erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Classen DC et al. | Clinical and financial impact of intravenous erythromycin therapy in hospitalized patients. | 1999 | Ann Pharmacother | pmid:10410176 |
Lacey RW and Lewis EL | Further evolution of a strain of Staphylococcus aureus in vivo: evidence for significant inactivation of flucloxacillin by penicillinase. | 1975 | J. Med. Microbiol. | pmid:1040676 |
Ullmann U et al. | Comparative in-vitro activity of levofloxacin, other fluoroquinolones, doxycycline and erythromycin against Ureaplasma urealyticum and Mycoplasma hominis. | 1999 | J. Antimicrob. Chemother. | pmid:10404335 |
Bent S et al. | Antibiotics in acute bronchitis: a meta-analysis. | 1999 | Am. J. Med. | pmid:10403354 |
Vesce F et al. | Effect of different classes of antibiotics on amniotic prostaglandin E release. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10402215 |
Watanabe M et al. | Role of CYP3A in haloperidol N-dealkylation and pharmacokinetics in rats. | 1999 | Fundam Clin Pharmacol | pmid:10392310 |
Kawanami R et al. | [Successful treatment of allergic bronchopulmonary aspergillosis with erythromycin and fluconazole]. | 1999 | Nihon Kokyuki Gakkai Zasshi | pmid:10390974 |
Mazzei T et al. | Pharmacokinetics of dirithromycin in patients with mild or moderate cirrhosis. | 1999 | Antimicrob. Agents Chemother. | pmid:10390202 |
Tanaka T et al. | Effect of EM574 on postprandial pancreaticobiliary secretion, gastric motor activity, and emptying in conscious dogs. | 1999 | Dig. Dis. Sci. | pmid:10389679 |
Cook M and Lynch WH | A sensitive nested reverse transcriptase PCR assay to detect viable cells of the fish pathogen Renibacterium salmoninarum in Atlantic salmon (Salmo salar L.). | 1999 | Appl. Environ. Microbiol. | pmid:10388701 |
Francis GS | Cardiac complications in the intensive care unit. | 1999 | Clin. Chest Med. | pmid:10386256 |
Valisena S et al. | Molecular typing of erythromycin-resistant streptococcus pyogenes strains with the M phenotype isolated in Italy. | 1999 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:10385014 |
Tzelepi E et al. | Erythromycin resistance amongst group A beta-haemolytic streptococci isolated in a paediatric hospital in Athens, Greece. | 1999 | J. Antimicrob. Chemother. | pmid:10382903 |
McConnell SA et al. | Lack of effect of dirithromycin on theophylline pharmacokinetics in healthy volunteers. | 1999 | J. Antimicrob. Chemother. | pmid:10382900 |
Bébéar CM et al. | In-vitro activity of grepafloxacin, a new fluoroquinolone, against mycoplasmas. | 1999 | J. Antimicrob. Chemother. | pmid:10382895 |
Nishijima T et al. | Distribution of mefE and ermB genes in macrolide-resistant strains of Streptococcus pneumoniae and their variable susceptibility to various antibiotics. | 1999 | J. Antimicrob. Chemother. | pmid:10382884 |
Ruckdeschel G and Dalhoff A | The in-vitro activity of moxifloxacin against Legionella species and the effects of medium on susceptibility test results. | 1999 | J. Antimicrob. Chemother. | pmid:10382872 |
Feighner SD et al. | Receptor for motilin identified in the human gastrointestinal system. | 1999 | Science | pmid:10381885 |
Huber R et al. | Increase of cellular hypoxic tolerance by erythromycin and other antibiotics. | 1999 | Neuroreport | pmid:10380977 |
Hägg S et al. | Absence of interaction between erythromycin and a single dose of clozapine. | 1999 | Eur. J. Clin. Pharmacol. | pmid:10379638 |
Griga T et al. | [Effect of stomach motility on measuring stomach permeability with saccharose in vivo]. | 1999 | Z Gastroenterol | pmid:10378362 |
Alvarez-Elcoro S and Enzler MJ | The macrolides: erythromycin, clarithromycin, and azithromycin. | 1999 | Mayo Clin. Proc. | pmid:10377939 |
Taege AJ | Listeriosis: recognizing it, treating it, preventing it. | 1999 | Cleve Clin J Med | pmid:10375847 |
Gao W et al. | [Analysis of 9 cases of pulmonary tuberculosis complicated with legionnaires disease]. | 1997 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:10374448 |
Hume EB et al. | Clarithromycin for experimental Staphylococcus aureus keratitis. | 1999 | Curr. Eye Res. | pmid:10372997 |
