erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Alexander RE and Grogan DM | Long-acting erythromycins: assessing their role in treating outpatient odontogenic infections. | 2009 | Tex Dent J | pmid:19472551 |
Majumdar S et al. | Vitreal kinetics of quinidine in rabbits in the presence of topically coadministered P-glycoprotein substrates/modulators. | 2009 | Drug Metab. Dispos. | pmid:19406953 |
Zonenschain D et al. | Erythromycin- and tetracycline-resistant lactobacilli in Italian fermented dry sausages. | 2009 | J. Appl. Microbiol. | pmid:19426258 |
Bostan K et al. | Prevalence and antibiotic susceptibility of thermophilic Campylobacter species on beef, mutton, and chicken carcasses in Istanbul, Turkey. | 2009 | Microb. Drug Resist. | pmid:19432522 |
Crider KS et al. | Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. | 2009 | Arch Pediatr Adolesc Med | pmid:19884587 |
Markel DC et al. | Inhibitory effects of erythromycin on wear debris-induced VEGF/Flt-1 gene production and osteolysis. | 2009 | Inflamm. Res. | pmid:19262986 |
Zheng J et al. | Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin. | 2009 | J. Mol. Biol. | pmid:19265703 |
Zou X et al. | Oxygen uptake rate optimization with nitrogen regulation for erythromycin production and scale-up from 50 L to 372 m3 scale. | 2009 | Bioresour. Technol. | pmid:18929481 |
Chan JC et al. | Epidemiological analysis of Streptococcus pyogenes infections in Hong Kong. | 2009 | Pathology | pmid:20001348 |
Hariharan H et al. | Antimicrobial drug resistance as determined by the E-test in Campylobacter jejuni, C. coli, and C. lari isolates from the ceca of broiler and layer chickens in Grenada. | 2009 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:18329712 |
Sader HS et al. | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. | 2009 | Antimicrob. Agents Chemother. | pmid:19289528 |
Razzaq A et al. | Erythromycin establishes early oral feeding in neonates operated for congenital intestinal atresias. | 2009 | Pediatr. Surg. Int. | pmid:19290531 |
Lindqvist M et al. | A clonal outbreak of methicillin-susceptible Staphylococcus aureus with concomitant resistance to erythromycin, clindamycin and tobramycin in a Swedish county. | 2009 | Scand. J. Infect. Dis. | pmid:19294581 |
Sambo N et al. | Effect of the aqueous extract of Psidium guajava on erythromycin-induced liver damage in rats. | 2009 | Niger J Physiol Sci | pmid:20234760 |
Kumar S et al. | Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection. | 2009 | Drug Metab. Dispos. | pmid:19299527 |
Graham JS et al. | A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. | 2009 | Cancer Chemother. Pharmacol. | pmid:18654747 |
May T et al. | Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. | 2009 | Antimicrob. Agents Chemother. | pmid:19721076 |
Ghosh P et al. | Modeling a macrocyclic bis[spirodiepoxide] strategy to erythronolide A. | 2009 | Org. Lett. | pmid:19725523 |
Marcellini L et al. | Esculentin-1b(1-18)--a membrane-active antimicrobial peptide that synergizes with antibiotics and modifies the expression level of a limited number of proteins in Escherichia coli. | 2009 | FEBS J. | pmid:19725877 |
Nam HM et al. | Antimicrobial resistance of streptococci isolated from mastitic bovine milk samples in Korea. | 2009 | J. Vet. Diagn. Invest. | pmid:19737768 |
Cui L et al. | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. | 2009 | Antimicrob. Agents Chemother. | pmid:19124662 |
Biedenbach DJ et al. | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. | 2009 | Antimicrob. Agents Chemother. | pmid:19124664 |
Morgenstern K et al. | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. | 2009 | Antimicrob. Agents Chemother. | pmid:19075048 |
Jakeman DL et al. | Antimicrobial activities of jadomycin B and structurally related analogues. | 2009 | Antimicrob. Agents Chemother. | pmid:19075054 |
