erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hoban DJ et al. | Macrolide-resistant Streptococcus pneumoniae in Canada during 1998-1999: prevalence of mef(A) and erm(B) and susceptibilities to ketolides. | 2001 | Antimicrob. Agents Chemother. | pmid:11408241 |
Nilius AM et al. | Comparative in vitro activity of ABT-773, a novel antibacterial ketolide. | 2001 | Antimicrob. Agents Chemother. | pmid:11408246 |
LeBlanc DJ et al. | Broad geographical distribution of homologous erythromycin, kanamycin, and streptomycin resistance determinants among group D streptococci of human and animal origin. | 1986 | Antimicrob. Agents Chemother. | pmid:3010845 |
Lee H et al. | Isolation of antibiotic hypersusceptibility mutants of Acinetobacter spp. by selection for DNA release. | 2003 | Antimicrob. Agents Chemother. | pmid:12654657 |
Conejo Mdel C et al. | Activities of ABT-773 against Listeria monocytogenes and coryneform bacteria of clinical interest. | 2003 | Antimicrob. Agents Chemother. | pmid:12654678 |
Ng LK et al. | Can Etest be used to determine Vibrio cholerae susceptibility to erythromycin? | 2003 | Antimicrob. Agents Chemother. | pmid:12654699 |
Sutcliffe J et al. | Detection of erythromycin-resistant determinants by PCR. | 1996 | Antimicrob. Agents Chemother. | pmid:8913465 |
Vowels BR et al. | Effects of topical erythromycin on ecology of aerobic cutaneous bacterial flora. | 1996 | Antimicrob. Agents Chemother. | pmid:8913472 |
van der Linden M et al. | Clonal spread of mef-positive macrolide-resistant Streptococcus pneumoniae isolates causing invasive disease in adults in Germany. | 2007 | Antimicrob. Agents Chemother. | pmid:17325214 |
O'Hara K and Yamamoto K | Reaction of roxithromycin and clarithromycin with macrolide-inactivating enzymes from highly erythromycin-resistant Escherichia coli. | 1996 | Antimicrob. Agents Chemother. | pmid:8849224 |
Ishida K et al. | In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. | 1994 | Antimicrob. Agents Chemother. | pmid:8031048 |
Martin JR et al. | Uptake, accumulation, and egress of erythromycin by tissue culture cells of human origin. | 1985 | Antimicrob. Agents Chemother. | pmid:3994346 |
Hunaiti AA and Kolattukudy PE | Source of methylmalonyl-coenzyme A for erythromycin synthesis: methylmalonyl-coenzyme A mutase from Streptomyces erythreus. | 1984 | Antimicrob. Agents Chemother. | pmid:6143534 |
Nielsen EI et al. | Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization. | 2011 | Antimicrob. Agents Chemother. | pmid:21807983 |
Pankuch GA et al. | MIC and time-kill study of antipneumococcal activities of RPR 106972 (a new oral streptogramin), RP 59500 (quinupristin-dalfopristin), pyostacine (RP 7293), penicillin G, cefotaxime, erythromycin, and clarithromycin against 10 penicillin-susceptible and -resistant pneumococci. | 1996 | Antimicrob. Agents Chemother. | pmid:8878583 |
Alcaide F et al. | In vitro activities of eight macrolide antibiotics and RP-59500 (quinupristin-dalfopristin) against viridans group streptococci isolated from blood of neutropenic cancer patients. | 1996 | Antimicrob. Agents Chemother. | pmid:8878591 |
Wolter N et al. | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. | 2008 | Antimicrob. Agents Chemother. | pmid:18056269 |
Zhu W et al. | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. | 2008 | Antimicrob. Agents Chemother. | pmid:18056272 |
Zaknoon F et al. | Antibacterial properties of an oligo-acyl-lysyl hexamer targeting Gram-negative species. | 2012 | Antimicrob. Agents Chemother. | pmid:22751534 |
Kataja J et al. | Erythromycin resistance genes in group A streptococci in Finland. The Finnish Study Group for Antimicrobial Resistance. | 1999 | Antimicrob. Agents Chemother. | pmid:9869564 |
Morosini MI et al. | In vitro activity of telithromycin against Spanish Streptococcus pneumoniae isolates with characterized macrolide resistance mechanisms. | 2001 | Antimicrob. Agents Chemother. | pmid:11502509 |
Mitten MJ et al. | Efficacies of ABT-773, a new ketolide, against experimental bacterial infections. | 2001 | Antimicrob. Agents Chemother. | pmid:11502533 |
Kenny GE and Cartwright FD | Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones. | 2001 | Antimicrob. Agents Chemother. | pmid:11502536 |
