erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Thomas L et al. | Ophthalmic Considerations in Stevens-Johnson Syndrome. | 2016 | J. Pediatr. | pmid:27318376 |
Salimi A et al. | Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. | 2016 | Xenobiotica | pmid:26068526 |
Tang C et al. | The incidence and drug resistance of Clostridium difficile infection in Mainland China: a systematic review and meta-analysis. | 2016 | Sci Rep | pmid:27897206 |
Sun H et al. | Mechanism Underlying Time-dependent Cross-phenomenon between Concentration-response Curves and Concentration Addition Curves: A Case Study of Sulfonamides-Erythromycin mixtures on Escherichia coli. | 2016 | Sci Rep | pmid:27644411 |
Mombelli A et al. | Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci. | 2016 | J. Periodontol. | pmid:26654350 |
Ulanovsky I et al. | Erythromycin Prophylaxis for Neonatal Conjunctivitis: Ointment Versus Drops. | 2016 | Isr. Med. Assoc. J. | pmid:28471562 |
Tack J et al. | Motilin-induced gastric contractions signal hunger in man. | 2016 | Gut | pmid:25539673 |
Zmantar T et al. | Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity. | 2016 | Microb. Pathog. | pmid:27816681 |
Barbanti F and Spigaglia P | Characterization of Clostridium difficile PCR-ribotype 018: A problematic emerging type. | 2016 | Anaerobe | pmid:27725230 |
Mayor-Ibarguren A et al. | Periorificial Lesions in a Young Girl. | 2016 | Actas Dermosifiliogr | pmid:26935746 |
Hu P et al. | Erythromycin triggers intussusception in a pediatric patient with Henoch-Schönlein purpura. | 2016 | Turk J Gastroenterol | pmid:27782898 |
Heß S and Gallert C | Growth Behavior of E. coli, Enterococcus and Staphylococcus Species in the Presence and Absence of Sub-inhibitory Antibiotic Concentrations: Consequences for Interpretation of Culture-Based Data. | 2016 | Microb. Ecol. | pmid:27220972 |
de Jesus Gaffney V et al. | Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water. | 2016 | Environ. Toxicol. Chem. | pmid:27061931 |
Caumes E et al. | [Donovanosis (granuloma inguinale)]. | 2016 | Ann Dermatol Venereol | pmid:27773509 |
DeLorenzo ME et al. | Exposure of the grass shrimp, Palaemonetes pugio, to antimicrobial compounds affects associated Vibrio bacterial density and development of antibiotic resistance. | 2016 | Environ. Toxicol. | pmid:25348372 |
Caumes E et al. | [Lymphogranuloma venereum]. | 2016 | Ann Dermatol Venereol | pmid:27773504 |
Xu JY et al. | Lysine Malonylome May Affect the Central Metabolism and Erythromycin Biosynthesis Pathway in Saccharopolyspora erythraea. | 2016 | J. Proteome Res. | pmid:27090497 |
Benamrouche N et al. | Microbiological and molecular characterization of Corynebacterium diphtheriae isolated in Algeria between 1992 and 2015. | 2016 | Clin. Microbiol. Infect. | pmid:27585941 |
Kang CH and So JS | Antibiotic and heavy metal resistance in Shewanella putrefaciens strains isolated from shellfishes collected from West Sea, Korea. | 2016 | Mar. Pollut. Bull. | pmid:27555484 |
Rizzotti L et al. | Biocide and antibiotic resistance of Enterococcus faecalis and Enterococcus faecium isolated from the swine meat chain. | 2016 | Food Microbiol. | pmid:27554158 |
Choe YJ et al. | Emergence of antibiotic-resistant non-vaccine serotype pneumococci in nasopharyngeal carriage in children after the use of extended-valency pneumococcal conjugate vaccines in Korea. | 2016 | Vaccine | pmid:27546875 |
Kang CH et al. | Antimicrobial susceptibility of Vibrio alginolyticus isolated from oyster in Korea. | 2016 | Environ Sci Pollut Res Int | pmid:27543129 |
Metcalf BJ et al. | Using whole genome sequencing to identify resistance determinants and predict antimicrobial resistance phenotypes for year 2015 invasive pneumococcal disease isolates recovered in the United States. | 2016 | Clin. Microbiol. Infect. | pmid:27542334 |
Parasrampuria DA et al. | Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. | 2016 | Br J Clin Pharmacol | pmid:27530188 |
Hua CZ et al. | [An analysis of 181 cases with blood stream infection caused by Streptococcus agalactiae in children from 2011 to 2015: a multi-center retrospective study]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:27510868 |
Johanesen P and Lyras D | Methods for Determining Transfer of Mobile Genetic Elements in Clostridium difficile. | 2016 | Methods Mol. Biol. | pmid:27507343 |
