| MeSH term | MeSH ID | Detail |
|---|---|---|
| Seroma | D049291 | 2 associated lipids |
| Bile Reflux | D001655 | 2 associated lipids |
| Wounds, Gunshot | D014948 | 2 associated lipids |
| Granuloma, Lethal Midline | D006103 | 2 associated lipids |
| Pancreatic Fistula | D010185 | 2 associated lipids |
| Furunculosis | D005667 | 2 associated lipids |
| Porphyrias | D011164 | 2 associated lipids |
| Periodontal Abscess | D010508 | 2 associated lipids |
| Hyperemesis Gravidarum | D006939 | 2 associated lipids |
| Hypoventilation | D007040 | 2 associated lipids |
erythromycin
erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with erythromycin?
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (35)
- J. Antimicrob. Chemother. (18)
- Clin. Infect. Dis. (2)
- Others (29)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with erythromycin
PubChem Associated disorders and diseases
What pathways are associated with erythromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with erythromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (20)
- J. Antimicrob. Chemother. (9)
- Drug Metab. Dispos. (2)
- Others (20)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with erythromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with erythromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with erythromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (19)
- J. Antimicrob. Chemother. (10)
- Drug Metab. Dispos. (5)
- Others (29)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with erythromycin?
Mouse Model
Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with erythromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Piccinelli G et al. | Characterization and antibiotic susceptibility of Streptococcus agalactiae isolates causing urinary tract infections. | 2015 | Infect. Genet. Evol. | pmid:26144658 |
| Wang P et al. | Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates. | 2015 | Int. J. Infect. Dis. | pmid:26141418 |
| Høye S | An extraordinary tale of an ordinary case. | 2015 | Tidsskr. Nor. Laegeforen. | pmid:26130550 |
| Loose LM et al. | Adolescent with respiratory impairments and short-lived fever. | 2015 | Tidsskr. Nor. Laegeforen. | pmid:26130549 |
| Liu J et al. | Preparation and characterization of erythromycin molecularly imprinted polymers based on distillation-precipitation polymerization. | 2015 | J Sep Sci | pmid:26118901 |
| Fathollahipour S et al. | Electrospinning of PVA/chitosan nanocomposite nanofibers containing gelatin nanoparticles as a dual drug delivery system. | 2015 | J Biomed Mater Res A | pmid:26112829 |
| Xing L et al. | ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer. | 2015 | PLoS ONE | pmid:26107936 |
| Jakubů V et al. | Minimum inhibitory concentrations of erythromycin and other antibiotics for Czech strains of Bordetella pertussis. | 2015 | Epidemiol Mikrobiol Imunol | pmid:25872990 |
| Koutsogiannidis CP et al. | Decreased DNA Disruption in the Porcine Neocortex with Erythromycin Preconditioning during Prolonged Hypothermic Circulatory Arrest: Evidence for Neuroprotection. | 2015 | J Card Surg | pmid:25858150 |
| KovaÄ J et al. | Antibiotic resistance modulation and modes of action of (-)-α-pinene in Campylobacter jejuni. | 2015 | PLoS ONE | pmid:25830640 |
| Abukar AA et al. | Unusual cause of infective endocarditis in an elderly patient with a rare condition. | 2015 | BMJ Case Rep | pmid:25820110 |
| Aydin S et al. | Combined effect of erythromycin, tetracycline and sulfamethoxazole on performance of anaerobic sequencing batch reactors. | 2015 | Bioresour. Technol. | pmid:25817031 |
