erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kuwahara T et al. | Clinical characteristics and management of periesophageal vagal nerve injury complicating left atrial ablation of atrial fibrillation: lessons from eleven cases. | 2013 | J. Cardiovasc. Electrophysiol. | pmid:23551640 |
Lozada LE et al. | Development of pyloric stenosis after a 4-day course of oral erythromycin. | 2013 | Pediatr Emerg Care | pmid:23558266 |
Cuello-GarcÃa CA et al. | Treating BCG-induced disease in children. | 2013 | Cochrane Database Syst Rev | pmid:23440826 |
Jersild Jespersen M et al. | [Sparse effect of long-term treatment with macrolides in patients with chronic obstructive pulmonary disease]. | 2013 | Ugeskr. Laeg. | pmid:23462037 |
Nie XP et al. | Toxic effects of erythromycin, ciprofloxacin and sulfamethoxazole exposure to the antioxidant system in Pseudokirchneriella subcapitata. | 2013 | Environ. Pollut. | pmid:22982550 |
Berghaus LJ et al. | Mutant prevention concentration and mutant selection window for 10 antimicrobial agents against Rhodococcus equi. | 2013 | Vet. Microbiol. | pmid:23915992 |
Janssen P et al. | The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. | 2013 | Am. J. Gastroenterol. | pmid:24005344 |
Parrott N et al. | An unusual cause of persistent postpartum vaginal discharge. | 2013 | Int J STD AIDS | pmid:23970614 |
Pelchovich G et al. | The contribution of common rpsL mutations in Escherichia coli to sensitivity to ribosome targeting antibiotics. | 2013 | Int. J. Med. Microbiol. | pmid:23972615 |
Ishihara K et al. | Distribution of antimicrobial-resistant lactic acid bacteria in natural cheese in Japan. | 2013 | Microbiol. Immunol. | pmid:23930694 |
Pedersen JM et al. | Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | 2013 | Toxicol. Sci. | pmid:24014644 |
Zhang L et al. | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23937982 |
Herath SC and Poole P | Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD). | 2013 | Cochrane Database Syst Rev | pmid:24288145 |
Liang JH and Han X | Structure-activity relationships and mechanism of action of macrolides derived from erythromycin as antibacterial agents. | 2013 | Curr Top Med Chem | pmid:24200358 |
Matejcek A and Goldman RD | Treatment and prevention of ophthalmia neonatorum. | 2013 | Can Fam Physician | pmid:24235191 |
Kamal A et al. | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. | 2013 | Bioorg. Med. Chem. Lett. | pmid:24206766 |
Rallis E et al. | Topical 5% benzoyl peroxide and 3% erythromycin gel: experience with 191 patients with papulopustular acne. | 2013 | Acta Dermatovenerol Croat | pmid:24183219 |
Sugino K et al. | Granulomatous-lymphocytic interstitial lung disease in a patient with common variable immunodeficiency. | 2013 | Intern. Med. | pmid:24292765 |
Goh S et al. | Phage Ï•C2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains. | 2013 | MBio | pmid:24255122 |
Horácio AN et al. | The majority of adult pneumococcal invasive infections in Portugal are still potentially vaccine preventable in spite of significant declines of serotypes 1 and 5. | 2013 | PLoS ONE | pmid:24066064 |
Guo L et al. | Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. | 2013 | Toxicol. Sci. | pmid:24052561 |
Hirano E et al. | Erythromycin treatment suppresses myocardial injury in autoimmune myocarditis in rats via suppression of superoxide production. | 2013 | Int. J. Cardiol. | pmid:22727964 |
Sripriya J et al. | Laser receptive polyelectrolyte thin films doped with biosynthesized silver nanoparticles for antibacterial coatings and drug delivery applications. | 2013 | Int J Pharm | pmid:24096301 |
Wang HB et al. | Molecular epidemiological analysis of group A Streptococci isolated from children in Chaoyang District of Beijing, 2011: emm types, virulence factor genes and erythromycin resistant genes. | 2013 | Biomed. Environ. Sci. | pmid:24099615 |
