erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wapnick S et al. | Reduction of postoperative infection in elective colon surgery with preoperative administration of kanamycin and erythromycin. | 1979 | Surgery | pmid:371048 |
Pennathur A et al. | Erythromycin, motilin, and the esophagus. | 1993 | Surgery | pmid:8342132 |
Bell GA et al. | Prophylactic antibiotics in elective colon surgery. | 1983 | Surgery | pmid:6849206 |
Hocking MP | Postoperative gastroparesis and tachygastria--response to electric stimulation and erythromycin. | 1993 | Surgery | pmid:8367808 |
Kaufman HS et al. | The effect of erythromycin on motility of the duodenum, sphincter of Oddi, and gallbladder in the prairie dog. | 1993 | Surgery | pmid:8367809 |
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Jarrett F et al. | Clinical experience with prophylactic antibiotic bowel suppression in burn patients. | 1978 | Surgery | pmid:347612 |
Washington BC et al. | Cefamandole-erythromycin-heparin peritoneal irrigation: an adjunct to the surgical treatment of diffuse bacterial peritonitis. | 1983 | Surgery | pmid:6623358 |
Barnes RW et al. | Studies of sterility of calf venous blood. | 1968 | Surgery | pmid:4300855 |
Nakabayashi T et al. | Erythromycin induces pyloric relaxation accompanied by a contraction of the gastric body after pylorus-preserving gastrectomy. | 2003 | Surgery | pmid:12796733 |
Sigaroudinia MO and Quayle AR | Oral erythromycin relieves dysphagia in a patient with known oesophageal hypomotility disorder who has had a Nissen's fundoplication. | 2011 | Surgeon | pmid:21550524 |
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LaMont JT | Postoperative juandice. | 1974 | Surg. Clin. North Am. | pmid:4597042 |
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Farmer RG | Preoperative preparation of the patients with carcinoma of the colon. | 1975 | Surg. Clin. North Am. | pmid:1105833 |
Jones FE et al. | Experimental evaluation of "instant" preparation of the colon with povidone-iodine. | 1975 | Surg. Clin. North Am. | pmid:1198291 |
Richards KE et al. | Monilial sepsis in the surgical patient. | 1972 | Surg. Clin. North Am. | pmid:4344114 |
Carver DH | Antibiotics in pediatric surgery. | 1970 | Surg. Clin. North Am. | pmid:4317769 |
Nichols RL and Condon RE | Antibiotic preparation of the colon: failure of commonly used regimens. | 1971 | Surg. Clin. North Am. | pmid:4932924 |
Yiannakopoulou E et al. | Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review. | 2012 | Surg Laparosc Endosc Percutan Tech | pmid:22678313 |
Nichols RL et al. | Effect of preoperative neomycin-erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. 1973. | 2000 | Surg Infect (Larchmt) | pmid:12594901 |
Parker TH and O'Leary JP | Effect of preparation of the small intestine on microflora and postoperative wound infection. | 1978 | Surg Gynecol Obstet | pmid:625675 |
Vargish T et al. | A randomized prospective evaluation of orally administered antibiotics in operations on the colon. | 1978 | Surg Gynecol Obstet | pmid:341376 |
Figueras-Felip J et al. | Oral is superior to systemic antibiotic prophylaxis in operations upon the colon and rectum. | 1984 | Surg Gynecol Obstet | pmid:6710299 |
Salvati EP et al. | Value of subcutaneous and intraperitoneal antibiotics in reducing infection in clean contaminated operations of the colon. | 1988 | Surg Gynecol Obstet | pmid:3420506 |
Mehigan D et al. | The role of systemic antibiotics in operations upon the colon. | 1981 | Surg Gynecol Obstet | pmid:7280947 |
PULASKI EJ and WESOLOWSKI SA | The use of erythromycin in certain surgical infections. | 1954 | Surg Gynecol Obstet | pmid:13137583 |
Eaton RG and Butsch DP | Antibiotic guidelines for hand infections. | 1970 | Surg Gynecol Obstet | pmid:4312012 |
Bell GA et al. | Intravenous prophylactic antimicrobial drugs in elective colorectal operations. | 1983 | Surg Gynecol Obstet | pmid:6828981 |
Roberts TL et al. | Antibiotic penetration into normal and inflamed tissues as reflected by peripheral lymph. | 1977 | Surg Forum | pmid:617531 |
GERBER B et al. | The excretion of antibiotics in pancreatic fluid. | 1957 | Surg Forum | pmid:13529603 |
Jarrett F et al. | Antibiotic bowel preparation and burn wound colonization. | 1976 | Surg Forum | pmid:1019996 |
Jun BY et al. | Premedication with erythromycin improves endoscopic visualization of the gastric mucosa in patients with subtotal gastrectomy: a prospective, randomized, controlled trial. | 2014 | Surg Endosc | pmid:24380989 |
Hau T et al. | Antibiotics in surgery. | 1983 | Surg Annu | pmid:6353632 |
Lanzarotti C and Rossi G | Effect of netupitant, a highly selective NKâ‚ receptor antagonist, on the pharmacokinetics of midazolam, erythromycin, and dexamethasone. | 2013 | Support Care Cancer | pmid:23729226 |
Nelson K et al. | Cancer and chemotherapy-related upper gastrointestinal symptoms: the role of abnormal gastric motor function and its evaluation in cancer patients. | 2002 | Support Care Cancer | pmid:12353123 |
WASZ-HOECKERT O | [CHEMOTHERAPEUTIC AGENTS AND ANTIBIOTICS IN PEDIATRICS]. | 1964 | Suom Laakaril | pmid:14145132 |
KAIPAINEN WJ | [Erythromycin]. | 1954 | Suom Laakaril | pmid:13178935 |
Jokinen MA | Bacteremia following dental extraction and its prophylaxis. | 1970 | Suom Hammaslaak Toim | pmid:4989524 |
Unge J et al. | The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance. | 1998 | Structure | pmid:9862810 |
Schlünzen F et al. | Structural basis for the antibiotic activity of ketolides and azalides. | 2003 | Structure | pmid:12623020 |
Wekselman I et al. | The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel. | 2017 | Structure | pmid:28689968 |
Pecevski J et al. | The effect of erythromycin and its thiocarbamide derivative on the induction of meiotic chromosome rearrangements in irradiated male mice. | 1977 | Strahlentherapie | pmid:841613 |
Tsarev VN et al. | [A trial of the use of rulid, sumamed and makropen in the combined treatment of generalized periodontitis at a stage of exacerbation]. | 1997 | Stomatologiia (Mosk) | pmid:9411932 |
Filatova NA et al. | [The prospects for using the new macrolide antibiotic azithromycin (Sumamed) in the combined treatment of periodontitis]. | 1995 | Stomatologiia (Mosk) | pmid:7770869 |