erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Altomare G et al. | Treatment of bullous pemphigoid with erythromycin: a reappraisal. | 1999 Oct-Nov | Eur J Dermatol | pmid:10610238 |
Czeizel AE et al. | A population-based case-control teratologic study of oral erythromycin treatment during pregnancy. | 1999 Nov-Dec | Reprod. Toxicol. | pmid:10613401 |
Urmösi J | [Thrombophlebitis of the sinus cavernosus]. | 1975 | Stomatol DDR | pmid:1061410 |
National guideline for the management of Chlamydia trachomatis genital tract infection. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). | 1999 | Sex Transm Infect | pmid:10616372 | |
National guideline for the management of non-gonococcal urethritis. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases) | 1999 | Sex Transm Infect | pmid:10616373 | |
National guideline for the management of early syphilis. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). | 1999 | Sex Transm Infect | pmid:10616379 | |
National guideline for the management of lymphogranuloma venereum. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). | 1999 | Sex Transm Infect | pmid:10616382 | |
National guideline for the management of chancroid. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). | 1999 | Sex Transm Infect | pmid:10616383 | |
Chieppa DM et al. | Effects of erythromycin on human colonic circular muscle in idiopathic chronic constipation. | 2000 | Eur. J. Clin. Invest. | pmid:10620004 |
Novikova SI et al. | Introduction of a mini-gene encoding a five-amino acid peptide confers erythromycin resistance on Bacillus subtilis and provides temporary erythromycin protection in Proteus mirabilis. | 2000 | FEMS Microbiol. Lett. | pmid:10620668 |
Desaki M et al. | Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623585 |
Kdesh A et al. | Effect of erythromycin on myocardial repolarization in patients with community-acquired pneumonia. | 1999 | South. Med. J. | pmid:10624910 |
Gallardo MA and Thomas I | Hypersensitivity reaction to erythromycin. | 1999 | Cutis | pmid:10626100 |
Lagrou K et al. | Macrolide resistance in Belgian Streptococcus pneumoniae. | 2000 | J. Antimicrob. Chemother. | pmid:10629023 |
GarcÃa Sánchez MJ et al. | [Bacterial resistances]. | 1999 | Aten Primaria | pmid:10630037 |
Sullivan S et al. | Stevens-Johnson syndrome secondary to erythromycin. | 1999 | Ann Pharmacother | pmid:10630839 |
Trinkle R | Comment: evaluation of the clinical and financial impact of intravenous erythromycin therapy in hospitalized patients. | 1999 | Ann Pharmacother | pmid:10630842 |
Puri SK and Singh N | Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys. | 2000 | Exp. Parasitol. | pmid:10631075 |
Weston WL and Morelli JG | Steroid rosacea in prepubertal children. | 2000 | Arch Pediatr Adolesc Med | pmid:10632252 |
Hypertrophic pyloric stenosis in infants following pertussis prophylaxis with erythromycin--Knoxville, Tennessee, 1999. | 1999 | MMWR Morb. Mortal. Wkly. Rep. | pmid:10634345 | |
Nasrin D et al. | Antibiotic resistance in Streptococcus pneumoniae isolated from children. | 1999 | J Paediatr Child Health | pmid:10634983 |
MartÃnez-Maldonado M | Postinfectious glomerulonephritis. | 2000 | Am. J. Kidney Dis. | pmid:10636819 |
Wu YJ | Highlights of semi-synthetic developments from erythromycin A. | 2000 | Curr. Pharm. Des. | pmid:10637376 |
Bajic S et al. | Analysis of erythromycin by liquid chromatography/mass spectrometry using involatile mobile phases with a novel atmospheric pressure ionization source. | 2000 | Rapid Commun. Mass Spectrom. | pmid:10637421 |
Gisby J and Bryant J | Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections. | 2000 | Antimicrob. Agents Chemother. | pmid:10639346 |
Brueggemann AB et al. | In vitro activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. | 2000 | Antimicrob. Agents Chemother. | pmid:10639382 |
