a long and winding road: lessons from mitemcinal (GM-611) on diabetic gastroparesis. | 2009 | Regul. Pept. | pmid:19345243 |
Kotova NV | [Kinetic and equilibrium parameters of erythromycin sorption on various sorbents]. | 2009 | Antibiot. Khimioter. | pmid:20583559 |
Kim BS et al. | Case of minocycline-effective confluent and reticulated papillomatosis with unusual location on forehead. | 2009 | J. Dermatol. | pmid:19348668 |
Stang EM and White MC | Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation. | 2009 | Nat Chem | pmid:21378935 |
Khosla C | Structures and mechanisms of polyketide synthases. | 2009 | J. Org. Chem. | pmid:19711990 |
del Pozo JL et al. | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. | 2009 | Antimicrob. Agents Chemother. | pmid:18725436 |
Rowe RA et al. | Mechanisms of resistance for Streptococcus pyogenes in northern Utah. | 2009 | Clin Lab Sci | pmid:19354028 |
Vaudaux P et al. | Comparative activity of oritavancin against meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from Geneva University Hospital. | 2009 | Int. J. Antimicrob. Agents | pmid:19744838 |
Diop A et al. | [Quality control of antibiotics used in Senegal]. | 2009 | Med Trop (Mars) | pmid:19702146 |
Kamada K et al. | Characterization and monitoring of pseudo-polymorphs in manufacturing process by NIR. | 2009 | Int J Pharm | pmid:19007870 |
Ali-Khan AS et al. | Erythromycin sclerotherapy in the management of seroma. | 2009 | J Plast Reconstr Aesthet Surg | pmid:19010103 |
Benouda A et al. | [Place of Streptococcus pyogenes in the throat infection in Morocco and overview of its susceptibility to antibiotics]. | 2009 | Pathol. Biol. | pmid:19095378 |
Orlando R et al. | Irreversible CYP3A inhibition accompanied by plasma protein-binding displacement: a comparative analysis in subjects with normal and impaired liver function. | 2009 | Clin. Pharmacol. Ther. | pmid:19020496 |
Ozaki K et al. | Effects of mitemcinal (GM-611), an orally active erythromycin-derived prokinetic agent, on delayed gastric emptying and postprandial glucose in a new minipig model of diabetes. | 2008 Sep-Oct | J. Diabetes Complicat. | pmid:18413164 |
Rassi H and Ghasemi SF | Production of novel chemotherapeutic drugs by Streptomycetes. | 2008 Oct-Dec | Lik. Sprava | pmid:19663015 |
Pomero G et al. | [Neonatal group B Streptococcus infection: an integrated approach (of clinical pathologists, gynecologists, midwives, pediatricians-neonatologists) of the functional area of Cuneo (Italy)]. | 2008 Nov-Dec | Pediatr Med Chir | pmid:19431950 |
Vlieghe ER et al. | Trends of norfloxacin and erythromycin resistance of Campylobacter jejuni/Campylobacter coli isolates recovered from international travelers, 1994 to 2006. | 2008 Nov-Dec | J Travel Med | pmid:19090796 |
Van Der Beek MT et al. | Mycobacterium chelonae keratitis in a patient with Sjögren's syndrome. | 2008 Mar-Apr | Eur J Ophthalmol | pmid:18320526 |
Angel MR et al. | Prevalence of inducible clindamycin resistance in gram positive organisms in a tertiary care centre. | 2008 Jul-Sep | Indian J Med Microbiol | pmid:18695329 |
Farrant P et al. | Is erythromycin an effective treatment for chronic bullous disease of childhood? A national survey of members of the British Society for Paediatric Dermatology. | 2008 Jul-Aug | Pediatr Dermatol | pmid:18789096 |
MacLaren R et al. | Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. | 2008 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:18596312 |
Bitarães EL et al. | Compliance with antibiotic prophylaxis in children with sickle cell anemia: a prospective study. | 2008 Jul-Aug | J Pediatr (Rio J) | pmid:18688558 |
Landzinski J et al. | Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. | 2008 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:18165446 |
Nouri M et al. | Effect of erythromycin and gentamicin on abomasal emptying rate in suckling calves. | 2008 Jan-Feb | J. Vet. Intern. Med. | pmid:18289310 |
Winters M et al. | Epidemiology of invasive pneumococcal disease in BC during the introduction of conjugated pneumococcal vaccine. | 2008 Jan-Feb | Can J Public Health | pmid:18435393 |
Gunes N et al. | Erythromycin residue in honey from the Southern Marmara region of Turkey. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:19680838 |
Weidlich M et al. | Differential activity profiles of translation inhibitors in whole-cell and cell-free approaches. | 2008 | Lett. Appl. Microbiol. | pmid:18028330 |
Flamaing J et al. | Pneumococcal bacteraemia in Belgium (1994 2004): the pre-conjugate vaccine era. | 2008 | J. Antimicrob. Chemother. | pmid:17999974 |
Lai X et al. | Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material. | 2008 | Int J Pharm | pmid:18054184 |
