erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ogawa T et al. | [Effect of erythromycin on early delayed gastric emptying after pylorus preserving pancreatoduodenectomy--case report]. | 1996 | Nihon Shokakibyo Gakkai Zasshi | pmid:8865759 |
Xu G et al. | Effect of macrolide antibiotics on macrophage functions. | 1996 | Microbiol. Immunol. | pmid:8865152 |
Burnens AP et al. | Sequential development of resistance to fluoroquinolones and erythromycin in an isolate of Campylobacter jejuni. | 1996 | Zentralbl. Bakteriol. | pmid:8861869 |
Lacey RW | Lack of evidence for mutation to erythromycin resistance in clinical strains of Staphylococcus aureus. | 1977 | J. Clin. Pathol. | pmid:886013 |
Vanakoski J et al. | Grapefruit juice does not enhance the effects of midazolam and triazolam in man. | 1996 | Eur. J. Clin. Pharmacol. | pmid:8858279 |
Watkins PB | Erythromycin breath test and clinical transplantation. | 1996 | Ther Drug Monit | pmid:8857552 |
Hofstetter A | [Mycoplasma infections of urogenital tract]. | 1977 | Hautarzt | pmid:885718 |
Raab W | [Acute side effects of erythromycin, lincomycin and clindamycin]. | 1977 | Int J Clin Pharmacol Biopharm | pmid:885668 |
Chang AD et al. | Bacillary angiomatosis associated with extensive esophageal polyposis: a new mucocutaneous manifestation of acquired immunodeficiency disease (AIDS). | 1996 | Am. J. Gastroenterol. | pmid:8855753 |
Vermot D et al. | Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis. | 1996 | Antimicrob. Agents Chemother. | pmid:8851620 |
Amsden GW | Erythromycin, clarithromycin, and azithromycin: are the differences real? | 1996 Jan-Feb | Clin Ther | pmid:8851453 |
Wondrack L et al. | Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides. | 1996 | Antimicrob. Agents Chemother. | pmid:8849266 |
Weiss K et al. | Comparison of antimicrobial susceptibilities of Corynebacterium species by broth microdilution and disk diffusion methods. | 1996 | Antimicrob. Agents Chemother. | pmid:8849254 |
Masuda N et al. | Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa. | 1996 | Antimicrob. Agents Chemother. | pmid:8849250 |
Doern GV et al. | Emergence of high rates of antimicrobial resistance among viridans group streptococci in the United States. | 1996 | Antimicrob. Agents Chemother. | pmid:8849246 |
O'Hara K and Yamamoto K | Reaction of roxithromycin and clarithromycin with macrolide-inactivating enzymes from highly erythromycin-resistant Escherichia coli. | 1996 | Antimicrob. Agents Chemother. | pmid:8849224 |
Kim KH et al. | Periauricular eczematization in childhood atopic dermatitis. | 1996 Jul-Aug | Pediatr Dermatol | pmid:8844743 |
Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella spp. associated with bovine respiratory disease. | 1996 | J. Vet. Diagn. Invest. | pmid:8844577 |
Ednie LM et al. | Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci. | 1996 | Antimicrob. Agents Chemother. | pmid:8843313 |
Sutcliffe J et al. | Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. | 1996 | Antimicrob. Agents Chemother. | pmid:8843287 |
Vaara M and Porro M | Group of peptides that act synergistically with hydrophobic antibiotics against gram-negative enteric bacteria. | 1996 | Antimicrob. Agents Chemother. | pmid:8843284 |
Tschida SJ et al. | QTc-interval prolongation associated with slow intravenous erythromycin lactobionate infusions in critically ill patients: a prospective evaluation and review of the literature. | 1996 Jul-Aug | Pharmacotherapy | pmid:8840374 |
Viravan C et al. | A prospective clinical and bacteriologic study of inguinal buboes in Thai men. | 1996 | Clin. Infect. Dis. | pmid:8838178 |
Schierholz JM et al. | Drug delivery concepts for the efficacious prevention of foreign-body infections. | 1996 | Zentralbl. Bakteriol. | pmid:8837400 |
Chapuis C et al. | An economic approach to the MIC. | 1996 | Zentralbl. Bakteriol. | pmid:8837370 |
Ehret JM et al. | A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin. | 1996 Jul-Aug | Sex Transm Dis | pmid:8836018 |
Lanbeck P and Paulsen O | Cytotoxic effects of four antibiotics on endothelial cells. | 1995 | Pharmacol. Toxicol. | pmid:8835360 |