House B et al. | Acid-stress-induced changes in enterohaemorrhagic Escherichia coli O157 : H7 virulence. | 2009 | Microbiology (Reading, Engl.) | pmid:19497950 |
Wu L et al. | In vitro effects of erythromycin on RANKL and nuclear factor-kappa B by human TNF-alpha stimulated Jurkat cells. | 2009 | Int. Immunopharmacol. | pmid:19500694 |
Takagi Y et al. | Erythromycin-induced CXCR4 expression on microvascular endothelial cells. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19502290 |
Ozaki K et al. | Effects of mitemcinal (GM-611), an orally active erythromycin-derived prokinetic agent, on delayed gastric emptying and postprandial glucose in a new minipig model of diabetes. | 2008 Sep-Oct | J. Diabetes Complicat. | pmid:18413164 |
Rassi H and Ghasemi SF | Production of novel chemotherapeutic drugs by Streptomycetes. | 2008 Oct-Dec | Lik. Sprava | pmid:19663015 |
Pomero G et al. | [Neonatal group B Streptococcus infection: an integrated approach (of clinical pathologists, gynecologists, midwives, pediatricians-neonatologists) of the functional area of Cuneo (Italy)]. | 2008 Nov-Dec | Pediatr Med Chir | pmid:19431950 |
Vlieghe ER et al. | Trends of norfloxacin and erythromycin resistance of Campylobacter jejuni/Campylobacter coli isolates recovered from international travelers, 1994 to 2006. | 2008 Nov-Dec | J Travel Med | pmid:19090796 |
Van Der Beek MT et al. | Mycobacterium chelonae keratitis in a patient with Sjögren's syndrome. | 2008 Mar-Apr | Eur J Ophthalmol | pmid:18320526 |
Angel MR et al. | Prevalence of inducible clindamycin resistance in gram positive organisms in a tertiary care centre. | 2008 Jul-Sep | Indian J Med Microbiol | pmid:18695329 |
Farrant P et al. | Is erythromycin an effective treatment for chronic bullous disease of childhood? A national survey of members of the British Society for Paediatric Dermatology. | 2008 Jul-Aug | Pediatr Dermatol | pmid:18789096 |
MacLaren R et al. | Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. | 2008 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:18596312 |
Bitarães EL et al. | Compliance with antibiotic prophylaxis in children with sickle cell anemia: a prospective study. | 2008 Jul-Aug | J Pediatr (Rio J) | pmid:18688558 |
Landzinski J et al. | Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. | 2008 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:18165446 |
Nouri M et al. | Effect of erythromycin and gentamicin on abomasal emptying rate in suckling calves. | 2008 Jan-Feb | J. Vet. Intern. Med. | pmid:18289310 |
Winters M et al. | Epidemiology of invasive pneumococcal disease in BC during the introduction of conjugated pneumococcal vaccine. | 2008 Jan-Feb | Can J Public Health | pmid:18435393 |
Ilisz I et al. | Enantioseparation of beta-methyl-substituted amino acids with cyclodextrins by capillary zone electrophoresis. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18514044 |
Verma P et al. | A curious eruption: erythema gyratum repens in resolving pustular psoriasis. | 2008 | J Eur Acad Dermatol Venereol | pmid:18005020 |
Montagnani F et al. | Pneumococcal disease in a paediatric population in a hospital of central Italy: a clinical and microbiological case series from 1992 to 2006. | 2008 | J. Infect. | pmid:18222005 |
Chen Y et al. | Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation. | 2008 | Appl. Environ. Microbiol. | pmid:18223111 |
Buiter HJ et al. | Erythromycin precipitation in vena femoralis: investigation of crystals found in postmortem material of an intensive care unit patient. | 2008 | Ther Drug Monit | pmid:18223476 |
Ressner RA et al. | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. | 2008 | Antimicrob. Agents Chemother. | pmid:18180346 |
Sader HS et al. | Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. | 2008 | Antimicrob. Agents Chemother. | pmid:18180353 |