Wolter N et al. | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. | 2008 | Antimicrob. Agents Chemother. | pmid:18056269 |
Lopanik NB et al. | In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. | 2008 | Chem. Biol. | pmid:19022178 |
Roy SK et al. | Zinc supplementation in children with cholera in Bangladesh: randomised controlled trial. | 2008 | BMJ | pmid:18184631 |
Kim BJ et al. | Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets. | 2008 | Diabetes | pmid:18184929 |
Tinley C et al. | Pseudodendritic keratitis in children. | 2008 | Eye (Lond) | pmid:18188170 |
Römer M et al. | Phase transformation of erythromycin A dihydrate during fluid bed drying. | 2008 | J Pharm Sci | pmid:18200525 |
Elevi Bardavid R and Oren A | Sensitivity of Haloquadratum and Salinibacter to antibiotics and other inhibitors: implications for the assessment of the contribution of Archaea and Bacteria to heterotrophic activities in hypersaline environments. | 2008 | FEMS Microbiol. Ecol. | pmid:18205815 |
Anderson JF et al. | Antibiotic resistance of enterococci in American bison (Bison bison) from a nature preserve compared to that of Enterococci in pastured cattle. | 2008 | Appl. Environ. Microbiol. | pmid:18245252 |
Gul HC et al. | Macrolide-lincosamide-streptogramin B resistant phenotypes and genotypes for methicillin-resistant Staphylococcus aureus in Turkey, from 2003 to 2006. | 2008 | Pol. J. Microbiol. | pmid:19275044 |
Banche G et al. | In vitro compared activity of telithromycin and azithromycin against northwest Italian isolates of Streptococcus pyogenes and Streptococcus pneumoniae with different erythromycin susceptibility. | 2008 | Lett. Appl. Microbiol. | pmid:19241525 |
Yogo K et al. | Effects of oral mitemcinal (GM-611), erythromycin, EM-574 and cisapride on gastric emptying in conscious rhesus monkeys. | 2008 | Dig. Dis. Sci. | pmid:17934842 |
Miroshnyk I et al. | A new insight into solid-state conformation of macrolide antibiotics. | 2008 | Bioorg. Med. Chem. | pmid:17936632 |
Yasuda K et al. | A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. | 2008 | Drug Metab. Dispos. | pmid:18505790 |
Caldwell DB et al. | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. | 2008 | Antimicrob. Agents Chemother. | pmid:18779354 |
Saijo T et al. | A case of Legionella pneumophila pneumonia followed by invasive aspergillosis. | 2008 | Jpn. J. Infect. Dis. | pmid:18806346 |
Hyo Y et al. | Characteristic cell wall ultrastructure of a macrolide-resistant Staphylococcus capitis strain isolated from a patient with chronic sinusitis. | 2008 | Med Mol Morphol | pmid:18807142 |
Nagano N et al. | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. | 2008 | Antimicrob. Agents Chemother. | pmid:18809936 |
Reeves AR et al. | Knockout of the erythromycin biosynthetic cluster gene, eryBI, blocks isoflavone glucoside bioconversion during erythromycin fermentations in Aeromicrobium erythreum but not in Saccharopolyspora erythraea. | 2008 | Appl. Environ. Microbiol. | pmid:18836015 |
Gentry DR et al. | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. | 2008 | Antimicrob. Agents Chemother. | pmid:18838584 |
Gaudreau C et al. | Comparison of disk diffusion and agar dilution methods for erythromycin, ciprofloxacin, and tetracycline susceptibility testing of Campylobacter coli and for tetracycline susceptibility testing of Campylobacter jejuni subsp. jejuni. | 2008 | Antimicrob. Agents Chemother. | pmid:18838597 |
Balassoulis G et al. | Efficacy and safety of erythromycin as sclerosing agent in patients with recurrent malignant pleural effusion. | 2008 | Am. J. Clin. Oncol. | pmid:18845999 |
Kim JM et al. | Gene mutations of 23S rRNA associated with clarithromycin resistance in Helicobacter pylori strains isolated from Korean patients. | 2008 | J. Microbiol. Biotechnol. | pmid:18852516 |
Yamazaki T et al. | The intracellular accumulation of phagocytic and epithelial cells and the inhibitory effect on Chlamydophila (Chlamydia) pneumoniae of telithromycin and comparator antimicrobials. | 2008 | J Chemother | pmid:18676220 |
Appendino G et al. | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. | 2008 | J. Nat. Prod. | pmid:18681481 |
Chng C et al. | A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18685110 |
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Sadeghi-Khomami A et al. | Glycosidase inhibition by macrolide antibiotics elucidated by STD-NMR spectroscopy. | 2008 | Chem. Biol. | pmid:18635010 |
Koenig JB et al. | Use of multichannel electrointestinography for noninvasive assessment of myoelectrical activity in the cecum and large colon of horses. | 2008 | Am. J. Vet. Res. | pmid:18518649 |
