erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lee SY et al. | 23S rRNA point mutation associated with erythromycin resistance in Treponema denticola. | 2002 | FEMS Microbiol. Lett. | pmid:11886748 |
Versteegh FG et al. | [Perinatal pertussis: from mother to child]. | 2002 | Ned Tijdschr Geneeskd | pmid:11887627 |
Chung WO et al. | Distribution of erm(F) and tet(Q) genes in 4 oral bacterial species and genotypic variation between resistant and susceptible isolates. | 2002 | J. Clin. Periodontol. | pmid:11895543 |
Kodama H et al. | [Studies on the group A type 12 hemolytic streptococci (author's transl)]. | 1979 | Kansenshogaku Zasshi | pmid:119007 |
Fowler SM et al. | CYP3A4 active site volume modification by mutagenesis of leucine 211. | 2002 | Drug Metab. Dispos. | pmid:11901100 |
Chávez M et al. | Evaluation of the new VITEK 2 system for determination of the susceptibility of clinical isolates of Streptococcus pneumoniae. | 2002 | Chemotherapy | pmid:11901253 |
Kobayashi K et al. | Fine structure of erythromycin-resistant, conditional asporogenous mutant of Bacillus subtilis 168. | 1979 | J Electron Microsc (Tokyo) | pmid:119024 |
Moore BS and Hertweck C | Biosynthesis and attachment of novel bacterial polyketide synthase starter units. | 2002 | Nat Prod Rep | pmid:11902441 |
Kuroha M et al. | Effects of altered plasma alpha-1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis. | 2001 | J. Vet. Pharmacol. Ther. | pmid:11903873 |
Liau SS et al. | Pharmacological modulation of human gastric volumes demonstrated noninvasively using SPECT imaging. | 2001 | Neurogastroenterol. Motil. | pmid:11903914 |
Viramontes BE et al. | Validation of a stable isotope gastric emptying test for normal, accelerated or delayed gastric emptying. | 2001 | Neurogastroenterol. Motil. | pmid:11903917 |
Prieto J and Ramos C | [Questions and answers on the class effect]. | 2002 | Enferm. Infecc. Microbiol. Clin. | pmid:11904096 |
Ajello M et al. | Anti-invasive activity of bovine lactoferrin towards group A streptococci. | 2002 | Biochem. Cell Biol. | pmid:11908635 |
Schmitz FJ et al. | Molecular characterization of ketolide-resistant erm(A)-carrying Staphylococcus aureus isolates selected in vitro by telithromycin, ABT-773, quinupristin and clindamycin. | 2002 | J. Antimicrob. Chemother. | pmid:11909834 |
Pendland SL et al. | In vitro bactericidal activity of ABT-773 and amoxicillin against erythromycin-susceptible and -resistant strains of Streptococcus pyogenes. | 2002 | J. Antimicrob. Chemother. | pmid:11909842 |
Sène D et al. | [Legionellosis in HIV-1 infected patients. 4 case reports]. | 2002 | Presse Med | pmid:11913078 |
Terzidou V and Bennett PR | Preterm labour. | 2002 | Curr. Opin. Obstet. Gynecol. | pmid:11914686 |
Long PF et al. | Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. | 2002 | Mol. Microbiol. | pmid:11918808 |
More on erythromycin and pyloric stenosis. | 2002 | Arch. Dis. Child. | pmid:11919096 | |
Walsh CT | Combinatorial biosynthesis of antibiotics: challenges and opportunities. | 2002 | Chembiochem | pmid:11921390 |
Lauzurica R et al. | Tacrolimus-associated severe bilateral corneal ulcer after renal transplantation. | 2002 | Transplantation | pmid:11923710 |
Hoffman CF et al. | A case report of bacillary angiomatosis in a patient infected with human immunodeficiency virus. | 2002 | Cutis | pmid:11926335 |
Chen CL et al. | Efficacy of a motilin receptor agonist (ABT-229) for the treatment of gastro-oesophageal reflux disease. | 2002 | Aliment. Pharmacol. Ther. | pmid:11929393 |
Fosse T et al. | High prevalence of cfxA beta-lactamase in aminopenicillin-resistant Prevotella strains isolated from periodontal pockets. | 2002 | Oral Microbiol. Immunol. | pmid:11929554 |
Wang BY et al. | Genetic exchange between Treponema denticola and Streptococcus gordonii in biofilms. | 2002 | Oral Microbiol. Immunol. | pmid:11929558 |
Kuriyama T et al. | Bacteriology and antimicrobial susceptibility of gram-positive cocci isolated from pus specimens of orofacial odontogenic infections. | 2002 | Oral Microbiol. Immunol. | pmid:11929563 |
