erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Raczyńska-Bojanowska K et al. | Carboxylation of propionyl-CoA in erythromycin biosynthesis. | 1970 | Acta Biochim. Pol. | pmid:5495362 |
Ruczaj Z et al. | On the release of enzymes upon lysozyme treatment of Streptomyces. | 1969 | Acta Biochim. Pol. | pmid:4312597 |
Tixador R et al. | Preliminary results of Cytos 2 experiment. | 1985 | Acta Astronaut | pmid:11542841 |
Kasey CM et al. | Development of Transcription Factor-Based Designer Macrolide Biosensors for Metabolic Engineering and Synthetic Biology. | 2018 | ACS Synth Biol | pmid:28950701 |
McCusker KP and Fujimori DG | The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance. | 2012 | ACS Chem. Biol. | pmid:22208312 |
Koryakina I et al. | Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. | 2017 | ACS Chem. Biol. | pmid:28103677 |
Sundermann U et al. | Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase. | 2013 | ACS Chem. Biol. | pmid:23181268 |
Buchholz TJ et al. | Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. | 2009 | ACS Chem. Biol. | pmid:19146481 |
Leirós M et al. | Mitigation of ROS insults by Streptomyces secondary metabolites in primary cortical neurons. | 2014 | ACS Chem Neurosci | pmid:24219236 |
Wang X et al. | Mesoporous titanium zirconium oxide nanospheres with potential for drug delivery applications. | 2013 | ACS Appl Mater Interfaces | pmid:24150740 |