erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Carbonell N et al. | Erythromycin infusion prior to endoscopy for acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trial. | 2006 | Am. J. Gastroenterol. | pmid:16771939 |
Glupczynski Y and Burette A | Failure of azythromycin to eradicate Campylobacter pylori from the stomach because of acquired resistance during treatment. | 1990 | Am. J. Gastroenterol. | pmid:2153337 |
Maganti K et al. | Oral erythromycin and symptomatic relief of gastroparesis: a systematic review. | 2003 | Am. J. Gastroenterol. | pmid:12591038 |
Janssen P et al. | The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. | 2013 | Am. J. Gastroenterol. | pmid:24005344 |
DiBaise JK et al. | Effects of low doses of erythromycin on the 13C Spirulina platensis gastric emptying breath test and electrogastrogram: a controlled study in healthy volunteers. | 2001 | Am. J. Gastroenterol. | pmid:11467630 |
DITTLER EL | Upper abdominal pain and intrahepatic cholestasis as manifestations of sensitivity to ilosone. | 1962 | Am. J. Gastroenterol. | pmid:14028076 |
VIRANUVATTI V and BISESHURARIT P | Clinical trial of erythromycin in amebic liver abscess. | 1955 | Am. J. Gastroenterol. | pmid:13228406 |
Hakkal HG | Pseudomembraneous colitis associated with antibiotics. | 1976 | Am. J. Gastroenterol. | pmid:1274934 |
Jones KL et al. | The effect of erythromycin on gastric emptying is modified by physiological changes in the blood glucose concentration. | 1999 | Am. J. Gastroenterol. | pmid:10445530 |
Fiorucci S et al. | Effect of erythromycin on gastric and gallbladder emptying and gastrointestinal symptoms in scleroderma patients is maintained medium term. | 1994 | Am. J. Gastroenterol. | pmid:8147358 |
Rayner CK et al. | The stimulation of antral motility by erythromycin is attenuated by hyperglycemia. | 2000 | Am. J. Gastroenterol. | pmid:11007223 |
Resnick J et al. | Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part II. | 1997 | Am. J. Gastroenterol. | pmid:9177505 |
Camilleri M | The current role of erythromycin in the clinical management of gastric emptying disorders. | 1993 | Am. J. Gastroenterol. | pmid:8424415 |
Keshavarzian A and Isaac RM | Erythromycin accelerates gastric emptying of indigestible solids and transpyloric migration of the tip of an enteral feeding tube in fasting and fed states. | 1993 | Am. J. Gastroenterol. | pmid:8424419 |
Mantides A et al. | The effect of erythromycin in gastric emptying of solids and hypertonic liquids in healthy subjects. | 1993 | Am. J. Gastroenterol. | pmid:8424420 |
Richards RD et al. | The treatment of idiopathic and diabetic gastroparesis with acute intravenous and chronic oral erythromycin. | 1993 | Am. J. Gastroenterol. | pmid:8424421 |
Bonacini M et al. | Effect of intravenous erythromycin on postoperative ileus. | 1993 | Am. J. Gastroenterol. | pmid:8424422 |
Weber FH et al. | Erythromycin: a motilin agonist and gastrointestinal prokinetic agent. | 1993 | Am. J. Gastroenterol. | pmid:8470625 |
McNulty CA | The treatment of Campylobacter-associated gastritis. | 1987 | Am. J. Gastroenterol. | pmid:3493685 |
Koutsoumbi P et al. | The effect of erythromycin on human esophageal motility is mediated by serotonin receptors. | 2000 | Am. J. Gastroenterol. | pmid:11151866 |
Portincasa P et al. | The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones: a randomized, placebo-controlled ultrasonographic study. | 2000 | Am. J. Gastroenterol. | pmid:11151875 |
Carmagnola S et al. | Mechanoreceptors of the proximal stomach and perception of gastric distension. | 2005 | Am. J. Gastroenterol. | pmid:16086705 |
Ecker JA et al. | Pseudomembraneous enterocolitis--an unwelcome gastrointestinal complication of antibiotic therapy. | 1970 | Am. J. Gastroenterol. | pmid:4319211 |
