erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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De Rosa R et al. | [Disappearance of Streptococcus pyogenes macrolide resistance in an area of northeastern Italy: a possible link with rational long-acting macrolide consumption]. | 2009 | Infez Med | pmid:19602920 |
Tornese G et al. | Erythromycin in whooping cough. | 2009 | BMJ | pmid:19564191 |
Sun W et al. | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. | 2009 | Antimicrob. Agents Chemother. | pmid:19546358 |
Tazumi A et al. | Molecular characterization of macrolide resistance determinants [erm(B) and mef(A)] in Streptococcus pneumoniae and viridans group streptococci (VGS) isolated from adult patients with cystic fibrosis (CF). | 2009 | J. Antimicrob. Chemother. | pmid:19584106 |
Orscheln RC et al. | contribution of genetically restricted, methicillin-susceptible strains to the ongoing epidemic of community-acquired Staphylococcus aureus infections. | 2009 | Clin. Infect. Dis. | pmid:19589082 |
Li X et al. | Emerging macrolide resistance in Mycoplasma pneumoniae in children: detection and characterization of resistant isolates. | 2009 | Pediatr. Infect. Dis. J. | pmid:19633515 |
Alighardashi A et al. | Acute sensitivity of activated sludge bacteria to erythromycin. | 2009 | J. Hazard. Mater. | pmid:19674840 |
Melnik BC et al. | Anti-acne agents attenuate FGFR2 signal transduction in acne. | 2009 | J. Invest. Dermatol. | pmid:19225542 |
Sadreddini S et al. | A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritis. | 2009 | Int J Rheum Dis | pmid:20374316 |
Chawengsub Y et al. | Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries. | 2009 | J. Biol. Chem. | pmid:19737933 |
Toomey N et al. | Assessment of antimicrobial resistance transfer between lactic acid bacteria and potential foodborne pathogens using in vitro methods and mating in a food matrix. | 2009 | Foodborne Pathog. Dis. | pmid:19799525 |
Siira L et al. | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. | 2009 | Antimicrob. Agents Chemother. | pmid:19273677 |
Shah SS et al. | Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats. | 2009 | J. Vet. Med. Sci. | pmid:19801894 |
Liu Y et al. | Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China. | 2009 | Antimicrob. Agents Chemother. | pmid:19273684 |
Xin D et al. | Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China. | 2009 | Antimicrob. Agents Chemother. | pmid:19273685 |
Kelmer G et al. | Evaluation of indwelling intravenous catheters for the regional perfusion of the limbs of horses. | 2009 | Vet. Rec. | pmid:19855112 |
Donnellan F et al. | Avoiding errors with intravenous erythromycin administration. | 2009 | Eur. J. Intern. Med. | pmid:19237080 |
Mirza S et al. | Crystal morphology engineering of pharmaceutical solids: tabletting performance enhancement. | 2009 | AAPS PharmSciTech | pmid:19184449 |
Princivalli MS et al. | Lactobacillus rhamnosus GG inhibits invasion of cultured human respiratory cells by prtF1-positive macrolide-resistant group A streptococci. | 2009 | Lett. Appl. Microbiol. | pmid:19187508 |
Nakao K et al. | Susceptibilities of 23 Desulfovibrio isolates from humans. | 2009 | Antimicrob. Agents Chemother. | pmid:19786606 |
Kouvela EC et al. | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. | 2009 | Antimicrob. Agents Chemother. | pmid:19164155 |
Kim BS et al. | Case of minocycline-effective confluent and reticulated papillomatosis with unusual location on forehead. | 2009 | J. Dermatol. | pmid:19348668 |
Laisi S et al. | Amoxicillin may cause molar incisor hypomineralization. | 2009 | J. Dent. Res. | pmid:19278983 |
Jeon B and Zhang Q | Sensitization of Campylobacter jejuni to fluoroquinolone and macrolide antibiotics by antisense inhibition of the CmeABC multidrug efflux transporter. | 2009 | J. Antimicrob. Chemother. | pmid:19279049 |
Zhang H et al. | Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. | 2009 | Microb Biotechnol | pmid:21261933 |
Ward KW et al. | Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug-drug interactions. | 2009 | Xenobiotica | pmid:19280525 |
Devasia RA et al. | Compliance with azithromycin versus erythromycin in the setting of a pertussis outbreak. | 2009 | Am. J. Med. Sci. | pmid:19301451 |
Bukvić Krajacić M et al. | Novel ureas and thioureas of 15-membered azalides with antibacterial activity against key respiratory pathogens. | 2009 | Eur J Med Chem | pmid:19303171 |
Ng PC | Use of oral erythromycin for the treatment of gastrointestinal dysmotility in preterm infants. | 2009 | Neonatology | pmid:19218823 |
Cusano F et al. | Erlotinib-induced pustular eruption. | 2009 | G Ital Dermatol Venereol | pmid:19218915 |
Ren W et al. | Effect of oral erythromycin therapy in patients with aseptic loosening of joint prostheses. | 2009 | Bone | pmid:19154802 |