Wang X et al. | Mesoporous titanium zirconium oxide nanospheres with potential for drug delivery applications. | 2013 | ACS Appl Mater Interfaces | pmid:24150740 |
Wu C et al. | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. | 2013 | J. Nat. Prod. | pmid:24164206 |
Arao M et al. | Clostridium difficile colitis induced by long-term low-dosage erythromycin. | 2013 | Pediatr. Infect. Dis. J. | pmid:24008746 |
Li YY et al. | Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains. | 2013 | BMC Genomics | pmid:23902230 |
González-Pleiter M et al. | Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment. | 2013 | Water Res. | pmid:23399078 |
Odhav A et al. | Subconjunctival latex paint from occupational injury. | 2013 | J Emerg Med | pmid:23399395 |
Ziesenitz VC et al. | Cytochrome P450-3A phenotyping using midazolam is not altered by OATP1B1 polymorphisms. | 2013 | Clin. Pharmacol. Ther. | pmid:23549145 |
Kirm B et al. | SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea. | 2013 | Microb. Cell Fact. | pmid:24341557 |
Olender A et al. | The cause of Actinomyces canalictulis--a case study. | 2013 | Ann Agric Environ Med | pmid:24364446 |
Yin YD et al. | [Survey of macrolide resistance in Mycoplasma pneumoniae in adult patients with community-acquired pneumonia in Beijing, China]. | 2013 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:24503430 |
Cai G et al. | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. | 2013 | J. Nat. Prod. | pmid:24224794 |
Ansari NN et al. | Treatment of chronic rhinosinusitis using erythromycin phonophoresis. | 2013 | Physiother Theory Pract | pmid:22891948 |
Fang J et al. | Dissecting the function of a protruding loop in AcrB trimerization. | 2013 | J. Biomol. Struct. Dyn. | pmid:22877148 |
Chen DK et al. | [Mechanism of hetero-erythromycin resistant Staphylococcus aureus and a comparison of detection methods]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:24548451 |
Opdam FL et al. | Breath tests to phenotype drug disposition in oncology. | 2013 | Clin Pharmacokinet | pmid:23868281 |
Tsujimoto M et al. | Effects of decreased vitamin D and accumulated uremic toxin on human CYP3A4 activity in patients with end-stage renal disease. | 2013 | Toxins (Basel) | pmid:23965431 |
Broad J and Sanger GJ | The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin. | 2013 | Br. J. Pharmacol. | pmid:23190027 |
Hao H et al. | Mutational and transcriptomic changes involved in the development of macrolide resistance in Campylobacter jejuni. | 2013 | Antimicrob. Agents Chemother. | pmid:23274667 |
Yang J et al. | Characterization of chicken cytochrome P450 1A4 and 1A5: inter-paralog comparisons of substrate preference and inhibitor selectivity. | 2013 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:23474502 |
Zhang Q et al. | High-resolution melting analysis for the detection of two erythromycin-resistant Bordetella pertussis strains carried by healthy schoolchildren in China. | 2013 | Clin. Microbiol. Infect. | pmid:23480481 |
Prabu D and Menon T | Genotyping of erythromycin resistant group C & G streptococci isolated in Chennai, south India. | 2013 | Indian J. Med. Res. | pmid:23481067 |
Zhang Y et al. | Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23481648 |
Koulaouzidis A et al. | Do prokinetics influence the completion rate in small-bowel capsule endoscopy? A systematic review and meta-analysis. | 2013 | Curr Med Res Opin | pmid:23790243 |
Lin MH et al. | Penetration of erythromycin through Staphylococcus epidermidis biofilm. | 2013 | Chin. Med. J. | pmid:23876889 |
Winnicka K et al. | The effect of PAMAM dendrimers on the antibacterial activity of antibiotics with different water solubility. | 2013 | Molecules | pmid:23881050 |
Hennenberg M et al. | The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle, and is a minor regulator of α1-adrenergic contraction. | 2013 | J. Biomed. Sci. | pmid:23815815 |
