erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Prueksaritanont T et al. | Simvastatin does not affect CYP3A activity, quantified by the erythromycin breath test and oral midazolam pharmacokinetics, in healthy male subjects. | 2000 | J Clin Pharmacol | pmid:11075313 |
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Putrament A et al. | Manganese mutagenesis in yeast. IV. The effects of magnesium, protein synthesis inhibitors and hydroxyurea on AntR induction in mitochondrial DNA. | 1975 | Mol. Gen. Genet. | pmid:1107804 |
Salvatore P et al. | A new vector for insertion of any DNA fragment into the chromosome of transformable Neisseriae. | 2000 | Plasmid | pmid:11078653 |
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Singh KV et al. | Efficacy of telithromycin (HMR 3647) against enterococci in a mouse peritonitis model. | 2000 | Antimicrob. Agents Chemother. | pmid:11083653 |
Mikoc A et al. | Construction and characterization of a Streptomyces rimosus recA mutant: the RecA-deficient strain remains viable. | 2000 | Mol. Gen. Genet. | pmid:11085261 |
Gouda H et al. | Three-dimensional structure-activity relationship analysis between motilin and motilide using conformational analysis and a novel molecular superposing method. | 2000 | Chem. Pharm. Bull. | pmid:11086932 |
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Giovanetti E et al. | In vitro activity of ketolides telithromycin and HMR 3004 against italian isolates of Streptococcus pyogenes and Streptococcus pneumoniae with different erythromycin susceptibility. | 2000 | J. Antimicrob. Chemother. | pmid:11102408 |
Granizo JJ et al. | Streptococcus pyogenes resistance to erythromycin in relation to macrolide consumption in Spain (1986-1997). | 2000 | J. Antimicrob. Chemother. | pmid:11102415 |
Johansen HK et al. | Antagonism between penicillin and erythromycin against Streptococcus pneumoniae in vitro and in vivo. | 2000 | J. Antimicrob. Chemother. | pmid:11102417 |
Andrews JM et al. | The in vitro activity of ABT773, a new ketolide antimicrobial agent. | 2000 | J. Antimicrob. Chemother. | pmid:11102425 |
Bird PA and Sturgess AD | Clinical ergotism with severe bilateral upper limb ischaemia precipitated by an erythromycin--ergotamine drug interaction. | 2000 | Aust N Z J Med | pmid:11108077 |
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Bar J et al. | Effect of antibiotic therapy in preterm premature rupture of the membranes on neonatal mortality and morbidity. | 2000 | Am J Perinatol | pmid:11110340 |
Schumacher J et al. | Surgical and medical treatment of an Arabian filly with proliferative enteropathy caused by Lawsonia intracellularis. | 2000 Nov-Dec | J. Vet. Intern. Med. | pmid:11110386 |
Laven RA and Proven MJ | Use of an antibiotic footbath in the treatment of bovine digital dermatitis. | 2000 | Vet. Rec. | pmid:11110490 |
Carević O et al. | Correlation between erythromycin and acid phosphatase in mouse liver. | 1975 | Biochim. Biophys. Acta | pmid:1111590 |
Brennan S et al. | Directed neutrophil migration to IL-8 is increased in cystic fibrosis: a study of the effect of erythromycin. | 2001 | Thorax | pmid:11120907 |
Credito KL et al. | Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 compared to their susceptibilities to 11 other agents. | 2001 | Antimicrob. Agents Chemother. | pmid:11120946 |
Singh KV et al. | Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility. | 2001 | Antimicrob. Agents Chemother. | pmid:11120975 |
Palavecino EL et al. | Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile. | 2001 | Antimicrob. Agents Chemother. | pmid:11120993 |
Syrogiannopoulos GA et al. | Identification of an erm(A) erythromycin resistance methylase gene in Streptococcus pneumoniae isolated in Greece. | 2001 | Antimicrob. Agents Chemother. | pmid:11120994 |
Citron DM and Appleman MD | Comparative in vitro activities of ABT-773 against 362 clinical isolates of anaerobic bacteria. | 2001 | Antimicrob. Agents Chemother. | pmid:11120995 |