erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chen C et al. | Blocking the flow of propionate into TCA cycle through a mutB knockout leads to a significant increase of erythromycin production by an industrial strain of Saccharopolyspora erythraea. | 2017 | Bioprocess Biosyst Eng | pmid:27709326 |
Kasetty G et al. | The Nonantibiotic Macrolide EM703 Improves Survival in a Model of Quinolone-Treated Pseudomonas aeruginosa Airway Infection. | 2017 | Antimicrob. Agents Chemother. | pmid:28652240 |
Di Sante L et al. | pHTβ-promoted mobilization of non-conjugative resistance plasmids from Enterococcus faecium to Enterococcus faecalis. | 2017 | J. Antimicrob. Chemother. | pmid:28645197 |
Ramos CJ and Antonetti DA | The role of small GTPases and EPAC-Rap signaling in the regulation of the blood-brain and blood-retinal barriers. | 2017 | Tissue Barriers | pmid:28632993 |
Sader HS et al. | Antimicrobial Susceptibility Trends among Staphylococcus aureus Isolates from U.S. Hospitals: Results from 7 Years of the Ceftaroline (AWARE) Surveillance Program, 2010 to 2016. | 2017 | Antimicrob. Agents Chemother. | pmid:28630196 |
Post A et al. | Antibiotic susceptibility profiles among Campylobacter isolates obtained from international travelers between 2007 and 2014. | 2017 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:28623550 |
Gonser LI et al. | Systemic therapy of ocular and cutaneous rosacea in children. | 2017 | J Eur Acad Dermatol Venereol | pmid:28621909 |
Ishikawa Y et al. | Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin. | 2017 | Biopharm Drug Dispos | pmid:28425104 |
Rea E and Husbands E | Erythromycin: prophylaxis against recurrent small bowel obstruction. | 2017 | BMJ Support Palliat Care | pmid:28356304 |
Hawkins PA et al. | Cross-resistance to lincosamides, streptogramins A and pleuromutilins in Streptococcus agalactiae isolates from the USA. | 2017 | J. Antimicrob. Chemother. | pmid:28333320 |
Jia L et al. | Synthesis and antibacterial evaluation of novel 11-O-carbamoyl clarithromycin ketolides. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28711353 |
Adhikari RP et al. | Inducible clindamycin and methicillin resistant Staphylococcus aureus in a tertiary care hospital, Kathmandu, Nepal. | 2017 | BMC Infect. Dis. | pmid:28693489 |
Wang HK et al. | Clinical features and molecular characteristics of childhood community-associated methicillin-resistant Staphylococcus aureus infection in a medical center in northern Taiwan, 2012. | 2017 | BMC Infect. Dis. | pmid:28679429 |
Haynes KM et al. | Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli. | 2017 | J. Med. Chem. | pmid:28650638 |
Dalal A et al. | Interventions for the prevention of recurrent erysipelas and cellulitis. | 2017 | Cochrane Database Syst Rev | pmid:28631307 |
Štšepetova J et al. | Assessment of phenotypic and genotypic antibiotic susceptibility of vaginal Lactobacillus sp. | 2017 | J. Appl. Microbiol. | pmid:28574626 |
Tanaka Y et al. | Applicability of ribosome engineering to vitamin B12 production by Propionibacterium shermanii. | 2017 | Biosci. Biotechnol. Biochem. | pmid:28532245 |
Demczuk WHB et al. | Phylogenetic analysis of emergent Streptococcus pneumoniae serotype 22F causing invasive pneumococcal disease using whole genome sequencing. | 2017 | PLoS ONE | pmid:28531208 |
Cheled-Shoval S et al. | From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds. | 2017 | Molecules | pmid:28513558 |
Sato T et al. | Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA. | 2017 | Microbiol. Immunol. | pmid:28504455 |
Wozniak A et al. | Importance of adhesins in the recurrence of pharyngeal infections caused by Streptococcus pyogenes. | 2017 | J. Med. Microbiol. | pmid:28463664 |
Pavlova A et al. | Toward the rational design of macrolide antibiotics to combat resistance. | 2017 | Chem Biol Drug Des | pmid:28419786 |
Szczepanska B et al. | Prevalence and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolated from children and environmental sources in urban and suburban areas. | 2017 | BMC Microbiol. | pmid:28376713 |
Mingmongkolchai S and Panbangred W | In vitro evaluation of candidate Bacillus spp. for animal feed. | 2017 | J. Gen. Appl. Microbiol. | pmid:28331163 |
Attaran B et al. | Effect of biofilm formation by clinical isolates of on the efflux-mediated resistance to commonly used antibiotics. | 2017 | World J. Gastroenterol. | pmid:28275296 |
