erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zou X et al. | Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter. | 2012 | Bioprocess Biosyst Eng | pmid:22139481 |
Fischer H et al. | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. | 2012 | J. Med. Chem. | pmid:22122484 |
Back EE et al. | High rates of perinatal group B Streptococcus clindamycin and erythromycin resistance in an upstate New York hospital. | 2012 | Antimicrob. Agents Chemother. | pmid:22143529 |
Perić M et al. | Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin. | 2012 | J. Med. Chem. | pmid:22148880 |
Reil M et al. | Seasonality of Clostridium difficile infections in Southern Germany. | 2012 | Epidemiol. Infect. | pmid:22152928 |
Osman KM et al. | Antimicrobial susceptibility and molecular typing of multiple Chlamydiaceae species isolated from genital infection of women in Egypt. | 2012 | Microb. Drug Resist. | pmid:22455539 |
Marlow N et al. | Characteristics of children with cerebral palsy in the ORACLE children study. | 2012 | Dev Med Child Neurol | pmid:22458348 |
Lialikov SA et al. | [Monitoring of side effects and estimation of cycloferon efficacy in treatment of children with frequent and prolonged diseases]. | 2012 | Antibiot. Khimioter. | pmid:23700934 |
Laurens C et al. | Clinical and antimicrobial susceptibility data of 140 Streptococcus pseudopneumoniae isolates in France. | 2012 | Antimicrob. Agents Chemother. | pmid:22644030 |
Thumu SC and Halami PM | Presence of erythromycin and tetracycline resistance genes in lactic acid bacteria from fermented foods of Indian origin. | 2012 | Antonie Van Leeuwenhoek | pmid:22644346 |
Chuang CC et al. | Staphylococcus aureus ocular infection: methicillin-resistance, clinical features, and antibiotic susceptibilities. | 2012 | PLoS ONE | pmid:22880135 |
Block SL | Etiologic and therapeutic pitfalls of newborn conjunctivitis. | 2012 | Pediatr Ann | pmid:22881420 |
Nelson CG and Burke TR | Samarium iodide-mediated Reformatsky reactions for the stereoselective preparation of β-hydroxy-γ-amino acids: synthesis of isostatine and dolaisoleucine. | 2012 | J. Org. Chem. | pmid:22136325 |
Sun J et al. | Enterococcus faecalis from patients with chronic periodontitis: virulence and antimicrobial resistance traits and determinants. | 2012 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:21660501 |
Smith EM et al. | In vitro inhibition of cytochrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes. | 2012 | Aquat. Toxicol. | pmid:22000335 |
Lu S and Zgurskaya HI | Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter. | 2012 | Mol. Microbiol. | pmid:23057817 |
Parhi A et al. | Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23058886 |
Bech-Nielsen GV et al. | Manipulation of the gut microbiota in C57BL/6 mice changes glucose tolerance without affecting weight development and gut mucosal immunity. | 2012 | Res. Vet. Sci. | pmid:21543097 |
Lancaster CS et al. | OATP1B1 polymorphism as a determinant of erythromycin disposition. | 2012 | Clin. Pharmacol. Ther. | pmid:22990751 |
Rubio-López V et al. | Molecular epidemiology, antimicrobial susceptibilities and resistance mechanisms of Streptococcus pyogenes isolates resistant to erythromycin and tetracycline in Spain (1994-2006). | 2012 | BMC Microbiol. | pmid:22998619 |
Henningsen E and Bygum A | Budesonide-induced periorificial dermatitis presenting as chalazion and blepharitis. | 2011 Sep-Oct | Pediatr Dermatol | pmid:21895758 |
Ezhova NM et al. | [Molecularly imprinted hydrophilic polymer sorbents for selective sorption of erythromycin]. | 2011 Nov-Dec | Prikl. Biokhim. Mikrobiol. | pmid:22288199 |
Stang EM and White MC | On the macrocyclization of the erythromycin core: preorganization is not required. | 2011 | Angew. Chem. Int. Ed. Engl. | pmid:21344559 |
Ridley EJ and Davies AR | Practicalities of nutrition support in the intensive care unit: the usefulness of gastric residual volume and prokinetic agents with enteral nutrition. | 2011 | Nutrition | pmid:21295944 |