Barbanti F et al. | Transfer of Clostridium difficile Genetic Elements Conferring Resistance to Macrolide-Lincosamide-Streptogramin B (MLSB) Antibiotics. | 2016 | Methods Mol. Biol. | pmid:27507342 |
Gaglio R et al. | Evaluation of antimicrobial resistance and virulence of enterococci from equipment surfaces, raw materials, and traditional cheeses. | 2016 | Int. J. Food Microbiol. | pmid:27467501 |
Burr LD et al. | Macrolide Treatment Inhibits Pseudomonas aeruginosa Quorum Sensing in Non-Cystic Fibrosis Bronchiectasis. An Analysis from the Bronchiectasis and Low-Dose Erythromycin Study Trial. | 2016 | Ann Am Thorac Soc | pmid:27464029 |
Ben Salem I et al. | Removal of Penicillin G and Erythromycin with Ionizing Radiation Followed by Biological Treatment. | 2016 | Curr. Microbiol. | pmid:27447798 |
Wu L et al. | Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells. | 2016 | PLoS ONE | pmid:27447724 |
He M et al. | Mechanism of synergy between SIPI-8294 and β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. | 2016 | Lett. Appl. Microbiol. | pmid:27173151 |
Patel MB et al. | Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. | 2016 | Bioorg. Med. Chem. | pmid:27166575 |
Mendes RE et al. | In Vitro Activity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States. | 2016 | Antimicrob. Agents Chemother. | pmid:27161634 |
Taylor SJ et al. | A randomised controlled feasibility and proof-of-concept trial in delayed gastric emptying when metoclopramide fails: We should revisit nasointestinal feeding versus dual prokinetic treatment: Achieving goal nutrition in critical illness and delayed gastric emptying: Trial of nasointestinal feeding versus nasogastric feeding plus prokinetics. | 2016 | Clin Nutr ESPEN | pmid:28531392 |
Tan C et al. | Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease. | 2016 | Mediators Inflamm. | pmid:27127346 |
Zheng Z et al. | Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives. | 2016 | J. Antibiot. | pmid:27118243 |
Mikhail M et al. | Orbital cellulitis and multiple abscess formation after strabismus surgery. | 2016 | Can. J. Ophthalmol. | pmid:27085279 |
Chen Y et al. | TEMPO-oxidized Konjac glucomannan as appliance for the preparation of hard capsules. | 2016 | Carbohydr Polym | pmid:27083368 |
Del Grosso M et al. | ICESpy009, a Conjugative Genetic Element Carrying mef(E) in Streptococcus pyogenes. | 2016 | Antimicrob. Agents Chemother. | pmid:27067338 |
Aydin S | Enhanced biodegradation of antibiotic combinations via the sequential treatment of the sludge resulting from pharmaceutical wastewater treatment using white-rot fungi Trametes versicolor and Bjerkandera adusta. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27033714 |
Shi HY et al. | [Effect of quorum sensing system on the infection of MRSA and the intervention of erythromycin on it]. | 2016 | Zhonghua Yi Xue Za Zhi | pmid:27760665 |
Hsieh PF et al. | The Klebsiella pneumoniae YfgL (BamB) lipoprotein contributes to outer membrane protein biogenesis, type-1 fimbriae expression, anti-phagocytosis, and in vivo virulence. | 2016 | Virulence | pmid:27029012 |
Baker KR et al. | A High-Throughput Approach To Identify Compounds That Impair Envelope Integrity in Escherichia coli. | 2016 | Antimicrob. Agents Chemother. | pmid:27458225 |
Juda M et al. | The prevalence of genotypes that determine resistance to macrolides, lincosamides, and streptogramins B compared with spiramycin susceptibility among erythromycin-resistant Staphylococcus epidermidis. | 2016 | Mem. Inst. Oswaldo Cruz | pmid:27008373 |
Cui B et al. | Selection of suitable reference genes for gene expression studies in Staphylococcus capitis during growth under erythromycin stress. | 2016 | Mol. Genet. Genomics | pmid:27000656 |
Lewis K et al. | The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials. | 2016 | Crit Care | pmid:27527069 |
Zhang A et al. | Molecular subtyping and erythromycin resistance of Campylobacter in China. | 2016 | J. Appl. Microbiol. | pmid:26999516 |
Pierattini EC et al. | Morpho-physiological response of Populus alba to erythromycin: A timeline of the health status of the plant. | 2016 | Sci. Total Environ. | pmid:27366984 |
