erythromycin

erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with erythromycin?

erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with erythromycin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Tuberculosis D014376 20 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Adenocarcinoma D000230 166 associated lipids
Bacterial Infections D001424 21 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Stomach Diseases D013272 7 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Alveolitis, Extrinsic Allergic D000542 6 associated lipids
Per page 10 20 50 100 | Total 442

PubChem Associated disorders and diseases

What pathways are associated with erythromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with erythromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with erythromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with erythromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with erythromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with erythromycin?

Mouse Model

Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).

Knock-out

Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with erythromycin

Download all related citations
Per page 10 20 50 100 | Total 13660
Authors Title Published Journal PubMed Link
Mets L and Bogorad L Altered chlorplast ribosomal proteins associated with erythromycin-resistant mutants in two genetic systems of Chlamydomonas reinhardi. 1972 Proc. Natl. Acad. Sci. U.S.A. pmid:4509340
Dunkle JA et al. Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20876128
Bulkley D et al. Revisiting the structures of several antibiotics bound to the bacterial ribosome. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20876130
Shet MS et al. Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8265621
Morona JK et al. Attachment of capsular polysaccharide to the cell wall of Streptococcus pneumoniae type 2 is required for invasive disease. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16707578
Kaempfer R Ribosomal subunit exchange during protein synthesis. 1968 Proc. Natl. Acad. Sci. U.S.A. pmid:4880603
Donadio S et al. An erythromycin analog produced by reprogramming of polyketide synthesis. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8346223
Kramer BP and Fussenegger M Hysteresis in a synthetic mammalian gene network. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15972812
Linnane AW et al. The biogenesis of mitochondria. V. Cytoplasmic inheritance of erythromycin resistance in Saccharomyces cerevisiae. 1968 Proc. Natl. Acad. Sci. U.S.A. pmid:5238670
Linnane AW et al. The biogenesis of mitochondria, VI. Biochemical basis of the resistance of Saccharomyces cerevisiae toward antibiotics which specifically inhibit mitochondrial protein synthesis. 1968 Proc. Natl. Acad. Sci. U.S.A. pmid:5240029
Chattopadhyay S et al. Reactivation of denatured proteins by 23S ribosomal RNA: role of domain V. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8710862
Sigmund CD and Morgan EA Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6752954
Doersen CJ and Stanbridge EJ Cytoplasmic inheritance of erythromycin resistance in human cells. 1979 Proc. Natl. Acad. Sci. U.S.A. pmid:291986
Ekroos M and Sjögren T Structural basis for ligand promiscuity in cytochrome P450 3A4. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16954191
LeBlanc DJ et al. "Conjugal" transfer of plasmid DNA among oral streptococci. 1978 Proc. Natl. Acad. Sci. U.S.A. pmid:277950
GUILD WR and ROBINSON M Evidence for message reading from a unique strand of pneumococcal DNA. 1963 Proc. Natl. Acad. Sci. U.S.A. pmid:13951226
Xue Q et al. A multiplasmid approach to preparing large libraries of polyketides. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10518520
Chng C et al. A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18685110
