erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Aarestrup FM and Carstensen B | Effect of tylosin used as a growth promoter on the occurrence of macrolide-resistant enterococci and staphylococci in pigs. | 1998 | Microb. Drug Resist. | pmid:9988049 |
Pesco-Koplowitz L et al. | Lack of effect of erythromycin and ketoconazole on the pharmacokinetics and pharmacodynamics of steady-state intranasal levocabastine. | 1999 | J Clin Pharmacol | pmid:9987703 |
Schierholz JM et al. | Killing effects of antibiotics and two-fold antimicrobial combinations on proliferating and non growing staphylococci. | 1998 | Zentralbl. Bakteriol. | pmid:9987191 |
Silva JP and Ferreira JP | Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method. | 1999 Jan-Feb | J Microencapsul | pmid:9972506 |
Syphilis: CDC recommended treatment schedules--1976. | 1976 | Obstet Gynecol | pmid:995345 | |
Huang GC et al. | Eradiction of H. pylori results in regression of B-cell low grade gastric MALToma with evident B-symptoms. | 1998 Nov-Dec | Hepatogastroenterology | pmid:9951945 |
Hanada E et al. | Pharmacodynamic analysis of the electrocardiographic interaction between disopyramide and erythromycin in rats. | 1999 | J Pharm Sci | pmid:9950644 |
Solov'eva SV et al. | [Detection of tetracycline- and erythromycin-resistant urogenital Mycoplasma strains using PCR]. | 1998 Nov-Dec | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:9949490 |
Dillon JR et al. | A comparison of the in vitro activity of rosamicin, erythromycin, spiramycin, penicillin and tetracycline against N. gonorrhoeae, including beta-lactamase producing isolates. | 1978 | J. Antimicrob. Chemother. | pmid:99424 |
Principi N and Esposito S | Comparative tolerability of erythromycin and newer macrolide antibacterials in paediatric patients. | 1999 | Drug Saf | pmid:9935275 |
Montes LF | Familial benign chronic pemphigus (Hailey-Hailey disease). | 1976 | J. Cutan. Pathol. | pmid:993398 |
Gore RM et al. | Drug-induced disorders of the stomach and duodenum. | 1999 Jan-Feb | Abdom Imaging | pmid:9933666 |
Lau J et al. | Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. | 1999 | Biochemistry | pmid:9931032 |
Gurycová D | First isolation of Francisella tularensis subsp. tularensis in Europe. | 1998 | Eur. J. Epidemiol. | pmid:9928875 |
GarcÃa-Arata MI et al. | Mutations in 23S rRNA in Helicobacter pylori conferring resistance to erythromycin do not always confer resistance to clarithromycin. | 1999 | Antimicrob. Agents Chemother. | pmid:9925537 |
Sanders CJ and Mulder MM | Periurethral gland abscess: aetiology and treatment. | 1998 | Sex Transm Infect | pmid:9924469 |
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Jensen LB et al. | Presence of erm gene classes in gram-positive bacteria of animal and human origin in Denmark. | 1999 | FEMS Microbiol. Lett. | pmid:9919664 |
Pacey MS et al. | Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity. | 1998 | J. Antibiot. | pmid:9918396 |
Calista D et al. | Guess What! Localised bacillary angiomatosis of the tongue. | 1998 | Eur J Dermatol | pmid:9917173 |
Kaji M et al. | [Effects of long-term preoperative administration of low-dose erythromycin on warm ischemia-reperfusion pulmonary injury]. | 1998 | Nihon Kokyuki Gakkai Zasshi | pmid:9916477 |
Petersdorf RG | Antimicrobial prophylaxis of bacterial endocarditis. Prudent caution or bacterial overkill? | 1978 | Am. J. Med. | pmid:99033 |
Karbowski M et al. | Free radical-induced megamitochondria formation and apoptosis. | 1999 | Free Radic. Biol. Med. | pmid:9895232 |
Ziermann R and Betlach MC | Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains. | 1999 | BioTechniques | pmid:9894599 |
Matsubara S et al. | [Severe Legionella micdadei pneumonia effectively treated with hemofiltration therapy]. | 1998 | Nihon Kokyuki Gakkai Zasshi | pmid:9893432 |