Arum ES and Jacobs NF | Nongonococcal urethritis. | 1976 | Cutis | pmid:1037101 |
Gregory ST and Dahlberg AE | Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA. | 1999 | J. Mol. Biol. | pmid:10369764 |
Cilostazol for intermittent claudication. | 1999 | Med Lett Drugs Ther | pmid:10368703 | |
Petrakis IE et al. | Hyperglycaemia attenuates erythromycin-induced acceleration of solid-phase gastric emptying in idiopathic and diabetic gastroparesis. | 1999 | Scand. J. Gastroenterol. | pmid:10365900 |
Schulte W et al. | [Diffuse panbronchiolitis. A rare differential diagnosis of chronic obstructive lung disease]. | 1999 | Dtsch. Med. Wochenschr. | pmid:10365176 |
Tamayo M et al. | Dissemination of a chloramphenicol- and tetracycline-resistant but penicillin-susceptible invasive clone of serotype 5 Streptococcus pneumoniae in Colombia. | 1999 | J. Clin. Microbiol. | pmid:10364609 |
Viñado B et al. | [Resistance to erythromycin in strains of Streptococcus pyogenes isolated in the province of Barcelona]. | 1999 | Med Clin (Barc) | pmid:10363246 |
Irokawa T et al. | Cholinomimetic action of macrolide antibiotics on airway gland electrolyte secretion. | 1999 | Am. J. Physiol. | pmid:10362719 |
Janovska D et al. | Administration of antibiotics in combination. Determination of antibacterial effectivity of blood serum and urine after simultaneous administration of macrolides and tetracyclines. | 1976 | J Hyg Epidemiol Microbiol Immunol | pmid:1035924 |
Kalima P et al. | Epidemiology of Streptococcus pneumoniae infections at the Edinburgh City Hospital: 1980-95. | 1999 | Epidemiol. Infect. | pmid:10355789 |
Leal AL and Castañeda E | [Susceptibility to antimicrobial agents in isolates from invasive Streptococcus pneumoniae in Colombia]. | 1999 | Rev. Panam. Salud Publica | pmid:10355313 |
Erickson PR and Herzberg MC | Emergence of antibiotic resistant Streptococcus sanguis in dental plaque of children after frequent antibiotic therapy. | 1999 May-Jun | Pediatr Dent | pmid:10355009 |
Fearfield LA and Staughton RC | Severe vulval apocrine acne successfully treated with prednisolone and isotretinoin. | 1999 | Clin. Exp. Dermatol. | pmid:10354177 |
Rosato A et al. | Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin. | 1999 | J. Antimicrob. Chemother. | pmid:10350387 |
Wasilewski MM et al. | Five-day dirithromycin therapy is as effective as seven-day erythromycin therapy for acute exacerbations of chronic bronchitis. | 1999 | J. Antimicrob. Chemother. | pmid:10350384 |
Simon MW | Treatment of acute sinusitis in childhood with ceftibuten. | 1999 | Clin Pediatr (Phila) | pmid:10349523 |
Greiver M | Practice tips. Incorporating a rapid group A streptococcus assay with the sore throat score. | 1999 | Can Fam Physician | pmid:10349060 |
Roberts MC et al. | Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes. | 1999 | Antimicrob. Agents Chemother. | pmid:10348754 |
Champney WS and Tober CL | Molecular investigation of the postantibiotic effects of clarithromycin and erythromycin on Staphylococcus aureus cells. | 1999 | Antimicrob. Agents Chemother. | pmid:10348746 |
Dujovne CA | Experimental investigations on the different hepatotoxic potential of erythromycin derivatives. | 1976 | Med Chir Dig | pmid:1034861 |
Mikami Y et al. | Production of erythromycin E by pathogenic Nocardia brasiliensis. | 1999 | J. Antibiot. | pmid:10344579 |
Parsons IC et al. | Structural elucidation of a novel erythromycin, 13-cyclopentyl-13-desethyl-erythromycin B, from a recombinant Saccharopolyspora erythraea strain, NRRL 2338 pIG/1. | 1999 | J. Antibiot. | pmid:10344576 |
Levert H et al. | Time and concentration dependent influence of dirithromycin on neutrophils oxidative burst. | 1999 | J. Antibiot. | pmid:10344566 |
Mertens PR et al. | Long-term extracorporeal bilirubin elimination: A case report on cascade resin plasmaperfusion. | 1998 | Blood Purif. | pmid:10343081 |
Dornbusch K et al. | Postantibiotic effect and postantibiotic sub-mic effect of dirithromycin and erythromycin against respiratory tract pathogenic bacteria. | 1999 | APMIS | pmid:10335955 |
