erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cho T et al. | [Effects of EM on the intracellular Ca 2+ response in A549 cells]. | 2000 | Jpn J Antibiot | pmid:10756443 |
Nakamura A et al. | [Selective suppression of aminoglycoside 3'-phosphorylating enzyme activities by macrolides--a study by using macrolide-resistant bacteria]. | 2000 | Jpn J Antibiot | pmid:10756446 |
Homa K et al. | [Erythromycin sensitivity of Shigella flexneri and S. sonnei]. | 2000 | Jpn J Antibiot | pmid:10756447 |
Sakamoto M et al. | [Usefulness of clarithromycin in paitents with unresectable non-small-cell lung cancer--clinical evaluation of those who survived for a long time and those succumbed in a short period]. | 2000 | Jpn J Antibiot | pmid:10756453 |
Miyazawa T and Iino Y | [Effect of macrolides on ligand expression by T lymphocytes obtained from human peripheral blood]. | 2000 | Jpn J Antibiot | pmid:10756457 |
Enomoto F et al. | [Involvement of adhesion molecules in experimental otitis media in rats--an in vitro evaluation]. | 2000 | Jpn J Antibiot | pmid:10756459 |
Obori M et al. | [Effects of 14-member cyclic macrolide compounds on rat leukocyte chemotaxis]. | 2000 | Jpn J Antibiot | pmid:10756460 |
Takahashi T et al. | [Efficacy of erythromycin (EM) on a rabbit model of Pseudomonas aeruginosa-induced chronic bronchiolitis--its action on apoptosis]. | 2000 | Jpn J Antibiot | pmid:10756461 |
Dezaki S et al. | [Effects of macrolides on several transcription factors]. | 2000 | Jpn J Antibiot | pmid:10756462 |
Komiyane M and Tamaoki K | [Clinical effects of macrolides on psoriasis vulgaris]. | 2000 | Jpn J Antibiot | pmid:10756468 |
Cojocaru I et al. | [Dermatologic preparations with erythromycin--the correlation of the pharmaceutical form-therapeutic effect]. | 1997 Jul-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:10756791 |
Fowler SM et al. | Amino acid 305 determines catalytic center accessibility in CYP3A4. | 2000 | Biochemistry | pmid:10757990 |
Curran JB et al. | Infection of abnormal heart valves and total joint prosthesis following dental procedures. | 1976 Jul-Aug | Northwest Dent | pmid:1075923 |
Van Herwaarden MA et al. | The effect of motilin agonist ABT-229 on gastro-oesophageal reflux, oesophageal motility and lower oesophageal sphincter characteristics in GERD patients. | 2000 | Aliment. Pharmacol. Ther. | pmid:10759625 |
Douthwaite S et al. | Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. | 2000 | Mol. Microbiol. | pmid:10760175 |
Miller P et al. | Neural and muscular receptors for motilin in the rabbit colon. | 2000 | Peptides | pmid:10764957 |
Evans AJ and Krentz AJ | Should cisapride be avoided in patients with diabetic gastroparesis? | 1999 Sep-Dec | J. Diabetes Complicat. | pmid:10765008 |
Osterholm MT | Erythromycin remains gold standard for treatment of pertussis in infants. | 2000 | Clin. Infect. Dis. | pmid:10766495 |
Quirós LM et al. | Glycosylation of macrolide antibiotics. Purification and kinetic studies of a macrolide glycosyltransferase from Streptomyces antibioticus. | 2000 | J. Biol. Chem. | pmid:10766792 |
Suwa M et al. | Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei. | 2000 | Gene | pmid:10767533 |
Nieto JE et al. | In vitro effects of erythromycin, lidocaine, and metoclopramide on smooth muscle from the pyloric antrum, proximal portion of the duodenum, and middle portion of the jejunum of horses. | 2000 | Am. J. Vet. Res. | pmid:10772106 |
Roussel AJ et al. | Prokinetic effects of erythromycin on the ileum, cecum, and pelvic flexure of horses during the postoperative period. | 2000 | Am. J. Vet. Res. | pmid:10772107 |
Ghidini A et al. | Successful outcome after antibiotic treatment of postamniocentesis membrane rupture and chorioamnionitis in multiple pregnancy. | 1999 | Am J Perinatol | pmid:10772199 |
Najib MM et al. | Cost-effectiveness of sparfloxacin compared with other oral antimicrobials in outpatient treatment of community-acquired pneumonia. | 2000 | Pharmacotherapy | pmid:10772376 |
