erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Oyarzún E et al. | Antibiotic treatment in preterm labor and intact membranes: a randomized, double-blinded, placebo-controlled trial. | 1998 May-Jun | J Matern Fetal Med | pmid:9642605 |
Shimatani T | Involvement of cholinergic motor neurons in pharmacological regulation of gastrointestinal motility by glucagon in conscious dogs. | 1997 Aug-Oct | J Smooth Muscle Res | pmid:9639019 |
Havlik J and Holý M | [Erythromycin stearate Spofa--coated tablets for pediatric practice]. | 1976 | Cesk Pediatr | pmid:963828 |
Novaes AB et al. | Immediate implants placed into infected sites: a histomorphometric study in dogs. | 1998 May-Jun | Int J Oral Maxillofac Implants | pmid:9638015 |
Stassi DL et al. | Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9636144 |
Wandel C et al. | Effect of CYP3A inhibition on vesnarinone metabolism in humans. | 1998 | Clin. Pharmacol. Ther. | pmid:9630823 |
Wirsing von König CH et al. | Factors influencing the spread of pertussis in households. | 1998 | Eur. J. Pediatr. | pmid:9625336 |
Souli M et al. | In vitro activity of BAY 12-8039, a new fluoroquinolone, against species representative of respiratory tract pathogens. | 1998 | Int. J. Antimicrob. Agents | pmid:9624540 |
Roblin PM and Hammerschlag MR | In vitro activity of a new ketolide antibiotic, HMR 3647, against Chlamydia pneumoniae. | 1998 | Antimicrob. Agents Chemother. | pmid:9624507 |
Reinert RR et al. | In vitro activities of the new ketolide antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany. | 1998 | Antimicrob. Agents Chemother. | pmid:9624505 |
Kataja J et al. | Different erythromycin resistance mechanisms in group C and group G streptococci. | 1998 | Antimicrob. Agents Chemother. | pmid:9624500 |
Muli F and Struthers JK | Use of a continuous-culture biofilm system to study the antimicrobial susceptibilities of Gardnerella vaginalis and Lactobacillus acidophilus. | 1998 | Antimicrob. Agents Chemother. | pmid:9624489 |
Rosato A et al. | A new ketolide, HMR 3004, active against streptococci inducibly resistant to erythromycin. | 1998 | Antimicrob. Agents Chemother. | pmid:9624482 |
Widdowson CA and Klugman KP | Emergence of the M phenotype of erythromycin-resistant pneumococci in South Africa. | 1998 Apr-Jun | Emerging Infect. Dis. | pmid:9621199 |
Kruppa A et al. | Immediate reaction to roxithromycin and prick test cross-sensitization to erythromycin and clarithromycin. | 1998 | Dermatology (Basel) | pmid:9621142 |
Kudoh S et al. | Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620913 |
Krone LV | The importance of multiple antibiotic coverage for hospitalized patients when the community acquired pneumonia is Legionnaire's disease. | 1998 | WMJ | pmid:9617308 |
Syphilis--recommended treatment schedules, 1976. | 1976 | Am Fam Physician | pmid:961559 | |
Bourrat E et al. | [Rosacea with ocular involvement in a child]. | 1996 | Ann Dermatol Venereol | pmid:9615130 |
Mathis C and Malbert CH | Changes in pyloric resistance induced by erythromycin. | 1998 | Neurogastroenterol. Motil. | pmid:9614671 |
Gaisser S et al. | Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. | 1998 | Mol. Gen. Genet. | pmid:9613575 |
Neubrand M and Sauerbruch T | Erythromycin, a motilin agonist, increases postprandial gallbladder emptying during therapy with ursodeoxycholic acid. | 1998 | Z Gastroenterol | pmid:9612923 |
Kudoh S | Erythromycin treatment in diffuse panbronchiolitis. | 1998 | Curr Opin Pulm Med | pmid:9612675 |
Paesen J et al. | Study of the stability of erythromycin in a hydrophilic creme basis by liquid chromatography. | 1998 | J Pharm Biomed Anal | pmid:9608426 |
Vachálková A and Novotný L | Polarographic testing of carcinogenicity of some chemotherapeutics. | 1997 | Neoplasma | pmid:9605013 |
Farrell AM et al. | Pyoderma gangrenosum of the penis. | 1998 | Br. J. Dermatol. | pmid:9602887 |