Nguyen NQ et al. | Plasma erythromycin concentrations predict feeding outcomes in critically ill patients with feed intolerance. | 2011 | Crit. Care Med. | pmid:21297459 |
Thenmozhi R et al. | Characterization of biofilms in different clinical M serotypes of Streptococcus pyogenes. | 2011 | J. Basic Microbiol. | pmid:21298675 |
Tosin M et al. | In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines. | 2011 | Chem. Commun. (Camb.) | pmid:21301753 |
Mingoia M et al. | Heterogeneity of Tn5253-like composite elements in clinical Streptococcus pneumoniae isolates. | 2011 | Antimicrob. Agents Chemother. | pmid:21263055 |
Yuan H et al. | [The effect of erythromycin on transforming growth factor-β(1) and secretory leukocyte proteinase inhibitor in a rat model of chronic obstructive pulmonary disease]. | 2011 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:22041779 |
Vadlapatla RK et al. | Differential effect of P-gp and MRP2 on cellular translocation of gemifloxacin. | 2011 | Int J Pharm | pmid:21864659 |
Watanabe I et al. | Combined effect of disopyramide and erythromycin on ventricular repolarization in dogs with complete atrioventricular block. | 2011 | Int Heart J | pmid:22188715 |
Lubell Y et al. | Susceptibility of bacterial isolates from community-acquired infections in sub-Saharan Africa and Asia to macrolide antibiotics. | 2011 | Trop. Med. Int. Health | pmid:21740488 |
Spigaglia P et al. | Multidrug resistance in European Clostridium difficile clinical isolates. | 2011 | J. Antimicrob. Chemother. | pmid:21771851 |
Jupelli M et al. | Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life. | 2011 | Lab. Invest. | pmid:21769086 |
RodrÃguez C et al. | [Resistance phenotypes and genotypes of Streptococcus pyogenes clinical isolates in Chile over a 10-year period]. | 2011 | Rev Med Chil | pmid:22215392 |
Clifford V et al. | Variation in erythromycin and clindamycin resistance patterns between New Zealand and Australian group B streptococcus isolates. | 2011 | Aust N Z J Obstet Gynaecol | pmid:21806568 |
Khan NW et al. | Antimicrobial activity of erythromycin and clarithromycin against clinical isolates of Escherichia coli, Staphylococcus aureus, Klebsiella and Proteus by disc diffusion method. | 2011 | Pak J Pharm Sci | pmid:21190914 |
Lee HY et al. | Improved precursor-directed biosynthesis in E. coli via directed evolution. | 2011 | J. Antibiot. | pmid:21081955 |
Liu Y et al. | The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21570844 |
Samra Z et al. | Susceptibility of Ureaplasma urealyticum to tetracycline, doxycycline, erythromycin, roxithromycin, clarithromycin, azithromycin, levofloxacin and moxifloxacin. | 2011 | J Chemother | pmid:21571622 |
Tazi A et al. | Invasive group B streptococcal infections in adults, France (2007-2010). | 2011 | Clin. Microbiol. Infect. | pmid:21883671 |
Fenoll A et al. | Increase in serotype 19A prevalence and amoxicillin non-susceptibility among paediatric Streptococcus pneumoniae isolates from middle ear fluid in a passive laboratory-based surveillance in Spain, 1997-2009. | 2011 | BMC Infect. Dis. | pmid:21910891 |
Maezono H et al. | Antibiofilm effects of azithromycin and erythromycin on Porphyromonas gingivalis. | 2011 | Antimicrob. Agents Chemother. | pmid:21911560 |
Lehtopolku M et al. | Ribosomal mutations as the main cause of macrolide resistance in Campylobacter jejuni and Campylobacter coli. | 2011 | Antimicrob. Agents Chemother. | pmid:21911571 |
Drago L et al. | Macrolide resistance and in vitro selection of resistance to antibiotics in Lactobacillus isolates. | 2011 | J. Microbiol. | pmid:21887650 |
Liu K et al. | Direct entry to erythronolides via a cyclic bis[allene]. | 2011 | J. Am. Chem. Soc. | pmid:21894913 |
Öberg AI et al. | β-Adrenergic inhibition of contractility in L6 skeletal muscle cells. | 2011 | PLoS ONE | pmid:21829455 |
Osman M and Ghosh SK | Semiparametric bayesian testing procedure for noninferiority trials with binary endpoints. | 2011 | J Biopharm Stat | pmid:21830923 |
