erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Janković S et al. | A case of syphilitic interstitial pulmonary fibrosis. | 1998 | Croat. Med. J. | pmid:9841951 |
Drici MD et al. | Cardiac actions of erythromycin: influence of female sex. | 1998 | JAMA | pmid:9842954 |
Tan HH et al. | Bacterial skin infections at a tertiary dermatological centre. | 1998 | Singapore Med J | pmid:9844495 |
BÃ¥verud V et al. | Clostridium difficile associated with acute colitis in mares when their foals are treated with erythromycin and rifampicin for Rhodococcus equi pneumonia. | 1998 | Equine Vet. J. | pmid:9844966 |
Santoro J et al. | In vitro activity of josamycin and rosamicin against Bacteroides fragilis compared with clindamycin, erythromycin, and metronidazole. | 1976 | Antimicrob. Agents Chemother. | pmid:984752 |
Strausbaugh LJ et al. | Comparative pharmacology of josamycin and erythromycin stearate. | 1976 | Antimicrob. Agents Chemother. | pmid:984786 |
Shadomy S et al. | Josamycin and rosamicin: in vitro comparisons with erythromycin and clindamycin. | 1976 | Antimicrob. Agents Chemother. | pmid:984811 |
Johnson AP et al. | In-vitro activity of sanfetrinem against isolates of Streptococcus pneumoniae and Staphylococcus aureus. | 1998 | J. Antimicrob. Chemother. | pmid:9848449 |
Soriano F et al. | In-vitro antimicrobial activity of HMR 3004 (RU 64004) against erythromycin A-sensitive and -resistant Corynebacterium spp. isolated from clinical specimens. | 1998 | J. Antimicrob. Chemother. | pmid:9848450 |
Barry AL et al. | Susceptibility to RPR 106,972, quinupristin/dalfopristin and erythromycin among recent clinical isolates of enterococci, staphylococci and streptococci from North American medical centres. | 1998 | J. Antimicrob. Chemother. | pmid:9848451 |
Belkengren R and Sapala S | Pediatric management problems. Left corneal abrasion. | 1998 Jul-Aug | Pediatr Nurs | pmid:9849269 |
Yamazaki H and Shimada T | Formation in vitro of an inhibitory cytochrome P450 x Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes. | 1998 | Xenobiotica | pmid:9849646 |
Roy SK et al. | A randomized clinical trial to compare the efficacy of erythromycin, ampicillin and tetracycline for the treatment of cholera in children. | 1998 Jul-Aug | Trans. R. Soc. Trop. Med. Hyg. | pmid:9850410 |
Hsueh PR et al. | Dissemination of high-level penicillin-, extended-spectrum cephalosporin-, and erythromycin-resistant Streptococcus pneumoniae clones in Taiwan. | 1999 | J. Clin. Microbiol. | pmid:9854097 |
Weissman KJ et al. | Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase. | 1998 | Chem. Biol. | pmid:9862800 |
Unge J et al. | The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance. | 1998 | Structure | pmid:9862810 |
Coulie B et al. | Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans. | 1998 | Gut | pmid:9863486 |
Delaforge M | Importance of metabolism in pharmacological studies: possible in vitro predictability. | 1998 | Nucl. Med. Biol. | pmid:9863553 |
Toyota K | Pyloric opening and closure evaluated by means of strain gauge force transducers. | 1998 | J Smooth Muscle Res | pmid:9866113 |
Wald ER | Sinusitis. | 1998 | Pediatr Ann | pmid:9866138 |
Frick PA et al. | Prevalence of antimicrobial drug-resistant Streptococcus pneumoniae in Washington State. | 1998 | West. J. Med. | pmid:9866434 |
Kataja J et al. | Erythromycin resistance genes in group A streptococci in Finland. The Finnish Study Group for Antimicrobial Resistance. | 1999 | Antimicrob. Agents Chemother. | pmid:9869564 |
Faghih R et al. | Preparation of 9-deoxo-4"-deoxy-6,9-epoxyerythromycin lactams "motilactides": potent and orally active prokinetic agents. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871545 |
Waddell ST et al. | Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: I. 4", 11 and 12-OMe derivatives via direct methylation. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871616 |