Dicuonzo G et al. | Erythromycin-resistant pharyngeal isolates of Streptococcus pyogenes recovered in Italy. | 2002 | Antimicrob. Agents Chemother. | pmid:12435707 |
Mavroidi A et al. | Multidrug-resistant strains of Neisseria gonorrhoeae in Greece. | 2001 | Antimicrob. Agents Chemother. | pmid:11502546 |
Xu CW et al. | First report of macrolide resistance gene erm(T) harbored by a novel small plasmid from Erysipelothrix rhusiopathiae. | 2015 | Antimicrob. Agents Chemother. | pmid:25666150 |
Osada Y and Ogawa H | Antimycoplasmal activity of ofloxacin (DL-8280). | 1983 | Antimicrob. Agents Chemother. | pmid:6573869 |
Akshay S et al. | Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis. | 2011 | Antimicrob. Agents Chemother. | pmid:21730122 |
Yu KW and Neu HC | In vitro activity of dirithromycin (LY 237216) compared with activities of other macrolide antibiotics. | 1990 | Antimicrob. Agents Chemother. | pmid:2126695 |
Hunt Gerardo S et al. | Comparison of Etest to broth microdilution method for testing Streptococcus pneumoniae susceptibility to levofloxacin and three macrolides. | 1996 | Antimicrob. Agents Chemother. | pmid:8891154 |
Brandt-Rauf P et al. | Fluorescent assay for estimating the binding of erythromycin derivatives to ribosomes. | 1978 | Antimicrob. Agents Chemother. | pmid:356727 |
Hächler H et al. | Genetic characterization of a Clostridium difficile erythromycin-clindamycin resistance determinant that is transferable to Staphylococcus aureus. | 1987 | Antimicrob. Agents Chemother. | pmid:2821888 |
Arthur M et al. | Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genes. | 1990 | Antimicrob. Agents Chemother. | pmid:2291670 |
Kohno Y et al. | Comparative pharmacokinetics of clarithromycin (TE-031), a new macrolide antibiotic, and erythromycin in rats. | 1989 | Antimicrob. Agents Chemother. | pmid:2526615 |
McCashion RN and Lynch WH | Effects of polymyxin B nonapeptide on Aeromonas salmonicida. | 1987 | Antimicrob. Agents Chemother. | pmid:2823698 |
Xie Z et al. | Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates. | 2005 | Antimicrob. Agents Chemother. | pmid:16251329 |
Hedberg ST et al. | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. | 2009 | Antimicrob. Agents Chemother. | pmid:19188396 |
Nielsen A et al. | Method for screening compounds that influence virulence gene expression in Staphylococcus aureus. | 2010 | Antimicrob. Agents Chemother. | pmid:19917763 |
Nash KA et al. | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. | 2009 | Antimicrob. Agents Chemother. | pmid:19171799 |
Mazzei T et al. | Pharmacokinetics of dirithromycin in patients with mild or moderate cirrhosis. | 1999 | Antimicrob. Agents Chemother. | pmid:10390202 |
Giovanetti E et al. | Presence of the tet(O) gene in erythromycin- and tetracycline-resistant strains of Streptococcus pyogenes and linkage with either the mef(A) or the erm(A) gene. | 2003 | Antimicrob. Agents Chemother. | pmid:12936983 |
Azoulay-Dupuis E et al. | Efficacy of cethromycin, a new ketolide, against Streptococcus pneumoniae susceptible or resistant to erythromycin in a murine pneumonia model. | 2006 | Antimicrob. Agents Chemother. | pmid:16940099 |
Achard A et al. | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. | 2008 | Antimicrob. Agents Chemother. | pmid:18519724 |
Mascio CT et al. | Bactericidal action of daptomycin against stationary-phase and nondividing Staphylococcus aureus cells. | 2007 | Antimicrob. Agents Chemother. | pmid:17923487 |
Schwaiger K and Bauer J | Detection of the erythromycin rRNA methylase gene erm(A) in Enterococcus faecalis. | 2008 | Antimicrob. Agents Chemother. | pmid:18505854 |
Caldwell DB et al. | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. | 2008 | Antimicrob. Agents Chemother. | pmid:18779354 |
Morio F et al. | Antimicrobial susceptibilities and clinical sources of Dialister species. | 2007 | Antimicrob. Agents Chemother. | pmid:17923492 |
Limburg E et al. | Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057. | 2004 | Antimicrob. Agents Chemother. | pmid:14742220 |
Bingen E et al. | Telithromycin susceptibility and genomic diversity of macrolide-resistant serotype III group B streptococci isolated in perinatal infections. | 2004 | Antimicrob. Agents Chemother. | pmid:14742237 |