Roseghini M et al. | Choline esters and biogenic amines in the hypobranchial gland of 55 molluscan species of the neogastropod Muricoidea superfamily. | 1996 | Toxicon | pmid:8835333 |
Cooper AJ et al. | The erythromycin resistance gene from the Bacteroides conjugal transposon Tcr Emr 7853 is nearly identical to ermG from Bacillus sphaericus. | 1996 | Antimicrob. Agents Chemother. | pmid:8834912 |
Edelstein PH et al. | Activity of trovafloxacin (CP-99,219) against Legionella isolates: in vitro activity, intracellular accumulation and killing in macrophages, and pharmacokinetics and treatment of guinea pigs with L. pneumophila pneumonia. | 1996 | Antimicrob. Agents Chemother. | pmid:8834872 |
Luo G et al. | Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase. | 1996 | Bioorg. Med. Chem. | pmid:8831969 |
Liu J et al. | Inhibitory effect of erythromycin on ion transport by stria vascularis and vestibular dark cells. | 1996 | Acta Otolaryngol. | pmid:8831844 |
Enomoto F et al. | [Evaluation of the effect of erythromycin on otitis media with effusion in experimental rat models]. | 1996 | Nippon Jibiinkoka Gakkai Kaiho | pmid:8831236 |
Biedenbach DJ and Jones RN | The comparative antimicrobial activity of levofloxacin tested against 350 clinical isolates of streptococci. | 1996 | Diagn. Microbiol. Infect. Dis. | pmid:8831045 |
Hong T et al. | Direct application of Etest to gram-positive cocci from blood cultures: quick and reliable minimum inhibitory concentration data. | 1996 | Diagn. Microbiol. Infect. Dis. | pmid:8831041 |
Donadio S et al. | Erythromycin production in Saccharopolyspora erythraea does not require a functional propionyl-CoA carboxylase. | 1996 | Mol. Microbiol. | pmid:8830278 |
Barrio J et al. | Rosacea-like demodicosis in an HIV-positive child. | 1996 | Dermatology (Basel) | pmid:8829498 |
Steele RW | Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. | 1996 | Clin Pediatr (Phila) | pmid:8829012 |
Deguchi K et al. | [Antimicrobial activities of cefozopran against Streptococcus pneumoniae from children]. | 1996 | Jpn J Antibiot | pmid:8828071 |
Scrivener CJ and Vizard AL | Efficacy of a single dose of erythromycin or penicillin/streptomycin for the treatment of ovine dermatophilosis. | 1995 | Aust. Vet. J. | pmid:8825319 |
Zhang XJ and Thomas PE | Erythromycin as a specific substrate for cytochrome P4503A isozymes and identification of a high-affinity erythromycin N-demethylase in adult female rats. | 1996 | Drug Metab. Dispos. | pmid:8825186 |
Brunner H | [Pneumonia caused by mycoplasma pneumoniae. On the differential diagnosis of acute pneumonias (author's transl)]. | 1977 | Schweiz. Rundsch. Med. Prax. | pmid:882509 |
Funabashi Y et al. | Microbial conversion of EM574 and EM523, gastrointestinal motor stimulating agents. | 1996 | J. Antibiot. | pmid:8823514 |
Funabashi Y et al. | Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity. | 1996 | J. Antibiot. | pmid:8823513 |
Kao CM et al. | Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase. | 1996 | Biochemistry | pmid:8823171 |
Wang Y et al. | RNA molecules that specifically and stoichiometrically bind aminoglycoside antibiotics with high affinities. | 1996 | Biochemistry | pmid:8823168 |
Steiner A and Roussel AJ | Drugs coordinating and restoring gastrointestinal motility and their effect on selected hypodynamic gastrointestinal disorders in horses and cattle. | 1995 | Zentralbl Veterinarmed A | pmid:8822186 |
Luurila H et al. | Interaction between erythromycin and the benzodiazepines diazepam and flunitrazepam. | 1996 | Pharmacol. Toxicol. | pmid:8822046 |
Müller-Wening W et al. | [Clinical and radiological findings in 78 children during the 1974/75 mycoplasma-pneumonia-epidemic (author's transl)]. | 1977 | Monatsschr Kinderheilkd | pmid:882103 |
Enhanced surveillance of non-toxigenic Corynebacterium diphtheriae infections. | 1996 | Commun Dis Rep CDR Wkly | pmid:8821021 | |
Ding SL et al. | Acute interstitial nephritis and acute renal failure following erythromycin treatment: case report. | 1996 | N. Z. Med. J. | pmid:8816724 |