He HJ et al. | Erythromycin resistance features and biofilm formation affected by subinhibitory erythromycin in clinical isolates of Staphylococcus epidermidis. | 2016 | J Microbiol Immunol Infect | pmid:24768213 |
Bhadra PK et al. | Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B. | 2016 | Org. Biomol. Chem. | pmid:27273525 |
Topp E et al. | Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. | 2016 | Sci. Total Environ. | pmid:27096634 |
Katayama Y et al. | Neuroprotective effects of erythromycin on ischemic injury following permanent focal cerebral ischemia in rats. | 2016 | Neurol. Res. | pmid:27078702 |
Li X et al. | Macrolides use and the risk of sudden cardiac death. | 2016 | Expert Rev Anti Infect Ther | pmid:27086751 |
Argyropoulos P et al. | Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. | 2016 | Biochim. Biophys. Acta | pmid:26592346 |
Sari E et al. | Fabrication of surface plasmon resonance nanosensor for the selective determination of erythromycin via molecular imprinted nanoparticles. | 2016 | Talanta | pmid:26838449 |
Magnussen MD et al. | Antibacterial resistance in Streptococcus pyogenes (GAS) from healthy carriers and tonsillitis patients and association with antibacterial sale in the Faroe Islands. | 2016 | APMIS | pmid:26833774 |
Seki M et al. | A Chronic Respiratory Pasteurella multocida Infection Is Well-Controlled by Long-Term Macrolide Therapy. | 2016 | Intern. Med. | pmid:26831030 |
Deloose E et al. | The motilin receptor agonist erythromycin stimulates hunger and food intake through a cholinergic pathway. | 2016 | Am. J. Clin. Nutr. | pmid:26817505 |
Liu X et al. | Proteomic response of methicillin-resistant S. aureus to a synergistic antibacterial drug combination: a novel erythromycin derivative and oxacillin. | 2016 | Sci Rep | pmid:26806358 |
Prabhasankar VP et al. | Removal rates of antibiotics in four sewage treatment plants in South India. | 2016 | Environ Sci Pollut Res Int | pmid:26797959 |
Seefeldt AC et al. | Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. | 2016 | Nucleic Acids Res. | pmid:26792896 |
Li M et al. | Sugar-Grafted Cyclodextrin Nanocarrier as a "Trojan Horse" for Potentiating Antibiotic Activity. | 2016 | Pharm. Res. | pmid:26792570 |
Lapierre L et al. | Characterization of Antimicrobial Susceptibility and Its Association with Virulence Genes Related to Adherence, Invasion, and Cytotoxicity in Campylobacter jejuni and Campylobacter coli Isolates from Animals, Meat, and Humans. | 2016 | Microb. Drug Resist. | pmid:26779841 |
Pan M and Chu LM | Phytotoxicity of veterinary antibiotics to seed germination and root elongation of crops. | 2016 | Ecotoxicol. Environ. Saf. | pmid:26773832 |
Rodrigues S et al. | Acute and chronic effects of erythromycin exposure on oxidative stress and genotoxicity parameters of Oncorhynchus mykiss. | 2016 | Sci. Total Environ. | pmid:26760278 |
Cheng Y et al. | Comparative study between macrolide regulatory proteins MphR(A) and MphR(E) in ligand identification and DNA binding based on the rapid in vitro detection system. | 2016 | Anal Bioanal Chem | pmid:26753969 |
Entorf M et al. | Comparative erythromycin and tylosin susceptibility testing of streptococci from bovine mastitis. | 2016 | Vet. Microbiol. | pmid:26732695 |
Gupta P et al. | Nascent peptide assists the ribosome in recognizing chemically distinct small molecules. | 2016 | Nat. Chem. Biol. | pmid:26727240 |
Zhou J et al. | A seventeen-year observation of the antimicrobial susceptibility of clinical Campylobacter jejuni and the molecular mechanisms of erythromycin-resistant isolates in Beijing, China. | 2016 | Int. J. Infect. Dis. | pmid:26594011 |
Maye S et al. | Transformation of serum-susceptible Escherichia coli O111 with p16Slux plasmid to allow for real-time monitoring of complement-based inactivation of bacterial growth in bovine milk. | 2016 | J. Dairy Sci. | pmid:26585477 |
Nenquin M and Henquin JC | Sulphonylurea receptor-1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells. | 2016 | Diabetes Obes Metab | pmid:26584950 |
Arenz S et al. | A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. | 2016 | Nat Commun | pmid:27380950 |
Wu H et al. | In vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26552796 |
Berg L et al. | [Cutaneous diphtheria after a minor injury in Sri Lanka]. | 2016 | Hautarzt | pmid:26525966 |