Karrer S et al. | [Acne comedonica following radiation therapy]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9601475 |
Ng P et al. | Diffuse panbronchiolitis: case report and review of the literature. | 1998 | Australas Radiol | pmid:9599832 |
Muranaka H et al. | [Superoxide radical scavenging activity of an erythromycin-iron complex (the second report)]. | 1998 | Jpn J Antibiot | pmid:9597516 |
Tanabe O et al. | [Mechanism of erythromycin action on gene expression of airway epithelial cells]. | 1998 | Jpn J Antibiot | pmid:9597514 |
Kyo S et al. | [Effects of macrolides on intracellular Ca2+ response by airway epithelium]. | 1998 | Jpn J Antibiot | pmid:9597513 |
Nakada M et al. | [Inhibitory effects of macrolide antibiotics at low concentrations on vero toxin production by pathogenic E. coli O157]. | 1998 | Jpn J Antibiot | pmid:9597511 |
Kozeki S et al. | [Study on bacterial biofilm destruction by various antibacterial agents]. | 1998 | Jpn J Antibiot | pmid:9597510 |
Yoshimine H et al. | [Inhibition of neutrophil-derived IL-8 production caused by EM (erythromycin) 201 derivative: modification of the activities by the 5-position desosamine side chain]. | 1998 | Jpn J Antibiot | pmid:9597508 |
Sugiyama Y et al. | [Changes in cytokine production by pulmonary alveolar macrophages collected from rats that have been treated with erythromycin for an extended period]. | 1998 | Jpn J Antibiot | pmid:9597506 |
Abe S et al. | [Effect of macrolides on IL-8 gene expression by cultured airway epithelial cells]. | 1998 | Jpn J Antibiot | pmid:9597504 |
Nishimura J et al. | [Effects of erythromycin on Pseudomonas aeruginosa pyocyanine-induced IL-8 production and its biological activity (the 2nd report)]. | 1998 | Jpn J Antibiot | pmid:9597503 |
Okura M et al. | [Multicenter study on clinical effects of a small dose of erythromycin on chronic lung disorders of premature infants--single blind comparison of treated and untreated groups. A committee for the Study of EM Therapy for Chronic Lung Diseases of Premature Infants]. | 1998 | Jpn J Antibiot | pmid:9597500 |
Miyazawa T et al. | [Mucous pathology and macrolide treatment of paranasal sinusitis in children]. | 1998 | Jpn J Antibiot | pmid:9597499 |
Kishi K et al. | [Study of efficacy of macrolide therapy applied to Kartagener's syndrome]. | 1998 | Jpn J Antibiot | pmid:9597497 |
Shirai R et al. | [Evaluation of the duration of medication with erythromycin for treatment of diffuse panbronchitis--a comparison between interruption of medication and continued administration]. | 1998 | Jpn J Antibiot | pmid:9597496 |
Nakada K et al. | [Therapeutic guideline for diffuse panbronchitis (draft). Subcommittee on Diffuse Lung Diseases, Research Committee on Respiratory Diseases Organized by the Ministry of Health and Welfare]. | 1998 | Jpn J Antibiot | pmid:9597494 |
Kawasaki S et al. | [Effects of a steroid and macrolide antibiotic on adhesion of neutrophils to the airway epithelial cells]. | 1998 | Jpn J Antibiot | pmid:9597483 |
Takeda H et al. | [Bone absorption suppression by broad spectrum antibiotics]. | 1998 | Jpn J Antibiot | pmid:9597475 |
Tamaoki J et al. | [Effects of macrolide antibiotics on iNOS gene expression and NO production by alveolar macrophages]. | 1998 | Jpn J Antibiot | pmid:9597474 |
Hikariyama T et al. | [Study of suppression of neutrophil functions and prevention of vascular endothelial injury by macrolide antibiotics]. | 1998 | Jpn J Antibiot | pmid:9597473 |
Hori S et al. | [Effects of macrolide drugs on endogenous glucocorticoids]. | 1997 | Jpn J Antibiot | pmid:9597471 |
Nonaka M et al. | [Effects of macrolide antibiotics on fibroblasts]. | 1997 | Jpn J Antibiot | pmid:9597470 |
Miyashima S et al. | [Effects of erythromycin on a mouse hypersensitivity pneumonia model]. | 1997 | Jpn J Antibiot | pmid:9597469 |
Kaseta M et al. | [Study of therapeutic effects of macrolide antibiotics on patients with anti-HTLV-1 antibody positive DPB (diffuse panbronchitis)]. | 1997 | Jpn J Antibiot | pmid:9597466 |