Liu YQ et al. | Quantitative determination of erythromycylamine in human plasma by liquid chromatography-mass spectrometry and its application in a bioequivalence study of dirithromycin. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18296129 |
Nishino K et al. | The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes. | 2008 | J. Infect. Chemother. | pmid:18297445 |
Min YH et al. | Translational attenuation and mRNA stabilization as mechanisms of erm(B) induction by erythromycin. | 2008 | Antimicrob. Agents Chemother. | pmid:18299414 |
Hernould M et al. | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. | 2008 | Antimicrob. Agents Chemother. | pmid:18268083 |
Farran L et al. | Efficacy of enteral decontamination in the prevention of anastomotic dehiscence and pulmonary infection in esophagogastric surgery. | 2008 | Dis. Esophagus | pmid:18269652 |
Gallerani M and Boari B | Hallucinations and tremors due to oral therapeutic doses of erythromycin and methylprednisolone. | 2008 | Intern Emerg Med | pmid:18270792 |
Lawrence L et al. | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. | 2008 | Antimicrob. Agents Chemother. | pmid:18316525 |
Keatinge-Clay A | Crystal structure of the erythromycin polyketide synthase dehydratase. | 2008 | J. Mol. Biol. | pmid:18952099 |
Fenoll A et al. | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. | 2008 | Antimicrob. Agents Chemother. | pmid:18725443 |
Hatfaludi T et al. | Characterization of TolC efflux pump proteins from Pasteurella multocida. | 2008 | Antimicrob. Agents Chemother. | pmid:18725450 |
Andreis U et al. | Gastric motility evaluated by electrogastrography and alternating current biosusceptometry in dogs. | 2008 | Physiol Meas | pmid:18698113 |
Perrin MJ et al. | Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-Ã -go-go-related gene channels. | 2008 | Mol. Pharmacol. | pmid:18701618 |
Bergseng H et al. | Invasive group B streptococcus (GBS) disease in Norway 1996-2006. | 2008 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:18560908 |
Waites KB et al. | Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. | 2008 | Antimicrob. Agents Chemother. | pmid:18663020 |
Bukhari IA | Oral erythromycin is ineffective in the treatment of pityriasis rosea. | 2008 | J Drugs Dermatol | pmid:18664152 |
Schreiber F and Szewzyk U | Environmentally relevant concentrations of pharmaceuticals influence the initial adhesion of bacteria. | 2008 | Aquat. Toxicol. | pmid:18359104 |
de la Pedrosa EG et al. | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). | 2008 | Antimicrob. Agents Chemother. | pmid:18362188 |
Higashide M et al. | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. | 2008 | Antimicrob. Agents Chemother. | pmid:18362191 |
Urich SK and Petersen JM | In vitro susceptibility of isolates of Francisella tularensis types A and B from North America. | 2008 | Antimicrob. Agents Chemother. | pmid:18411318 |
Laohavaleeson S et al. | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. | 2008 | Antimicrob. Agents Chemother. | pmid:18411322 |
Hsieh YC et al. | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. | 2008 | Antimicrob. Agents Chemother. | pmid:18413298 |
Janapatla RP et al. | The prevalence of erythromycin resistance in group B streptococcal isolates at a University Hospital in Taiwan. | 2008 | Microb. Drug Resist. | pmid:19025386 |
Harita S et al. | Effect of long-term and low-dose administration of erythromycin on proliferation of T lymphocytes stimulated with mitogens. | 2008 | J Chemother | pmid:19028624 |
Nishio N et al. | Cat scratch disease with encephalopathy in a 9-year-old girl. | 2008 | Pediatr Int | pmid:19067901 |
Fenoll A et al. | Has the licensing of respiratory quinolones for adults and the 7-valent pneumococcal conjugate vaccine (PCV-7) for children had herd effects with respect to antimicrobial non-susceptibility in invasive Streptococcus pneumoniae? | 2008 | J. Antimicrob. Chemother. | pmid:18819966 |
Gulay Z et al. | Macrolide resistance determinants in erythromycin-resistant Streptococcus pneumoniae in Turkey. | 2008 | Jpn. J. Infect. Dis. | pmid:19050364 |
Kirtsreesakul V et al. | Microbiology and antimicrobial susceptibility patterns of commensal flora in the middle nasal meatus. | 2008 | Ann. Otol. Rhinol. Laryngol. | pmid:19140538 |
Watanabe K et al. | Drug-resistant pneumococci in children with acute lower respiratory infections in Vietnam. | 2008 | Pediatr Int | pmid:19143975 |
Neureiter D et al. | Differential diagnostic challenge of chronic neutrophilic leukemia in a patient with prolonged leukocytosis. | 2008 | J Hematop | pmid:19669201 |