erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cheftel E et al. | [Toxic food infection caused by Shigella flexneri in a military unit]. | 1997 Sep-Oct | Sante | pmid:9480034 |
Saito A | [Emerging infectious diseases--Legionella pneumophila infections]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9480307 |
Kurmanova KB et al. | [Efficacy of pefloxacin in the treatment of complicated relapsing erysipelas]. | 1997 | Antibiot. Khimioter. | pmid:9480650 |
Stout JE et al. | Comparative activity of ciprofloxacin, ofloxacin, levofloxacin, and erythromycin against Legionella species by broth microdilution and intracellular susceptibility testing in HL-60 cells. | 1998 | Diagn. Microbiol. Infect. Dis. | pmid:9488830 |
Anderson KL et al. | Conjugal transfer of transposon Tn1545 into the cellulolytic bacterium Eubacterium cellulosolvens. | 1998 | Lett. Appl. Microbiol. | pmid:9489031 |
Hoppe JE | [Pertussis: current aspects of diagnosis, therapy and prevention]. | 1998 | Ther Umsch | pmid:9492614 |
Pereda A et al. | The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea. | 1998 | Microbiology (Reading, Engl.) | pmid:9493390 |
Kondoh K and Hashiba M | [Inhibitory effect of macrolide antibiotics on biofilm formation by Pseudomonas aeruginosa]. | 1998 | Nippon Jibiinkoka Gakkai Kaiho | pmid:9493436 |
Wong PW et al. | Multiple organ toxicity from addition of erythromycin to long-term lovastatin therapy. | 1998 | South. Med. J. | pmid:9496876 |
Kataja J et al. | Clonal spread of group A streptococcus with the new type of erythromycin resistance. Finnish Study Group for Antimicrobial Resistance. | 1998 | J. Infect. Dis. | pmid:9498465 |
Woodward A and Sillin LF | Oral erythromycin improves gastrointestinal motility and transit after subtotal but not total gastrectomy for cancer. | 1998 | Br J Surg | pmid:9501836 |
Wong SL et al. | The effect of erythromycin on the CYP3A component of sertindole clearance in healthy volunteers. | 1997 | J Clin Pharmacol | pmid:9505999 |
Kamoun A et al. | [Pneumococcal infections: penicillin resistance and therapeutic implications]. | 1995 | Tunis Med | pmid:9506153 |
Rivera P et al. | [Collagenous colitis: presentation of 12 cases]. | 1997 | Gastroenterol Hepatol | pmid:9508483 |
Tsiaoussis I et al. | Gallbladder fasting volume is reduced and gallbladder postprandial emptying is enhanced by intravenous erythromycin. | 1998 | Dig. Dis. Sci. | pmid:9508522 |
Chen JD et al. | Effects of octreotide and erythromycin on gastric myoelectrical and motor activities in patients with gastroparesis. | 1998 | Dig. Dis. Sci. | pmid:9508540 |
Hay PE | Therapy of bacterial vaginosis. | 1998 | J. Antimicrob. Chemother. | pmid:9511031 |
Manninen R et al. | Reliability of disc diffusion susceptibility testing of Streptococcus pneumoniae and adjustment of laboratory-specific breakpoints. Finnish Study Group for Antimicrobial Resistance. | 1998 | J. Antimicrob. Chemother. | pmid:9511033 |
Williams JD et al. | Comparative in-vitro activity of quinupristin/dalfopristin against Enterococcus spp. | 1997 | J. Antimicrob. Chemother. | pmid:9511061 |
Jorgensen JH and McElmeel ML | Activity of quinupristin/dalfopristin and its components against Haemophilus influenzae. | 1997 | J. Antimicrob. Chemother. | pmid:9511067 |
Perez-Trallero E et al. | Emergence of Streptococcus pyogenes strains resistant to erythromycin in Gipuzkoa, Spain. | 1998 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9512178 |
Noguchi N and Katayama J | Expression in Pseudomonas aeruginosa of an erythromycin-resistance determinant that encodes the mphA gene for macrolide 2'-phosphotransferase I from Escherichia coli. | 1998 | Biol. Pharm. Bull. | pmid:9514620 |
Wynn RL | Serious erythromycin interactions caused by inhibition of drug metabolism in the liver. | 1996 Nov-Dec | Gen Dent | pmid:9515389 |
Lu G et al. | Effect of motilin and erythromycin on calcium-activated potassium channels in rabbit colonic myocytes. | 1998 | Gastroenterology | pmid:9516395 |
Sato K et al. | Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9517602 |