Dellagrammaticas HD et al. | Effect of low-dose oral erythromycin on gastric aspirates in ventilated neonates less than 32 weeks of gestation. Preliminary results. | 2002 | Biol. Neonate | pmid:11937729 |
Braga PC | Relationship between differences in 16-, 14-, and 15-membered ring macrolides and Streptococcus pyogenes resistance. | 2002 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:11939399 |
Andrisano V et al. | Stereoselective binding of 2-(4-biphenylyl)-3-substituted-3-hydroxypropionic acids on an immobilised human serum albumin chiral stationary phase. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:11939547 |
Liu F et al. | Establishment of multidrug-resistance cell line C(6)/adr and reversal of drug-resistance. | 2002 | Chin. Med. J. | pmid:11940340 |
Nakabayashi T et al. | Gastropyloric motor activity and the effects of erythromycin given orally after esophagectomy. | 2002 | Am. J. Surg. | pmid:11943134 |
Kurowski WM et al. | Factors influencing the formation and stability of D-glucoside 3-dehydrogenase activity in cultures of Agrobacterium tumefaciens. | 1975 | J. Gen. Microbiol. | pmid:1194891 |
Nakamura H et al. | Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:11950784 |
Bryskier A | Viridans group streptococci: a reservoir of resistant bacteria in oral cavities. | 2002 | Clin. Microbiol. Infect. | pmid:11952717 |
King A et al. | Erythromycin susceptibility of viridans streptococci from the normal throat flora of patients treated with azithromycin or clarithromycin. | 2002 | Clin. Microbiol. Infect. | pmid:11952721 |
Suzuki T et al. | Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11956054 |
Okamoto H et al. | High frequency of erythromycin A resistance and distribution of mefE and ermB genes in clinical isolates of Streptococcus pneumoniae in Japan. | 2002 | J. Infect. Chemother. | pmid:11957116 |
Farrow KA et al. | Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens. | 2002 | Antimicrob. Agents Chemother. | pmid:11959553 |
Culebras E et al. | Macrolide and tetracycline resistance and molecular relationships of clinical strains of Streptococcus agalactiae. | 2002 | Antimicrob. Agents Chemother. | pmid:11959603 |
Winn PJ et al. | Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11959989 |
Ekins S et al. | Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. | 2002 | Mol. Pharmacol. | pmid:11961113 |
Martin JM et al. | Erythromycin-resistant group A streptococci in schoolchildren in Pittsburgh. | 2002 | N. Engl. J. Med. | pmid:11961148 |
Huovinen P | Macrolide-resistant group a streptococcus--now in the United States. | 2002 | N. Engl. J. Med. | pmid:11961156 |
Thiele J and Kvasnicka HM | CD34+ stem cells in chronic myeloproliferative disorders. | 2002 | Histol. Histopathol. | pmid:11962756 |
Waugh AC and Long PF | Prospects for generating new antibiotics. | 2002 | Sci Prog | pmid:11969120 |
Nissan A et al. | Direct inhibitory effect of erythromycin on human alimentary tract smooth muscle. | 2002 | Am. J. Surg. | pmid:11975929 |
Fukuda M and Sasaki K | [Antibiotic ophthalmic solutions evaluated by pharmacokinetic parameters of maximum concentration in the aqueous]. | 2002 | Nippon Ganka Gakkai Zasshi | pmid:11979978 |
Jones FE et al. | Experimental evaluation of "instant" preparation of the colon with povidone-iodine. | 1975 | Surg. Clin. North Am. | pmid:1198291 |
Jarvest RL et al. | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. | 2002 | J. Med. Chem. | pmid:11985462 |
Biagi G et al. | Erythro- and threo-2-hydroxynonyl substituted 2-phenyladenines and 2-phenyl-8-azaadenines: ligands for A1 adenosine receptors and adenosine deaminase. | 2002 | Farmaco | pmid:11989801 |
San Pedro de Saenz B et al. | FDE to macrolides. | 2002 | Allergy | pmid:11991294 |
Gaisser S et al. | Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. | 2002 | Mol. Microbiol. | pmid:11994157 |
Kudelina RI and Olsuf'ev NG | [Further study of the sensitivity to erythromycin of strains of the causative agent of tularemia from different geographical sites]. | 1975 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:1199584 |