Pankuch GA et al. | Susceptibilities of penicillin- and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU 66647), a new ketolide, compared with susceptibilities to 17 other agents. | 1998 | Antimicrob. Agents Chemother. | pmid:9517943 |
Dzyubak E and Yap MN | The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling. | 2016 | Antimicrob. Agents Chemother. | pmid:27645242 |
Blais J et al. | Inhibition of Toxoplasma gondii protein synthesis by azithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8215287 |
Dever LL et al. | Comparative in vitro activities of clarithromycin, azithromycin, and erythromycin against Borrelia burgdorferi. | 1993 | Antimicrob. Agents Chemother. | pmid:8215288 |
Pérez-Trallero E et al. | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). | 2010 | Antimicrob. Agents Chemother. | pmid:20439616 |
Johnson SR et al. | In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins. | 2014 | Antimicrob. Agents Chemother. | pmid:25199775 |
Conte JE et al. | Intrapulmonary pharmacokinetics of clarithromycin and of erythromycin. | 1995 | Antimicrob. Agents Chemother. | pmid:7726492 |
Hsueh PR et al. | High incidence of erythromycin resistance among clinical isolates of Streptococcus agalactiae in Taiwan. | 2001 | Antimicrob. Agents Chemother. | pmid:11600380 |
Nagai K et al. | Activities of a new fluoroketolide, HMR 3787, and its (des)-fluor derivative RU 64399 compared to those of telithromycin, erythromycin A, azithromycin, clarithromycin, and clindamycin against macrolide-susceptible or -resistant Streptococcus pneumoniae and S. pyogenes. | 2001 | Antimicrob. Agents Chemother. | pmid:11600391 |
Okamoto H et al. | In vivo efficacy of telithromycin (HMR3647) against Streptococcus pneumoniae and Haemophilus influenzae. | 2001 | Antimicrob. Agents Chemother. | pmid:11600393 |
Hao H et al. | Mutational and transcriptomic changes involved in the development of macrolide resistance in Campylobacter jejuni. | 2013 | Antimicrob. Agents Chemother. | pmid:23274667 |
Miller AA et al. | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. | 2008 | Antimicrob. Agents Chemother. | pmid:18519725 |
Wolff BJ et al. | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. | 2008 | Antimicrob. Agents Chemother. | pmid:18644962 |
Rikihisa Y and Jiang BM | In vitro susceptibilities of Ehrlichia risticii to eight antibiotics. | 1988 | Antimicrob. Agents Chemother. | pmid:3142345 |
Lawrence L et al. | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. | 2008 | Antimicrob. Agents Chemother. | pmid:18316525 |
Robertson JA et al. | Standardized method for determining antimicrobial susceptibility of strains of Ureaplasma urealyticum and their response to tetracycline, erythromycin, and rosaramicin. | 1981 | Antimicrob. Agents Chemother. | pmid:7283415 |
Mushtaq A et al. | Differential Antimicrobial Susceptibilities of Granulicatella adiacens and Abiotrophia defectiva. | 2016 | Antimicrob. Agents Chemother. | pmid:27216060 |
DiSanto AR and Chodos DJ | Influence of study design in assessing food effects on absorption of erythromycin base and erythromycin stearate. | 1981 | Antimicrob. Agents Chemother. | pmid:7283417 |
Montilla A et al. | Genetic environment of the lnu(B) gene in a Streptococcus agalactiae clinical isolate. | 2014 | Antimicrob. Agents Chemother. | pmid:24957835 |
Truong-Bolduc QC et al. | Transcriptional Regulator TetR21 Controls the Expression of the Staphylococcus aureus LmrS Efflux Pump. | 2017 | Antimicrob. Agents Chemother. | pmid:28584148 |
Benoni G et al. | Pharmacokinetics and human tissue penetration of flurithromycin. | 1988 | Antimicrob. Agents Chemother. | pmid:3245699 |
Blackwell GA and Hall RM | The Determinant and the Genes in Acinetobacter Plasmids Are Each Part of Discrete Modules Flanked by Inversely Oriented p (XerC-XerD) Sites. | 2017 | Antimicrob. Agents Chemother. | pmid:28533235 |
Tiemei Z et al. | Resistance phenotypes and genotypes of erythromycin-resistant Streptococcus pneumoniae isolates in Beijing and Shenyang, China. | 2004 | Antimicrob. Agents Chemother. | pmid:15388475 |
Fuchs PC et al. | Selection of zone size interpretive criteria for disk diffusion susceptibility tests of three antibiotics against Streptococcus pneumoniae, using the New Guidelines of the National Committee for Clinical Laboratory Standards. | 2002 | Antimicrob. Agents Chemother. | pmid:11796348 |