Nowakiewicz A et al. | Determination of antimicrobial resistance of Enterococcus strains isolated from pigs and their genotypic characterization by method of amplification of DNA fragments surrounding rare restriction sites (ADSRRS fingerprinting). | 2017 | J. Med. Microbiol. | pmid:28260584 |
Hodge S et al. | Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases. | 2017 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:28258107 |
Lee JH et al. | Genetic Diversity and Antibiotic Resistance of Enterococcus faecalis Isolates from Traditional Korean Fermented Soybean Foods. | 2017 | J. Microbiol. Biotechnol. | pmid:28237994 |
Calle-Miguel L et al. | [Resistance rates and phenotypic characterization of Streptococcus pyogenes in a paediatric population in Northern Spain (2005-2015)]. | 2017 | Rev Esp Quimioter | pmid:28233483 |
Selwood DL | Macrocycles, the edge of drug-likeness chemical space or Goldilocks zone? | 2017 | Chem Biol Drug Des | pmid:28205398 |
Pergola S et al. | Genetic diversity and antimicrobial resistance profiles of Campylobacter coli and Campylobacter jejuni isolated from broiler chicken in farms and at time of slaughter in central Italy. | 2017 | J. Appl. Microbiol. | pmid:28194914 |
Huang YW et al. | Overexpression of SmeDEF Efflux Pump Decreases Aminoglycoside Resistance in Stenotrophomonas maltophilia. | 2017 | Antimicrob. Agents Chemother. | pmid:28193669 |
Ge LL et al. | [Antibiotic resistance analysis of isolates from the hospitalized children in Shanxi Children's Hospital from 2012 to 2014]. | 2017 | Zhonghua Er Ke Za Zhi | pmid:28173648 |
Giguère S | Treatment of Infections Caused by Rhodococcus equi. | 2017 | Vet. Clin. North Am. Equine Pract. | pmid:28161038 |
Wang Y et al. | Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28129976 |
Descours G et al. | Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila. | 2017 | Antimicrob. Agents Chemother. | pmid:28069647 |
Owen L et al. | A Multifactorial Comparison of Ternary Combinations of Essential Oils in Topical Preparations to Current Antibiotic Prescription Therapies for the Control of Acne Vulgaris-Associated Bacteria. | 2017 | Phytother Res | pmid:28124400 |
Chen K et al. | Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China. | 2017 | BMC Infect. Dis. | pmid:28122513 |
Berni E et al. | Risk of cardiovascular events, arrhythmia and all-cause mortality associated with clarithromycin versus alternative antibiotics prescribed for respiratory tract infections: a retrospective cohort study. | 2017 | BMJ Open | pmid:28115334 |
Wei L et al. | Transformation of erythromycin during secondary effluent soil aquifer recharging: Removal contribution and degradation path. | 2017 | J Environ Sci (China) | pmid:28115128 |
Koryakina I et al. | Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. | 2017 | ACS Chem. Biol. | pmid:28103677 |
Sugimoto N et al. | Invasive pneumococcal disease caused by mucoid serotype 3 Streptococcus pneumoniae: a case report and literature review. | 2017 | BMC Res Notes | pmid:28057059 |
Liu J et al. | Modulation of erythromycin-induced biochemical responses in crucian carp by ketoconazole. | 2017 | Environ Sci Pollut Res Int | pmid:28004371 |
Li B et al. | Antimicrobial Resistance of Campylobacter Species Isolated from Broilers in Live Bird Markets in Shanghai, China. | 2017 | Foodborne Pathog. Dis. | pmid:27854542 |
Shrivastav AM et al. | Highly sensitive and selective erythromycin nanosensor employing fiber optic SPR/ERY imprinted nanostructure: Application in milk and honey. | 2017 | Biosens Bioelectron | pmid:27825873 |
Liu J et al. | Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea. | 2017 | Metab. Eng. | pmid:27794466 |
Kassem II et al. | Antimicrobial-Resistant Campylobacter in Organically and Conventionally Raised Layer Chickens. | 2017 | Foodborne Pathog. Dis. | pmid:27768387 |
Song KH et al. | Characteristics of cefazolin inoculum effect-positive methicillin-susceptible staphylococcus aureus infection in a multicentre bacteraemia cohort. | 2017 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:27714592 |
Kullin B et al. | Toxin A-negative toxin B-positive ribotype 017 Clostridium difficile is the dominant strain type in patients with diarrhoea attending tuberculosis hospitals in Cape Town, South Africa. | 2017 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:27696234 |
Pavlović D et al. | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. | 2017 | Eur J Med Chem | pmid:27657812 |
Marlow N et al. | The ORACLE Children Study: educational outcomes at 11 years of age following antenatal prescription of erythromycin or co-amoxiclav. | 2017 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:27515985 |