Pankuch GA et al. | Susceptibilities of penicillin- and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU 66647), a new ketolide, compared with susceptibilities to 17 other agents. | 1998 | Antimicrob. Agents Chemother. | pmid:9517943 |
Lalloo AK et al. | Development of a capillary electrophoretic method for the separation of the macrolide antibiotics, erythromycin, josamycin and oleandomycin. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9518167 |
Lalloo AK and Kanfer I | Determination of erythromycin and related substances by capillary electrophoresis. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9518168 |
Service RF | Hijacking a cell's chemical paths to make new antibiotics. | 1997 | Science | pmid:9518361 |
Esposito S et al. | Clinical comparison of cefaclor twice daily versus amoxicillin-clavulanate or erythromycin three times daily in the treatment of patients with streptococcal pharyngitis. | 1998 Jan-Feb | Clin Ther | pmid:9522105 |
Lester GD et al. | Effect of erythromycin lactobionate on myoelectric activity of ileum, cecum, and right ventral colon, and cecal emptying of radiolabeled markers in clinically normal ponies. | 1998 | Am. J. Vet. Res. | pmid:9522953 |
Liu PC et al. | Susceptibility of different isolates of Vibrio harveyi to antibiotics. | 1997 | Microbios | pmid:9523424 |
Janicka G et al. | [Resistance to antibiotics of Streptococcus pneumoniae strains]. | 1997 | Pol. Merkur. Lekarski | pmid:9523479 |
Roberts GJ et al. | Bacteremia of dental origin and antimicrobial sensitivity following oral surgical procedures in children. | 1998 Jan-Feb | Pediatr Dent | pmid:9524970 |
Ponomareva TR and Smolianskaia AZ | [Prevalence of markers characteristic for penicillinase plasmids in clinical strains of straphylococci]. | 1976 | Antibiotiki | pmid:952503 |
Seppälä H et al. | A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes. | 1998 | Antimicrob. Agents Chemother. | pmid:9527769 |
den Hollander JG et al. | Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo. | 1998 | Antimicrob. Agents Chemother. | pmid:9527789 |
Constantine PA | Antibiotic therapy and serum digoxin toxicity. | 1998 | Am Fam Physician | pmid:9531908 |
Salmon SA et al. | Minimum inhibitory concentrations for selected antimicrobial agents against organisms isolated from the mammary glands of dairy heifers in New Zealand and Denmark. | 1998 | J. Dairy Sci. | pmid:9532511 |
Molinari JA | Multifactorial aspects of legionellosis. | 1997 | Compend Contin Educ Dent | pmid:9533308 |
Doucet-Populaire F et al. | Molecular basis of clarithromycin activity against Mycobacterium avium and Mycobacterium smegmatis. | 1998 | J. Antimicrob. Chemother. | pmid:9533459 |
Nasher MA and Hay RJ | Synergy of antibiotics against Streptomyces somaliensis isolates in vitro. | 1998 | J. Antimicrob. Chemother. | pmid:9533473 |
Stout JE et al. | Activity of azithromycin, clarithromycin, roxithromycin, dirithromycin, quinupristin/dalfopristin and erythromycin against Legionella species by intracellular susceptibility testing in HL-60 cells. | 1998 | J. Antimicrob. Chemother. | pmid:9533475 |
Choi MG et al. | Dose-related effects of N-demethyl-N-isopropyl-8, 9-anhydroerythromycin A 6,9-hemiacetal on gastric emptying of solids in healthy human volunteers. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9535992 |
Lyon AJ et al. | Randomised trial of erythromycin on the development of chronic lung disease in preterm infants. | 1998 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:9536833 |
Jacobsen JR et al. | Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. | 1998 | Biochemistry | pmid:9538011 |
Williamson KM et al. | Effects of erythromycin or rifampin on losartan pharmacokinetics in healthy volunteers. | 1998 | Clin. Pharmacol. Ther. | pmid:9542475 |
Norcia LJ et al. | In vitro microbiological characterization of novel macrolide CP-163,505 for animal health specific use. | 1998 | J. Antibiot. | pmid:9544934 |
Thomas AR et al. | Prolongation of the QT interval related to cisapride-diltiazem interaction. | 1998 Mar-Apr | Pharmacotherapy | pmid:9545159 |
Fitzgerald NB et al. | Sonication-dependent electroporation of the erythromycin-producing bacterium Saccharopolyspora erythraea. | 1998 | Appl. Environ. Microbiol. | pmid:9546194 |