Jiang LJ et al. | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. | 2009 | Antimicrob. Agents Chemother. | pmid:19223626 |
Nagai K et al. | Susceptibility to telithromycin in 1,011 Streptococcus pyogenes isolates from 10 central and Eastern European countries. | 2002 | Antimicrob. Agents Chemother. | pmid:11796375 |
Naik S and Ruck R | In vitro activities of several new macrolide antibiotics against Mycobacterium avium complex. | 1989 | Antimicrob. Agents Chemother. | pmid:2817858 |
Williams MD et al. | Early treatment of Campylobacter jejuni enteritis. | 1989 | Antimicrob. Agents Chemother. | pmid:2818711 |
Swenson JM et al. | Susceptibility of Clostridium botulinum to thirteen antimicrobial agents. | 1980 | Antimicrob. Agents Chemother. | pmid:6998374 |
Wang H et al. | High prevalence of fluoroquinolone-resistant group B streptococci among clinical isolates in China and predominance of sequence type 19 with serotype III. | 2013 | Antimicrob. Agents Chemother. | pmid:23295933 |
Wingard JB et al. | A novel cell-associated protection assay demonstrates the ability of certain antibiotics to protect ocular surface cell lines from subsequent clinical Staphylococcus aureus challenge. | 2011 | Antimicrob. Agents Chemother. | pmid:21628536 |
Gisby J and Bryant J | Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections. | 2000 | Antimicrob. Agents Chemother. | pmid:10639346 |
Brueggemann AB et al. | In vitro activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. | 2000 | Antimicrob. Agents Chemother. | pmid:10639382 |
Allen NE | Macrolide resistance in Staphylococcus aureus: inducers of macrolide resistance. | 1977 | Antimicrob. Agents Chemother. | pmid:856018 |
Brummett RE and Fox KE | Vancomycin- and erythromycin-induced hearing loss in humans. | 1989 | Antimicrob. Agents Chemother. | pmid:2669623 |
Shungu DL et al. | In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens. | 1983 | Antimicrob. Agents Chemother. | pmid:6219622 |
Veiga-Crespo P et al. | Synergism between outer membrane proteins and antimicrobials. | 2011 | Antimicrob. Agents Chemother. | pmid:21321143 |
Srinivasan VB et al. | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. | 2009 | Antimicrob. Agents Chemother. | pmid:19770280 |
Lehtopolku M et al. | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. | 2010 | Antimicrob. Agents Chemother. | pmid:20038624 |
Kadlec K and Schwarz S | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. | 2009 | Antimicrob. Agents Chemother. | pmid:19470508 |
Wong H et al. | Characterization of ermA in macrolide-susceptible strains of methicillin-resistant Staphylococcus aureus. | 2009 | Antimicrob. Agents Chemother. | pmid:19487445 |
Kuo MS et al. | Microbial glycosylation of erythromycin A. | 1989 | Antimicrob. Agents Chemother. | pmid:2619274 |
Severin JA et al. | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. | 2010 | Antimicrob. Agents Chemother. | pmid:20837756 |
Jeong JW et al. | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. | 2010 | Antimicrob. Agents Chemother. | pmid:20855730 |
Chakraborty A et al. | In vitro sensitivity and resistance of 46 Leptospira strains isolated from rats in the Philippines to 14 antimicrobial agents. | 2010 | Antimicrob. Agents Chemother. | pmid:20855741 |
Duarte RS et al. | Distribution of antimicrobial resistance and virulence-related genes among Brazilian group B streptococci recovered from bovine and human sources. | 2005 | Antimicrob. Agents Chemother. | pmid:15616281 |
Donati M et al. | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. | 2010 | Antimicrob. Agents Chemother. | pmid:20855744 |
Xiong L et al. | Binding site of the bridged macrolides in the Escherichia coli ribosome. | 2005 | Antimicrob. Agents Chemother. | pmid:15616307 |
Muto Y et al. | Macrolide accumulation by Bacteroides fragilis ATCC 25285. | 1989 | Antimicrob. Agents Chemother. | pmid:2719467 |
Floyd JL et al. | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. | 2010 | Antimicrob. Agents Chemother. | pmid:20855745 |
Abbanat D et al. | In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides. | 2005 | Antimicrob. Agents Chemother. | pmid:15616310 |