Kato Y et al. | Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. | 2002 | J. Am. Chem. Soc. | pmid:11996558 |
Munckhof WJ et al. | Recent appearance of clindamycin resistance in community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in south-east Queensland. | 2002 | Med. J. Aust. | pmid:11999249 |
Moonmangmee D et al. | L-erythrulose production by oxidative fermentation is catalyzed by PQQ-containing membrane-bound dehydrogenase. | 2002 | Biosci. Biotechnol. Biochem. | pmid:11999403 |
Coates P et al. | Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study. | 2002 | Br. J. Dermatol. | pmid:12000382 |
Champney WS and Miller M | Inhibition of 50S ribosomal subunit assembly in Haemophilus influenzae cells by azithromycin and erythromycin. | 2002 | Curr. Microbiol. | pmid:12000992 |
Hsueh PR et al. | Increased prevalence of erythromycin resistance in streptococci: substantial upsurge in erythromycin-resistant M phenotype in Streptococcus pyogenes (1979-1998) but not in Streptococcus pneumoniae (1985-1999) in Taiwan. | 2002 | Microb. Drug Resist. | pmid:12002646 |
Zampaloni C et al. | Erythromycin resistance in italian isolates of Streptococcus pyogenes and correlations with pulsed-field gel electrophoresis analysis. | 2002 | Microb. Drug Resist. | pmid:12002648 |
Grignon B et al. | Validation of diffusion methods for macrolide susceptibility testing of Helicobacter pylori. | 2002 | Microb. Drug Resist. | pmid:12002651 |
Nilius AM et al. | Comparison of selection for mutants with reduced susceptibility to ABT-773, erythromycin and rifampicin in respiratory tract pathogens. | 2002 | J. Antimicrob. Chemother. | pmid:12003979 |
Jung R et al. | Intracellular activity of ABT-773 and other antimicrobial agents against Legionella pneumophila. | 2002 | J. Antimicrob. Chemother. | pmid:12003984 |
Pendland SL et al. | In vitro bactericidal activity and post-antibiotic effect of ABT-773 versus co-amoxiclav against anaerobes. | 2002 | J. Antimicrob. Chemother. | pmid:12003989 |
Wynn RL et al. | Antibiotics in treating oral-facial infections of odontogenic origin: an update. | 2001 May-Jun | Gen Dent | pmid:12004720 |
Orenstein SR | Erythromycin and gastroduodenal contractile activity. | 2002 | Curr Gastroenterol Rep | pmid:12010623 |
Minga KA et al. | [Bacillary angiomatosis in an adult infected with HIV-1 at an early stage of immunodepression in Abidjan, Côte d'Ivoire]. | 2002 | Bull Soc Pathol Exot | pmid:12012962 |
Braga PC | Rokitamycin: bacterial resistance to a 16-membered ring macrolide differs from that to 14- and 15-membered ring macrolides. | 2002 | J Chemother | pmid:12017366 |
Abdelghaffar H et al. | Structure-activity relationships among 9-N-alkyl derivatives of erythromycylamine and their effect on the oxidative burst of human neutrophils in vitro. | 2002 | J Chemother | pmid:12017367 |
Jang SS and Hirsh DC | Rapidly growing members of the genus Mycobacterium affecting dogs and cats. | 2002 May-Jun | J Am Anim Hosp Assoc | pmid:12022405 |
Ishihara H et al. | Distribution and variation of bacitracin synthetase gene sequences in laboratory stock strains of Bacillus licheniformis. | 2002 | Curr. Microbiol. | pmid:12029522 |
Van Vlem B et al. | In vitro evaluation of motilin agonism by macrolide immunosuppressive drugs. | 2002 | Nephrol. Dial. Transplant. | pmid:12032184 |
Celik H and Ayar A | Effects of erythromycin on pregnancy duration and birth weight in lipopolysaccharide-induced preterm labor in pregnant rats. | 2002 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:12039458 |
Ortega E et al. | In vitro and ex vivo effects of erythromycin A, azithromycin and josamycin on the splenic response to specific antigens and mitogens. | 2002 | J. Antimicrob. Chemother. | pmid:12039899 |
Leblond FA et al. | Downregulation of intestinal cytochrome p450 in chronic renal failure. | 2002 | J. Am. Soc. Nephrol. | pmid:12039987 |
Facinelli B and Varaldo PE | Activity of roxithromycin against respiratory pathogens. | 1991 | J Chemother | pmid:12041781 |
Soler T et al. | [In vitro susceptibility of streptococcus pneumoniae strains isolated from lower respiratory infections in Instituto Nacional del Tórax (INT)]. | 2002 | Rev Med Chil | pmid:12043373 |