| Cui B et al. | Effects of erythromycin on the phenotypic and genotypic biofilm expression in two clinical Staphylococcus capitis subspecies and a functional analysis of Ica proteins in S. capitis. | 2015 | J. Med. Microbiol. | pmid:25813821 |
| Chew ML et al. | Effect of the gastrointestinal prokinetic agent erythromycin on the pharmacokinetics of pregabalin controlled-release in healthy individuals: a phase I, randomized crossover trial. | 2015 | Clin Drug Investig | pmid:25808394 |
| GarcÃa-Mayor MA et al. | Occurrence of erythromycin residues in sheep milk. Validation of an analytical method. | 2015 | Food Chem. Toxicol. | pmid:25637760 |
| van Eijk E et al. | Complete genome sequence of the Clostridium difficile laboratory strain 630Δerm reveals differences from strain 630, including translocation of the mobile element CTn5. | 2015 | BMC Genomics | pmid:25636331 |
| Gao P et al. | Impacts of coexisting antibiotics, antibacterial residues, and heavy metals on the occurrence of erythromycin resistance genes in urban wastewater. | 2015 | Appl. Microbiol. Biotechnol. | pmid:25631280 |
| Lin X et al. | Macrolides for diffuse panbronchiolitis. | 2015 | Cochrane Database Syst Rev | pmid:25618845 |
| Sakata H | The change of macrolide resistance rates in group A Streptococcus isolates from children between 2002 and 2013 in Asahikawa city. | 2015 | J. Infect. Chemother. | pmid:25618777 |
| Johnson AC et al. | Assessing the concentrations and risks of toxicity from the antibiotics ciprofloxacin, sulfamethoxazole, trimethoprim and erythromycin in European rivers. | 2015 | Sci. Total Environ. | pmid:25617699 |
| Wang P et al. | Development of an efficient conjugation-based genetic manipulation system for Pseudoalteromonas. | 2015 | Microb. Cell Fact. | pmid:25612661 |
| Blix HS et al. | Antibiotic prescriptions and cycles of Mycoplasma pneumoniae infections in Norway: can a nationwide prescription register be used for surveillance? | 2015 | Epidemiol. Infect. | pmid:25388750 |
| MarÃn M et al. | Clostridium difficile isolates with high linezolid MICs harbor the multiresistance gene cfr. | 2015 | Antimicrob. Agents Chemother. | pmid:25385106 |
| Igbinosa IH | Prevalence and detection of antibiotic-resistant determinant in Salmonella isolated from food-producing animals. | 2015 | Trop Anim Health Prod | pmid:25348646 |
| Kam Y et al. | Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". | 2015 | Int. J. Cancer | pmid:25156304 |
| Lo HH et al. | Antibiotic susceptibility pattern and erythromycin resistance mechanisms in beta-hemolytic group G Streptococcus dysgalactiae subspecies equisimilis isolates from central Taiwan. | 2015 | J Microbiol Immunol Infect | pmid:24856419 |
| Muralidharan V and Striepen B | Teaching old drugs new tricks to stop malaria invasion in its tracks. | 2015 | BMC Biol. | pmid:26349580 |
| Li X et al. | Differential roles of the hemerythrin-like proteins of Mycobacterium smegmatis in hydrogen peroxide and erythromycin susceptibility. | 2015 | Sci Rep | pmid:26607739 |
| Cheng C et al. | Ciprofloxacin plus erythromycin or ambroxol ameliorates endotracheal tube-associated Pseudomonas aeruginosa biofilms in a rat model. | 2015 | Pathol. Res. Pract. | pmid:26601615 |
| Michael-Kordatou I et al. | Erythromycin oxidation and ERY-resistant Escherichia coli inactivation in urban wastewater by sulfate radical-based oxidation process under UV-C irradiation. | 2015 | Water Res. | pmid:26360228 |
| Arinto-Garcia R et al. | Comparing Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry and Phenotypic and Molecular Methods for Identification of Species within the Streptococcus anginosus Group. | 2015 | J. Clin. Microbiol. | pmid:26354817 |
| Han X et al. | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. | 2015 | Bioorg. Med. Chem. | pmid:26349628 |