Winn PJ et al. Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11959989
Kapur S et al. Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:21127271
Komuro I et al. Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBPbeta. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18719105
Kulesa A et al. Combinatorial drug discovery in nanoliter droplets. 2018 Proc. Natl. Acad. Sci. U.S.A. pmid:29899149
Barany F et al. Staphylococcal plasmids that replicate and express erythromycin resistance in both Streptococcus pneumoniae and Escherichia coli. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6283551
TAUBMAN SB et al. ANTIBIOTIC GLYCOSIDES. IV. STUDIES ON THE MECHANISM OF ERYTHROMYCIN RESISTANCE IN BACILLUS SUBTILIS. 1963 Proc. Natl. Acad. Sci. U.S.A. pmid:14082362
Svetlov MS et al. Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics. 2017 Proc. Natl. Acad. Sci. U.S.A. pmid:29229833
Moore SD and Sauer RT Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:19015512
Auerbach T et al. The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20080686
Ishitsuka H and Kaji A Release of tRNA from ribosomes by a factor other than G factor. 1970 Proc. Natl. Acad. Sci. U.S.A. pmid:4921327
Nashimoto H and Nomura M Structure and function of bacterial ribosomes. XI. Dependence of 50S ribosomal assembly on simultaneous assembly of 30S subunits. 1970 Proc. Natl. Acad. Sci. U.S.A. pmid:4922290
Douthwaite S et al. Evidence for functional interaction between domains II and V of 23S ribosomal RNA from an erythromycin-resistant mutant. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:3909142
McDaniel R et al. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10051557
Brill S et al. Transforming a drug/H+ antiporter into a polyamine importer by a single mutation. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:23035252
Sartakova M et al. Development of an extrachromosomal cloning vector system for use in Borrelia burgdorferi. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10781091
Blockey NJ Conservative management of acute osteomyelitis. 1971 Proc. R. Soc. Med. pmid:5210802
Williams RF Some features of antibiotic resistance in staphylococci: mercury resistance and multiple antibiotic resistance. 1971 Proc. R. Soc. Med. pmid:5206605
Jackson DM The burnt child and his family. What the burnt child goes through. 1968 Proc. R. Soc. Med. pmid:4972634
Saslaw S and Carlisle HN Studies on therapy of staphylococcal infections in monkeys. I. Comparison of cloxacillin, triacetyloleandomycin and erythromycin. 1967 Aug-Sep Proc. Soc. Exp. Biol. Med. pmid:4962963
Warren GH and Gray J Effect of sublethal concentrations of penicillins on the lysis of bacteria by lysozyme and trypsin. 1965 Proc. Soc. Exp. Biol. Med. pmid:4379190
Hunt DE et al. In vitro comparison of actinobolin and other antibiotics used in the treatment of periodontal disease and dental caries. 1. 1972 Proc. Soc. Exp. Biol. Med. pmid:4626939
Kendler J et al. Perfusion of the isolated rat liver with erythromycin estolate and other derivatives. 1972 Proc. Soc. Exp. Biol. Med. pmid:5023324
HAIGHT TH and FINLAND M The antibacterial action of erythromycin. 1952 Proc. Soc. Exp. Biol. Med. pmid:13047351
KJELLANDER JO et al. IN VITRO ACTIVITY OF PENICILLINS AGAINST STAPHYLOCOCCUS ALBUS. 1963 Aug-Sep Proc. Soc. Exp. Biol. Med. pmid:14073098
Zimmerman HJ et al. Studies on the vitro cytotoxicity of erythromycin estolate. 1973 Proc. Soc. Exp. Biol. Med. pmid:4765955
Friend C et al. Antibiotic effect of tylosin on a mycoplasma contaminant in a tissue culture leukemia cell line. 1966 Proc. Soc. Exp. Biol. Med. pmid:4287117
WARREN GH and GRAY J PRODUCTION OF A POLYSACCHARIDE BY STAPHYLOCOCCUS AUREUS. II. EFFECT OF TEMPERATURE AND ANTIBIOTICS. 1963 Proc. Soc. Exp. Biol. Med. pmid:14101212