Akiyama H et al. | Streptococci isolated from various skin lesions: the interaction with Staphylococcus aureus strains. | 1999 | J. Dermatol. Sci. | pmid:9890370 |
El Younis CM et al. | Rapid marked response of severe hyperemesis gravidarum to oral erythromycin. | 1998 | Am J Perinatol | pmid:9890250 |
Wu K et al. | Enterococcus faecalis pheromone-responding plasmid pAD1 gives rise to an aggregation (clumping) response when cells are exposed to subinhibitory concentrations of chloramphenicol, erythromycin, or tetracycline. | 1999 | Plasmid | pmid:9887311 |
Riippi M et al. | The effect of compression force on surface structure, crushing strength, friability and disintegration time of erythromycin acistrate tablets. | 1998 | Eur J Pharm Biopharm | pmid:9885307 |
Khanna M et al. | Selection of suitable marker genes for the development of cloning vectors and electroporation in different strains of Amycolatopsis mediterranei. | 1998 | Microbiol. Res. | pmid:9880927 |
Muller-Serieys C | [Bacterial resistance and new therapeutic perspectives]. | 1998 | Presse Med | pmid:9879336 |
Zgurskaya HI and Nikaido H | AcrA is a highly asymmetric protein capable of spanning the periplasm. | 1999 | J. Mol. Biol. | pmid:9878415 |
Manna PK and Basu SK | Preparation and evaluation of erythromycin fumarate--a new derivative of erythromycin. | 1998 | Drug Dev Ind Pharm | pmid:9876541 |
Sol V et al. | Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873665 |
Denis A and Agouridas C | Synthesis of 6-O-methyl-azithromycin and its ketolide analogue via Beckmann rearrangement of 9(E)-6-O-methyl-erythromycin oxime. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873555 |
Brand RE et al. | Gastroparesis as a cause of nausea and vomiting after high-dose chemotherapy and haemopoietic stem-cell transplantation. | 1998 Dec 19-26 | Lancet | pmid:9872252 |
Waddell ST et al. | Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: I. 4", 11 and 12-OMe derivatives via direct methylation. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871616 |
Faghih R et al. | Preparation of 9-deoxo-4"-deoxy-6,9-epoxyerythromycin lactams "motilactides": potent and orally active prokinetic agents. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871545 |
Kataja J et al. | Erythromycin resistance genes in group A streptococci in Finland. The Finnish Study Group for Antimicrobial Resistance. | 1999 | Antimicrob. Agents Chemother. | pmid:9869564 |
Frick PA et al. | Prevalence of antimicrobial drug-resistant Streptococcus pneumoniae in Washington State. | 1998 | West. J. Med. | pmid:9866434 |
Wald ER | Sinusitis. | 1998 | Pediatr Ann | pmid:9866138 |
Toyota K | Pyloric opening and closure evaluated by means of strain gauge force transducers. | 1998 | J Smooth Muscle Res | pmid:9866113 |
Delaforge M | Importance of metabolism in pharmacological studies: possible in vitro predictability. | 1998 | Nucl. Med. Biol. | pmid:9863553 |
Coulie B et al. | Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans. | 1998 | Gut | pmid:9863486 |
Unge J et al. | The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance. | 1998 | Structure | pmid:9862810 |
Weissman KJ et al. | Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase. | 1998 | Chem. Biol. | pmid:9862800 |
Hsueh PR et al. | Dissemination of high-level penicillin-, extended-spectrum cephalosporin-, and erythromycin-resistant Streptococcus pneumoniae clones in Taiwan. | 1999 | J. Clin. Microbiol. | pmid:9854097 |
Roy SK et al. | A randomized clinical trial to compare the efficacy of erythromycin, ampicillin and tetracycline for the treatment of cholera in children. | 1998 Jul-Aug | Trans. R. Soc. Trop. Med. Hyg. | pmid:9850410 |
Yamazaki H and Shimada T | Formation in vitro of an inhibitory cytochrome P450 x Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes. | 1998 | Xenobiotica | pmid:9849646 |
Belkengren R and Sapala S | Pediatric management problems. Left corneal abrasion. | 1998 Jul-Aug | Pediatr Nurs | pmid:9849269 |