Zheng B et al. | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac). | 2009 | Antimicrob. Agents Chemother. | pmid:19029325 |
Liu Y et al. | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. | 2009 | Antimicrob. Agents Chemother. | pmid:19029328 |
Siibak T et al. | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. | 2009 | Antimicrob. Agents Chemother. | pmid:19029332 |
Kelly MP et al. | Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. | 2009 | Mol. Psychiatry | pmid:19030002 |
Soriano F et al. | In vitro activity of ciprofloxacin, moxifloxacin, vancomycin and erythromycin against planktonic and biofilm forms of Corynebacterium urealyticum. | 2009 | J. Antimicrob. Chemother. | pmid:19056748 |
Kehrenberg C et al. | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. | 2009 | Antimicrob. Agents Chemother. | pmid:19047652 |
Ritz N et al. | Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics. | 2009 | Antimicrob. Agents Chemother. | pmid:18955515 |
Hariharan S et al. | Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroids. | 2009 | Pharm. Res. | pmid:18958406 |
Asmah N et al. | Prevalence of erythromycin and clindamycin resistance among clinical isolates of the Streptococcus anginosus group in Germany. | 2009 | J. Med. Microbiol. | pmid:19141740 |
Gebeile-Chauty S et al. | [Is retention justified after interceptive treatment of Class II malocclusion?]. | 2009 | Orthod Fr | pmid:19954738 |
Makarieva TN et al. | Isorhizochalin: a minor unprecedented bipolar sphingolipid of stereodivergent biogenesis from the Rhizochalina incrustata. | 2009 | Lipids | pmid:19882184 |
Fukuchi Y et al. | [Potential role of macrolides in the treatment of COPD: current evidence. (discussion)]. | 2009 | Jpn J Antibiot | pmid:20055117 |
El Aila NA et al. | Genotyping of Streptococcus agalactiae (group B streptococci) isolated from vaginal and rectal swabs of women at 35-37 weeks of pregnancy. | 2009 | BMC Infect. Dis. | pmid:19747377 |
Strieker M et al. | Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. | 2009 | J. Am. Chem. Soc. | pmid:19722489 |
Bohlin C et al. | Oxidation of the erythro and threo forms of the phenolic lignin model compound 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol by laccases and model oxidants. | 2009 | Bioorg. Chem. | pmid:19646732 |
Robinson TV et al. | Dihydroxylation of 4-substituted 1,2-dioxines: a concise route to branched erythro sugars. | 2009 | J. Org. Chem. | pmid:19588997 |
Du Y and He Q | [Molecular mechanism of erythromycin in the improvement of paraquat-damaged vascular endothelial cell barrier function]. | 2009 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:20067116 |
Hariharan S et al. | Interaction of ocular hypotensive agents (PGF2 alpha analogs-bimatoprost, latanoprost, and travoprost) with MDR efflux pumps on the rabbit cornea. | 2009 | J Ocul Pharmacol Ther | pmid:20028257 |
Dehning S et al. | Symptom exacerbation in tourette syndrome due to bacterial reinfection. | 2009 | J Clin Psychiatry | pmid:20031107 |
Srinivasan VB et al. | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. | 2009 | Antimicrob. Agents Chemother. | pmid:19770280 |
Stavri M et al. | Antibacterial diterpenes from Plectranthus ernstii. | 2009 | J. Nat. Prod. | pmid:19445517 |
Tanaka Y et al. | Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes. | 2009 | Appl. Environ. Microbiol. | pmid:19447953 |
Tyrrell GJ et al. | Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae pre- and post-seven valent pneumococcal conjugate vaccine introduction in Alberta, Canada, 2000-2006. | 2009 | Vaccine | pmid:19464534 |
Malc E et al. | Inactivation of the 20S proteasome maturase, Ump1p, leads to the instability of mtDNA in Saccharomyces cerevisiae. | 2009 | Mutat. Res. | pmid:19467248 |
Yam WK and Wahab HA | Molecular insights into 14-membered macrolides using the MM-PBSA method. | 2009 | J Chem Inf Model | pmid:19469526 |
Hu WS et al. | Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. | 2009 | Antimicrob. Agents Chemother. | pmid:19470505 |
Kadlec K and Schwarz S | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. | 2009 | Antimicrob. Agents Chemother. | pmid:19470508 |
Galaction AI et al. | [Separation of erythromycin by direct pertraction from simulated broths]. | 2009 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:21495378 |
Velicko I et al. | [Lymphogranuloma venereum--increased spread in Sweden. A rare Chlamydia subtype which become more and more common among men who have sex with men]. | 2009 Jan 7-13 | Lakartidningen | pmid:19235318 |
Corso A et al. | Prevalence of mef and ermB genes in invasive pediatric erythromycin-resistant Streptococcus pneumoniae isolates from Argentina. | 2009 Jan-Mar | Rev. Argent. Microbiol. | pmid:19391523 |
Cuffini AM et al. | The erythromycin-resistance in S. pyogenes does not limit the human polymorphonuclear cell antimicrobial activity. | 2009 Jan-Mar | Int J Immunopathol Pharmacol | pmid:19309572 |
