erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pichichero ME | Group A streptococcal tonsillopharyngitis: cost-effective diagnosis and treatment. | 1995 | Ann Emerg Med | pmid:7864482 |
Hueston WJ | Albuterol delivered by metered-dose inhaler to treat acute bronchitis. | 1994 | J Fam Pract | pmid:7864949 |
Marco F et al. | [Erythromycin-sensitive Streptococcus pyogenes]. | 1994 | Enferm. Infecc. Microbiol. Clin. | pmid:7865567 |
Rennie KA et al. | In vitro activity of dirithromycin, a new macrolide antibiotic, against Mycoplasma species. | 1994 | Diagn. Microbiol. Infect. Dis. | pmid:7867300 |
Liu YG et al. | [Clinical study of erythromycin action on gallbladder motility in patients with non-ulcer dyspepsia]. | 1994 | Zhonghua Nei Ke Za Zhi | pmid:7867425 |
Moinard D et al. | Effect of medium pH on the activity of dirithromycin and erythromycylamine in Bactec broth against Mycobacterium avium complex. | 1994 | J. Antimicrob. Chemother. | pmid:7868412 |
Waites KB et al. | Isolation of Ureaplasma urealyticum from low birth weight infants. | 1995 | J. Pediatr. | pmid:7869217 |
Farmer JA and Gotto AM | Antihyperlipidaemic agents. Drug interactions of clinical significance. | 1994 | Drug Saf | pmid:7873090 |
Hamada K et al. | Antitumor effect of erythromycin in mice. | 1995 Jan-Feb | Chemotherapy | pmid:7875024 |
Pogrel MA | Antibiotics in general practice. | 1994 | Dent Update | pmid:7875362 |
Shinkwin CA and Gibbin KP | Neonatal upper airway obstruction caused by chlamydial rhinitis. | 1995 | J Laryngol Otol | pmid:7876741 |
Luurila H et al. | Lack of interaction of erythromycin with temazepam. | 1994 | Ther Drug Monit | pmid:7878692 |
Korsrud GO et al. | Investigation of Charm Test II receptor assays for the detection of antimicrobial residues in suspect meat samples. | 1994 | Analyst | pmid:7879886 |
Walsh TN et al. | Gastric motility following oesophagectomy. | 1995 | Br J Surg | pmid:7881968 |
Linton KJ et al. | Cloning of the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraea. | 1995 | Gene | pmid:7883182 |
Ross JI et al. | Identification of a chromosomally encoded ABC-transport system with which the staphylococcal erythromycin exporter MsrA may interact. | 1995 | Gene | pmid:7883194 |
Kanavaki S et al. | Antibiotic resistance of clinical isolates of Streptococcus pneumoniae in Greece. | 1994 | J. Clin. Microbiol. | pmid:7883901 |
Nirankari VS et al. | Antibiotic prophylaxis in corneal storage media. | 1994 | Trans Am Ophthalmol Soc | pmid:7886863 |
McCarty JM | Comparative efficacy and safety of cefprozil versus penicillin, cefaclor and erythromycin in the treatment of streptococcal pharyngitis and tonsillitis. | 1994 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:7889958 |
Nolen T | Comparative studies of cefprozil in the management of skin and soft-tissue infections. | 1994 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:7889961 |
Koley AP et al. | CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers. | 1995 | J. Biol. Chem. | pmid:7890608 |
Horsmans Y and Geubel AP | Amoxycillin-clavulanic acid-erythromycin cross-liver toxicity: a case report. | 1994 | J. Hepatol. | pmid:7890912 |
Victorova LS et al. | Synthesis of thioamide bond catalyzed by E. coli ribosomes. | 1976 | FEBS Lett. | pmid:789114 |
Oakley A et al. | Propionibacterium: resistance of acne to antibiotics. | 1995 | N. Z. Med. J. | pmid:7891939 |
Fujita K et al. | Decline of erythromycin resistance of group A streptococci in Japan. | 1994 | Pediatr. Infect. Dis. J. | pmid:7892073 |
Lown KS et al. | Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test. | 1994 Nov-Dec | Drug Metab. Dispos. | pmid:7895614 |
