erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Janier M | [Syphilis (except congenital syphilis)]. | 1999 Aug-Sep | Ann Dermatol Venereol | pmid:10530355 |
Schmidtke LM and Carson J | Induction, characterisation and pathogenicity in rainbow trout Oncorhynchus mykiss (Walbaum) of Lactococcus garvieae L-forms. | 1999 | Vet. Microbiol. | pmid:10535774 |
Nicholas KC et al. | Periadenitis mucosa necrotica recurrens. | 1975 | J Oral Surg | pmid:1053656 |
Tobback K et al. | Micellar electrokinetic capillary chromatography of macrolide antibiotics. Separation of tylosin, erythromycin and their related substances. | 1999 | J Chromatogr A | pmid:10536850 |
Maeda K et al. | [A case of common variable immunodeficiency that responded to long-term erythromycin chemotherapy]. | 1999 | Nihon Kokyuki Gakkai Zasshi | pmid:10540836 |
Aoki Y and Kao PN | Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells. | 1999 | Antimicrob. Agents Chemother. | pmid:10543746 |
Netherwood T et al. | Probiotics shown to change bacterial community structure in the avian gastrointestinal tract. | 1999 | Appl. Environ. Microbiol. | pmid:10543832 |
Jobe DA et al. | Detection of borreliacidal antibodies in Lyme borreliosis patient sera containing antimicrobial agents. | 1999 | Clin. Diagn. Lab. Immunol. | pmid:10548588 |
Zallen RD and Curry JT | A study of antibiotic usage in compound mandibular fractures. | 1975 | J Oral Surg | pmid:1055204 |
Watanabe M et al. | Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo. | 1999 | Xenobiotica | pmid:10553724 |
Erythromycin and gastroparesis? Off-licence use: uncertain efficacy for a poorly defined disorder. | 1999 | Prescrire Int | pmid:10557568 | |
Malonza IM et al. | A randomized, double-blind, placebo-controlled trial of single-dose ciprofloxacin versus erythromycin for the treatment of chancroid in Nairobi, Kenya. | 1999 | J. Infect. Dis. | pmid:10558945 |
Reeves AR et al. | Transcriptional organization of the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea. | 1999 | J. Bacteriol. | pmid:10559177 |
Denis A et al. | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560728 |
Bauer JF et al. | Role of an isomorphic desolvate in dissolution failures of an erythromycin tablet formulation. | 1999 | J Pharm Sci | pmid:10564073 |
Morel P et al. | Clinical efficacy and safety of a topical combination of retinaldehyde 0.1% with erythromycin 4% in acne vulgaris. | 1999 | Clin. Exp. Dermatol. | pmid:10564319 |
Matsuoka M et al. | Cloning and sequences of inducible and constitutive macrolide resistance genes in Staphylococcus aureus that correspond to an ABC transporter. | 1999 | FEMS Microbiol. Lett. | pmid:10564793 |
Menezes CM et al. | In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence. | 1999 Jul-Aug | Rev. Inst. Med. Trop. Sao Paulo | pmid:10564920 |
Melo-Cristino J and Fernandes ML | Streptococcus pyogenes isolated in Portugal: macrolide resistance phenotypes and correlation with T types. Portuguese Surveillance Group for the Study of Respiratory Pathogens. | 1999 | Microb. Drug Resist. | pmid:10566873 |
Mostaghim D and Millard HD | Bacterial endocarditis: a retrospective study. | 1975 | Oral Surg. Oral Med. Oral Pathol. | pmid:1057148 |
Kondo T et al. | Application of liquid chromatography-turbo ion spray tandem mass spectrometry for quantitative analysis of a potent motilin receptor agonist, EM574, and its metabolites in human plasma. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10574195 |
Clarke AE et al. | Interaction of bile with erythromycin Lactobionate in vitro. | 1975 | Aust N Z J Med | pmid:1057910 |
Peng L and Nimni ME | Delivery of erythromycin to subcutaneous tissues in rats by means of a trans-phase delivery system. | 1999 | J. Pharm. Pharmacol. | pmid:10579684 |
Brown MS et al. | Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643. | 1999 | J. Antibiot. | pmid:10580387 |
Kudo S | [Diffuse panbronchiolitis and erythromycin therapy]. | 1999 | Nippon Naika Gakkai Zasshi | pmid:10581765 |
Klausner MA | Astemizole use with erythromycin. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10582723 |