Kalkay MN et al. | Campylobacter-induced toxic megacolon. | 1983 | Am. J. Gastroenterol. | pmid:6613968 |
Laine L and Jensen DM | Management of patients with ulcer bleeding. | 2012 | Am. J. Gastroenterol. | pmid:22310222 |
Slotkin RI et al. | The effect of antibiotics on Mycoplasma pneumoniae in vitro and in vivo. | 1967 | Am. J. Epidemiol. | pmid:5006447 |
Derrick CW and Dillon HC | Erythromycin therapy for streptococcal pharyngitis. | 1976 | Am. J. Dis. Child. | pmid:766615 |
BURNS L and HODGMAN J | STUDIES OF PREMATURES GIVEN ERYTHROMYCIN ESTOLATE. | 1963 | Am. J. Dis. Child. | pmid:14057607 |
Bass JW et al. | Antimicrobials in the treatment of acute otitis media. A second clinical trial. | 1973 | Am. J. Dis. Child. | pmid:4632555 |
Pai CH et al. | Erythromycin in treatment of Campylobacter enteritis in children. | 1983 | Am. J. Dis. Child. | pmid:6600579 |
Disney FA and Pichichero ME | Treatment of Staphylococcus aureus infections in children in office practice. | 1983 | Am. J. Dis. Child. | pmid:6600877 |
Aiello LF and Luby JP | Concomitant Mycoplasma and adenovirus infection in a family. | 1974 | Am. J. Dis. Child. | pmid:4374082 |
Lloyd-Still JD et al. | Erythromycin estolate hepatotoxicity. | 1978 | Am. J. Dis. Child. | pmid:629252 |
Wannamaker LW | Perplexity and precision in the diagnosis of streptococcal pharyngitis. | 1972 | Am. J. Dis. Child. | pmid:5056872 |
Fischer PR and Shigeoka AO | Familial occurrence of Stevens-Johnson syndrome. | 1983 | Am. J. Dis. Child. | pmid:6604452 |
HUXTABLE KA et al. | STAPHYLOCOCCAL PNEUMONIA IN CHILDHOOD; LONG-TERM FOLLOW-UP. | 1964 | Am. J. Dis. Child. | pmid:14168063 |
Feigin RD et al. | Osteomyelitis of the calcaneus. Report of eight cases. | 1970 | Am. J. Dis. Child. | pmid:5410295 |
Sprauer MA et al. | Prevention of secondary transmission of pertussis in households with early use of erythromycin. | 1992 | Am. J. Dis. Child. | pmid:1733147 |
Dillon HC and Ware JC | Sources and susceptibilities of staphylococci isolated from children. A seven-year survey. | 1981 | Am. J. Dis. Child. | pmid:7234768 |
Breese BB et al. | Streptococcal infections in children. Comparison of the therapeutic effectiveness of erythromycin administered twice daily with erythromycin, penicillin phenoxymethyl, and clindamycin administered three times daily. | 1974 | Am. J. Dis. Child. | pmid:4213398 |
Warkany J | A warfarin embryopathy? | 1975 | Am. J. Dis. Child. | pmid:1121959 |
Khuri-Bulos N et al. | Bacteroides brain abscess treated with clindamycin. | 1973 | Am. J. Dis. Child. | pmid:4723176 |
Davis SD et al. | Partial antibiotic therapy in Haemophilus infuenzae meningitis. Its effect on cerebrospinal fluid abnormalities. | 1975 | Am. J. Dis. Child. | pmid:1080009 |
Hughes WT and Wan RT | Impetigo contagiosa: etiology, complications, and comparison of therapeutic effectiveness of erythromycin and antibiotic ointment. | 1967 | Am. J. Dis. Child. | pmid:4290285 |
Breese BB et al. | B-hemolytic streptococcal illness. A comparison of the effectiveness of penicillin G, triacetyloleandomycin, and erythromycin estolate. | 1966 | Am. J. Dis. Child. | pmid:5322797 |
Lascari AD et al. | Varicella-like rash associated with Mycoplasma infection. | 1974 | Am. J. Dis. Child. | pmid:4855375 |
Klugman KP et al. | Clinical and nasopharyngeal isolates of unusual multiply resistant pneumococci. | 1986 | Am. J. Dis. Child. | pmid:3766492 |
Halsey NA et al. | Nosocomial pertussis: a failure of erythromycin treatment and prophylaxis. | 1980 | Am. J. Dis. Child. | pmid:7377164 |
HALTALIN KC and NELSON JD | HAND-FOOT SYNDROME DUE TO STREPTOCOCCAL INFECTION. | 1965 | Am. J. Dis. Child. | pmid:14237416 |
Bass JW et al. | Susceptibility of Bordetella pertussis to nine antimicrobial agents. | 1969 | Am. J. Dis. Child. | pmid:4303822 |