Bernstein SC and Roenigk RK | Surgical pearl: erythromycin ointment for topical antibiotic wound care. | 1995 | J. Am. Acad. Dermatol. | pmid:7896958 |
Pascual C et al. | In vitro detection of specific IgE antibodies to erythromycin. | 1995 | J. Allergy Clin. Immunol. | pmid:7897148 |
Langlois R et al. | The distance between two functionally significant regions of the 50 S Escherichia coli ribosome: the erythromycin binding site and proteins L7/L12. | 1976 | J. Mol. Biol. | pmid:789892 |
Paul MA et al. | Bacillary angiomatosis in an immunocompetent child: the first reported case. | 1994 | Pediatr Dermatol | pmid:7899186 |
Chiappini J et al. | [Subacute idiopathic eosinophilic pneumopathy with favorable outcome without corticotherapy]. | 1995 | Rev Mal Respir | pmid:7899663 |
Sun WM et al. | Relationship between surface electrogastrography and antropyloric pressures. | 1995 | Am. J. Physiol. | pmid:7900804 |
Takeyama K et al. | Effect of macrolide antibiotics on ciliary motility in rabbit airway epithelium in-vitro. | 1993 | J. Pharm. Pharmacol. | pmid:7901376 |
Tanis AA et al. | Side-effects of oral erythromycin for treatment of diabetic gastroparesis. | 1993 | Lancet | pmid:7901719 |
Roden DM | Torsade de pointes. | 1993 | Clin Cardiol | pmid:7902224 |
Eggenberger K | [Early congenital syphilis (a report of two cases). 2 (author's transl)]. | 1976 | Schweiz. Rundsch. Med. Prax. | pmid:790375 |
Potekaev NS et al. | [An unusual variant of secondary recurrent syphilis in an HIV-infected patient]. | 1993 | Ter. Arkh. | pmid:7906439 |
Karvonen SL et al. | Systemic corticosteroid and isotretinoin treatment in cystic acne. | 1993 | Acta Derm. Venereol. | pmid:7906462 |
Seppälä H et al. | Evaluation of methods for epidemiologic typing of group A streptococci. | 1994 | J. Infect. Dis. | pmid:7908926 |
Ruffin WK | Erythromycin: a postoperative jumpstart? | 1994 | Am. J. Gastroenterol. | pmid:7909647 |
Fomina IP | [Second international conference on macrolides, azalides and streptogramins (Venice, Italy, January 19-22, 1994)]. | 1994 | Antibiot. Khimioter. | pmid:7914722 |
Patterson DJ | Prokinetic agents in postgastrectomy patients. | 1994 | Gastroenterol. Clin. North Am. | pmid:7915253 |
Hassel B | [Acute hypothermia and adverse effects on the central nervous system during erythromycin therapy]. | 1994 | Tidsskr. Nor. Laegeforen. | pmid:7915859 |
Eady EA et al. | Effects of benzoyl peroxide and erythromycin alone and in combination against antibiotic-sensitive and -resistant skin bacteria from acne patients. | 1994 | Br. J. Dermatol. | pmid:7918006 |
Kajiwara M et al. | Biosynthesis of erythromycin: origin of the methyl protons. | 1994 | Chem. Pharm. Bull. | pmid:7923474 |
Ginsburg CM et al. | Concentrations of erythromycin in serum and tonsil: comparison of the estolate and ethyl succinate suspensions. | 1976 | J. Pediatr. | pmid:792404 |
Ginsburg CM and Eichenwald HF | Erythromycin: a review of its uses in pediatric practice. | 1976 | J. Pediatr. | pmid:792407 |
Turgeon DK et al. | P450 3A activity and cyclosporine dosing in kidney and heart transplant recipients. | 1994 | Clin. Pharmacol. Ther. | pmid:7924120 |
Jones RN et al. | Validation of NCCLS macrolide (azithromycin, clarithromycin, and erythromycin) interpretive criteria for Haemophilus influenzae tested with the Haemophilus test medium. National Committee for Clinical Laboratory Standards. | 1994 | Diagn. Microbiol. Infect. Dis. | pmid:7924221 |
Oda H et al. | Erythromycin inhibits neutrophil chemotaxis in bronchoalveoli of diffuse panbronchiolitis. | 1994 | Chest | pmid:7924482 |
