erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jaglic Z et al. | Distribution, characterization and genetic bases of erythromycin resistance in staphylococci and enterococci originating from livestock. | 2012 | Zoonoses Public Health | pmid:21843202 |
Berger A et al. | Two cases of cutaneous diphtheria associated with occupational pig contact in Germany. | 2013 | Zoonoses Public Health | pmid:23280311 |
Campagnolo ER et al. | Pet-associated Campylobacteriosis: A persisting public health concern. | 2018 | Zoonoses Public Health | pmid:28834267 |
Pan DY et al. | Effect of oral erythromycin on patients with diabetic gastroparesis. | 1995 | Zhonghua Yi Xue Za Zhi (Taipei) | pmid:7634182 |
Jang TN et al. | A randomized comparative study on the safety and efficacy of clarithromycin and erythromycin in treating community-acquired pneumonia. | 1995 | Zhonghua Yi Xue Za Zhi (Taipei) | pmid:7796357 |
Ko YY et al. | Recurrent infection of Legionella pneumonia: a case report. | 1996 | Zhonghua Yi Xue Za Zhi (Taipei) | pmid:8768386 |
Tai CY et al. | [Bullous epidermolytic and atrophic dermatitis medicamentosa: report of 4 cases]. | 1974 | Zhonghua Yi Xue Za Zhi | pmid:4273908 |
Cai XJ et al. | [Protective effects of erythromycin on human bronchial epithelial cells impaired by interleukin-4]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:22094097 |
Bai H et al. | [Susceptibility study on urogenital Chlamydia trachomatis to 19 kinds of antibiotics]. | 1995 | Zhonghua Yi Xue Za Zhi | pmid:7600311 |
Wang J et al. | [Drug susceptibility and homologous analysis on Corynebacterium striatum strains isolated from inpatients]. | 2014 | Zhonghua Yi Xue Za Zhi | pmid:25410920 |
Lü P et al. | [Transfer of erythromycin-resistance among strains and species of bacteria: plasmid conjugation method in enterococcal isolates]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17988534 |
Chen DK et al. | [Mechanism of hetero-erythromycin resistant Staphylococcus aureus and a comparison of detection methods]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:24548451 |
He ZY et al. | [Effects of erythromycin on hydrogen peroxide-induced interleukin-8 synthesis and regulation of glutathione in human bronchial epithelial cells]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16061006 |
Shi HY et al. | [Effect of quorum sensing system on the infection of MRSA and the intervention of erythromycin on it]. | 2016 | Zhonghua Yi Xue Za Zhi | pmid:27760665 |
Shi X et al. | [The research of the innate defense regulator peptide on the effects of methicillin resistant staphylococcus aureus biofilm]. | 2018 | Zhonghua Yi Xue Za Zhi | pmid:29397617 |
Li LH et al. | [Effect of low dose erythromycin on the proliferation of granulation tissue after tracheal injury]. | 2017 | Zhonghua Yi Xue Za Zhi | pmid:28316160 |
Chen SZ et al. | [Erythromycin inhibits the proliferation of HERG K+ channel highly expressing cancer cells and shows synergy with anticancer drugs]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:17313833 |
Liu CL et al. | [Current infection of Mycoplasma pneumoniae in adults: clinical analysis of 13 hospitalized patients]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16796860 |
Chang HY et al. | [The study on reversing mechanism of multidrug resistance of K562/A02 cell line by curcumin and erythromycin]. | 2006 | Zhonghua Xue Ye Xue Za Zhi | pmid:16875558 |
Luan R et al. | [Erythromycin for improving enteral nutrition tolerance in adult critical patients: a systematic review and meta-analysis]. | 2014 | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | pmid:24912643 |
Liu JF et al. | [Effect of erythromycin on electrical activity and gastric emptying of the intrathoracic stomach after esophagectomy for esophageal cancer]. | 2013 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:24061999 |
Fu D et al. | [Contractile effect of erythromycin on the gallbladder]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8762558 |
Zhou Y et al. | [Detection and the antibiotic susceptibility analysis of mycoplasma and chlamydia in urogenital tract infections of 327 cases patients with tubal infertility]. | 2011 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:21977592 |
Feng B et al. | [Acetaminophen absorption test for determination of diabetic gastroparesis and effects of erythromycin on gastric emptying]. | 1996 | Zhonghua Nei Ke Za Zhi | pmid:9387657 |
Song JF et al. | [Resistant rate to antibiotics in Tian Tan Hospital for 3 years]. | 1992 | Zhonghua Nei Ke Za Zhi | pmid:1303851 |