Jones KL et al. | Hyperglycemia attenuates the gastrokinetic effect of erythromycin and affects the perception of postprandial hunger in normal subjects. | 1999 | Diabetes Care | pmid:10333955 |
Wu SW et al. | The Staphylococcus aureus transposon Tn551: complete nucleotide sequence and transcriptional analysis of the expression of the erythromycin resistance gene. | 1999 | Microb. Drug Resist. | pmid:10332716 |
Bojarska-Dahlig H et al. | L-aspartate of erythromycin A cyclic 11,12-carbonate, a new semisynthetic erythromycin derivative. | 1976 | J. Antibiot. | pmid:1033178 |
Cazzola M et al. | Comparative study of dirithromycin and azithromycin in the treatment of acute bacterial exacerbations of chronic bronchitis. | 1999 | J Chemother | pmid:10326742 |
York MK et al. | Characterization of antimicrobial resistance in Streptococcus pyogenes isolates from the San Francisco Bay area of northern California. | 1999 | J. Clin. Microbiol. | pmid:10325315 |
van Ketel WG | Immediate- and delayed-type allergy to erythromycin. | 1976 | Contact Derm. | pmid:1032135 |
Fisher AA | The safety of topical erythromycin. | 1976 | Contact Derm. | pmid:1032121 |
Di Nucci A et al. | [Metabolism of erythromycin and erythromycin aspartate in the microsomal fraction of the rat liver]. | 1976 | Boll. Soc. Ital. Biol. Sper. | pmid:1030960 |
Baggot JD and Gingerich DA | Pharmacokinetic interpretation of erythromycin and tylosin activity in serum after intravenous administration of a single dose to cows. | 1976 | Res. Vet. Sci. | pmid:1030820 |
Manzo L et al. | [Effects of phenobarbital on the distribution of erythromycin and erythromycin aspartate in the rat]. | 1976 Jan-Jun | G Ital Chemioter | pmid:1029694 |
Stille W | [Legionnaire's disease]. | 1978 | MMW Munch Med Wochenschr | pmid:102952 |
Rosenthal AL et al. | Polyacrylic bone cement containing erythromycin and colistin. I. In vitro bacteriological activity and diffusion properties of erythromycin, colistin and erythromycin/colistin comibination. | 1976 | J. Int. Med. Res. | pmid:1028631 |
Melon J and Reginster M | [Passage into normal salivary, lacrimal and nasal secretions of ampicillin and erythromycin administered intramuscularly]. | 1976 | Acta Otorhinolaryngol Belg | pmid:1028340 |
Gregotti C et al. | [Effects of phenobarbital on the hepatic microsome metabolism of erythromycin in rats]. | 1976 | Boll. Soc. Ital. Biol. Sper. | pmid:1027460 |
Klein JO | Middle ear disease in children. | 1976 | Hosp Pract | pmid:1026633 |
Bystedt H et al. | Concentrations of azidocillin, erythromycin, doxycycline and clindamycin in human mandibular bone. | 1978 | Int J Oral Surg | pmid:102599 |
Morris LA and Kanouse DE | Consumer reactions to differing amounts of written drug information. | 1980 Jul-Aug | Drug Intell Clin Pharm | pmid:10247887 |
Tran JQ et al. | Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban. | 1999 | J Clin Pharmacol | pmid:10234600 |
Siedlik PH et al. | Erythromycin coadministration increases plasma atorvastatin concentrations. | 1999 | J Clin Pharmacol | pmid:10234598 |
Bassetti M et al. | Streptococcus pyogenes erythromycin resistance in Italy. | 1999 Mar-Apr | Emerging Infect. Dis. | pmid:10221991 |
Jackson LA et al. | Lack of association between first myocardial infarction and past use of erythromycin, tetracycline, or doxycycline. | 1999 Mar-Apr | Emerging Infect. Dis. | pmid:10221884 |
Perez-Trallero E et al. | Clonal differences among erythromycin-resistant Streptococcus pyogenes in Spain. | 1999 Mar-Apr | Emerging Infect. Dis. | pmid:10221875 |
Bercault N and Linassier P | [The value of sepsis isolation to diminish the spread of multidrug-resistant bacteria in intensive care. Consequences on the incidence of nosocomial infections]. | 1999 | Rev Med Interne | pmid:10220829 |
Torii A | [Effective treatment in combination with erythromycin and cisapride for chronic idiopathic intestinal pseudo-obstruction (CIIP)]. | 1999 | Nihon Shokakibyo Gakkai Zasshi | pmid:10214084 |
Kim RB et al. | Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. | 1999 | Pharm. Res. | pmid:10213372 |