Honma Y et al. | Effect of erythromycin on Shigella infection of Caco-2 cells. | 2000 | FEMS Immunol. Med. Microbiol. | pmid:10640609 |
Sharma PK et al. | Erythromycin in pityriasis rosea: A double-blind, placebo-controlled clinical trial. | 2000 | J. Am. Acad. Dermatol. | pmid:10642679 |
Santos R et al. | Bacillary angiomatosis by Bartonella quintana in an HIV-infected patient. | 2000 | J. Am. Acad. Dermatol. | pmid:10642694 |
Lebwohl M et al. | Clinically significant therapeutic interactions for the practicing dermatologist. | 1999 | Adv Dermatol | pmid:10643493 |
Heidenreich A et al. | Gastroparesis after retroperitoneal surgery successfully treated with erythromycin. | 2000 | J. Urol. | pmid:10647677 |
Medhus AW et al. | Low-dose intravenous erythromycin: effects on postprandial and fasting motility of the small bowel. | 2000 | Aliment. Pharmacol. Ther. | pmid:10651665 |
Mackinnon AM | The problem of intrahepatic cholestasis. | 1975 | Aust N Z J Med | pmid:1065291 |
Tsutsumi M et al. | Inhibitory effects of combined administration of antibiotics and anti-inflammatory drugs on lung tumor development initiated by N-nitrosobis(2-hydroxypropyl)amine in rats. | 2000 | Carcinogenesis | pmid:10657965 |
Allevi P et al. | A new convenient transformation of erythromycin A into clarithromycin. | 1999 | Bioorg. Med. Chem. | pmid:10658579 |
Nakahara S et al. | Bronchial amyloidosis successfully treated with low-dose long-term erythromycin therapy. | 1999 | Kurume Med J | pmid:10659597 |
From the Centers for Disease Control and Prevention. Hypertrophic pyloric stenosis in infants following pertussis prophylaxis with erythromycin--Knoxville, Tennessee, 1999. | 2000 | JAMA | pmid:10659863 | |
Descheemaeker P et al. | Macrolide resistance and erythromycin resistance determinants among Belgian Streptococcus pyogenes and Streptococcus pneumoniae isolates. | 2000 | J. Antimicrob. Chemother. | pmid:10660498 |
Wilkinson B et al. | Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. | 2000 | Chem. Biol. | pmid:10662692 |
Tang L et al. | Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases. | 2000 | Chem. Biol. | pmid:10662693 |
Moutard I et al. | In vitro effects of spiramycin and dirithromycin on IL1 beta production by human LPS-stimulated mononuclear cells. | 1999 Sep-Oct | Therapie | pmid:10667098 |
Mordi MN et al. | Acid-catalyzed degradation of clarithromycin and erythromycin B: a comparative study using NMR spectroscopy. | 2000 | J. Med. Chem. | pmid:10669574 |
Munroe CO and Lazarus TL | Prevention of infective endocarditis. | 1976 | Dent J | pmid:1067255 |
Gibson J et al. | Oral staphylococcal mucositis: A new clinical entity in orofacial granulomatosis and Crohn's disease. | 2000 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:10673652 |
Holen S | Antibiotics used traditionally in periodontal therapy. | 1976 | J. Periodontol. | pmid:1067412 |
Biddle JW and Thornsberry C | In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae. | 1979 | Antimicrob. Agents Chemother. | pmid:106776 |
Kohri K et al. | Macrolide antibiotics inhibit nitric oxide generation by rat pulmonary alveolar macrophages. | 2000 | Eur. Respir. J. | pmid:10678622 |
Poyart C et al. | Characterization of the Tn916-like transposon Tn3872 in a strain of abiotrophia defectiva (Streptococcus defectivus) causing sequential episodes of endocarditis in a child. | 2000 | Antimicrob. Agents Chemother. | pmid:10681362 |
Tang X and Cheng D | [The value of erythromycin pleurodesis in the treatment of malignant pleural effusions]. | 1997 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:10683963 |
Berg TG et al. | Ureaplasma/Mycoplasma-infected amniotic fluid: pregnancy outcome in treated and nontreated patients. | 1999 | J Perinatol | pmid:10685238 |
Fail PA et al. | Comparative effects of quinacrine and erythromycin in adult female rats: a nonsurgical sterilization study. | 2000 | Fertil. Steril. | pmid:10685548 |
