erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Folwaczny C et al. | [Effects of various prokinetic drugs on gastrointestinal transit times in patients with progressive systemic scleroderma]. | 1997 | Z Gastroenterol | pmid:9432812 |
Wienbeck M and Barnert J | [Principles of pharmacotherapy]. | 1990 | Z Gastroenterol | pmid:2162581 |
Schusdziarra V | [Motilin and motilides--future perspectives for therapy of gastrointestinal motility disorders]. | 1992 | Z Gastroenterol | pmid:1413940 |
Naumann G | [The detection of the agent of Legionnaires' disease--a confirmation of Koch's postulates]. | 1983 | Z Erkr Atmungsorgane | pmid:6356647 |
Fischer P and Schilling W | [Therapeutic results in lung diseases caused by atypical mycobacteria]. | 1984 | Z Erkr Atmungsorgane | pmid:6202070 |
Kirsten D and Meister W | [Present possibilities of antibiotic therapy in chronic non-specific respiratory diseases (author's transl)]. | 1976 | Z Erkr Atmungsorgane | pmid:1049185 |
Ocklitz HW et al. | [Pediatric guidelines. 3. Antibiotics--indications]. | 1968 | Z Arztl Fortbild (Jena) | pmid:4978334 |
Dietzsch HJ et al. | [Abscessed (staphylococcal) pneumonia in childhood]. | 1972 | Z Arztl Fortbild (Jena) | pmid:4118084 |
Handrick W et al. | [Contribution to the diagnosis and therapy of juvenile pneumonia]. | 1981 | Z Arztl Fortbild (Jena) | pmid:7340181 |
Heite HJ | [Therapy of venereal infections]. | 1971 | Z Allgemeinmed | pmid:5108596 |
Uh Y et al. | Correlation of serotypes and genotypes of macrolide-resistant Streptococcus agalactiae. | 2005 | Yonsei Med. J. | pmid:16127771 |
Hatipoglu ON and Tasan Y | A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. | 2000 | Yonsei Med. J. | pmid:10957888 |
Uh Y et al. | Macrolide resistance trends in beta-hemolytic streptococci in a tertiary Korean hospital. | 2007 | Yonsei Med. J. | pmid:17963333 |
Kim HY and Uh Y | Macrolide resistance in beta-hemolytic streptococci: changes after the implementation of the separation of prescribing and dispensing of medications policy in Korea. | 2004 | Yonsei Med. J. | pmid:15344198 |
Marmiroli N and Bilinski CA | Partial restoration of meiosis in an apomictic strain of Saccharomyces cerevisiae: a model system for investigation of nucleomitochondrial interactions during sporulation. | 1985 | Yeast | pmid:3916858 |
Goffrini P et al. | RAG1 and RAG2: nuclear genes involved in the dependence/independence on mitochondrial respiratory function for growth on sugars. | 1989 Mar-Apr | Yeast | pmid:2711752 |
Xu J et al. | [Prognosticating the region-selectivity in the O-methylation reaction of erythromycins by conformational search model]. | 2003 | Yao Xue Xue Bao | pmid:12778744 |
Liu L et al. | [Synthesis of derivatives of (9S)-12-methylene erythromycin and their antibacterial activity in vitro]. | 2005 | Yao Xue Xue Bao | pmid:16220785 |
Sun W et al. | [Glycosyl isomerization based on the biosynthesis of natural-product sugar from microorganism]. | 2013 | Yao Xue Xue Bao | pmid:23672013 |
Chen SX et al. | [Synthesis and antibacterial activity of 3-hydroxy-6-O-methylerythromycin-9-O-substituted oxime derivatives]. | 2001 | Yao Xue Xue Bao | pmid:12579933 |