Isoherranen N et al. | The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation. | 2008 | Drug Metab. Dispos. | pmid:17954524 |
Starner TD et al. | Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilms. | 2008 | Antimicrob. Agents Chemother. | pmid:17954687 |
Morozumi M et al. | Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. | 2008 | Antimicrob. Agents Chemother. | pmid:17954691 |
Dias R and Caniça M | Trends in resistance to penicillin and erythromycin of invasive pneumococci in Portugal. | 2008 | Epidemiol. Infect. | pmid:17697443 |
Pedersen M and Hammer K | The role of MOR and the CI operator sites on the genetic switch of the temperate bacteriophage TP901-1. | 2008 | J. Mol. Biol. | pmid:18930065 |
Parrella E and Longo VD | The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. | 2008 | Methods | pmid:18930829 |
Dogan B et al. | Antistreptococcal treatment of guttate psoriasis: a controlled study. | 2008 | Int. J. Dermatol. | pmid:18937661 |
Gai Y et al. | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18996692 |
Kenyon S et al. | Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial. | 2008 | Lancet | pmid:18804274 |
Russell AR and Steer PJ | Antibiotics in preterm labour--the ORACLE speaks. | 2008 | Lancet | pmid:18804275 |
Ramstedt KL et al. | Changes in gallbladder volume in healthy dogs after food was withheld for 12 hours followed by ingestion of a meal or a meal containing erythromycin. | 2008 | Am. J. Vet. Res. | pmid:18447796 |
Prasher P et al. | Bilateral chronic peripheral ulcerative keratitis secondary to cat-scratch disease. | 2008 | Eye Contact Lens | pmid:18463489 |
Fenoll A et al. | In vitro activity of oral cephalosporins against pediatric isolates of Streptococcus pneumoniae non-susceptible to penicillin, amoxicillin or erythromycin. | 2008 | J Chemother | pmid:18467242 |
Lambertsen L et al. | Erythromycin resistance caused by erm(A) subclass erm(TR) in a Danish invasive pneumococcal isolate: are erm(A) pneumococcal isolates overlooked? | 2008 | Scand. J. Infect. Dis. | pmid:18584554 |
Vaara M et al. | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. | 2008 | Antimicrob. Agents Chemother. | pmid:18591267 |
Amsler KM et al. | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. | 2008 | Antimicrob. Agents Chemother. | pmid:18591277 |
DiPersio LP et al. | Prevalence of the erm(T) gene in clinical isolates of erythromycin-resistant group D Streptococcus and Enterococcus. | 2008 | Antimicrob. Agents Chemother. | pmid:18285483 |
Khalil H et al. | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. | 2008 | Antimicrob. Agents Chemother. | pmid:18285485 |
Cochetti I et al. | erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003. | 2008 | Antimicrob. Agents Chemother. | pmid:18285489 |
Cassiday PK et al. | Co-infection with two different strains of Bordetella pertussis in an infant. | 2008 | J. Med. Microbiol. | pmid:18287306 |
Yang Y | [Mechanism and clinical application of erythromycin as a gastrointestinal prokinetic agent in children]. | 2008 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:18289489 |
Inoue D et al. | Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14. | 2008 | Respirology | pmid:18339018 |
Ahlin G et al. | Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. | 2008 | J. Med. Chem. | pmid:18788725 |
Hayashi S et al. | Characterization of multinuclear hepatocytes induced in rats by mitemcinal (GM-611), an erythromycin derivative. | 2008 | Toxicol Pathol | pmid:18776165 |
Liu ZQ et al. | Efflux pump gene hefA of Helicobacter pylori plays an important role in multidrug resistance. | 2008 | World J. Gastroenterol. | pmid:18777600 |
Venkatasubramani N et al. | Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study. | 2008 | BMC Gastroenterol | pmid:18718006 |
Komuro I et al. | Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBPbeta. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18719105 |