Pillans PI | Drug associated hepatic reactions in New Zealand: 21 years experience. | 1996 | N. Z. Med. J. | pmid:8816722 |
Hall LM et al. | Genetic relatedness within and between serotypes of Streptococcus pneumoniae from the United Kingdom: analysis of multilocus enzyme electrophoresis, pulsed-field gel electrophoresis, and antimicrobial resistance patterns. | 1996 | J. Clin. Microbiol. | pmid:8815096 |
Blandino G et al. | In vitro activity of cefdinir against respiratory pathogens isolated in Sicily with reference to beta-lactamase production. | 1996 | J Chemother | pmid:8808715 |
Cellesi C et al. | Susceptibility of macrolide and beta-lactam antibiotics of Streptococcus pyogenes strains isolated over a four-year period in central Italy. | 1996 | J Chemother | pmid:8808714 |
de Graaf-Strukowska L et al. | Two non-diabetic patients with delayed gastric emptying during CAPD effectively treated with erythromycin. | 1995 | Nephrol. Dial. Transplant. | pmid:8808241 |
Tamaoki J et al. | Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas. | 1996 | Antimicrob. Agents Chemother. | pmid:8807072 |
Roberts MC et al. | Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola. | 1996 | Antimicrob. Agents Chemother. | pmid:8807063 |
Pankuch GA et al. | Antipneumococcal activities of RP 59500 (quinupristin-dalfopristin), penicillin G, erythromycin, and sparfloxacin determined by MIC and rapid time-kill methodologies. | 1996 | Antimicrob. Agents Chemother. | pmid:8807057 |
Kiss L et al. | Coagulase-negative staphylococci in air samples from operating theatres. | 1996 | Acta Microbiol Immunol Hung | pmid:8806942 |
Recommended treatment of syphilis and gonorrhea. Advisory Committee on venereal Disease Control, Health and Welfare Canada. | 1977 | Can Med Assoc J | pmid:880529 | |
Stevens DL | Invasive group A streptococcal disease. | 1996 | Infect Agents Dis | pmid:8805078 |
Traub WH and Leonhard B | Antibiotic susceptibility of clinical isolates of Streptococcus pneumoniae. | 1996 Jul-Aug | Chemotherapy | pmid:8804790 |
Son DS et al. | Contribution of alpha 1-acid glycoprotein to plasma protein binding of some basic antimicrobials in pigs. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8803875 |
Eden CG et al. | Human immunodeficiency virus-related bacillary angiomatosis of the penis. | 1996 | Br J Urol | pmid:8800916 |
Chennareddy SB et al. | Erythromycin-induced polymorphous ventricular tachycardia with normal QT interval. | 1996 | Am. Heart J. | pmid:8800045 |
Franko JP | Erythromycin for treatment of acute bronchitis. | 1996 | J Fam Pract | pmid:8797744 |
van Embden JD et al. | Drug resistance in group D streptococci of clinical and nonclinical origin: prevalence, transferability, and plasmid properties. | 1977 | Antimicrob. Agents Chemother. | pmid:879758 |
Griffith RS et al. | Synergistic action of erythromycin and cefamandole against Bacteroides fragilis subsp. fragilis. | 1977 | Antimicrob. Agents Chemother. | pmid:879736 |
Hsieh MH et al. | Drug-induced torsades de pointes in one patient with congenital long QT syndrome. | 1996 | Int. J. Cardiol. | pmid:8792191 |
Wehrmann T et al. | Effect of erythromycin on human biliary motility. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791972 |
Laine L et al. | Prospective evaluation of the macrolide antibiotic dirithromycin for the treatment of Helicobacter pylori. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791949 |
Inatomi N et al. | Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs. | 1996 | Jpn. J. Pharmacol. | pmid:8791169 |
Bohlen DM et al. | Lack of effect of ivermectin on antipyrine and erythromycin disposition in calves. | 1995 | J. Vet. Pharmacol. Ther. | pmid:8789704 |
Mehaffey PC et al. | Evaluation of in vitro spectra of activity of azithromycin, clarithromycin, and erythromycin tested against strains of Neisseria gonorrhoeae by reference agar dilution, disk diffusion, and Etest methods. | 1996 | J. Clin. Microbiol. | pmid:8789046 |
Welsh L et al. | In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8787907 |