Warren GH and Gray J Effect of antimicrobial drug combinations on enzymic lysis of Staphylococcus aureus. 1967 Proc. Soc. Exp. Biol. Med. pmid:6066156
Burton JA and Schanker LS Absorption of antibiotics from the rat lung. 1974 Proc. Soc. Exp. Biol. Med. pmid:4406162
LEE CC et al. Renal clearance of erythromycin. 1955 Proc. Soc. Exp. Biol. Med. pmid:14371707
Drew BJ and Ide B T wave alternans. 1994 Prog Cardiovasc Nurs pmid:7846007
Puri SK and Dutta GP Antibiotics in the chemotherapy of malaria. 1982 Prog Drug Res pmid:6755556
Kirst HA Semi-synthetic derivatives of erythromycin. 1993 Prog Med Chem pmid:8303037
Kim KH and Martin YC Conformational study of erythromycin analogues. 1989 Prog. Clin. Biol. Res. pmid:2726866
Pestka S Insights into protein biosynthesis and ribosome function through inhibitors. 1976 Prog. Nucleic Acid Res. Mol. Biol. pmid:778922
Sato Y et al. Macrolide antibiotics promote the LPS-induced upregulation of prostaglandin E receptor EP2 and thus attenuate macrolide suppression of IL-6 production. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17324565
Vesce F et al. Effect of different classes of antibiotics on amniotic prostaglandin E release. 1999 Prostaglandins Other Lipid Mediat. pmid:10402215
Cupp-Vickery JR et al. Preliminary crystallographic analysis of an enzyme involved in erythromycin biosynthesis: cytochrome P450eryF. 1994 Proteins pmid:7846029
Osterman IA et al. A nascent proteome study combining click chemistry with 2DE. 2013 Proteomics pmid:23161590
Lebioda J and Budzanowska E [Unsuccessful treatment of early symptomatic syphilis following oral administration of detreomycin, erythromycin and oxyterracin]. 1971 Prz. Lek. pmid:5093024
Biesiada G et al. [Whooping cough in a previously vaccinated patient--case report]. 2005 Prz. Lek. pmid:16095161
Wojas-Pelc A et al. [A case of acne infantum--reviews of the literature regarding therapy]. 2006 Prz. Lek. pmid:17479876
Niczyporuk W and Zajac W [Isolation of Nichols strain of Treponema pallidum with changed sensitivity to erythromycin]. 1985 Mar-Apr Przegl Dermatol pmid:3901131
Mielech R et al. [Studies on the effect of most frequently used antibiotics on the course of syphilitic infection]. 1968 Mar-Apr Przegl Dermatol pmid:4877997
Rdzanek I and Weyman-Rzucidlo D [Recent views on the etiology and therapy of erythrasma]. 1967 Jan-Feb Przegl Dermatol pmid:6044676
Jakubowski A et al. [Experimental studies in vivo on the effect upon Trepomena pallidum of some antibiotics other than penicillin]. 1968 Jan-Feb Przegl Dermatol pmid:4867335
Jopkiewicz R and Prohaska J [Attempted treatment of pyogenic skin diseases with antibiotic solution ionophoresis]. 1966 Sep-Oct Przegl Dermatol pmid:5918980
Rubisz-Brzezińska J et al. [Akne-Mycyna in the local treatment of acne]. 1990 Jan-Feb Przegl Dermatol pmid:2143300
Bowszyc J and Dratwiński Z [Value of erythromycin in the treatment of gonorrhea]. 1973 Przegl Dermatol pmid:4794819
Dratwiński Z [A case of failure in the treatment of early syphilis with erythromycin]. 1971 Jan-Feb Przegl Dermatol pmid:5554743
Mroczkowski TF et al. [Treatment of non-gonococcal urethritis in men with cyclic erythromycin carbonate (Davercin)]. 1984 Jul-Aug Przegl Dermatol pmid:6515035
Stapiński A et al. [Davercin--cyclic erythromycin carbonate in the treatment of gonorrhea]. 1984 May-Jun Przegl Dermatol pmid:6395198
Wojtkiewiczowa J and Toruniowa B [Trials of early syphilis therapy with erythromycin]. 1965 Sep-Oct Przegl Dermatol pmid:5324563
STAUBER M and KAJZER T [THE APPEARANCE AND COURSE OF THE HERXHEIMER-LUKASIEWICZ REACTION FOLLOWING THE ADMINISTRATION OF VARIOUS ANTIBIOTICS]. 1963 Mar-Jun Przegl Dermatol pmid:14128497
Szreder I and Stapiński A [Treatment of early syphilis with cyclic erythromycin carbonate (Davercin-Polfa)]. 1985 Sep-Oct Przegl Dermatol pmid:3915128