Baronsky J et al. | Perfusion calorimetry in the characterization of solvates forming isomorphic desolvates. | 2011 | Eur J Pharm Sci | pmid:21726637 |
Pannu J et al. | In vitro antibacterial activity of NB-003 against Propionibacterium acnes. | 2011 | Antimicrob. Agents Chemother. | pmid:21746943 |
Albarellos GA et al. | Pharmacokinetics of erythromycin after intravenous, intramuscular and oral administration to cats. | 2011 | Vet. J. | pmid:19854664 |
Haenni M et al. | ermB-mediated erythromycin resistance in Streptococcus uberis from bovine mastitis. | 2011 | Vet. J. | pmid:20667752 |
Palmieri C et al. | Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis. | 2011 | Antimicrob. Agents Chemother. | pmid:21115784 |
Bosnjakovic A et al. | Poly(amidoamine) dendrimer-erythromycin conjugates for drug delivery to macrophages involved in periprosthetic inflammation. | 2011 | Nanomedicine | pmid:21059404 |
Bonofiglio L et al. | Dissemination of an erythromycin-resistant penicillin-nonsusceptible Streptococcus pneumoniae Poland(6B)-20 clone in Argentina. | 2011 | Microb. Drug Resist. | pmid:21128835 |
Zanoni RG et al. | Occurrence of Helicobacter pullorum in turkeys. | 2011 | Vet. Microbiol. | pmid:21144678 |
Altraif I et al. | Effect of erythromycin before endoscopy in patients presenting with variceal bleeding: a prospective, randomized, double-blind, placebo-controlled trial. | 2011 | Gastrointest. Endosc. | pmid:21145052 |
Bopp LH et al. | Activities of tigecycline and comparators against Legionella pneumophila and Legionella micdadei extracellularly and in human monocyte-derived macrophages. | 2011 | Diagn. Microbiol. Infect. Dis. | pmid:21146719 |
Braga TM et al. | Involvement, and dissemination, of the enterococcal small multidrug resistance transporter QacZ in resistance to quaternary ammonium compounds. | 2011 | J. Antimicrob. Chemother. | pmid:21147826 |
Panigaj M et al. | Expression of prion protein in mouse erythroid progenitors and differentiating murine erythroleukemia cells. | 2011 | PLoS ONE | pmid:21912705 |
Maragno AL et al. | ISG15 modulates development of the erythroid lineage. | 2011 | PLoS ONE | pmid:22022510 |
Kreft A et al. | JAK2-V617F-mutated myeloproliferative neoplasms reveal different allele burden within hematopoietic cell lineages: a microdissection study of bone marrow trephine biopsies. | 2011 | Virchows Arch. | pmid:22006129 |
Zaed AM and Sutherland A | Total synthesis of clavaminol A, C and H. | 2011 | Org. Biomol. Chem. | pmid:21879135 |
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Taillon MP et al. | Potentially new isobaric metabolite of fluvastatin observed by LC-MS/MS during incurred sample analysis. | 2011 | Bioanalysis | pmid:21877892 |
de Morais e Silva FA et al. | Rosacea fulminans in pregnancy with ocular perforation. | 2011 | J Dtsch Dermatol Ges | pmid:21366860 |
Koulnis M et al. | Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response. | 2011 | PLoS ONE | pmid:21760888 |
Serisier DJ and Martin ML | Long-term, low-dose erythromycin in bronchiectasis subjects with frequent infective exacerbations. | 2011 | Respir Med | pmid:21367595 |
Feneran AN et al. | Retinoid plus antimicrobial combination treatments for acne. | 2011 | Clin Cosmet Investig Dermatol | pmid:21760743 |
Almofti YA et al. | Impact of erythromycin resistance on the virulence properties and fitness of Campylobacter jejuni. | 2011 | Microb. Pathog. | pmid:21377522 |
Mueller DH et al. | Constraints to implementing the Essential Health Package in Malawi. | 2011 | PLoS ONE | pmid:21695115 |
Luo DQ et al. | In vitro activities of erythromycin, tetracycline and levofloxacin alone and in dual combinations against ureaplasma spp. | 2011 | Chemotherapy | pmid:21430380 |
Yongsheng J et al. | Antitumor activity of erythromycin on human neuroblastoma cell line (SH-SY5Y). | 2011 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:21336720 |
Pérez-Trallero E et al. | In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates. | 2011 | Antimicrob. Agents Chemother. | pmid:21343452 |