Austin BA and Fleischer AB | The extinction of topical erythromycin therapy for acne vulgaris and concern for the future of topical clindamycin. | 2017 | J Dermatolog Treat | pmid:27425633 |
Jakubů V et al. | Trends in the Minimum Inhibitory Concentrations of Erythromycin, Clarithromycin, Azithromycin, Ciprofloxacin, and Trimethoprim/Sulfamethoxazole for Strains of Bordetella pertussis isolated in the Czech Republic in 1967-2015. | 2017 | Cent. Eur. J. Public Health | pmid:29346850 |
Romero L et al. | Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults. | 2017 | Cochrane Database Syst Rev | pmid:29226307 |
Naimi HM et al. | Determination of antimicrobial susceptibility patterns in Staphylococcus aureus strains recovered from patients at two main health facilities in Kabul, Afghanistan. | 2017 | BMC Infect. Dis. | pmid:29187146 |
Ricker EB and Nuxoll E | Synergistic effects of heat and antibiotics on Pseudomonas aeruginosa biofilms. | 2017 | Biofouling | pmid:29039211 |
Bitew A et al. | Species distribution and antibiotic susceptibility profile of bacterial uropathogens among patients complaining urinary tract infections. | 2017 | BMC Infect. Dis. | pmid:28962545 |
Öksüz L and Gürler N | [Serotype distribution and antibiotic resistance of Streptococcus pneumoniae strains isolated from the adult patients in a Turkish üniversity hospital]. | 2017 | Mikrobiyol Bul | pmid:28929957 |
GarcÃa-Iglesias P et al. | Management of non variceal upper gastrointestinal bleeding: position statement of the Catalan Society of Gastroenterology. | 2017 | Gastroenterol Hepatol | pmid:28109636 |
Argemi X et al. | VISLISI trial, a prospective clinical study allowing identification of a new metalloprotease and putative virulence factor from Staphylococcus lugdunensis. | 2017 | Clin. Microbiol. Infect. | pmid:28017792 |
Ksia S et al. | Molecular Characteristics of Erythromycin-Resistant Streptococcus pyogenes Strains Isolated from Children Patients in Tunis, Tunisia. | 2017 | Microb. Drug Resist. | pmid:27991848 |
Olajuyigbe OO et al. | In vitro pharmacological interaction of caffeine and first-line antibiotics is antagonistic against clinically important bacterial pathogens. | 2017 | Acta Biochim. Pol. | pmid:28612062 |
Pfaller MA et al. | Ceftaroline Activity Against Multidrug-Resistant Streptococcus pneumoniae from U.S. Medical Centers (2014) and Molecular Characterization of a Single Ceftaroline Nonsusceptible Isolate. | 2017 | Microb. Drug Resist. | pmid:27918694 |
Chang KH et al. | Comparison of antibiotic regimens in preterm premature rupture of membranes: neonatal morbidity and 2-year follow-up of neurologic outcome. | 2017 | J. Matern. Fetal. Neonatal. Med. | pmid:27687157 |
Yi M et al. | Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis. | 2017 | Arch. Biochem. Biophys. | pmid:28347661 |
Weber JM et al. | Application of In Vitro Transposon Mutagenesis to Erythromycin Strain Improvement in Saccharopolyspora erythraea. | 2017 | Methods Mol. Biol. | pmid:27709581 |
Duelge KJ et al. | An LC-MS/MS method for the determination of antibiotic residues in distillers grains. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28415016 |
Svetlov MS et al. | Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29229833 |
Atkinson CT et al. | Expression of acquired macrolide resistance genes in Haemophilus influenzae. | 2017 | J. Antimicrob. Chemother. | pmid:28961896 |
Tay JH et al. | Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis. | 2017 | J. Am. Chem. Soc. | pmid:28627172 |
Hong M et al. | C-assisted metabolomics analysis reveals the positive correlation between specific erythromycin production rate and intracellular propionyl-CoA pool size in Saccharopolyspora erythraea. | 2017 | Bioprocess Biosyst Eng | pmid:28567527 |
Na HK et al. | Erythromycin infusion prior to endoscopy for acute nonvariceal upper gastrointestinal bleeding: a pilot randomized controlled trial. | 2017 | Korean J. Intern. Med. | pmid:28352063 |
Li LH et al. | [Effect of low dose erythromycin on the proliferation of granulation tissue after tracheal injury]. | 2017 | Zhonghua Yi Xue Za Zhi | pmid:28316160 |
Fohner AE et al. | PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics. | 2017 | Pharmacogenet. Genomics | pmid:28146011 |
Michael-Kordatou I et al. | On the capacity of ozonation to remove antimicrobial compounds, resistant bacteria and toxicity from urban wastewater effluents. | 2017 | J. Hazard. Mater. | pmid:26947803 |