Durak H et al. | Lung clearance of aerosolized 99mTc erythromycin lactobionate in rabbits. | 1996 | Nucl. Med. Biol. | pmid:8782239 |
Heath CH et al. | Delay in appropriate therapy of Legionella pneumonia associated with increased mortality. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8781878 |
Bussières J et al. | Optional elements in the chloroplast DNAs of chlamydomonas eugametos and C. moewusii: unidirectional gene conversion and co-conversion of adjacent markers in high-viability crossses. | 1996 | Curr. Genet. | pmid:8781180 |
Parkman HP et al. | Erythromycin inhibits rabbit pyloric smooth muscle through neuronal motilin receptors. | 1996 | Gastroenterology | pmid:8780573 |
Mota CR et al. | Severe carbamazepine toxicity induced by concurrent erythromycin therapy. | 1996 | Eur. J. Pediatr. | pmid:8777933 |
Hasfurther DL and Bailey PL | Failure of neuromuscular blockade reversal after rocuronium in a patient who received oral neomycin. | 1996 | Can J Anaesth | pmid:8773869 |
Granberry MC and Gardner SF | Erythromycin monotherapy associated with torsade de pointes. | 1996 | Ann Pharmacother | pmid:8773169 |
Isenberg SJ et al. | The influence of perinatal infective factors on ophthalmia neonatorum. | 1996 May-Jun | J Pediatr Ophthalmol Strabismus | pmid:8771523 |
Welling PG | How food and fluid affect drug absorption: results of initial studies. | 1977 | Postgrad Med | pmid:876907 |
Ko YY et al. | Recurrent infection of Legionella pneumonia: a case report. | 1996 | Zhonghua Yi Xue Za Zhi (Taipei) | pmid:8768386 |
Chen CK et al. | Factors involved in the transformation of previously non-transformable Clostridium perfringens type B. | 1996 | FEMS Microbiol. Lett. | pmid:8764481 |
Rémy AJ et al. | [Acute hepatitis caused by Campylobacter fetus]. | 1996 | Gastroenterol. Clin. Biol. | pmid:8763076 |
Fu D et al. | [Contractile effect of erythromycin on the gallbladder]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8762558 |
Alcalde AI et al. | Study of the action of intramuscularly administered erythromycin on the L-threonine transport and the digestive enzymatic activity in rabbit jejunum. | 1996 | Life Sci. | pmid:8761316 |
Stuart JM et al. | Antibiotic prescribing during an outbreak of meningococcal disease. | 1996 | Epidemiol. Infect. | pmid:8760956 |
Del Giudice L and Brunner A | Chromosomal and extrachromosomal inheritance of erythromycin-resistance in the "petite-negative" yeast Kluyveromyces lactis. | 1977 | Mol. Gen. Genet. | pmid:876030 |
Bianchi A et al. | [Comparative study of minimal inhibiting concentrations of doxycycline, ofloxacin and erythromycin against 18 recent isolates from Chlamydia trachomatis (1994-1995)]. | 1996 | Pathol. Biol. | pmid:8758473 |
Sakuragi T | [Study on levels of chemotherapeutics in prostatic tissue and prostatic fluid or seminal plasma. 2. Concentrations of erythromycin (EM), aminobenzylpenicillin (ABPC)-methylchlorophenylisoxazolylpenicillin (MCIPC) and sulfamethoxazole-trimethoprim (SMX-TMP) (AUTHOR'S TRANSL)]. | 1979 | Nippon Hinyokika Gakkai Zasshi | pmid:87532 |
Fontán PA et al. | Haemophilus influenzae type b exoproducts induce chemotaxis and macrolide antibiotic release by human polymorphonuclear leukocytes. | 1996 Jan-Feb | Chemotherapy | pmid:8751269 |
Piérard-Franchimont C et al. | A double-blind controlled evaluation of the sebosuppressive activity of topical erythromycin-zinc complex. | 1995 | Eur. J. Clin. Pharmacol. | pmid:8751022 |
Seppälä H et al. | Outpatient use of erythromycin: link to increased erythromycin resistance in group A streptococci. | 1995 | Clin. Infect. Dis. | pmid:8749619 |
Tenover FC et al. | Evaluation of commercial methods for determining antimicrobial susceptibility of Streptococcus pneumoniae. | 1996 | J. Clin. Microbiol. | pmid:8748262 |
Eady EA et al. | The effects of acne treatment with a combination of benzoyl peroxide and erythromycin on skin carriage of erythromycin-resistant propionibacteria. | 1996 | Br. J. Dermatol. | pmid:8745894 |
Abeck D and Ballard RC | Chancroid. | 1996 | Curr. Probl. Dermatol. | pmid:8743258 |