Garlaschi ML et al. | In-vitro susceptibility of Haemophilus influenzae to loracarbef (LY 163892) and other oral antibiotics. Collaborative Study Group on Pediatric Infectious Disease in Lombardy. | 1991 | J Chemother | pmid:12043716 |
Kim YH et al. | Purification and characterization of an erythromycin esterase from an erythromycin-resistant Pseudomonas sp. | 2002 | FEMS Microbiol. Lett. | pmid:12044681 |
Lehman SS | Ophthalmia neonatorum associated with isoimmune neonatal neutropenia. | 2002 May-Jun | J Pediatr Ophthalmol Strabismus | pmid:12051286 |
Thielemans L et al. | The motilin pharmacophore in CHO cells expressing the human motilin receptor. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054506 |
Crowe MC et al. | Characterization of erythromycin analogs by collisional activated dissociation and infrared multiphoton dissociation in a quadrupole ion trap. | 2002 | J. Am. Soc. Mass Spectrom. | pmid:12056564 |
Samonis G et al. | Effects of erythromycin, clarithromycin, roxithromycin and azithromycin on murine gut colonization by Candida albicans. | 2002 | Med. Mycol. | pmid:12058726 |
Kobayashi Y et al. | Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. | 2002 | Mol. Pharmacol. | pmid:12065749 |
Li Y et al. | [Attenuated mRNA induction of molecules associated with neutrophil migration by 14-membered ring macrolides inhibits bleomycin induced acute lung injury in mice]. | 2002 | J Nippon Med Sch | pmid:12068316 |
Krcmery V et al. | Trends in Streptococcus pyogenes resistance to erythromycin in Slovakia: is there a correlation with consumption? | 2002 | Scand. J. Infect. Dis. | pmid:12069033 |
Gianneechini RE et al. | Antimicrobial susceptibility of udder pathogens isolated from dairy herds in the west littoral region of Uruguay. | 2002 | Acta Vet. Scand. | pmid:12071114 |
Arkwright PD et al. | Age-related prevalence and antibiotic resistance of pathogenic staphylococci and streptococci in children with infected atopic dermatitis at a single-specialty center. | 2002 | Arch Dermatol | pmid:12071821 |
Reignier J et al. | Erythromycin and early enteral nutrition in mechanically ventilated patients. | 2002 | Crit. Care Med. | pmid:12072674 |
Miskovitz P | Gastric prokinetic motility therapy to facilitate early enteral nutrition in the intensive care unit. | 2002 | Crit. Care Med. | pmid:12072701 |
Henneberg JP and Neubert U | [Borrelia burgdorferi Group: in-vitro antibiotic sensitivity]. | 2002 | Orv Hetil | pmid:12073540 |
Nishikawa K et al. | Functional characteristics of the pylorus in patients undergoing pylorus--preserving gastrectomy for early gastric cancer. | 2002 | Surgery | pmid:12075173 |
Cervin A et al. | One-year low-dose erythromycin treatment of persistent chronic sinusitis after sinus surgery: clinical outcome and effects on mucociliary parameters and nasal nitric oxide. | 2002 | Otolaryngol Head Neck Surg | pmid:12075221 |
Thiboutot D et al. | A randomized, parallel, vehicle-controlled comparison of two erythromycin/benzoyl peroxide preparations for acne vulgaris. | 2002 | Clin Ther | pmid:12075945 |
Bousquet-Melou A and Toutain PL | Effects of altered plasma alpha1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis. | 2002 | J. Vet. Pharmacol. Ther. | pmid:12081621 |
Pfeifer B et al. | Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. | 2002 | Appl. Environ. Microbiol. | pmid:12089005 |
DomÃnguez E et al. | Antibiotic resistance in Staphylococcus isolates obtained from fecal samples of healthy children. | 2002 | J. Clin. Microbiol. | pmid:12089295 |
Cooper WO et al. | Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. | 2002 | Arch Pediatr Adolesc Med | pmid:12090829 |
Draelos ZD and Tanghetti EA | Optimizing the use of tazarotene for the treatment of facial acne vulgaris through combination therapy. | 2002 | Cutis | pmid:12095065 |
von Hunolstein C et al. | Penicillin tolerance amongst non-toxigenic Corynebacterium diphtheriae isolated from cases of pharyngitis. | 2002 | J. Antimicrob. Chemother. | pmid:12096018 |