Pai MP et al. | Macrolide drug interactions: an update. | 2000 | Ann Pharmacother | pmid:10772438 |
Gunics G et al. | Interaction between antibiotics and non-conventional antibiotics on bacteria. | 2000 | Int. J. Antimicrob. Agents | pmid:10773495 |
Matsuoka M | [Study of macrolide, lincosamide, and streptogramin B antibiotics resistance in Staphylococcus aureus]. | 2000 | Yakugaku Zasshi | pmid:10774259 |
Donders GG | Treatment of sexually transmitted bacterial diseases in pregnant women. | 2000 | Drugs | pmid:10776830 |
Collins JM | Cytochrome P-450 and other determinants of pharmacokinetics, toxicity, and efficacy in humans. | 2000 | Clin. Cancer Res. | pmid:10778942 |
Hirth J et al. | The effect of an individual's cytochrome CYP3A4 activity on docetaxel clearance. | 2000 | Clin. Cancer Res. | pmid:10778948 |
Sartakova M et al. | Development of an extrachromosomal cloning vector system for use in Borrelia burgdorferi. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781091 |
Clark RF et al. | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10782693 |
Fanos V et al. | Flurithromycin-induced acute interstitial nephritis. | 2000 | Pediatr. Infect. Dis. J. | pmid:10783037 |
Schwarz UI et al. | P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans. | 2000 | Int J Clin Pharmacol Ther | pmid:10783825 |
Graham AE et al. | Efficient large-scale radical deoxygenation in alcoholic solvents using sodium hypophosphite and a phase-transfer agent: application to erythromycins. | 2000 | J. Org. Chem. | pmid:10789478 |
Hoey J | Hypertrophic pyloric stenosis caused by erythromycin. | 2000 | CMAJ | pmid:10789643 |
Khan SA et al. | Transfer of erythromycin resistance from poultry to human clinical strains of Staphylococcus aureus. | 2000 | J. Clin. Microbiol. | pmid:10790109 |
Emerson BB et al. | Hemophilus influenzae type B susceptibility to 17 antibiotics. | 1975 | J. Pediatr. | pmid:1079251 |
Gaisser S et al. | A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. | 2000 | Mol. Microbiol. | pmid:10792725 |
Sato F et al. | EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs. | 2000 | Eur. J. Pharmacol. | pmid:10794824 |
Petrakis IE et al. | Erythromycin enhances solid-phase gastric emptying in induced-hyperglycemia in patients with truncal vagotomy and pyloroplasty. | 2000 | Dig. Dis. Sci. | pmid:10795758 |
Ng E and Shah V | Erythromycin for feeding intolerance in preterm infants. | 2000 | Cochrane Database Syst Rev | pmid:10796273 |
Arzese AR et al. | Detection of tetQ and ermF antibiotic resistance genes in Prevotella and Porphyromonas isolates from clinical specimens and resident microbiota of humans. | 2000 | J. Antimicrob. Chemother. | pmid:10797077 |
Alós JI et al. | High prevalence of erythromycin-resistant, clindamycin/miocamycin-susceptible (M phenotype) Streptococcus pyogenes: results of a Spanish multicentre study in 1998. Spanish Group for the Study of Infection in the Primary Health Care Setting. | 2000 | J. Antimicrob. Chemother. | pmid:10797081 |
Rao GG | Should clindamycin be used in treatment of patients with infections caused by erythromycin-resistant staphylococci? | 2000 | J. Antimicrob. Chemother. | pmid:10797103 |
Davis SD et al. | Partial antibiotic therapy in Haemophilus infuenzae meningitis. Its effect on cerebrospinal fluid abnormalities. | 1975 | Am. J. Dis. Child. | pmid:1080009 |
Sarna SK et al. | Enteric locus of action of prokinetics: ABT-229, motilin, and erythromycin. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10801267 |
Mardones G and Venegas A | Chromogenic plate assay distinguishing bacteriolytic from bacteriostatic activity of an antibiotic agent. | 2000 | J. Microbiol. Methods | pmid:10802135 |
Lal R et al. | Regulation and manipulation of the gene clusters encoding type-I PKSs. | 2000 | Trends Biotechnol. | pmid:10802562 |
Lecomte T et al. | [Small bowel pseudo-obstruction revealing an early scleroderma. Long-term efficacy of octreotide and erythromycin]. | 2000 | Gastroenterol. Clin. Biol. | pmid:10804347 |