Mu Y et al. | Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics. | 2013 | Antimicrob. Agents Chemother. | pmid:23817373 |
González-Abad MJ and Alonso-Sanz M | [Incidence and susceptibility of Campylobacter jejuni in pediatric patients: involvement in bacteremia]. | 2013 | Rev Esp Quimioter | pmid:23817644 |
Sanz-RodrÃguez N et al. | [Accuracy of Etest method to study Campylobacter spp. susceptibility to erythromycin, ciprofloxacin and tetracycline]. | 2013 | Rev Esp Quimioter | pmid:23817649 |
James GD et al. | Use of long-term antibiotic treatment in COPD patients in the UK: a retrospective cohort study. | 2013 | Prim Care Respir J | pmid:23839240 |
Parhi AK et al. | Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23891185 |
Lee A | Gastroparesis: what is the current state-of-the-art for evaluation and medical management? What are the results? | 2013 | J. Gastrointest. Surg. | pmid:23801519 |
Liu ZX et al. | [Inhibition of methanogenium by erythromycin and its domestation]. | 2013 | Huan Jing Ke Xue | pmid:23798140 |
Pasquini L et al. | Impact of certain household micropollutants on bacterial behavior. Toxicity tests/study of extracellular polymeric substances in sludge. | 2013 | Sci. Total Environ. | pmid:23827359 |
Mu X et al. | Effects of erythromycin and rifampicin on immunomodulatory gene expression and cellular function in human polymorphonuclear leukocytes. | 2013 | Chemotherapy | pmid:24852442 |
Sundermann U et al. | Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase. | 2013 | ACS Chem. Biol. | pmid:23181268 |
Wittwer MB et al. | Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. | 2013 | J. Med. Chem. | pmid:23241029 |
Sun W et al. | [Glycosyl isomerization based on the biosynthesis of natural-product sugar from microorganism]. | 2013 | Yao Xue Xue Bao | pmid:23672013 |
Wang H et al. | High prevalence of fluoroquinolone-resistant group B streptococci among clinical isolates in China and predominance of sequence type 19 with serotype III. | 2013 | Antimicrob. Agents Chemother. | pmid:23295933 |
Everson GT et al. | Functional elements associated with hepatic regeneration in living donors after right hepatic lobectomy. | 2013 | Liver Transpl. | pmid:23239552 |
Kelmer G et al. | Evaluation of regional limb perfusion with erythromycin using the saphenous, cephalic, or palmar digital veins in standing horses. | 2013 | J. Vet. Pharmacol. Ther. | pmid:23240633 |
Pelchovich G et al. | Effect of ribosome-targeting antibiotics on streptomycin-resistant Mycobacterium mutants in the rpsL gene. | 2013 | Int. J. Antimicrob. Agents | pmid:23664678 |
Oplinger RW and Wagner EJ | Control of Flavobacterium psychrophilum: tests of erythromycin, streptomycin, osmotic and thermal shocks, and rapid pH change. | 2013 | J. Aquat. Anim. Health | pmid:23241009 |
Li N et al. | Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus and Candida albicans. | 2013 | Phytother Res | pmid:23192753 |
Chae HS et al. | Use of a novel Escherichia coli-leuconostoc shuttle vector for metabolic engineering of Leuconostoc citreum to overproduce D-lactate. | 2013 | Appl. Environ. Microbiol. | pmid:23241984 |
Papapetropoulos N et al. | Abscesses and wound infections due to Staphylococcus lugdunensis: report of 16 cases. | 2013 | Infection | pmid:23242962 |
Berger A et al. | Two cases of cutaneous diphtheria associated with occupational pig contact in Germany. | 2013 | Zoonoses Public Health | pmid:23280311 |
Juntunen P et al. | Absence of tetracycline resistance in Campylobacter coli isolates from Finnish finishing pigs treated with chlortetracycline. | 2013 | J. Appl. Microbiol. | pmid:23282197 |
Mavri A and Smole Možina S | Resistance to bile salts and sodium deoxycholate in macrolide- and fluoroquinolone-susceptible and resistant Campylobacter jejuni and Campylobacter coli strains. | 2013 | Microb. Drug Resist. | pmid:23289436 |