Biedenbach DJ et al. | Comparative in vitro evaluation of dirithromycin tested against recent clinical isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae, including effects of medium supplements and test conditions on MIC results. | 1999 | Diagn. Microbiol. Infect. Dis. | pmid:10212755 |
Dubois J and St-Pierre C | In vitro activity of gatifloxacin, compared with ciprofloxacin, clarithromycin, erythromycin, and rifampin, against Legionella species. | 1999 | Diagn. Microbiol. Infect. Dis. | pmid:10212753 |
Betriu C et al. | Incidence of erythromycin resistance in Streptococcus pyogenes: a 10-year study. | 1999 | Diagn. Microbiol. Infect. Dis. | pmid:10212752 |
McConnell SA and Amsden GW | Review and comparison of advanced-generation macrolides clarithromycin and dirithromycin. | 1999 | Pharmacotherapy | pmid:10212011 |
Lakritz J et al. | Comparison of microbiologic and high-performance liquid chromatography assays to determine plasma concentrations, pharmacokinetics, and bioavailability of erythromycin base in plasma of foals after intravenous or intragastric administration. | 1999 | Am. J. Vet. Res. | pmid:10211682 |
Tarsi R and Vitali C | [Erythromycin: serum and urine levels following rectal administration (author's transl)]. | 1976 Jul-Aug | Ann Sclavo | pmid:1020971 |
Burstin PP and Marshall CL | Infectious mononucleosis and bilateral peritonsillar abscesses resulting in airway obstruction. | 1998 | J Laryngol Otol | pmid:10209619 |
Imshenetskaia VF | [Erythromycin penetration into the cerebrospinal fluid of patients]. | 1976 | Antibiotiki | pmid:1020930 |
Mishra A et al. | The effects of erythromycin on the electrocardiogram. | 1999 | Chest | pmid:10208196 |
Vyhnálek J | [Distribution of erythromycin following intramuscular administration in laboratory animals]. | 1978 | Vet Med (Praha) | pmid:102070 |
Vermeulen B et al. | The formulation and stability of erythromycin-benzoyl peroxide in a topical gel. | 1999 | Int J Pharm | pmid:10205634 |
Sefton AM | Macrolides and changes in the oral flora. | 1999 | Int. J. Antimicrob. Agents | pmid:10204636 |
MiliavskiÄ AI and Kostenko AM | [Early prevention of syphilis (experimental study)]. | 1976 | Vestn Dermatol Venerol | pmid:1020461 |
Vasil'ev TV et al. | [Immediate results of treatment of syphilis with erythromycin simultaneously with bismuth preparations]. | 1976 | Vestn Dermatol Venerol | pmid:1020453 |
Hall JA and Washabau RJ | Diagnosis and treatment of gastric motility disorders. | 1999 | Vet. Clin. North Am. Small Anim. Pract. | pmid:10202795 |
Scarpignato C and Pelosini I | Management of irritable bowel syndrome: novel approaches to the pharmacology of gut motility. | 1999 | Can. J. Gastroenterol. | pmid:10202210 |
Jarrett F et al. | Antibiotic bowel preparation and burn wound colonization. | 1976 | Surg Forum | pmid:1019996 |
Sakaeva DD and Lazareva DN | [The effect of erythromycin on immunity in immunodeficiency]. | 1999 Jan-Feb | Eksp Klin Farmakol | pmid:10198768 |
Montenez JP et al. | Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10198278 |
Dorner S and Barta A | Probing ribosome structure by europium-induced RNA cleavage. | 1999 | Biol. Chem. | pmid:10195431 |
Stenson BJ et al. | Influence of erythromycin on establishment of feeding in preterm infants: observations from a randomised controlled trial. | 1998 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:10194995 |
Isohanni MH et al. | Effect of erythromycin and itraconazole on the pharmacokinetics of oral lignocaine. | 1999 | Pharmacol. Toxicol. | pmid:10193676 |
Mthwalo M et al. | Antibiotic resistance of nasopharyngeal isolates of Streptococcus pneumoniae from children in Lesotho. | 1998 | Bull. World Health Organ. | pmid:10191560 |
Kinirons MT et al. | Effects of ketoconazole on the erythromycin breath test and the dapsone recovery ratio. | 1999 | Br J Clin Pharmacol | pmid:10190659 |
Karlsson M et al. | Genetic basis of macrolide and lincosamide resistance in Brachyspira (Serpulina) hyodysenteriae. | 1999 | FEMS Microbiol. Lett. | pmid:10188254 |