Wang X et al. | [Effects of changes of plasma motilin level on the motility of gallbladder in patients with chronic renal failure]. | 1996 | Zhonghua Nei Ke Za Zhi | pmid:9275623 |
Chen J et al. | [An experimental study on the effect of azithromycin treatment in bleomycin-induced pulmonary fibrosis of rats]. | 1999 | Zhonghua Nei Ke Za Zhi | pmid:11798706 |
Zhao TM and Liu YN | [The phenotype and genotype patterns of erythromycin-resistant Streptococcus pneumoniae]. | 2004 | Zhonghua Nei Ke Za Zhi | pmid:15182500 |
Liu YG et al. | [Clinical study of erythromycin action on gallbladder motility in patients with non-ulcer dyspepsia]. | 1994 | Zhonghua Nei Ke Za Zhi | pmid:7867425 |
Su BH et al. | Effect of erythromycin on feeding intolerance in very low birth weight infants: a preliminary observation. | 1998 Sep-Oct | Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi | pmid:9823678 |
LEE PP et al. | [CASE OF POLIO-LIKE DISEASE DUE TO COXSACKIE A 7 VIRUS]. | 1964 Jul-Sep | Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi | pmid:14213951 |
Peng CF and Chen TS | In vitro activity of midecamycin against Staphylococcus aureus. | 1979 | Zhonghua Min Guo Wei Sheng Wu Xue Za Zhi | pmid:583273 |
Tang RB et al. | Campylobacter jejuni enteritis in children. | 1984 | Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi | pmid:6532655 |
Chang JC et al. | In vitro postantibiotic effect of roxithromycin and erythromycin against gram-positive cocci. | 1992 | Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi | pmid:1342645 |
Ding YF et al. | [Study on the molecule epidemiological between resistances of 7 genes interrelated 4 antibiotic to isolated Streptococcus pneumoniae in children]. | 2005 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:16185459 |
Wen B | [Observation on clinical features and therapy in 4 elderly cases with legionellosis]. | 1991 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:1863947 |
Ye Y et al. | [Clinic intervention study on urogenital mycoplasma infection of pregnant women]. | 2001 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:11718071 |
Xiong Y et al. | [Study on the molecular epidemiology of Streptococcus suis type 2 from healthy pigs in Guangxi]. | 2007 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:17939392 |
He JL et al. | [Distribution of anaerobes in periodontal abscess and its resistance to antibiotics]. | 2012 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:23328096 |
He Z and Li Y | [Diffuse panbronchiolitis]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9388854 |
Yuan H et al. | [The effect of erythromycin on transforming growth factor-β(1) and secretory leukocyte proteinase inhibitor in a rat model of chronic obstructive pulmonary disease]. | 2011 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:22041779 |
Yin YD et al. | [Survey of macrolide resistance in Mycoplasma pneumoniae in adult patients with community-acquired pneumonia in Beijing, China]. | 2013 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:24503430 |
Huang JQ and Xie CM | [The effects of erythromycin on the secretion of tumor necrosis factor-alpha and transforming growth factor-beta1 and expression of connexin 43 in human pleural mesothelial cells]. | 2003 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:12901826 |
Fan L and Xu J | [Application progress of macrolide sustained therapy for bronchiectasis]. | 2014 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:24694975 |
Wang BF | [A clinical study of 50 cases of Legionnaires disease]. | 1992 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1306405 |
Yu L and Ran PX | [Effects of erythromycin on the synthesis of interleukin-8 and gamma-glutamylcysteine synthetase induced by 4-hydroxynonenal in the bronchial epithelial cells]. | 2009 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:19567187 |
Zhong XN et al. | [An experimental study on airway inflammation and remodeling in a rat model of chronic bronchitis and emphysema]. | 2003 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:14720429 |
Xiao W et al. | [The imbalance of Th1/Th2 cytokine expression in peripheral blood mononuclear cell from asthmatic patients and the effect of erythromycin on these cytokines]. | 2000 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11778516 |
Gao W et al. | [Analysis of 9 cases of pulmonary tuberculosis complicated with legionnaires disease]. | 1997 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:10374448 |
Xu Z et al. | [Effects of erythromycin and fosfomycin on Pseudomonas aeruginosa biofilm in vitro]. | 2001 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11802985 |