Yamano K et al. | Quantitative prediction of metabolic inhibition of midazolam by erythromycin, diltiazem, and verapamil in rats: implication of concentrative uptake of inhibitors into liver. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10688631 |
Noerr B | Erythromycin. | 1999 | Neonatal Netw | pmid:10690102 |
Thwaites RT and Frost JA | Drug resistance in Campylobacter jejuni, C coli, and C lari isolated from humans in north west England and Wales, 1997. | 1999 | J. Clin. Pathol. | pmid:10690169 |
Vardy SJ and Rose GE | Prevention of cellulitis after open lacrimal surgery: a prospective study of three methods. | 2000 | Ophthalmology | pmid:10690832 |
Hill BC et al. | A simplified method for testing Bordetella pertussis for resistance to erythromycin and other antimicrobial agents. | 2000 | J. Clin. Microbiol. | pmid:10699011 |
Timosca S et al. | [Bacteremia following tooth extractions]. | 1976 | Rev Stomatol Chir Maxillofac | pmid:1070098 |
Suri A et al. | Effects of CYP3A inhibition on the metabolism of cilostazol. | 1999 | Clin Pharmacokinet | pmid:10702888 |
Bernabéu JA et al. | Microbiological bioassay of erythromycin thiocyanate: optimisation and validation. | 1999 | J Pharm Biomed Anal | pmid:10703990 |
Brisaert M et al. | Investigation of the chemical stability of an erythromycin-tretinoin lotion by the use of an optimization system. | 2000 | Int J Pharm | pmid:10704802 |
Faoagali JL et al. | Sensitivity of 941 beta haemolytic streptococci to antibacterial drugs. | 1976 | N. Z. Med. J. | pmid:1070586 |
Karam B et al. | Ergotism precipitated by erythromycin: a rare case of vasospasm. | 2000 | Eur J Vasc Endovasc Surg | pmid:10706847 |
Sazykin IuO et al. | [Ketolides--erythromycin derivatives with activity against macrolide-resistant bacteria]. | 2000 | Antibiot. Khimioter. | pmid:10707799 |
MacLaren R et al. | Sequential single doses of cisapride, erythromycin, and metoclopramide in critically ill patients intolerant to enteral nutrition: a randomized, placebo-controlled, crossover study. | 2000 | Crit. Care Med. | pmid:10708180 |
Krecic-Shepard ME et al. | Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans. | 2000 | J Clin Pharmacol | pmid:10709150 |
Moussa F et al. | Erythromycin eye ointment: effect on gastrointestinal motility. | 2000 | Am. J. Gastroenterol. | pmid:10710093 |
Dewan NA et al. | Acute exacerbation of COPD: factors associated with poor treatment outcome. | 2000 | Chest | pmid:10712989 |
López de Blanc S et al. | Bacillary angiomatosis affecting the oral cavity. Report of two cases and review. | 2000 | J. Oral Pathol. Med. | pmid:10718405 |
Chepkwony HK et al. | Separation of erythromycin and related substances on base-deactivated reversed-phase silica gel columns. | 2000 | J Chromatogr A | pmid:10722081 |
Portillo A et al. | Macrolide resistance genes in Enterococcus spp. | 2000 | Antimicrob. Agents Chemother. | pmid:10722498 |
Brophy DF et al. | Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers. | 2000 | Antimicrob. Agents Chemother. | pmid:10722500 |
Ono T et al. | Susceptibilities of oral and nasal isolates of Streptococcus mitis and Streptococcus oralis to macrolides and PCR detection of resistance genes. | 2000 | Antimicrob. Agents Chemother. | pmid:10722517 |
Strigl S et al. | In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae. | 2000 | Antimicrob. Agents Chemother. | pmid:10722526 |
Gracey HE et al. | Preparation and in vitro antibacterial activity of 6-O-methylerythromycin D. | 1999 | J. Antibiot. | pmid:10726932 |
Smith AJ et al. | Prokinetic effect of erythromycin after colorectal surgery: randomized, placebo-controlled, double-blind study. | 2000 | Dis. Colon Rectum | pmid:10733114 |
Karchmer AW et al. | Single-antibiotic therapy for streptococcal endocarditis. | 1979 | JAMA | pmid:107335 |