Kruszewska A et al. | Effect of auxotrophic starvation of mitochondrial marker transmission in the cdc8 mutant of Saccharomyces cerevisiae. | 1976 | Mol. Gen. Genet. | pmid:792682 |
Oishi K et al. | Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases. | 1994 | Infect. Immun. | pmid:7927669 |
Bariffi F et al. | Flurithromycin ethylsuccinate in the treatment of lower respiratory tract bacterial infections. | 1994 May-Jun | Infection | pmid:7927827 |
Chittum HS and Champney WS | Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli. | 1994 | J. Bacteriol. | pmid:7928988 |
Gu Z et al. | Properties of a pentapeptide inhibitor of peptidyltransferase that is essential for cat gene regulation by translation attenuation. | 1994 | J. Bacteriol. | pmid:7928994 |
Kuritzky L | The genericization of erythromycin. | 1994 | Hosp. Pract. (Off. Ed.) | pmid:7929677 |
Masuzawa T et al. | In vitro antibiotic susceptibilities of Borrelia isolates from erythema migrans lesion of Lyme disease patients in Japan. | 1994 | Microbiol. Immunol. | pmid:7935067 |
Plakunov VK and Myl'nikova SI | [2 mechanisms of tetracycline resistance in bacteria]. | 1976 | Antibiotiki | pmid:793507 |
Wrighton SA and Ring BJ | Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine. | 1994 | Pharm. Res. | pmid:7937537 |
Trédaniel J et al. | Diffuse panbronchiolitis: efficacy of low-dose erythromycin. | 1994 | Respir Med | pmid:7938804 |
Koselj M et al. | Drug interactions between cyclosporine and rifampicin, erythromycin, and azoles in kidney recipients with opportunistic infections. | 1994 | Transplant. Proc. | pmid:7940889 |
Roberts MC and Brown MB | Macrolide-lincosamide resistance determinants in streptococcal species isolated from the bovine mammary gland. | 1994 | Vet. Microbiol. | pmid:7941290 |
Pazzaglia G et al. | Persistent, recurring diarrhea in a colony of orangutans (Pongo pygmaeus) caused by multiple strains of Campylobacter spp. | 1994 | Acta Trop. | pmid:7942349 |
Colombo N et al. | Analytical-physical profile of the novel macrolide antibiotic flurithromycin ethylsuccinate. | 1994 | Arzneimittelforschung | pmid:7945521 |
Paris DG et al. | Torsades de pointes induced by erythromycin and terfenadine. | 1994 | Am J Emerg Med | pmid:7945604 |
Lynch VM et al. | A novel dioxabicyclo[3.3.1]nonane, a key intermediate in the synthesis of erythronolide B seco-acid. | 1994 | Acta Crystallogr C | pmid:7946151 |
Wenzel RP et al. | Comparison of josamycin and erythromycin in the therapy of Mycoplasma pneumoniae pneumonia. | 1976 | Antimicrob. Agents Chemother. | pmid:795375 |
Ramirez B et al. | Erythromycin enhances gastric emptying in patients with gastroparesis after vagotomy and antrectomy. | 1994 | Dig. Dis. Sci. | pmid:7956594 |
Rein MF | Biopharmacology of syphilotherapy. | 1976 | J Am Vener Dis Assoc | pmid:795799 |
Fraser RJ and Mittal RK | Erythromycin: the mechanism of its prokinetic action in the treatment of gastroparesis. | 1994 | Gastroenterology | pmid:7958712 |
Nikolich MP et al. | Characterization of a new type of Bacteroides conjugative transposon, Tcr Emr 7853. | 1994 | J. Bacteriol. | pmid:7961412 |
Satoh M et al. | EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965757 |
Witkamp RF et al. | Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig. | 1994 | J. Vet. Pharmacol. Ther. | pmid:7966553 |
Alary M et al. | Randomised comparison of amoxycillin and erythromycin in treatment of genital chlamydial infection in pregnancy. | 1994 | Lancet | pmid:7968119 |
Erythromycin-resistant Bordetella pertussis--Yuma County, Arizona, May-October 1994. | 1994 | MMWR Morb. Mortal. Wkly. Rep. | pmid:7968996 | |