Zarazaga M et al. | In vitro activities of ketolide HMR3647, macrolides, and other antibiotics against Lactobacillus, Leuconostoc, and Pediococcus isolates. | 1999 | Antimicrob. Agents Chemother. | pmid:10582908 |
McCrea J et al. | Concurrent administration of the erythromycin breath test (EBT) and oral midazolam as in vivo probes for CYP3A activity. | 1999 | J Clin Pharmacol | pmid:10586386 |
Durak H et al. | Tc-99m erythromycin lactobionate inhalation scintigraphy in parenchymal lung diseases. | 1999 | Nucl. Med. Biol. | pmid:10587109 |
Carsenti-Etesse H et al. | Gradient plate method to induce Streptococcus pyogenes resistance. | 1999 | J. Antimicrob. Chemother. | pmid:10588303 |
Marchese A et al. | Macrolide resistance mechanisms and expression of phenotypes among Streptococcus pneumoniae circulating in Italy. | 1999 | J. Antimicrob. Chemother. | pmid:10588306 |
Wilson R et al. | Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis. | 1999 | J. Antimicrob. Chemother. | pmid:10588312 |
Panagea S et al. | Should clindamycin be used as treatment of patients with infections caused by erythromycin-resistant staphylococci? | 1999 | J. Antimicrob. Chemother. | pmid:10588329 |
Varaldo PE et al. | Nationwide survey in Italy of treatment of Streptococcus pyogenes pharyngitis in children: influence of macrolide resistance on clinical and microbiological outcomes. Artemis-Italy Study Group. | 1999 | Clin. Infect. Dis. | pmid:10589905 |
Glass D et al. | A placebo-controlled clinical trial to compare a gel containing a combination of isotretinoin (0.05%) and erythromycin (2%) with gels containing isotretinoin (0.05%) or erythromycin (2%) alone in the topical treatment of acne vulgaris. | 1999 | Dermatology (Basel) | pmid:10592405 |
Debbia EA | [Antibiotic resistance: an always present problem]. | 1999 | Recenti Prog Med | pmid:10592734 |
Brixius B et al. | [Ventricular tachycardia after erythromycin administration in a newborn with congenital AV-block]. | 1999 Nov-Dec | Klin Padiatr | pmid:10592929 |
Damkier P et al. | Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. | 1999 | Br J Clin Pharmacol | pmid:10594487 |
Doumith M et al. | Interspecies complementation in Saccharopolyspora erythraea : elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives. | 1999 | Mol. Microbiol. | pmid:10594828 |
Portillo A et al. | Macrolide resistance phenotypes and mechanisms of resistance in Streptococcus pyogenes in La Rioja, Spain. | 1999 | Int. J. Antimicrob. Agents | pmid:10595574 |
Sugiyama Y et al. | Effects of long-term administration of erythromycin on cytokine production in rat alveolar macrophages. | 1999 | Eur. Respir. J. | pmid:10596699 |
Polk RE et al. | Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men. | 1999 | Pharmacotherapy | pmid:10600086 |
Esposito S et al. | In vitro activity of moxifloxacin compared to other fluoroquinolones against different erythromycin-resistant phenotypes of group A beta-hemolytic streptococcus. | 2000 Jan-Feb | Chemotherapy | pmid:10601794 |
Fluhr JW et al. | In-vitro and in-vivo efficacy of zinc acetate against propionibacteria alone and in combination with erythromycin. | 1999 | Zentralbl. Bakteriol. | pmid:10603662 |
Marre R and Trautmann M | [Community-acquired respiratory tract infections. Current data on the efficacy of various classes of antibiotics and antibiotic resistance of the main prevalent bacteria species]. | 1999 | Med. Klin. (Munich) | pmid:10603732 |
Ku YY et al. | Synthesis and antibacterial activities of novel 12-O-methylerythromycin A derivatives. | 1999 | J. Antibiot. | pmid:10604761 |
Ianaro A et al. | Anti-inflammatory activity of macrolide antibiotics. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10604943 |
Sato Y et al. | Adjuvant effect of a 14-member macrolide antibiotic on DNA vaccine. | 1999 | Cell. Immunol. | pmid:10607432 |
Wang JS et al. | Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro. | 1999 | Pharmacol. Toxicol. | pmid:10608481 |
Honein MA et al. | Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. | 1999 Dec 18-25 | Lancet | pmid:10609814 |