Gu XH et al. | [Effects of erythromycin on the twitching motility of Pseudomonas aeruginosa]. | 2007 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:17573001 |
Tan W et al. | [The mechanism and effect of erythromycin in development of pulmonary fibrosis]. | 1999 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11812357 |
Zhong XN and Guo SM | [An experimental study on pulmonary vascular inflammation in a rat model of chronic bronchitis and emphysema]. | 2006 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:17045040 |
Liu J et al. | [mRNA expression of basic fibroblast growth factor in the pulmonary tissues from rats repeatedly infected with mycoplasma pneumoniae]. | 1999 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11775917 |
Li Y et al. | [The effect of erythromycin on NF-kappa B activation and cytokines mRNA expression in bleomycin-induced pulmonary fibrosis in rats]. | 1999 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11776779 |
Tang YC | [Diagnosis and treatment of Legionnaires' disease from opportunistic infection]. | 1987 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:3440298 |
Lu W et al. | [Analysis of 37 cases of pneumonia of Legionnaires' disease]. | 1997 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:10072832 |
Xia AF | [Effect of oculentum erythromycin in the prevention of inflammatory conjunctivitis of neonates]. | 1993 | Zhonghua Hu Li Za Zhi | pmid:8339361 |
Li X | [Combination of commonly used antibiotics in intravenous infusions]. | 1991 | Zhonghua Hu Li Za Zhi | pmid:1889101 |
Zhang RL et al. | [Study on interventional methods and the pattern of maternal-fetal transmission of syphilis during pregnancy]. | 2007 | Zhonghua Fu Chan Ke Za Zhi | pmid:17961330 |
Zhang FC | [Radiologic manifestations of Legionnaires' disease (report of 2 cases)]. | 1985 | Zhonghua Fang She Xue Za Zhi | pmid:2938897 |
Ding YF et al. | [Relation of pbp2B, ermB, ermA/B, mefA genes with resistance to penicillin and erythromycin among Streptococcus pneumoniae isolates from children]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:15924755 |
Hua CZ et al. | [Antibiotics-resistance pattern and genetic type of Streptococcus pneumoniae isolated from children in Hangzhou]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:14990098 |
Ge LL et al. | [Antibiotic resistance analysis of isolates from the hospitalized children in Shanxi Children's Hospital from 2012 to 2014]. | 2017 | Zhonghua Er Ke Za Zhi | pmid:28173648 |
Su WD et al. | [Chymothorax in a newborn infant]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14723819 |
He S et al. | [Clinical analysis of scrub typhus-associated hemophagocytic syndrome]. | 2014 | Zhonghua Er Ke Za Zhi | pmid:25476431 |
Sun ZY et al. | [Epidemiological study of Streptococcus pneumoniae in the nasopharynx of healthy children under 5 years of age in Wuhan]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:17697628 |
Hua CZ et al. | [An analysis of 181 cases with blood stream infection caused by Streptococcus agalactiae in children from 2011 to 2015: a multi-center retrospective study]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:27510868 |
Wang CH et al. | [Effect of interstitial cells of Cajal on gastrointestinal motility induced by motilin receptor agonist ABT-229]. | 2010 | Zhonghua Er Ke Za Zhi | pmid:20654011 |
Liu H et al. | [A systematic review of the therapy for Mycoplasma pneumoniae infections in children]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:26875461 |
He JX et al. | [Demonstration of a mechanism of anti-inflammatory effect of erythromycin on allergic airway inflammation in rat]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:15833193 |
Yang H et al. | [Macrolide-resistant Streptococcus pneumoniae in the pediatric population in Beijing]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15733368 |
Hua CZ et al. | [Drug-resistance of staphylococcus aureus and detection of mecA gene in all strains isolated from children in Hangzhou]. | 2006 | Zhonghua Er Ke Za Zhi | pmid:16780714 |
Xu SN et al. | [Effect of erythromycin on apoptosis of epithelial cell in nasal polyps]. | 2006 | Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:17007374 |
Tang J and Li Y | [Effect of erythromycin on the expression of apoptotic gene on eosinophils in nasal polyps in vitro]. | 2003 | Zhonghua Er Bi Yan Hou Ke Za Zhi | pmid:15040110 |
Tang J et al. | [Effect of erythromycin on apoptosis of eosinophils in nasal polyps in vitro]. | 2002 | Zhonghua Er Bi Yan Hou Ke Za Zhi | pmid:12768725 |