Nolan J and Lyle WH | Erythromycin in the aqueous. Comparative concentrations form the estolate and from the base. | 1976 | Trans Ophthalmol Soc U K | pmid:797069 |
Hammerschlag MR | Chlamydia trachomatis in children. | 1994 | Pediatr Ann | pmid:7970898 |
Tyndall MW et al. | Single dose azithromycin for the treatment of chancroid: a randomized comparison with erythromycin. | 1994 Jul-Aug | Sex Transm Dis | pmid:7974076 |
White RJ | Why use erythromycin? | 1994 | Thorax | pmid:7974308 |
Vasil' M | [Therapy of clinically apparent forms of mastitis in lactating dairy cows using intra-mammary Sulphamycin (Polfa, PR)]. | 1994 | Vet Med (Praha) | pmid:7975049 |
Devereux RB et al. | Cost-effectiveness of infective endocarditis prophylaxis for mitral valve prolapse with or without a mitral regurgitant murmur. | 1994 | Am. J. Cardiol. | pmid:7977041 |
Isenberg SJ et al. | Povidone-iodine for ophthalmia neonatorum prophylaxis. | 1994 | Am. J. Ophthalmol. | pmid:7977595 |
Funderburg LG et al. | Seizure following addition of erythromycin to clozapine treatment. | 1994 | Am J Psychiatry | pmid:7977898 |
Goldman RC et al. | Tight binding of clarithromycin, its 14-(R)-hydroxy metabolite, and erythromycin to Helicobacter pylori ribosomes. | 1994 | Antimicrob. Agents Chemother. | pmid:7979278 |
Abdelghaffar H et al. | Effects of dirithromycin and erythromycylamine on human neutrophil degranulation. | 1994 | Antimicrob. Agents Chemother. | pmid:7979287 |
Roblin PM et al. | Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia. | 1994 | Antimicrob. Agents Chemother. | pmid:7979292 |
Tamaoki J et al. | Macrolide antibiotics protect against endotoxin-induced vascular leakage and neutrophil accumulation in rat trachea. | 1994 | Antimicrob. Agents Chemother. | pmid:7979298 |
Simkiss DE et al. | Erythromycin in neonatal postoperative intestinal dysmotility. | 1994 | Arch. Dis. Child. | pmid:7979468 |
Sazykin IuO | [Modern macrolides and azalides in the therapy of infectious-inflammatory diseases. A seminar, February 1994, Moscow]. | 1994 Feb-Mar | Antibiot. Khimioter. | pmid:7979801 |
Rahal JJ | Management of infections caused by antibiotic-resistant Streptococcus pneumoniae. | 1994 | N. Engl. J. Med. | pmid:7984204 |
Granström G and Granström M | Effect of erythromycin treatment on antibody responses in pertussis. | 1994 | Scand. J. Infect. Dis. | pmid:7984978 |
Watkins PB | Noninvasive tests of CYP3A enzymes. | 1994 | Pharmacogenetics | pmid:7987401 |
Mattila MJ et al. | Azithromycin does not alter the effects of oral midazolam on human performance. | 1994 | Eur. J. Clin. Pharmacol. | pmid:7988623 |
Maria VA et al. | Lymphocyte reactivity to ex-vivo drug antigens in drug-induced hepatitis. | 1994 | J. Hepatol. | pmid:7989705 |
Marzio L et al. | Migrating motor complex recorded spontaneously and induced by motilin and erythromycin in an ex vivo rabbit intestinal preparation. | 1994 | Peptides | pmid:7991450 |
Evangelista T et al. | [Acute polyradiculoneuritis associated with boutonneuse fever]. | 1994 Jul-Aug | Acta Med Port | pmid:7992646 |
Tagaya E et al. | Erythromycin inhibits cholinergic neuro-effector transmission in canine airway smooth muscle. | 1994 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:7994563 |
Veselov AIa | [Structure of drug resistance in Staphylococci]. | 1976 | Antibiotiki | pmid:799486 |
Krivoruk Y et al. | Metabolism of cytochrome P4503A substrates in vivo administered by the same route: lack of correlation between alfentanil clearance and erythromycin breath test. | 1994 | Clin. Pharmacol. Ther. | pmid:7995002 |
Maes BD et al. | [*C]octanoic acid breath test to measure gastric emptying rate of solids. | 1994 | Dig. Dis. Sci. | pmid:7995200 |