Ciraj AM et al. | Inducible clindamycin resistance among clinical isolates of Staphylococci. | 2009 Jan-Mar | Indian J Pathol Microbiol | pmid:19136780 |
Pană M et al. | The in vitro susceptibility to 7 antibiotics of Neisseria meningitidis strains isolated last years in Romania. | 2009 Jan-Mar | Roum Arch Microbiol Immunol | pmid:19507626 |
Acke E et al. | Antimicrobial resistance profiles and mechanisms of resistance in Campylobacter jejuni isolates from pets. | 2009 Jul-Aug | Foodborne Pathog. Dis. | pmid:19580444 |
Begovic J et al. | Human vaginal Lactobacillus rhamnosus harbor mutation in 23S rRNA associated with erythromycin resistance. | 2009 Jul-Aug | Res. Microbiol. | pmid:19619642 |
Nasr I et al. | Effects of tegaserod and erythromycin in upper gut dysmotility: a comparative study. | 2009 Jul-Aug | Indian J Gastroenterol | pmid:19937173 |
Hernandez-Da-Mota S and Escalante-Razo F | Bartonellosis causing bilateral Leber neuroretinitis: a case report. | 2009 Mar-Apr | Eur J Ophthalmol | pmid:19253255 |
Lucas CR et al. | Granulomatous periorificial dermatitis: a variant of granulomatous rosacea in children? | 2009 Mar-Apr | J Cutan Med Surg | pmid:19298782 |
Como-Sabetti K et al. | Community-associated methicillin-resistant Staphylococcus aureus: trends in case and isolate characteristics from six years of prospective surveillance. | 2009 May-Jun | Public Health Rep | pmid:19445419 |
Gündüz O et al. | Childhood pityriasis rosea. | 2009 Nov-Dec | Pediatr Dermatol | pmid:20199459 |
Dickerson RN et al. | Disparate response to metoclopramide therapy for gastric feeding intolerance in trauma patients with and without traumatic brain injury. | 2009 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:19892902 |
Moloney J and Stassen LF | Antibiotics in odontogenic infection. | 2009 Oct-Nov | J Ir Dent Assoc | pmid:19928373 |
Pistorino M and Pfeifer BA | Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli. | 2009 Sep-Oct | Biotechnol. Prog. | pmid:19634176 |
Mohammadizadeh M et al. | Efficacy of prophylactic oral erythromycin to improve enteral feeding tolerance in preterm infants: a randomised controlled study. | 2010 | Singapore Med J | pmid:21221501 |
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Suzuki T et al. | Regulation of lankamycin biosynthesis in Streptomyces rochei by two SARP genes, srrY and srrZ. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20378964 |
Van den Bossche L et al. | An interlaboratory study on the suitability of a gradient LC-UV method as a compendial method for the determination of erythromycin and its related substances. | 2010 | J Pharm Biomed Anal | pmid:20381987 |
Cooke FJ et al. | Clinical, molecular and epidemiological description of a cluster of community-associated methicillin-resistant Staphylococcus aureus isolates from injecting drug users with bacteraemia. | 2010 | Clin. Microbiol. Infect. | pmid:19912266 |
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Wu Z et al. | Synthesis and antibacterial activity of novel 4''-carbamates of 6,11-di-O-methylerythromycin A. | 2010 | J. Antibiot. | pmid:20448668 |
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Alsuwaidi AR et al. | Corynebacterium macginleyi conjunctivitis in Canada. | 2010 | J. Clin. Microbiol. | pmid:20702661 |
Chang X et al. | Identifying modules of coexpressed transcript units and their organization of Saccharopolyspora erythraea from time series gene expression profiles. | 2010 | PLoS ONE | pmid:20711345 |
Joo HS et al. | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. | 2010 | Antimicrob. Agents Chemother. | pmid:20713669 |
Eggo MC | Molecular regulation of thyroid gland function. | 2010 | Curr Opin Endocrinol Diabetes Obes | pmid:20616713 |
Hippalgaonkar K et al. | Interaction between topically and systemically coadministered P-glycoprotein substrates/inhibitors: effect on vitreal kinetics. | 2010 | Drug Metab. Dispos. | pmid:20595378 |
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Lehtopolku M et al. | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. | 2010 | Antimicrob. Agents Chemother. | pmid:20038624 |
McLemore R et al. | Development of a transmucosal technique for erythromycin delivery to treat gastroparesis. | 2010 | J Pharm Sci | pmid:20039386 |
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Jeong JW et al. | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. | 2010 | Antimicrob. Agents Chemother. | pmid:20855730 |
Chakraborty A et al. | In vitro sensitivity and resistance of 46 Leptospira strains isolated from rats in the Philippines to 14 antimicrobial agents. | 2010 | Antimicrob. Agents Chemother. | pmid:20855741 |
Donati M et al. | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. | 2010 | Antimicrob. Agents Chemother. | pmid:20855744 |
Floyd JL et al. | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. | 2010 | Antimicrob. Agents Chemother. | pmid:20855745 |