Yang F et al. | Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, China. | 2008 | Int. J. Antimicrob. Agents | pmid:18723327 |
Seemungal TA et al. | Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. | 2008 | Am. J. Respir. Crit. Care Med. | pmid:18723437 |
Mally M and Cornelis GR | Genetic tools for studying Capnocytophaga canimorsus. | 2008 | Appl. Environ. Microbiol. | pmid:18723653 |
Dorfman MS et al. | The pharmacodynamic properties of azithromycin in a kinetics-of-kill model and implications for bacterial conjunctivitis treatment. | 2008 | Adv Ther | pmid:18369536 |
Mendes RE et al. | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. | 2008 | Antimicrob. Agents Chemother. | pmid:18391032 |
Karabiber N and Mert Dinc B | Erythromycin-heteroresistant methicillin-resistant Staphylococcus aureus isolates from Turkey. | 2008 | Clin. Microbiol. Infect. | pmid:18397328 |
Korolkiewicz RP and Kuziemski K | Use of erythromycin in prevention or treatment of postoperative ileus. | 2008 | Urology | pmid:18400282 |
Luppens SB et al. | Effect of Veillonella parvula on the antimicrobial resistance and gene expression of Streptococcus mutans grown in a dual-species biofilm. | 2008 | Oral Microbiol. Immunol. | pmid:18402603 |
Min YH et al. | Molecular analysis of constitutive mutations in ermB and ermA selected in vitro from inducibly MLSB-resistant enterococci. | 2008 | Arch. Pharm. Res. | pmid:18409053 |
Besier S et al. | The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. | 2008 | Antimicrob. Agents Chemother. | pmid:18378706 |
Reinert RR et al. | Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. | 2008 | Antimicrob. Agents Chemother. | pmid:18378707 |
Kumari N et al. | Detection of pbp2b and ermB genes in clinical isolates of Streptococcus pneumoniae. | 2008 | J Infect Dev Ctries | pmid:19738350 |
Bendahou A et al. | Characterization of Staphylococcus species isolated from raw milk and milk products (lben and jben) in North Morocco. | 2008 | J Infect Dev Ctries | pmid:19738354 |
Betancor L et al. | Improved catalytic activity of a purified multienzyme from a modular polyketide synthase after coexpression with Streptomyces chaperonins in Escherichia coli. | 2008 | Chembiochem | pmid:19021139 |
Olsson C et al. | Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin. | 2008 | Gen. Comp. Endocrinol. | pmid:17582410 |
Rhodes LD et al. | Characterization of Renibacterium salmoninarum with reduced susceptibility to macrolide antibiotics by a standardized antibiotic susceptibility test. | 2008 | Dis. Aquat. Org. | pmid:18814542 |
Moore SD and Sauer RT | Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19015512 |
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Priscila G et al. | Expression of the bacterial hemoglobin gene from Vitreoscilla stercoraria increases rifamycin B production in Amycolatopsis mediterranei. | 2008 | J. Biosci. Bioeng. | pmid:19111646 |
Limouris GS et al. | Selective hepatic arterial infusion of In-111-DTPA-Phe1-octreotide in neuroendocrine liver metastases. | 2008 | Eur. J. Nucl. Med. Mol. Imaging | pmid:18536916 |
Crasta OR et al. | Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes. | 2008 | PLoS ONE | pmid:18478107 |
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Gan M et al. | Glycosides from the root of Iodes cirrhosa. | 2008 | J. Nat. Prod. | pmid:18327912 |
Bartels AL et al. | Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA. | 2008 | J Neural Transm (Vienna) | pmid:18265929 |
Zhang M et al. | Recombinant anti-vascular endothelial growth factor fusion protein efficiently suppresses choridal neovasularization in monkeys. | 2008 | Mol. Vis. | pmid:18246030 |
Li X et al. | Fluorinated porphyrin tweezer: a powerful reporter of absolute configuration for erythro and threo diols, amino alcohols, and diamines. | 2008 | J. Am. Chem. Soc. | pmid:18211067 |