Wang B et al. | Acid or erythromycin stress significantly improves transformation efficiency through regulating expression of DNA binding proteins in Lactococcus lactis F44. | 2017 | J. Dairy Sci. | pmid:28987584 |
Quinn KL et al. | Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. | 2017 | Drug Saf | pmid:28421551 |
Zhao L et al. | Occurrence of erythromycin and its degradation products residues in honey. Validation of an analytical method. | 2017 | J Sep Sci | pmid:28121061 |
Dreno B et al. | Skin microbiome and acne vulgaris: Staphylococcus, a new actor in acne. | 2017 | Exp. Dermatol. | pmid:28094874 |
Stieler AL et al. | Macrolide-induced hyperthermia in foals: Role of impaired sweat responses. | 2016 | Equine Vet. J. | pmid:26174202 |
Ray D et al. | Molecular characterization and evaluation of the emerging antibiotic-resistant Streptococcus pyogenes from eastern India. | 2016 | BMC Infect. Dis. | pmid:27955635 |
Ma Y et al. | Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates from a hospital in Shanghai, China. | 2016 | Front Med | pmid:27896620 |
Abreu AC et al. | Combinatorial approaches with selected phytochemicals to increase antibiotic efficacy against Staphylococcus aureus biofilms. | 2016 | Biofouling | pmid:27643487 |
Jurado-Tarifa E et al. | Genetic diversity and antimicrobial resistance of Campylobacter and Salmonella strains isolated from decoys and raptors. | 2016 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:27638115 |
Hu Z et al. | Short-term performance of enhanced biological phosphorus removal (EBPR) system exposed to erythromycin (ERY) and oxytetracycline (OTC). | 2016 | Bioresour. Technol. | pmid:27631889 |
Benamrouche N et al. | Microbiological and molecular characterization of Corynebacterium diphtheriae isolated in Algeria between 1992 and 2015. | 2016 | Clin. Microbiol. Infect. | pmid:27585941 |
Mushtaq A et al. | Differential Antimicrobial Susceptibilities of Granulicatella adiacens and Abiotrophia defectiva. | 2016 | Antimicrob. Agents Chemother. | pmid:27216060 |
Hong M et al. | Impacts of proline on the central metabolism of an industrial erythromycin-producing strain Saccharopolyspora erythraea via (13)C labeling experiments. | 2016 | J. Biotechnol. | pmid:27215341 |
StaceviÄienÄ— I et al. | Antibiotic resistance of Streptococcus pneumoniae, isolated from nasopharynx of preschool children with acute respiratory tract infection in Lithuania. | 2016 | BMC Infect. Dis. | pmid:27206423 |
Tatiya-Aphiradee N et al. | In vivo antibacterial activity of Garcinia mangostana pericarp extract against methicillin-resistant Staphylococcus aureus in a mouse superficial skin infection model. | 2016 | Pharm Biol | pmid:27180784 |
He M et al. | Mechanism of synergy between SIPI-8294 and β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. | 2016 | Lett. Appl. Microbiol. | pmid:27173151 |
Taylor SJ et al. | A randomised controlled feasibility and proof-of-concept trial in delayed gastric emptying when metoclopramide fails: We should revisit nasointestinal feeding versus dual prokinetic treatment: Achieving goal nutrition in critical illness and delayed gastric emptying: Trial of nasointestinal feeding versus nasogastric feeding plus prokinetics. | 2016 | Clin Nutr ESPEN | pmid:28531392 |
Guo Q et al. | Controlling the feed rate of propanol to optimize erythromycin fermentation by on-line capacitance and oxygen uptake rate measurement. | 2016 | Bioprocess Biosyst Eng | pmid:26615414 |
Liu H et al. | [A systematic review of the therapy for Mycoplasma pneumoniae infections in children]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:26875461 |
Poliquin V et al. | Preparedness for Implementing Change in Neonatal Ocular Prophylaxis Policies. | 2016 | J Obstet Gynaecol Can | pmid:26872748 |
Bouvet L et al. | Ultrasound Assessment of the Prokinetic Effect of Erythromycin in Trauma Patients with a Full Stomach: A Case Series. | 2016 | Anesth. Analg. | pmid:26859878 |
Moltó-GarcÃa B et al. | Molecular characterization and antimicrobial susceptibility of hemolytic Streptococcus agalactiae from post-menopausal women. | 2016 | Maturitas | pmid:26857873 |
Sari E et al. | Fabrication of surface plasmon resonance nanosensor for the selective determination of erythromycin via molecular imprinted nanoparticles. | 2016 | Talanta | pmid:26838449 |
Caspi M et al. | A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents. | 2016 | J. Mol. Med. | pmid:26620677 |
Yuan SF et al. | Levels of six antibiotics used in China estimated by means of wastewater-based epidemiology. | 2016 | Water Sci. Technol. | pmid:26901719 |