erythromycin
erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with erythromycin?
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (35)
- J. Antimicrob. Chemother. (18)
- J. Pharmacol. Exp. Ther. (2)
- Others (29)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with erythromycin
PubChem Associated disorders and diseases
What pathways are associated with erythromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with erythromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with erythromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with erythromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with erythromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (19)
- J. Antimicrob. Chemother. (10)
- Drug Metab. Dispos. (5)
- Others (29)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with erythromycin?
Mouse Model
Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with erythromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xu J et al. | [Prognosticating the region-selectivity in the O-methylation reaction of erythromycins by conformational search model]. | 2003 | Yao Xue Xue Bao | pmid:12778744 |
| Liu L et al. | [Synthesis of derivatives of (9S)-12-methylene erythromycin and their antibacterial activity in vitro]. | 2005 | Yao Xue Xue Bao | pmid:16220785 |
| Watanabe Y et al. | [Relationship between quality and serum level after the oral administration of commercial erythromycin tablets in man (author's transl)]. | 1977 | Yakugaku Zasshi | pmid:911413 |
| Matsuoka M | [Study of macrolide, lincosamide, and streptogramin B antibiotics resistance in Staphylococcus aureus]. | 2000 | Yakugaku Zasshi | pmid:10774259 |
| Nakamura H et al. | Effect of particle size on mixing degree in dispensation. | 2004 | Yakugaku Zasshi | pmid:15049131 |
| Nakamura H et al. | Effect of mixing method on the mixing degree during the preparation of triturations. | 2004 | Yakugaku Zasshi | pmid:15049130 |
| Watanabe Y et al. | [Effect of dissolving pH of enteric coating agent on bioavailability of enteric coated tablets of erythromycin in man (author's transl)]. | 1978 | Yakugaku Zasshi | pmid:30834 |
| Miyazaki M et al. | [Trends and antimicrobial susceptibilities of clinical methicillin-resistant Staphylococcus aureus isolates in Fukuoka University Chikushi Hospital 2008-2012]. | 2014 | Yakugaku Zasshi | pmid:24492229 |
| Otsuka M et al. | [Studies on fungicides. XIV. Effect of erythromycin on the growth of fungal mycelia (author's transl)]. | 1978 | Yakugaku Zasshi | pmid:566318 |
| Zhang Y et al. | [Erythromycin restores oxidative stress-induced corticosteroid responsiveness of human THP-1 cells by up-regulating the expression of histone deacetylase 2]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:24721407 |
| Ung D et al. | Metabolic interactions between prokinetic agents domperidone and erythromycin: an in vitro analysis. | 2009 | Xenobiotica | pmid:19575604 |
| Hu J et al. | Possible multiple transporters were involved in hepatobiliary excretion of antofloxacin in rats. | 2007 | Xenobiotica | pmid:17614005 |
| Salimi A et al. | Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. | 2016 | Xenobiotica | pmid:26068526 |
| Emoto C et al. | Cooperativity of alpha-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human. | 2001 | Xenobiotica | pmid:11491388 |
| Bickel MH et al. | Entero-bacterial formation of cyclohexylamine in rats ingesting cyclamate. | 1974 | Xenobiotica | pmid:4372812 |
| Yamazaki H et al. | Effects of roxithromycin, erythromycin and troleandomycin on their N-demethylation by rat and human cytochrome P450 enzymes. | 1996 | Xenobiotica | pmid:8948090 |
| Pasic J et al. | The interaction between chronic oral slow-release theophylline and single-dose intravenous erythromycin. | 1987 | Xenobiotica | pmid:3604256 |
| Yamazaki H and Shimada T | Formation in vitro of an inhibitory cytochrome P450 x Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes. | 1998 | Xenobiotica | pmid:9849646 |
| Ward KW et al. | Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug-drug interactions. | 2009 | Xenobiotica | pmid:19280525 |
| Kaye B and Roberts DW | The metabolism of oxamniquine in the gut wall. | 1980 | Xenobiotica | pmid:7395269 |