| Ozbayram EG et al. | Acute effects of various antibiotic combinations on acetoclastic methanogenic activity. | 2015 | Environ Sci Pollut Res Int | pmid:25408075 |
| Thomas L et al. | Ophthalmic Considerations in Stevens-Johnson Syndrome. | 2016 | J. Pediatr. | pmid:27318376 |
| Salimi A et al. | Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. | 2016 | Xenobiotica | pmid:26068526 |
| Tang C et al. | The incidence and drug resistance of Clostridium difficile infection in Mainland China: a systematic review and meta-analysis. | 2016 | Sci Rep | pmid:27897206 |
| Sun H et al. | Mechanism Underlying Time-dependent Cross-phenomenon between Concentration-response Curves and Concentration Addition Curves: A Case Study of Sulfonamides-Erythromycin mixtures on Escherichia coli. | 2016 | Sci Rep | pmid:27644411 |
| Mombelli A et al. | Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci. | 2016 | J. Periodontol. | pmid:26654350 |
| Ulanovsky I et al. | Erythromycin Prophylaxis for Neonatal Conjunctivitis: Ointment Versus Drops. | 2016 | Isr. Med. Assoc. J. | pmid:28471562 |
| Sagkan-Ozturk A et al. | Prokinetics stimulate the increase of ghrelin in mice. | 2016 | Bratisl Lek Listy | pmid:28127970 |
| Tack J et al. | Motilin-induced gastric contractions signal hunger in man. | 2016 | Gut | pmid:25539673 |
| Zmantar T et al. | Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity. | 2016 | Microb. Pathog. | pmid:27816681 |
| Barbanti F and Spigaglia P | Characterization of Clostridium difficile PCR-ribotype 018: A problematic emerging type. | 2016 | Anaerobe | pmid:27725230 |
| Mayor-Ibarguren A et al. | Periorificial Lesions in a Young Girl. | 2016 | Actas Dermosifiliogr | pmid:26935746 |
| Hu P et al. | Erythromycin triggers intussusception in a pediatric patient with Henoch-Schönlein purpura. | 2016 | Turk J Gastroenterol | pmid:27782898 |
| Heß S and Gallert C | Growth Behavior of E. coli, Enterococcus and Staphylococcus Species in the Presence and Absence of Sub-inhibitory Antibiotic Concentrations: Consequences for Interpretation of Culture-Based Data. | 2016 | Microb. Ecol. | pmid:27220972 |
| de Jesus Gaffney V et al. | Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water. | 2016 | Environ. Toxicol. Chem. | pmid:27061931 |
| Caumes E et al. | [Donovanosis (granuloma inguinale)]. | 2016 | Ann Dermatol Venereol | pmid:27773509 |
| Caumes E et al. | [Lymphogranuloma venereum]. | 2016 | Ann Dermatol Venereol | pmid:27773504 |
| Aslantaş Ö and Demir C | Investigation of the antibiotic resistance and biofilm-forming ability of Staphylococcus aureus from subclinical bovine mastitis cases. | 2016 | J. Dairy Sci. | pmid:27592437 |
| Budha NR et al. | Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. | 2016 | Clin Pharmacokinet | pmid:27225997 |
| Parasrampuria DA et al. | Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. | 2016 | Br J Clin Pharmacol | pmid:27530188 |
| Hua CZ et al. | [An analysis of 181 cases with blood stream infection caused by Streptococcus agalactiae in children from 2011 to 2015: a multi-center retrospective study]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:27510868 |
| Johanesen P and Lyras D | Methods for Determining Transfer of Mobile Genetic Elements in Clostridium difficile. | 2016 | Methods Mol. Biol. | pmid:27507343 |
| Barbanti F et al. | Transfer of Clostridium difficile Genetic Elements Conferring Resistance to Macrolide-Lincosamide-Streptogramin B (MLSB) Antibiotics. | 2016 | Methods Mol. Biol. | pmid:27507342 |
| Gaglio R et al. | Evaluation of antimicrobial resistance and virulence of enterococci from equipment surfaces, raw materials, and traditional cheeses. | 2016 | Int. J. Food Microbiol. | pmid:27467501 |