Lebioda J et al. [TPI and FTA tests in the evaluation of effectiveness of the oral treatment of early symptomatic syphilis with detreomycin, erythromycin and oxytetracycline with consideration of the clinical picture]. 1969 Przegl Dermatol pmid:4906972
Jakubowski A [Present state of experimental studies on the effect of antibiotics other than penicillin on Treponema pallidum in vitro]. 1969 Przegl Dermatol pmid:4906975
Tokinaga N et al. Hallucinations after a therapeutic dose of benzodiazepine hypnotics with co-administration of erythromycin. 1996 Psychiatry Clin. Neurosci. pmid:9014234
Petitjean F et al. [The effect of chloramphenicol on sleep in cat -- comparison with thiamphenicol, erythromycine, and oxytetracycline (author's transl)]. 1979 Psychopharmacology (Berl.) pmid:231275
Kim SW et al. Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment. 2006 Sep-Oct Psychosomatics pmid:16959934
BROWN WJ et al. ORAL PROPIONYL ERYTHROMYCIN IN TREATING EARLY SYPHILIS. 1963 Public Health Rep pmid:14062223
Kaufman A et al. Streptococcal sore throat followup program in a hospital clinic, New York City. 1975 Jul-Aug Public Health Rep pmid:808824
GREAVES AB Treatment of early syphilis with erythromycin. 1961 Public Health Rep pmid:13901357
Como-Sabetti K et al. Community-associated methicillin-resistant Staphylococcus aureus: trends in case and isolate characteristics from six years of prospective surveillance. 2009 May-Jun Public Health Rep pmid:19445419
Cazzola M et al. Pulmonary penetration of dirithromycin in patients suffering from acute exacerbation of chronic bronchitis. 1994 Pulm Pharmacol pmid:7549225
Li YJ et al. EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: importance in IL-8 transcription. 2013 Pulm Pharmacol Ther pmid:23291319
Tokuda A et al. Effects of macrolides on antigen-induced increases in cough reflex sensitivity in guinea pigs. 2010 Pulm Pharmacol Ther pmid:19835975
Celmer WD Stereochemical problems in macrolide antibiotics. 1971 Pure Appl. Chem. pmid:4947320
GRATER WC ANTIMICROBIAL THERAPY IN INFECTIOUS ASTHMA. 1965 May-Jun Q Rev Allergy Appl Immunol pmid:14315399
Gray IR The choice of antibiotic for treating infective endocarditis. 1975 Q. J. Med. pmid:1242238
Cocuzza G The microbiological characteristics of troleandomycin. 1975 Quad Antibiot pmid:1088736
Genazzani E The pharmacological and pharmacokinetic properties of troleandomycin. 1975 Quad Antibiot pmid:210708
POMINI P and TARTAGLIA G [On the therapeutic efficacy of a combination of demethylchlortetracycline with erythromycin laurylsulfate in obstetrics and gynecology]. 1962 Quad Clin Ostet Ginecol pmid:13972087
ERMIGLIA G and VASSALLO E [First findings in the use of erythromycin in obstetrics and gynecology]. 1954 Quad Clin Ostet Ginecol pmid:14357559
Visconti A et al. [The comparative evaluation of the main conventional and automated techniques for "in vitro" bacterial sensitivity testing to chemoantibiotics (author's transl)]. 1979 Quad Sclavo Diagn pmid:555527
Rubenstein HS Pharmacology related to dentistry. Part II of a series. Antimicrobial agents continued. 1978 R I Dent J pmid:287164
COHEN WB The uses of erythromycin in dermatology. 1954 R I Med J pmid:13145972
ZHDANOV VG and ALIKHANIAN SI [USE OF FAST NEUTRONS IN THE SELECTION OF ERYTHROMYCIN-PRODUCING ACTINOMYCES ERYTHREUS]. 1964 Radiobiologiia pmid:14153000
TAMBIEV AKh and BULGAKOVA VG [THE EFFECT OF INACTIVATION ON THE PROTECTIVE PROPERTIES OF CERTAIN ANTIBIOTICS]. 1963 Radiobiologiia pmid:14068191
Akira M et al. Diffuse panbronchiolitis: follow-up CT examination. 1993 Radiology pmid:8210390
de Zwart IM et al. Gastric motility: comparison of assessment with real-time MR imaging or barostat measurement initial experience. 2002 Radiology pmid:12147861
Moore EH et al. Legionnaires' disease in the renal transplant patient: clinical presentation and radiographic progression. 1984 Radiology pmid:6387784