Guan Y et al. | [Effect of combination of sub-MIC sodium houttuyfonate and erythromycin on biofilm of Staphylococcus epidermidis]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23724685 |
Guan Y et al. | [Preliminary study of effects of andrographolide on Staphylococcus epidermidis biofilms]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23126203 |
Jia P et al. | [Regulative effect of electroacupuncture of different frequencies on derangement of gastric electric rhythm in rabbits]. | 2006 | Zhongguo Zhen Jiu | pmid:17165505 |
Sun XR et al. | [Effect of motilin receptor agonist-erythromycin on the glucose responsive neurons in hypothalamus of rats]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21162186 |
Yu I et al. | [The effects of the erythromycin on the production of r-glutamylcys glutamylcysteine synthetase and glutathione in the bronchial epithelial cell]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21186628 |
Lei PS et al. | [Advance in synthesis of ketolides, a new class of erythromycin derivatives]. | 2004 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:15379279 |
Wang H et al. | Demethylation capacity of human fetal adrenal mitochondrial cytochrome P-450 in vitro. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452125 |
Huang SK et al. | [A combined perfusion-compartmental pharmacokinetic model used to estimate presystemic metabolism of erythromycin in dogs]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2954396 |
Ye H et al. | Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10 -[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid (YH-6) in comparison with other antibiotics in vitro. | 1999 | Zhongguo Yao Li Xue Bao | pmid:11270970 |
Du Y and He Q | [The mechanism of alleviation of paraquat induced vascular endothelial permeability by erythromycin through adenosine 3'5'-cyclic monophosphate pathway]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19930884 |
Lu NF et al. | [Study of erythromycin and metoclopramide in treatment of feeding intolerance of critically ill patients in intensive care unit]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20092709 |
Yu M et al. | [Mechanism reversing MDR of K562/A02 by garlicin combined with erythromycin]. | 2008 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:18928592 |
Xie L et al. | [Efficacy of low-dose oral erythromycin as an adjuvant therapy for cytomegalovirus infection]. | 2010 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:20199738 |
Yang Y | [Mechanism and clinical application of erythromycin as a gastrointestinal prokinetic agent in children]. | 2008 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:18289489 |
Thomas W and Speer CP | Prevention and therapy of bronchopulmonary dysplasia - evidence and clinical practice. | 2007 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:17582275 |
Wang LQ et al. | [Pharmacokinetics of erythromycin stinoprate capsule]. | 2005 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:15898434 |
Lin XM et al. | [Influence of neferine and erythromycin on cellular GSH concentration in K562/A02 cell line]. | 2004 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:16136961 |
Xu G | [Regulating effect of electro-acupuncture on dysrythmia of gastro-colonic electric activity induced by erythromycine in rabbits]. | 1994 | Zhen Ci Yan Jiu | pmid:7834859 |
Wu DQ et al. | [The expression of transforming growth factor beta-1 in rat model of chronic obstructive pulmonary disease and the effects of early drugs intervention]. | 2004 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:15476327 |
TartakovskiÄ IS et al. | [The action of interferon preparations on strains of Legionella of various serogroups and species]. | 1988 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:2469268 |
Chimirov OB | [Sensitivity to the differential dose of erythromycin and oleandomycin of various holarctic strains of tularemia microbe isolated in the Kazakh SSR]. | 1978 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:150182 |
Zueva VS and Pavlov EP | [The prevalence of staphylococci with extrachromosomal drug resistance factors in different collectives]. | 1972 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:4563840 |
Balaeva NM and Frolova OM | [Production of the mutant E strain of Rickettsia prowazekii by mutagen exposure]. | 1982 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:6818794 |
Naumkina EV et al. | [Ureaplasma urealyticum and Ureaplasma parvum in etiology of urogenital mixt-infections]. | 2006 May-Jun | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:16830600 |