Takahashi T et al. | Epidemiological study of erythromycin-resistant Streptococcus pyogenes from Korea and Japan by emm genotyping and multilocus sequence typing. | 2016 | Ann Lab Med | pmid:26522753 |
Ohbatake Y et al. | Elevated alpha1-acid glycoprotein in gastric cancer patients inhibits the anticancer effects of paclitaxel, effects restored by co-administration of erythromycin. | 2016 | Clin. Exp. Med. | pmid:26359244 |
Templeton I et al. | A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4. | 2016 | Biopharm Drug Dispos | pmid:26356245 |
Boetsch C et al. | Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions. | 2016 | Clin Pharmacokinet | pmid:26341813 |
Giuliano MW and Miller SJ | Site-Selective Reactions with Peptide-Based Catalysts. | 2016 | Top Curr Chem | pmid:26307403 |
Snoeys J et al. | Mechanistic understanding of the nonlinear pharmacokinetics and intersubject variability of simeprevir: A PBPK-guided drug development approach. | 2016 | Clin. Pharmacol. Ther. | pmid:26259716 |
Chen C et al. | Blocking the flow of propionate into TCA cycle through a mutB knockout leads to a significant increase of erythromycin production by an industrial strain of Saccharopolyspora erythraea. | 2017 | Bioprocess Biosyst Eng | pmid:27709326 |
Wozniak A et al. | Importance of adhesins in the recurrence of pharyngeal infections caused by Streptococcus pyogenes. | 2017 | J. Med. Microbiol. | pmid:28463664 |
Pavlova A et al. | Toward the rational design of macrolide antibiotics to combat resistance. | 2017 | Chem Biol Drug Des | pmid:28419786 |
Szczepanska B et al. | Prevalence and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolated from children and environmental sources in urban and suburban areas. | 2017 | BMC Microbiol. | pmid:28376713 |
Mingmongkolchai S and Panbangred W | In vitro evaluation of candidate Bacillus spp. for animal feed. | 2017 | J. Gen. Appl. Microbiol. | pmid:28331163 |
Wang Y et al. | Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28129976 |
Owen L et al. | A Multifactorial Comparison of Ternary Combinations of Essential Oils in Topical Preparations to Current Antibiotic Prescription Therapies for the Control of Acne Vulgaris-Associated Bacteria. | 2017 | Phytother Res | pmid:28124400 |
Chen K et al. | Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China. | 2017 | BMC Infect. Dis. | pmid:28122513 |
Berni E et al. | Risk of cardiovascular events, arrhythmia and all-cause mortality associated with clarithromycin versus alternative antibiotics prescribed for respiratory tract infections: a retrospective cohort study. | 2017 | BMJ Open | pmid:28115334 |
Wei L et al. | Transformation of erythromycin during secondary effluent soil aquifer recharging: Removal contribution and degradation path. | 2017 | J Environ Sci (China) | pmid:28115128 |
Koryakina I et al. | Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. | 2017 | ACS Chem. Biol. | pmid:28103677 |
Song KH et al. | Characteristics of cefazolin inoculum effect-positive methicillin-susceptible staphylococcus aureus infection in a multicentre bacteraemia cohort. | 2017 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:27714592 |
Austin BA and Fleischer AB | The extinction of topical erythromycin therapy for acne vulgaris and concern for the future of topical clindamycin. | 2017 | J Dermatolog Treat | pmid:27425633 |
Jakubů V et al. | Trends in the Minimum Inhibitory Concentrations of Erythromycin, Clarithromycin, Azithromycin, Ciprofloxacin, and Trimethoprim/Sulfamethoxazole for Strains of Bordetella pertussis isolated in the Czech Republic in 1967-2015. | 2017 | Cent. Eur. J. Public Health | pmid:29346850 |
Romero L et al. | Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults. | 2017 | Cochrane Database Syst Rev | pmid:29226307 |
Naimi HM et al. | Determination of antimicrobial susceptibility patterns in Staphylococcus aureus strains recovered from patients at two main health facilities in Kabul, Afghanistan. | 2017 | BMC Infect. Dis. | pmid:29187146 |
Yi M et al. | Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis. | 2017 | Arch. Biochem. Biophys. | pmid:28347661 |
Duelge KJ et al. | An LC-MS/MS method for the determination of antibiotic residues in distillers grains. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28415016 |
Svetlov MS et al. | Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29229833 |