erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ball SE et al. | Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4. | 1999 | Clin. Pharmacol. Ther. | pmid:10511065 |
Chantarotorn S et al. | Diffuse panbronchiolitis, the first case reports in Thailand. | 1999 | J Med Assoc Thai | pmid:10511794 |
Yoshida H and Furuta T | [Tissue penetration properties of macrolide antibiotics--comparative tissue distribution of erythromycin-stearate, clarithromycin, roxithromycin and azithromycin in rats]. | 1999 | Jpn J Antibiot | pmid:10516929 |
De Winter BY et al. | Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats. | 1999 | Gut | pmid:10517907 |
Xue Q et al. | A multiplasmid approach to preparing large libraries of polyketides. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10518520 |
Sheu BS et al. | A three-day course of intravenous omeprazole plus antibiotics for H. pylori-positive bleeding duodenal ulcer. | 1999 Jul-Aug | Hepatogastroenterology | pmid:10521999 |
Cocito C and Di Giambattista M | The in vitro binding of virginiamycin M to bacteria ribosomes and ribosomal subunits. | 1978 | Mol. Gen. Genet. | pmid:105240 |
Shortridge VD et al. | Prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from a multicenter antibiotic resistance surveillance study conducted in the United States in 1994-1995. | 1999 | Clin. Infect. Dis. | pmid:10524961 |
Yoh M et al. | Effect of subinhibitory concentrations of antimicrobial agents (quinolones and macrolide) on the production of verotoxin by enterohemorrhagic Escherichia coli O157:H7. | 1999 | Can. J. Microbiol. | pmid:10526400 |
Sato A et al. | Effects of organic anions and vinblastine on biliary excretion of erythromycin in rats. | 1999 | Pharmacology | pmid:10529657 |