Filić D et al. | Crystal structure and physicochemical properties of crystalline form of 2'-O-{3-[(7-chloro-4-quinolinyl)amino]propyl}-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A. | 2011 | J Pharm Sci | pmid:21394721 |
van den Bosch S et al. | Erythromycin to promote bedside placement of a self-propelled nasojejunal feeding tube in non-critically ill patients having pancreatitis: a randomized, double-blind, placebo-controlled study. | 2011 | Nutr Clin Pract | pmid:21447772 |
Louvet JN et al. | Simultaneous Gram and viability staining on activated sludge exposed to erythromycin: 3D CLSM time-lapse imaging of bacterial disintegration. | 2011 | Int J Hyg Environ Health | pmid:21420358 |
Serdoz F et al. | Development and pharmacokinetic evaluation of erythromycin lipidic formulations for oral administration in rainbow trout (Oncorhynchus mykiss). | 2011 | Eur J Pharm Biopharm | pmid:21402156 |
Dow GS et al. | Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice. | 2011 | Malar. J. | pmid:21645370 |
Piccialli V et al. | Isolation of a bis-iodurated tetra-THF as a trace product from the oxidation of squalene with RuOâ‚„ and its double ring expansion to a novel bis-THF-bis-THP compound. | 2011 | Molecules | pmid:21709619 |
Wu JC and Sung JJ | Pharmacologic therapy for nonvariceal upper gastrointestinal bleeding. | 2011 | Gastrointest. Endosc. Clin. N. Am. | pmid:21944417 |
Kovacs TO and Jensen DM | Endoscopic therapy for severe ulcer bleeding. | 2011 | Gastrointest. Endosc. Clin. N. Am. | pmid:21944418 |
Ozkok IP et al. | Respirometric assessment of substrate binding by antibiotics in peptone biodegradation. | 2011 | J Environ Sci Health A Tox Hazard Subst Environ Eng | pmid:22029701 |
Justa RF et al. | Bacillary angiomatosis in HIV-positive patient from Northeastern Brazil: a case report. | 2011 | Rev. Soc. Bras. Med. Trop. | pmid:22031085 |
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Gannon M et al. | Clinical inquiries. Which oral antibiotics are best for acne? | 2011 | J Fam Pract | pmid:21544278 |
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Chia HY et al. | Follicular spicules associated with Propionibacterium acnes in response to erythromycin. | 2011 | J. Dermatol. | pmid:21544949 |
Farkas B et al. | [Frequency and antibiotic resistance of Ureaplasma urealyticum and Mycoplasma hominis in genital samples of sexually active individuals]. | 2011 | Orv Hetil | pmid:21979223 |
Nguyen TT et al. | A food-grade system for inducible gene expression in Lactobacillus plantarum using an alanine racemase-encoding selection marker. | 2011 | J. Agric. Food Chem. | pmid:21504147 |
Tilmant K et al. | Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis. | 2011 | Toxicol In Vitro | pmid:21515356 |
Ma X and Ma S | Significant breakthroughs in search for anti-infectious agents derived from erythromycin A. | 2011 | Curr. Med. Chem. | pmid:21517774 |
Boecxstaens V et al. | Modulation of the postprandial acid and bile pockets at the gastro-oesophageal junction by drugs that affect gastric motility. | 2011 | Aliment. Pharmacol. Ther. | pmid:21517922 |
Sugawara A et al. | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21524580 |
Cong C et al. | Synthesis and antibacterial activity of novel 4″-O-benzimidazolyl clarithromycin derivatives. | 2011 | Eur J Med Chem | pmid:21524827 |
Ando F et al. | Synergic effects of β-estradiol and erythromycin on hERG currents. | 2011 | J. Membr. Biol. | pmid:21484263 |
Flaman AS et al. | The effect of interferon-α on the expression of cytochrome P450 3A4 in human hepatoma cells. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21466820 |
Zou LK et al. | Erythromycin resistance and virulence genes in Enterococcus faecalis from swine in China. | 2011 | New Microbiol. | pmid:21344149 |
Liu L et al. | Disappearance of sexual dimorphism in triptolide metabolism in monosodium glutamate treated neonatal rats. | 2011 | Arzneimittelforschung | pmid:21428244 |
Bansal BK et al. | Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health. | 2011 | Trop Anim Health Prod | pmid:20844949 |