erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ramirez B and Richter JE | Review article: promotility drugs in the treatment of gastro-oesophageal reflux disease. | 1993 | Aliment. Pharmacol. Ther. | pmid:8094981 |
Catnach SM et al. | Dose-dependent stimulation of gallbladder contraction by intravenous erythromycin in man. | 1993 | Aliment. Pharmacol. Ther. | pmid:8439638 |
Verhagen MA et al. | Effects of a new motilide, ABT-229, on gastric emptying and postprandial antroduodenal motility in healthy volunteers. | 1997 | Aliment. Pharmacol. Ther. | pmid:9663833 |
Haans JJ and Masclee AA | Review article: The diagnosis and management of gastroparesis. | 2007 | Aliment. Pharmacol. Ther. | pmid:18081647 |
McCallum RW and Cynshi O | Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesis - a randomized, multicentre, placebo-controlled study. | 2007 | Aliment. Pharmacol. Ther. | pmid:17894654 |
Winstead NS and Wilcox CM | Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage: a cost-effectiveness analysis. | 2007 | Aliment. Pharmacol. Ther. | pmid:17848180 |
Bell GD et al. | Short report: omeprazole plus antibiotic combinations for the eradication of metronidazole-resistant Helicobacter pylori. | 1992 | Aliment. Pharmacol. Ther. | pmid:1486161 |
Brand RM et al. | Transdermal delivery of erythromycin lactobionate--implications for the therapy of gastroparesis. | 1997 | Aliment. Pharmacol. Ther. | pmid:9218087 |
Annese V et al. | Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus. | 1997 | Aliment. Pharmacol. Ther. | pmid:9218089 |
van Erpecum KJ et al. | Review article: agents affecting gall-bladder motility--role in treatment and prevention of gallstones. | 2000 | Aliment. Pharmacol. Ther. | pmid:10903008 |
Chiba T et al. | Motilides accelerate regional gastrointestinal transit in the dog. | 2000 | Aliment. Pharmacol. Ther. | pmid:10886053 |
Landry C et al. | Could oral erythromycin optimize high energy continuous enteral nutrition? | 1996 | Aliment. Pharmacol. Ther. | pmid:8971296 |
Ehrenpreis ED et al. | Which form of erythromycin should be used to treat gastroparesis? A pharmacokinetic analysis. | 1998 | Aliment. Pharmacol. Ther. | pmid:9690728 |
Osato MS et al. | Comparative efficacy of new investigational agents against Helicobacter pylori. | 2001 | Aliment. Pharmacol. Ther. | pmid:11284777 |
Medhus AW et al. | Low-dose intravenous erythromycin: effects on postprandial and fasting motility of the small bowel. | 2000 | Aliment. Pharmacol. Ther. | pmid:10651665 |
Curry JI et al. | Review article: erythromycin as a prokinetic agent in infants and children. | 2001 | Aliment. Pharmacol. Ther. | pmid:11328252 |
Kendall BJ et al. | The effect of intravenous erythromycin on solid meal gastric emptying in patients with chronic symptomatic post-vagotomy-antrectomy gastroparesis. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146779 |
Boecxstaens V et al. | Modulation of the postprandial acid and bile pockets at the gastro-oesophageal junction by drugs that affect gastric motility. | 2011 | Aliment. Pharmacol. Ther. | pmid:21517922 |
Laine L et al. | Prospective evaluation of the macrolide antibiotic dirithromycin for the treatment of Helicobacter pylori. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791949 |
Mosonyi L et al. | [Infectious and neoplastic complications in rheumatoid arthritis]. | 1974-1975 | Allerg Immunol (Leipz) | pmid:4282826 |