Lin KJ et al. | Safety of macrolides during pregnancy. | 2013 | Am. J. Obstet. Gynecol. | pmid:23254249 |
Sánchez Valenzuela A et al. | Phenotypic and molecular antibiotic resistance profile of Enterococcus faecalis and Enterococcus faecium isolated from different traditional fermented foods. | 2013 | Foodborne Pathog. Dis. | pmid:23259502 |
Sanad YM et al. | Molecular epidemiology and public health relevance of Campylobacter isolated from dairy cattle and European starlings in Ohio, USA. | 2013 | Foodborne Pathog. Dis. | pmid:23259503 |
Haruna M et al. | Prevalence and antimicrobial resistance of Campylobacter isolates from beef cattle and pigs in Japan. | 2013 | J. Vet. Med. Sci. | pmid:23220905 |
Javid FA et al. | Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors. | 2013 | Eur. J. Pharmacol. | pmid:23201066 |
Goodman CD et al. | Chemobiosynthesis of new antimalarial macrolides. | 2013 | Antimicrob. Agents Chemother. | pmid:23208707 |
Hisatsune J et al. | Emergence of Staphylococcus aureus carrying multiple drug resistance genes on a plasmid encoding exfoliative toxin B. | 2013 | Antimicrob. Agents Chemother. | pmid:24080652 |
Elens L et al. | Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin. | 2013 | Pharmacogenet. Genomics | pmid:23324807 |
Boutouyrie-Dumont B | An aide memoire for model-based drug development--a new key for the interpretation of the erythromycin breath test--therapeutic index as a biomarker for smart drug development. | 2013 | Biomark Med | pmid:23387489 |
Liang JH et al. | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23375796 |
Drago L et al. | Phenotypic and genotypic antibiotic resistance in some probiotics proposed for medical use. | 2013 | Int. J. Antimicrob. Agents | pmid:23313535 |
Sanger GJ et al. | Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists. | 2013 | Br. J. Pharmacol. | pmid:23189978 |
Rams TE et al. | Antibiotic susceptibility of periodontal Enterococcus faecalis. | 2013 | J. Periodontol. | pmid:23106507 |
Osterman IA et al. | A nascent proteome study combining click chemistry with 2DE. | 2013 | Proteomics | pmid:23161590 |
Metzler K et al. | Minimal inhibitory and mutant prevention concentrations of azithromycin, clarithromycin and erythromycin for clinical isolates of Streptococcus pneumoniae. | 2013 | J. Antimicrob. Chemother. | pmid:23169894 |
Gómez-Sanz E et al. | Analysis of a novel erm(T)- and cadDX-carrying plasmid from methicillin-susceptible Staphylococcus aureus ST398-t571 of human origin. | 2013 | J. Antimicrob. Chemother. | pmid:23075692 |
Serisier DJ et al. | Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial. | 2013 | JAMA | pmid:23532242 |
Elborn JS and Tunney MM | Macrolides and bronchiectasis: clinical benefit with a resistance price. | 2013 | JAMA | pmid:23532247 |
Chan BC et al. | Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase. | 2013 | Phytomedicine | pmid:23541215 |
Tarran R et al. | Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23542952 |
Reveiz L and Cardona AF | Antibiotics for acute laryngitis in adults. | 2013 | Cochrane Database Syst Rev | pmid:23543536 |
Moriya S et al. | Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells. | 2013 | Int. J. Oncol. | pmid:23546223 |
Akiyoshi T et al. | Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. | 2013 | Drug Metab. Pharmacokinet. | pmid:23514827 |
Müller W et al. | German Francisella tularensis isolates from European brown hares (Lepus europaeus) reveal genetic and phenotypic diversity. | 2013 | BMC Microbiol. | pmid:23517149 |
Lasnier O et al. | Two cases of corneal abrasions in children exposed to liquid detergent capsules. | 2013 | Can. J. Ophthalmol. | pmid:23561618 |
Methicillin resistant Staphylococcus aureus (MRSA) in India: prevalence & susceptibility pattern. | 2013 | Indian J. Med. Res. | pmid:23563381 | |
Rogers GB et al. | Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition. | 2013 | Thorax | pmid:23564400 |