Brand RE et al. | Gastroparesis as a cause of nausea and vomiting after high-dose chemotherapy and haemopoietic stem-cell transplantation. | 1998 Dec 19-26 | Lancet | pmid:9872252 |
Denis A and Agouridas C | Synthesis of 6-O-methyl-azithromycin and its ketolide analogue via Beckmann rearrangement of 9(E)-6-O-methyl-erythromycin oxime. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873555 |
Sol V et al. | Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873665 |
Manna PK and Basu SK | Preparation and evaluation of erythromycin fumarate--a new derivative of erythromycin. | 1998 | Drug Dev Ind Pharm | pmid:9876541 |
Zgurskaya HI and Nikaido H | AcrA is a highly asymmetric protein capable of spanning the periplasm. | 1999 | J. Mol. Biol. | pmid:9878415 |
Muller-Serieys C | [Bacterial resistance and new therapeutic perspectives]. | 1998 | Presse Med | pmid:9879336 |
Khanna M et al. | Selection of suitable marker genes for the development of cloning vectors and electroporation in different strains of Amycolatopsis mediterranei. | 1998 | Microbiol. Res. | pmid:9880927 |
Riippi M et al. | The effect of compression force on surface structure, crushing strength, friability and disintegration time of erythromycin acistrate tablets. | 1998 | Eur J Pharm Biopharm | pmid:9885307 |
Wu K et al. | Enterococcus faecalis pheromone-responding plasmid pAD1 gives rise to an aggregation (clumping) response when cells are exposed to subinhibitory concentrations of chloramphenicol, erythromycin, or tetracycline. | 1999 | Plasmid | pmid:9887311 |
El Younis CM et al. | Rapid marked response of severe hyperemesis gravidarum to oral erythromycin. | 1998 | Am J Perinatol | pmid:9890250 |
Akiyama H et al. | Streptococci isolated from various skin lesions: the interaction with Staphylococcus aureus strains. | 1999 | J. Dermatol. Sci. | pmid:9890370 |
Matsubara S et al. | [Severe Legionella micdadei pneumonia effectively treated with hemofiltration therapy]. | 1998 | Nihon Kokyuki Gakkai Zasshi | pmid:9893432 |
Ziermann R and Betlach MC | Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains. | 1999 | BioTechniques | pmid:9894599 |
Karbowski M et al. | Free radical-induced megamitochondria formation and apoptosis. | 1999 | Free Radic. Biol. Med. | pmid:9895232 |
Petersdorf RG | Antimicrobial prophylaxis of bacterial endocarditis. Prudent caution or bacterial overkill? | 1978 | Am. J. Med. | pmid:99033 |
Kaji M et al. | [Effects of long-term preoperative administration of low-dose erythromycin on warm ischemia-reperfusion pulmonary injury]. | 1998 | Nihon Kokyuki Gakkai Zasshi | pmid:9916477 |
Calista D et al. | Guess What! Localised bacillary angiomatosis of the tongue. | 1998 | Eur J Dermatol | pmid:9917173 |
Pacey MS et al. | Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity. | 1998 | J. Antibiot. | pmid:9918396 |
Jensen LB et al. | Presence of erm gene classes in gram-positive bacteria of animal and human origin in Denmark. | 1999 | FEMS Microbiol. Lett. | pmid:9919664 |
Shelley WB et al. | Long-term antibiotic therapy for balanitis xerotica obliterans. | 1999 | J. Am. Acad. Dermatol. | pmid:9922014 |
Sanders CJ and Mulder MM | Periurethral gland abscess: aetiology and treatment. | 1998 | Sex Transm Infect | pmid:9924469 |
GarcÃa-Arata MI et al. | Mutations in 23S rRNA in Helicobacter pylori conferring resistance to erythromycin do not always confer resistance to clarithromycin. | 1999 | Antimicrob. Agents Chemother. | pmid:9925537 |
Gurycová D | First isolation of Francisella tularensis subsp. tularensis in Europe. | 1998 | Eur. J. Epidemiol. | pmid:9928875 |
Lau J et al. | Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. | 1999 | Biochemistry | pmid:9931032 |
Gore RM et al. | Drug-induced disorders of the stomach and duodenum. | 1999 Jan-Feb | Abdom Imaging | pmid:9933666 |
Montes LF | Familial benign chronic pemphigus (Hailey-Hailey disease). | 1976 | J. Cutan. Pathol. | pmid:993398 |