| Burr LD et al. | Macrolide Treatment Inhibits Pseudomonas aeruginosa Quorum Sensing in Non-Cystic Fibrosis Bronchiectasis. An Analysis from the Bronchiectasis and Low-Dose Erythromycin Study Trial. | 2016 | Ann Am Thorac Soc | pmid:27464029 |
| Ben Salem I et al. | Removal of Penicillin G and Erythromycin with Ionizing Radiation Followed by Biological Treatment. | 2016 | Curr. Microbiol. | pmid:27447798 |
| Wu L et al. | Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells. | 2016 | PLoS ONE | pmid:27447724 |
| Kwon JW | Environmental impact assessment of veterinary drug on fish aquaculture for food safety. | 2016 | Drug Test Anal | pmid:27443211 |
| Mikhail M et al. | Orbital cellulitis and multiple abscess formation after strabismus surgery. | 2016 | Can. J. Ophthalmol. | pmid:27085279 |
| Chen Y et al. | TEMPO-oxidized Konjac glucomannan as appliance for the preparation of hard capsules. | 2016 | Carbohydr Polym | pmid:27083368 |
| Del Grosso M et al. | ICESpy009, a Conjugative Genetic Element Carrying mef(E) in Streptococcus pyogenes. | 2016 | Antimicrob. Agents Chemother. | pmid:27067338 |
| Aydin S | Enhanced biodegradation of antibiotic combinations via the sequential treatment of the sludge resulting from pharmaceutical wastewater treatment using white-rot fungi Trametes versicolor and Bjerkandera adusta. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27033714 |
| Shi HY et al. | [Effect of quorum sensing system on the infection of MRSA and the intervention of erythromycin on it]. | 2016 | Zhonghua Yi Xue Za Zhi | pmid:27760665 |
| Hsieh PF et al. | The Klebsiella pneumoniae YfgL (BamB) lipoprotein contributes to outer membrane protein biogenesis, type-1 fimbriae expression, anti-phagocytosis, and in vivo virulence. | 2016 | Virulence | pmid:27029012 |
| Baker KR et al. | A High-Throughput Approach To Identify Compounds That Impair Envelope Integrity in Escherichia coli. | 2016 | Antimicrob. Agents Chemother. | pmid:27458225 |
| Juda M et al. | The prevalence of genotypes that determine resistance to macrolides, lincosamides, and streptogramins B compared with spiramycin susceptibility among erythromycin-resistant Staphylococcus epidermidis. | 2016 | Mem. Inst. Oswaldo Cruz | pmid:27008373 |
| Cui B et al. | Selection of suitable reference genes for gene expression studies in Staphylococcus capitis during growth under erythromycin stress. | 2016 | Mol. Genet. Genomics | pmid:27000656 |
| Lewis K et al. | The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials. | 2016 | Crit Care | pmid:27527069 |
| Zhang A et al. | Molecular subtyping and erythromycin resistance of Campylobacter in China. | 2016 | J. Appl. Microbiol. | pmid:26999516 |
| Pierattini EC et al. | Morpho-physiological response of Populus alba to erythromycin: A timeline of the health status of the plant. | 2016 | Sci. Total Environ. | pmid:27366984 |
| Mukai S et al. | Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. | 2016 | Int. J. Oncol. | pmid:26718641 |
| Sousa M et al. | Genetic Diversity and Antibiotic Resistance Among Coagulase-Negative Staphylococci Recovered from Birds of Prey in Portugal. | 2016 | Microb. Drug Resist. | pmid:26990729 |
| He HJ et al. | Erythromycin resistance features and biofilm formation affected by subinhibitory erythromycin in clinical isolates of Staphylococcus epidermidis. | 2016 | J Microbiol Immunol Infect | pmid:24768213 |
| Bhadra PK et al. | Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B. | 2016 | Org. Biomol. Chem. | pmid:27273525 |
| Morroni G et al. | Enterococcus faecium ST17 from Coastal Marine Sediment Carrying Transferable Multidrug Resistance Plasmids. | 2016 | Microb. Drug Resist. | pmid:26982016 |
| Topp E et al. | Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. | 2016 | Sci. Total Environ. | pmid:27096634 |