Potts JM et al. | Association of chronic urinary symptoms in women and Ureaplasma urealyticum. | 2000 | Urology | pmid:10736488 |
Dubini F et al. | [Research on erythromycin and spiramycin in saliva]. | 1976 | Dent Cadmos | pmid:1073735 |
Or YS et al. | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. | 2000 | J. Med. Chem. | pmid:10737737 |
Orrett FA | Methicillin resistance among Trinidadian isolates of community and hospital strains of Staphylococcus aureus and their patterns of resistance to non-beta-lactam antibiotics. | 1999 | Jpn. J. Infect. Dis. | pmid:10738361 |
Erythromycin use linked to pyloric stenosis. | 2000 | Am J Nurs | pmid:10738394 | |
Nielsen K et al. | Susceptibility of Legionella species to five antibiotics and development of resistance by exposure to erythromycin, ciprofloxacin, and rifampicin. | 2000 | Diagn. Microbiol. Infect. Dis. | pmid:10744366 |
Simango C and Mvududu F | Penicillin resistant Streptococcus pneumoniae isolates in Harare, Zimbabwe. | 1999 | Cent Afr J Med | pmid:10746390 |
Martinez JA et al. | Diffuse panbronchiolitis in Latin America. | 2000 | Am. J. Med. Sci. | pmid:10746829 |
Davies TA et al. | Antipneumococcal activity of telithromycin by agar dilution, microdilution, E test, and disk diffusion methodologies. | 2000 | J. Clin. Microbiol. | pmid:10747123 |
Luna VA et al. | A novel multiresistant Streptococcus pneumoniae serogroup 19 clone from Washington State identified by pulsed-field gel electrophoresis and restriction fragment length patterns. | 2000 | J. Clin. Microbiol. | pmid:10747146 |
Furneri PM et al. | Genetic basis of natural resistance to erythromycin in Mycoplasma hominis. | 2000 | J. Antimicrob. Chemother. | pmid:10747837 |
Faure C et al. | Effect of meal and intravenous erythromycin on manometric and electrogastrographic measurements of gastric motor and electrical activity. | 2000 | Dig. Dis. Sci. | pmid:10749328 |
Hoppe JE | Neonatal pertussis. | 2000 | Pediatr. Infect. Dis. J. | pmid:10749468 |
Zhao DM et al. | Effect of erythromycin on ATP-induced intracellular calcium response in A549 cells. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10749750 |
Clanton LJ and Bender J | Refractory spinal cord injury induced gastroparesis: resolution with erythromycin lactobionate, a case report. | 1999 | J Spinal Cord Med | pmid:10751126 |
Murata T et al. | [Serum concentration of erythromycin suppositories and clinical use in oral surgery (author's transl)]. | 1975 | Nihon Koku Geka Gakkai Zasshi | pmid:1075289 |
Solensky R et al. | Clinical approach to penicillin-allergic patients: a survey. | 2000 | Ann. Allergy Asthma Immunol. | pmid:10752918 |
Petrakis IE et al. | Induced-hyperglycemia attenuates erythromycin-induced acceleration of hypertonic liquid-phase gastric emptying in type-I diabetic patients. | 1999 | Dig Dis | pmid:10754365 |
Brenciaglia MI et al. | Helicobacter pylori: cultivability and antibiotic susceptibility of coccoid forms. | 2000 | Int. J. Antimicrob. Agents | pmid:10755237 |
Bellaïche G et al. | [Non-hemorrhagic and erythematous colitis associated with Klebsiella oxytoca after treatment with erythromycin]. | 2000 | Gastroenterol. Clin. Biol. | pmid:10755860 |
Stamm LV and Bergen HL | A point mutation associated with bacterial macrolide resistance is present in both 23S rRNA genes of an erythromycin-resistant Treponema pallidum clinical isolate. | 2000 | Antimicrob. Agents Chemother. | pmid:10755994 |
Bassetti M et al. | Erythromycin resistance in Streptococcus pyogenes in Italy. | 2000 Mar-Apr | Emerging Infect. Dis. | pmid:10756153 |
Majima Y et al. | [Study on a rat tracheal mucus producing model]. | 2000 | Jpn J Antibiot | pmid:10756441 |
Nakaya Y et al. | [Suppressive action of erythromycin on cultured tracheal epithelial cell chloride channel activated by interferon-gamma]. | 2000 | Jpn J Antibiot | pmid:10756442 |