erythromycin
erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with erythromycin?
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (35)
- J. Antimicrob. Chemother. (18)
- J. Pharmacol. Exp. Ther. (2)
- Others (29)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with erythromycin
PubChem Associated disorders and diseases
What pathways are associated with erythromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with erythromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with erythromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with erythromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with erythromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (19)
- J. Antimicrob. Chemother. (10)
- Drug Metab. Dispos. (5)
- Others (29)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with erythromycin?
Mouse Model
Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with erythromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Saitoh R et al. | Nonlinear intestinal pharmacokinetics of mitemcinal, the first acid-resistant non-peptide motilin receptor agonist, in rats. | 2007 | Xenobiotica | pmid:17926229 |
| Berg-Candolfi M et al. | Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. | 1996 | Xenobiotica | pmid:9173679 |
| Villa P et al. | Erythromycin toxicity in primary cultures of rat hepatocytes. | 1985 Aug-Sep | Xenobiotica | pmid:4072263 |
| Ward KW et al. | Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. | 2005 | Xenobiotica | pmid:16019946 |
| Molnari JC and Myers AL | Carbonyl reduction of bupropion in human liver. | 2012 | Xenobiotica | pmid:22339467 |
| Watanabe M et al. | Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo. | 1999 | Xenobiotica | pmid:10553724 |
| Kubo JI et al. | Pharmacokinetic evaluation of high pulmonary disposition of clarithromycin after systemic administration. | 2002 | Xenobiotica | pmid:12419017 |
| Trepanier LA and Miller JL | NADH-dependent reduction of sulphamethoxazole hydroxylamine in dog and human liver microsomes. | 2000 | Xenobiotica | pmid:11307968 |
| Guillouzo A et al. | Human hepatocyte cultures: a model of pharmaco-toxicological studies. | 1985 Aug-Sep | Xenobiotica | pmid:3907158 |
| Kanazu T et al. | Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans. | 2004 | Xenobiotica | pmid:15370956 |
| Attaran B et al. | Effect of biofilm formation by clinical isolates of on the efflux-mediated resistance to commonly used antibiotics. | 2017 | World J. Gastroenterol. | pmid:28275296 |
| Niv E et al. | Effect of erythromycin on image quality and transit time of capsule endoscopy: a two-center study. | 2008 | World J. Gastroenterol. | pmid:18442206 |
| Sári R et al. | Ethanol inhibits the motility of rabbit sphincter of Oddi in vitro. | 2004 | World J. Gastroenterol. | pmid:15526367 |
| Liu ZQ et al. | Efflux pump gene hefA of Helicobacter pylori plays an important role in multidrug resistance. | 2008 | World J. Gastroenterol. | pmid:18777600 |
| Leung WK et al. | Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy. | 2005 | World J. Gastroenterol. | pmid:16097060 |
| Lim CH et al. | Effect of DA-9701 on gastric emptying in a mouse model: assessment by ¹³C-octanoic acid breath test. | 2013 | World J. Gastroenterol. | pmid:23885150 |
| Jiang DP et al. | Treatment of pediatric Ogilvie's syndrome with low-dose erythromycin: a case report. | 2007 | World J. Gastroenterol. | pmid:17461506 |
| Suchitra AD et al. | Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice. | 2003 | World J. Gastroenterol. | pmid:12679931 |
| Matsunaga H et al. | Manometric evidence of improved early gastric stasis by erythromycin after pylorus-preserving pancreatoduodenectomy. | 2000 | World J Surg | pmid:11071469 |
| Raahave D et al. | Cefotaxime i.v. versus oral neomycin-erythromycin for prophylaxis of infections after colorectal operations. | 1988 | World J Surg | pmid:3041682 |