| Katayama Y et al. | Neuroprotective effects of erythromycin on ischemic injury following permanent focal cerebral ischemia in rats. | 2016 | Neurol. Res. | pmid:27078702 |
| Lenart-Boroń A et al. | Phenotypic and Molecular Antibiotic Resistance Determination of Airborne Coagulase Negative Staphylococcus spp. Strains from Healthcare Facilities in Southern Poland. | 2016 | Microb. Drug Resist. | pmid:26978225 |
| Li X et al. | Macrolides use and the risk of sudden cardiac death. | 2016 | Expert Rev Anti Infect Ther | pmid:27086751 |
| Barros RR et al. | Polyclonal spread of Streptococcus agalactiae resistant to clindamycin among pregnant women in Brazil. | 2016 | J. Antimicrob. Chemother. | pmid:27029847 |
| Seefeldt AC et al. | Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. | 2016 | Nucleic Acids Res. | pmid:26792896 |
| Li M et al. | Sugar-Grafted Cyclodextrin Nanocarrier as a "Trojan Horse" for Potentiating Antibiotic Activity. | 2016 | Pharm. Res. | pmid:26792570 |
| Lapierre L et al. | Characterization of Antimicrobial Susceptibility and Its Association with Virulence Genes Related to Adherence, Invasion, and Cytotoxicity in Campylobacter jejuni and Campylobacter coli Isolates from Animals, Meat, and Humans. | 2016 | Microb. Drug Resist. | pmid:26779841 |
| Pan M and Chu LM | Phytotoxicity of veterinary antibiotics to seed germination and root elongation of crops. | 2016 | Ecotoxicol. Environ. Saf. | pmid:26773832 |
| Rodrigues S et al. | Acute and chronic effects of erythromycin exposure on oxidative stress and genotoxicity parameters of Oncorhynchus mykiss. | 2016 | Sci. Total Environ. | pmid:26760278 |
| Cheng Y et al. | Comparative study between macrolide regulatory proteins MphR(A) and MphR(E) in ligand identification and DNA binding based on the rapid in vitro detection system. | 2016 | Anal Bioanal Chem | pmid:26753969 |
| Entorf M et al. | Comparative erythromycin and tylosin susceptibility testing of streptococci from bovine mastitis. | 2016 | Vet. Microbiol. | pmid:26732695 |
| Gupta P et al. | Nascent peptide assists the ribosome in recognizing chemically distinct small molecules. | 2016 | Nat. Chem. Biol. | pmid:26727240 |
| Nenquin M and Henquin JC | Sulphonylurea receptor-1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells. | 2016 | Diabetes Obes Metab | pmid:26584950 |
| Arenz S et al. | A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. | 2016 | Nat Commun | pmid:27380950 |
| Wu H et al. | In vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26552796 |
| Berg L et al. | [Cutaneous diphtheria after a minor injury in Sri Lanka]. | 2016 | Hautarzt | pmid:26525966 |
| Takahashi T et al. | Epidemiological study of erythromycin-resistant Streptococcus pyogenes from Korea and Japan by emm genotyping and multilocus sequence typing. | 2016 | Ann Lab Med | pmid:26522753 |
| Li J et al. | Rhubarb to Facilitate Placement of Nasojejunal Feeding Tubes in Patients in the Intensive Care Unit. | 2016 | Nutr Clin Pract | pmid:26459161 |
| Boetsch C et al. | Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions. | 2016 | Clin Pharmacokinet | pmid:26341813 |
| Giuliano MW and Miller SJ | Site-Selective Reactions with Peptide-Based Catalysts. | 2016 | Top Curr Chem | pmid:26307403 |
| Snoeys J et al. | Mechanistic understanding of the nonlinear pharmacokinetics and intersubject variability of simeprevir: A PBPK-guided drug development approach. | 2016 | Clin. Pharmacol. Ther. | pmid:26259716 |
| Naik KM and Nandibewoor ST | Investigation into the interaction of methylparaben and erythromycin with human serum albumin using multispectroscopic methods. | 2016 | Luminescence | pmid:26239839 |